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  • 2020-2024  (1,367)
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  • 1
    Online Resource
    Online Resource
    The mutation spectrum of Parkinson‐disease ‐related genes in early‐onset Parkinson's disease in ethnic Chinese
    Wiley ; 2022
    In:  European Journal of Neurology Vol. 29, No. 11 ( 2022-11), p. 3218-3228
    Details
    In: European Journal of Neurology, Wiley, Vol. 29, No. 11 ( 2022-11), p. 3218-3228
    Abstract: Recent genetic progress has shown many causative/risk genes linked to Parkinson's disease (PD), mainly in patients of European ancestry. The study aimed to investigate the PD‐related genes and determine the mutational spectrum of early‐onset PD in ethnic Chinese. Methods In this study, whole‐exome sequencing and/or gene dosage analysis were performed in 704 early‐onset PD (EOPD) patients (onset age ≤45 years) and 1866 controls. Twenty‐six PD‐related genes and 20 other genes linked to neurodegenerative and lysosome diseases were analysed. Results Eighty‐two (11.6%, 82/704) EOPD patients carrying rare pathogenic/likely pathogenic variants in PD‐related genes were identified. The mutation frequency in autosomal recessive inheritance EOPD (42.9%, 27/63) was much higher than that in autosomal dominant inheritance EOPD (0.9%, 12/110) or sporadic EOPD (8.1%, 43/531). Bi‐allelic mutations in PRKN were the most frequent, accounting for 5.1% of EOPD cases. Three common pathogenic variants, p.A53V in SNCA , p.G284R in PRKN and p.P53Afs*38 in CHCHD2 , occur exclusively in Asians. The putative damaging variants from GBA , PRKN , DJ1 , PLA2G6 and GCH1 contributed to the collective risk for EOPD. Notably, the protein‐truncating variants in CHCHD2 were enriched in EOPD, especially for p.P53Afs*38, which was also found in three patients from an independent cohort of patients with late‐onset PD ( n  = 1300). Functional experiments confirmed that truncated CHCHD2 variants cause loss of function and are linked to mitochondrial dysfunction. Conclusions Our study reveals that the genetic spectrum of EOPD in Chinese, which may help develop genetic scanning strategies, provided more evidence supporting CHCHD2 in PD.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.v29.11
    DOI: 10.1111/ene.15509
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020241-6
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  • 2
    Online Resource
    Online Resource
    Effects of Short‐Peptide‐Based Enteral Nutrition on the Intestinal Microcirculation and Mucosal Barrier in Mice with Severe Acute Pancreatitis
    Wiley ; 2020
    In:  Molecular Nutrition & Food Research Vol. 64, No. 5 ( 2020-03)
    Details
    In: Molecular Nutrition & Food Research, Wiley, Vol. 64, No. 5 ( 2020-03)
    Abstract: Short‐peptide‐based enteral nutrition (SPEN) is absorbed more efficiently in patients with severe acute pancreatitis (SAP). More importantly, SPEN decreases SAP‐induced enterogenous infection risk. This study aims to investigate whether SPEN alleviates intestinal bacterial translocation in mice with SAP, and the underlying mechanisms. Methods and results The SAP model is established after pre‐treatment with SPEN or intact‐protein‐based enteral nutrition. Although there is no improvement in pancreas injury, as evaluated through Hematoxylin‐Eosin staining or serum amylase, SPEN obviously attenuates intestinal bacterial translocation after SAP. To unveil the mechanisms, it is found that the intestinal mechanical barrier destroyed by SAP is significantly relieved by SPEN, which presents with recovered ZO‐1 expression, mucus layer, and goblet cell function. Additionally, SPEN alleviates local CCR6/CCL20 induced CD11c + dendritic cell infiltration, systemic immunosuppression, and inhibits the secretion of luminal secretory immunoglobulin A. Possibly responsible for SAP‐induced mucosal dysfunctions, destroyed intestinal mucosal microcirculation and local hypoxia are largely improved in SAP+SPEN group. Conclusion SPEN can improve downregulated intestinal mucosal microcirculation secondary to SAP, which may be responsible for mucosal inflammation relief, maintenance of the mechanical barrier and mucosal immunity, the correction of systemic immunosuppression, and play a protective role in defending commensal bacterial translocation after SAP.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    URL: Article
