In:
Medicine & Science in Sports & Exercise, Ovid Technologies (Wolters Kluwer Health), Vol. 52, No. 7 ( 2020-7), p. 1456-1469
Abstract:
This study aimed to examine the effects of treadmill training on anxious–depressive-like behaviors of transgenic Alzheimer rats in the early stage of Alzheimer’s disease (AD) and provided evidence of exercise in alleviating fear-avoidance behavior deficits. Methods Male 2-month-old TgF344-AD and wild-type rats were divided into wild-type ( n = 9), AD ( n = 8), and AD + treadmill exercise (Exe) groups ( n = 12). After 8 months of exercise, the passive avoidance test, Barnes maze task, novel object recognition test, and object location test were used to measure learning and memory function. The open-field test, elevated plus maze, sucrose preference test, and forced swim test were conducted to determine the anxious–depressive-like behavior of AD rats. Immunofluorescence staining, Western blot analysis, enzyme-linked immunosorbent assay analysis, and related assay kits were used to measure inflammatory cytokines, oxidative stress, amyloid-β production, and tau hyperphosphorylation. Results Behavioral tests revealed that 12-month-old animals did not show any spatial learning and memory deficits but did display anxious–depressive-like behavior (open field, center time: P = 0.008; center entries: P = 0.009; line crossings: P = 0.001). However, long-term exercise significantly inhibited anxious–depressive-like behavior in AD rats (center time: P = 0.016; center entries: P = 0.004; line crossings: P = 0.033). In addition, these animals displayed increased amyloid-β deposition, tau hyperphosphorylation, microgliosis, inflammatory cytokines release, and oxidative damage, which were attenuated significantly by long-term exercise training. Conclusion Long-term exercise training alleviated anxious–depressive-like behavior and improved fear-avoidance behavior in transgenic AD rats, supporting exercise training as an effective approach to prevent anxiety, depression, and fear-avoidance behavior deficits in the early stages of AD pathogenesis.
Type of Medium:
Online Resource
ISSN:
1530-0315
,
0195-9131
DOI:
10.1249/MSS.0000000000002294
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2020
detail.hit.zdb_id:
603994-7
detail.hit.zdb_id:
2031167-9
SSG:
31
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