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  • 1
    Online Resource
    Online Resource
    DOCK2 is involved in the host genetics and biology of severe COVID-19
    Springer Science and Business Media LLC ; 2022
    In:  Nature Vol. 609, No. 7928 ( 2022-09-22), p. 754-760
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 609, No. 7928 ( 2022-09-22), p. 754-760
    Abstract: Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1–5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene ( DOCK2 ), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis ( n  = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/s41586-022-05163-5
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Six-mode scrambler based on cascaded side-wall grating waveguides
    IOP Publishing ; 2021
    In:  Japanese Journal of Applied Physics Vol. 60, No. 6 ( 2021-06-01), p. 062002-
    Details
    In: Japanese Journal of Applied Physics, IOP Publishing, Vol. 60, No. 6 ( 2021-06-01), p. 062002-
    Abstract: A six-mode scrambler based on cascaded side-wall long-period-grating waveguides on a silica planar lightwave circuit (PLC) platform is proposed for mode-division-multiplexing (MDM) transmission. The device can be fabricated with only one-step etching since it does not use a surface grating. A mode-dependent loss (MDL) of the system is estimated and the MDL can be reduced with a multiple scrambling operation. Two gratings proposed here and a fiber-pigtailed module containing these gratings are fabricated and the expected proof-of-concept mode scrambling operation is confirmed. It is found that the connection between few-mode fiber (FMF) and PLC chip seems to be the dominant loss of the module. Considering these losses, the measured results are in good agreement with the calculated results.
    Type of Medium: Online Resource
    ISSN: 0021-4922 , 1347-4065
    URL: Article
    DOI: 10.35848/1347-4065/abfa31
    RVK:
    UA 4210.1
    RVK:
    UA 4210.2
    RVK:
    UA 4210
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 218223-3
    detail.hit.zdb_id: 797294-5
    detail.hit.zdb_id: 2006801-3
    detail.hit.zdb_id: 797295-7
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  • 3
    Online Resource
    Online Resource
    Even-denominator fractional quantum Hall state in conventional triple-gated quantum point contact
    IOP Publishing ; 2022
    In:  Applied Physics Express Vol. 15, No. 2 ( 2022-02-01), p. 025002-
    Details
    In: Applied Physics Express, IOP Publishing, Vol. 15, No. 2 ( 2022-02-01), p. 025002-
    Abstract: The even-denominator states have attracted considerable attention owing to their possible applications in future quantum technologies. In this letter, we first report a 3/2 diagonal resistance, indicating the existence of a 3/2 state in a nanometer-sized triple-gated quantum point contact (QPC) fabricated on a high-mobility (not ultra-high-mobility) single-layer two-dimensional (2D) GaAs wafer. The center gate plays a crucial role in realizing the QPC’s 3/2 state. Our observation of the 3/2 state using a conventional QPC device, which is a suitable building block for semiconductor quantum devices, paves a new path for the development of semiconductor-based quantum technologies.
    Type of Medium: Online Resource
    ISSN: 1882-0778 , 1882-0786
    URL: Article
    DOI: 10.35848/1882-0786/ac4c35
    RVK:
    UA 2244
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2417569-9
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  • 4
    Online Resource
    Online Resource
    Detections of [C ii] 158 μm and [O iii] 88 μm in a Local Lyman Continuum Emitter, Mrk 54, and Its Implications to High-redshift ALMA Studies*
    American Astronomical Society ; 2023
    In:  The Astrophysical Journal Vol. 948, No. 1 ( 2023-05-01), p. 3-
    Details
    In: The Astrophysical Journal, American Astronomical Society, Vol. 948, No. 1 ( 2023-05-01), p. 3-
    Abstract: We present integral field, far-infrared (FIR) spectroscopy of Mrk 54, a local Lyman continuum emitter, obtained with FIFI-LS on the Stratospheric Observatory for Infrared Astronomy. This is only the second time, after Haro 11, that [C ii ] 158 μ m and [O iii ] 88 μ m spectroscopy of the known LCEs have been obtained. We find that Mrk 54 has a strong [C ii ] emission that accounts for ∼1% of the total FIR luminosity, whereas it has only moderate [O iii ] emission, resulting in the low [O iii ]/[C ii ] luminosity ratio of 0.22 ± 0.06. In order to investigate whether [O iii ]/[C ii ] is a useful tracer of f esc (LyC escape fraction), we examine the correlations of [O iii ]/[C ii ] and (i) the optical line ratio of O 32 ≡ [O iii ] 5007 Å/[O ii ] 3727 Å, (ii) specific star formation rate, (iii) [O iii ] 88 μ m/[O i ] 63 μ m ratio, (iv) gas-phase metallicity, and (v) dust temperature based on a combined sample of Mrk 54 and the literature data from the Herschel Dwarf Galaxy Survey and the LITTLE THINGS Survey. We find that galaxies with high [O iii ]/[C ii ] luminosity ratios could be the result of high ionization (traced by O 32 ), bursty star formation, high ionized-to-neutral gas volume filling factors (traced by [O iii ] 88 μ m/[O i ] 63 μ m), and low gas-phase metallicities, which is in agreement with theoretical predictions. We present an empirical relation between the [O iii ]/[C ii ] ratio and f esc based on the combination of the [O iii ]/[C ii ] and O 32 correlation, and the known relation between O 32 and f esc . The relation implies that high-redshift galaxies with high [O iii ]/[C ii ] ratios revealed by the Atacama Large Millimeter/submillimeter Array may have f esc ≳ 0.1, significantly contributing to the cosmic reionization.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    URL: Article
    DOI: 10.3847/1538-4357/acc530
    RVK:
    UA 1000
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2023
    detail.hit.zdb_id: 2207648-7
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
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