    DOI: 10.1002/mnfr.v64.5
    DOI: 10.1002/mnfr.201901191
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2160372-8
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Enrichment of rare variants of BIN1 but not APOE genes in Chinese patients with Parkinson's disease
    Wiley ; 2022
    In:  Journal of Internal Medicine Vol. 291, No. 5 ( 2022-05), p. 698-701
    Details
    In: Journal of Internal Medicine, Wiley, Vol. 291, No. 5 ( 2022-05), p. 698-701
    Type of Medium: Online Resource
    ISSN: 0954-6820 , 1365-2796
    URL: Issue
    URL: Article
    DOI: 10.1111/joim.v291.5
    DOI: 10.1111/joim.13444
    RVK:
    XA 54380
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2006883-9
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  • 4
    Online Resource
    Online Resource
    Intragenic heterochromatin‐mediated alternative polyadenylation modulates miRNA and pollen development in rice
    Wiley ; 2021
    In:  New Phytologist Vol. 232, No. 2 ( 2021-10), p. 835-852
    Details
    In: New Phytologist, Wiley, Vol. 232, No. 2 ( 2021-10), p. 835-852
    Abstract: Despite a much higher proportion of intragenic heterochromatin‐containing genes in crop genomes, the importance of intragenic heterochromatin in crop development remains unclear. Intragenic heterochromatin can be recognised by a protein complex, ASI1–AIPP1–EDM2 (AAE) complex, to regulate alternative polyadenylation. Here, we investigated the impact of rice ASI1 on global poly(A) site usage through poly(A) sequencing and ASI1‐dependent regulation on rice development. We found that OsASI1 is essential for rice pollen development and flowering. OsASI1 dysfunction has an important impact on global poly(A) site usage, which is closely related to heterochromatin marks. Intriguingly, OsASI1 interacts with the intronic heterochromatin of OsXRNL , a nuclear XRN family exonuclease gene involved in the processing of an miRNA precursor, to promote the processing of full‐length OsXRNL and regulate miRNA abundance. We found that OsASI1‐mediated regulation of pollen development partially depends on OsXRNL. Finally, we characterised the rice AAE complex and its involvement in alternative polyadenylation and pollen development. Our findings help to elucidate an epigenetic mechanism governing miRNA abundance and rice development, and provide a valuable resource for studying the epigenetic mechanisms of many important processes in crops.
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.v232.2
    DOI: 10.1111/nph.17635
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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  • 5
    Online Resource
    Online Resource
    Cervical Alignment of Patients with Basilar Invagination: A Radiological Study
    Wiley ; 2022
    In:  Orthopaedic Surgery Vol. 14, No. 3 ( 2022-03), p. 566-576
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 14, No. 3 ( 2022-03), p. 566-576
    Abstract: To investigate the cervical alignment and the relative range of motion (ROM) in patients with basilar invagination (BI). Methods A total of 40 BI cases (38.1 years old ± 17.9 years old, 19 male and 21 female) and 80 asymptomatic individuals (33.8 years old ± 10.8 years old, 40 male and 40 female) were included. The Skull‐C 2 /Skull‐BV, Skull‐C 7 , C 2 ‐C 7 /BV‐C 7 wall angles, C 0 ‐C 2 /C 0 ‐BV, C 0 ‐C 7 , C 1 ‐C 7 , and C 2 ‐C 7 /BV‐C 7 angles were measured in dynamic X‐ray images (including neutral, extension, and flexion positions). Correlation between the upper and lower cervical curvatures were analyzed. The total, extension, and flexion ROMs of these angles were calculated, respectively. Results The BI patients had a smaller C 0 ‐C 2 /C 0 ‐BV angle (18.2° ± 16.4° vs 30.9° ± 9.3°), but larger C 2 ‐C 7 /BV‐C 7 (32.2° ± 16.1° vs 19.4° ± 10.6°) and C 2 ‐C 7 /BV‐C 7 wall angles (37.8° ± 17.2° vs 23.6° ± 10.2°) than the control group in neutral position. The upper and lower curvatures correlated negatively in neutral ( r  = −0.371), extension ( r  = −0.429), and flexion ( r  = −0.648) positions among BI patients, as well as in extension position ( r  = −0.317) among control group. The BI patients presented smaller total ROMs in Skull‐C 2 /Skull‐BV (12.3° ± 16.6° vs 19.7° ± 10.9°), C 0 ‐C 2 /C 0 ‐BV (8.1° ± 11.1° vs 17.6° ± 10.5°), and C 0 ‐C 7 angles (57.8° ± 14.2° vs 78.3° ± 17.9°), but a larger total ROM in C 2 ‐C 7 /BV‐C 7 wall angle (52.8° ± 13.9° vs 27.0° ± 16.1°) than the control group. The BI patients also presented smaller extension ROMs in Skull‐C 2 /Skull‐BV (6.9° ± 9.4° vs 12.5° ± 9.3°), Skull‐C 7 (24.5° ± 10.9° vs 30.7° ± 12.5°), and C 0 ‐C 2 /C 0 ‐BV angles (4.4° ± 7.8° vs 9.9° ± 8.6°) than the control group. Moreover, the BI patients showed smaller absolute values of flexion ROMs in Skull‐C 2 /Skull‐BV (−5.2° ± 9.4° vs −7.3° ± 8.0°), C 0 ‐C 2 /C 0 ‐BV (−3.2° ± 8.8° vs −7.7° ± 8.7°), and C 0 ‐C 7 angles (−33.2° ± 13.0° vs −52.8° ± 19.2°), but a larger absolute value of flexion ROM in C 2 ‐C 7 /BV‐C 7 wall angle (−33.9° ± 14.8° vs −8.2° ± 15.1°). Conclusion The cervical spine was stiffer in BI patients than the asymptomatic individuals, especially in the upper cervical curvature. The negative correlation between upper and lower cervical curvatures was more obvious in BI patients.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.v14.3
    DOI: 10.1111/os.13212
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2483883-4
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  • 6
    Online Resource
    Online Resource
    Clinical, radiographic, and esthetic evaluation of immediate implant placement with buccal bone dehiscence in the anterior maxilla: A 1‐year prospective case series
    Wiley ; 2023
    In:  Clinical Implant Dentistry and Related Research Vol. 25, No. 1 ( 2023-02), p. 3-10
    Details
    In: Clinical Implant Dentistry and Related Research, Wiley, Vol. 25, No. 1 ( 2023-02), p. 3-10
    Abstract: To evaluate the clinical, radiographic, and esthetic outcomes of immediate implant placement with buccal bone dehiscence in the anterior maxilla. Methods In this case series, implants were inserted immediately after tooth extraction in sockets with buccal bone dehiscence. Guided bone regeneration (GBR) with a papilla preservation flap and simultaneous connective tissue grafting (CTG) was used. The following outcome variables were measured: mid‐facial mucosal recession, probing depth, bleeding on probing, Pink Esthetic Score (PES), marginal bone loss, and thickness of buccal bone plate (TBP). Results 12 patients were recruited. Stable mid‐facial mucosal level (−0.03 ± 0.17 mm) and excellent soft‐tissue esthetic outcomes (PES, 9.17 ± 0.72) were achieved at 1 year. The TBP at platform level was 2.01 ± 0.31 mm at 1‐year follow up with a resorption rate of 28.90% ± 15.14%. Conclusions Immediate implant placement using GBR performed with a papilla preservation approach and simultaneous CTG is a feasible treatment procedure in compromised extraction sockets in the anterior region. Favorable esthetic outcomes and buccal bone thickness were obtained. Further studies were needed to evaluate the long‐term tissue alteration.
    Type of Medium: Online Resource
    ISSN: 1523-0899 , 1708-8208
    URL: Issue
    URL: Article
    DOI: 10.1111/cid.v25.1
    DOI: 10.1111/cid.13154
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2094120-1
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  • 7
    Online Resource
    Online Resource
    Prognostic value of anti‐HBc quantification in hepatitis B virus related acute‐on‐chronic liver failure
    Wiley ; 2021
    In:  Journal of Gastroenterology and Hepatology Vol. 36, No. 5 ( 2021-05), p. 1291-1299
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 36, No. 5 ( 2021-05), p. 1291-1299
    Abstract: It has been reported that serum quantification of anti‐HBc (qAnti‐HBc) could predict antiviral response in chronic hepatitis B (CHB) patients, while its role in hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) remains unclear. Its implication in HBV‐ACLF was evaluated in this study. Methods Baseline serum qAnti‐HBc levels were retrospectively detected in HBV‐ACLF and CHB patients using recently developed double‐sandwich immunoassay. The association of qAnti‐HBc level with clinical outcomes was evaluated by multiple logistic regression. Nomogram was adopted to formulate an algorithm incorporating qAnti‐HBc for the prediction of survival in HBV‐ACLF. The post‐hospitalization of HBV‐ACLF patients were followed‐up for 1 year. Results Eighty‐eight HBV‐ACLF as training set, 80 HBV‐ACLF as validation set and 216 CHB cases were included. Serum qAnti‐HBc level was significantly higher in HBV‐ACLF (4.95 ± 0.54 log 10  IU/mL) than CHB patients (4.47 ± 0.84 log 10  IU/mL) ( P   〈  0.01). Among HBV‐ACLF cases, both in training and validation set, patients with poor outcomes had lower qAnti‐HBc level. Area under receiver operating characteristic curve of the novel qAnti‐HBc inclusive model was 0.82, superior to 0.73 from model for end‐stage liver disease scores ( P  = 0.018), which was confirmed in validation set. During follow‐up, the qAnti‐HBc level declined at month 3 and month 6, then plateaued at 3.84 log 10  IU/mL. Conclusions Serum qAnti‐HBc level was associated with disease severity and might be served as a novel biomarker in the prediction of HBV‐ACLF clinical outcomes. The underlying immunological mechanism warrants further investigation.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.v36.5
    DOI: 10.1111/jgh.15310
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2006782-3
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  • 8
    Online Resource
    Online Resource
    Accuracy of dynamic navigation in implant surgery: A systematic review and meta‐analysis
    Wiley ; 2021
    In:  Clinical Oral Implants Research Vol. 32, No. 4 ( 2021-04), p. 383-393
    Details
    In: Clinical Oral Implants Research, Wiley, Vol. 32, No. 4 ( 2021-04), p. 383-393
    Abstract: To assess the accuracy of dynamic computer‐assisted implant surgery. Materials and methods An electronic search up to March 2020 was conducted using PubMed, Embase, and the Cochrane Central Register of Controlled Trial to identify studies using dynamic navigation in implant surgery, and additional manual search was performed as well. Clinical trials and model studies were selected. The primary outcome was accuracy. A single‐arm meta‐analysis of continuous data was conducted. Meta‐regression was utilized for comparison on study design, guidance method, jaw, and systems. Results Ten studies, four randomized controlled trials (RCT) and six prospective studies, met the inclusion criteria. A total of 1,298 drillings and implants were evaluated. The meta‐analysis of the accuracy (five clinical trials and five model studies) revealed average global platform deviation, global apex deviation, and angular deviation were 1.02 mm, 95% CI (0.83, 1.21), 1.33 mm, 95% CI (0.98, 1.67), and 3.59°, 95% CI (2.09, 5.09). Meta‐regression shown no difference between model studies and clinical trials ( p  = .295, 0.336, 0.185), drilling holes and implant ( p  = .36, 0.279, 0.695), maxilla and mandible ( p  = .875, 0.632, 0.281), and five different systems ( p  = .762, 0.342, 0.336). Conclusion Accuracy of dynamic computer‐aided implant surgery reaches a clinically acceptable range and has potential in clinical usage, but more patient‐centered outcomes and socio‐economic benefits should be reported.
    Type of Medium: Online Resource
    ISSN: 0905-7161 , 1600-0501
    URL: Issue
    URL: Article
    DOI: 10.1111/clr.v32.4
    DOI: 10.1111/clr.13719
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2027104-9
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  • 9
    Online Resource
    Online Resource
    The responses of human gingival fibroblasts to magnesium‐doped titanium
    Wiley ; 2020
    In:  Journal of Biomedical Materials Research Part A Vol. 108, No. 2 ( 2020-02), p. 267-278
    Details
    In: Journal of Biomedical Materials Research Part A, Wiley, Vol. 108, No. 2 ( 2020-02), p. 267-278
    Abstract: The titanium (Ti) implant is widely used in implant dentistry; yet peri‐implantitis has always been one of the most common and serious complications. Here, we demonstrated that magnesium‐doping would be an effective way of enhancing the integration between implant surfaces and gingival tissues, which is critical to peri‐implant health. The magnesium (2.76–6.35 at %) was immobilized onto the titanium substrate by a magnesium plasma immersion ion implantation (Mg‐PIII) technique. Mg‐PIII treatments did not alter surface topographies of the original titanium substrate but improved its hydrophilicity. The in vitro study including cell viability, adhesion, proliferation, migration, and real‐time polymerase chain reaction assays disclosed improved adhesion, proliferation, migration, and extracellular matrix remodeling abilities of human gingival fibroblasts (HGFs) on the magnesium‐doped titanium. The results of western blot suggested that the Mg‐modified titanium induced the phosphorylation of AKT through the activation of PI3K. Our results revealed that magnesium‐doping would potentially enhance soft tissue sealings by promoting cellular functions of HGFs in a dose‐dependent manner, boding well for its applications on surfaces of implant necks in early peri‐implant soft tissue integrations.
    Type of Medium: Online Resource
    ISSN: 1549-3296 , 1552-4965
    URL: Issue
    URL: Article
    DOI: 10.1002/jbm.a.v108.2
    DOI: 10.1002/jbm.a.36813
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1477192-5
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Improved positional accuracy of dental implant placement using a haptic and machine‐vision‐controlled collaborative surgery robot: A pilot randomized controlled trial
    Wiley ; 2024
    In:  Journal of Clinical Periodontology Vol. 51, No. 1 ( 2024-01), p. 24-32
    Details
    In: Journal of Clinical Periodontology, Wiley, Vol. 51, No. 1 ( 2024-01), p. 24-32
    Abstract: To compare the implant accuracy, safety and morbidity between robot‐assisted and freehand dental implant placement. Materials and Methods Subjects requiring single‐site dental implant placement were recruited. Patients were randomly allocated to freehand implant placement and robot‐assisted implant placement. Differences in positional accuracy of the implant, surgical morbidity and complications were assessed. The significance of intergroup differences was tested with an intention‐to‐treat analysis and a per‐protocol (PP) analysis (excluding one patient due to calibration error). Results Twenty patients (with a median age of 37, 13 female) were included. One subject assigned to the robotic arm was excluded from the PP analysis because of a large calibration error due to the dislodgement of the index. For robot‐assisted and freehand implant placement, with the PP analysis, the median (25th–75th percentile) platform global deviation, apex global deviation and angular deviation were 1.23 (0.9–1.4) mm/1.9 (1.2–2.3) mm ( p = .03, the Mann–Whitney U ‐test), 1.40 (1.1–1.6) mm/2.1 (1.7–3.9) mm ( p 〈 .01) and 3.0 (0.9–6.0)°/6.7 (2.2–13.9)° ( p = .08), respectively. Both methods showed limited damage to the alveolar ridge and had similar peri‐ and post‐operative morbidity and safety. Conclusions Robot‐assisted implant placement enabled greater positional accuracy of the implant compared to freehand placement in this pilot trial. The robotic system should be further developed to simplify surgical procedures and improve accuracy and be validated in properly sized trials assessing the full spectrum of relevant outcomes.
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpe.v51.1
    DOI: 10.1111/jcpe.13893
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2026349-1
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