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  • Wiley  (226)
  • 2020-2024  (226)
  • 1
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    Online Resource
    Effect of Ampelopsis brevipedunculata (Maxim.) Trautv extract on a model of atopic dermatitis in HaCaT cells and mice
    Wiley ; 2023
    In:  Food Science & Nutrition
    Details
    In: Food Science & Nutrition, Wiley
    Abstract: Ampelopsis brevipedunculata (Maxim.) Trautv. has been used for a long time as a folk remedy. According to studies, it possesses anti‐inflammatory, antioxidant, and antibacterial properties. However, its effects on atopic dermatitis (AD) are poorly studied. Thus, we investigated the therapeutic effect of A. brevipedunculata (Maxim.) Trautv. extract (ABE‐M) on 2,4‐dinitrochlorobenzene (DNCB)‐induced AD. For in vitro analysis, keratinocytes cell lines (HaCaT cells) were used. To evaluate the gene and protein expression levels of cytokines and chemokines, TNF‐α/IFN‐γ‐stimulated HaCaT cells were treated with ABE‐M. The cells and the supernatant were collected, then gene and protein levels were analyzed by real‐time polymerase chain reaction and enzyme‐linked immunosorbent assay analysis. For in vivo analysis, BALB/c mice (6 weeks) were randomly separated into five groups ( n  = 5). The mice were applied DNCB and phosphate‐buffered saline, dexamethasone (DX) or ABE‐M (50, 100, and 200 mg/kg) was orally administrated for 28 days. At the end, ear tissues and blood were collected for histological analysis and evaluation of cytokines and chemokines. In keratinocytes, ABE‐M inhibited the protein and mRNA levels of chemokines, and cytokines exposed by TNF‐α/IFN‐γ. Similarly, the expression of chemokines was suppressed by ABE‐M in AD animal model induced by DNCB and the level of pro‐inflammatory cytokines was decreased in a dose‐dependent manner. Our research indicates that ABE‐M could be a candidate material that can be used to improve skin immunity enhancement, health, and beauty.
    Type of Medium: Online Resource
    ISSN: 2048-7177 , 2048-7177
    URL: Article
    DOI: 10.1002/fsn3.3610
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2703010-6
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  • 2
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    Effect of postoperative radiotherapy for patients with differentiated thyroid cancer
    Wiley ; 2023
    In:  Clinical Endocrinology Vol. 98, No. 6 ( 2023-06), p. 803-812
    Details
    In: Clinical Endocrinology, Wiley, Vol. 98, No. 6 ( 2023-06), p. 803-812
    Abstract: We evaluated the efficacy and safety of postoperative radiotherapy (PORT) for differentiated thyroid cancer (DTC) with high risk features. Materials and Methods This retrospective study analyzed 187 patients treated for DTC from 1985 to 2019. DTC referred to nonanaplastic thyroid cancer originating from follicular cells. PORT was defined as the administration of external beam radiation to the thyroid and regional lymph nodes following surgery for initially diagnosed DTC. The patients were included in the analysis if they received PORT or exhibited any of the following features: (a) pT4 or pN1b according to the 8th American Joint Committee on Cancer, (b) poorly differentiated thyroid cancer (PDTC), or (c) unfavourable variants such as anaplastic foci and etc. After 1:1 propensity matching, a total of 108 patients were analyzed according to PORT receipt. The median follow‐up duration of the matched group was 10.4 years. Results After matching, most of the variables became balanced, but the PORT group still had more PDTC and DTC with anaplastic foci. Radioactive iodine (RAI) was less frequently administered in the PORT group. PORT yielded a significantly higher 5‐year locoregional recurrence free survival (LRFS) than the No PORT group (5‐year LRFS 86.1% vs. 72.7%, p  = 0.022), but the 10‐year cancer specific survival (CSS) was similar between them (97.8% vs. 85.9%, p  = 0.122). The multivariable analysis indicated that PORT was a favourable prognostic factor (Hazard ratio 0.3, 95% Confidence interval 0.1–0.8, p  = 0.02) for LRFS, but not for CSS. Among 133 patients without PORT for initial disease, 39 of them received salvage surgery followed by salvage PORT. No severe toxicity after PORT was reported. Conclusion PORT reduced locoregional recurrence in DTC patients without severe toxicity. PORT can be an effective and safe treatment to improve locoregional control in DTC with high risk features. However, further study is warranted to identify those who can benefit from PORT.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.v98.6
    DOI: 10.1111/cen.14865
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2004597-9
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  • 3
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    Experimental investigation of esophageal reconstruction with electrospun polyurethane nanofiber and 3D printing polycaprolactone scaffolds using a rat model
    Wiley ; 2021
    In:  Head & Neck Vol. 43, No. 3 ( 2021-03), p. 833-848
    Details
    In: Head & Neck, Wiley, Vol. 43, No. 3 ( 2021-03), p. 833-848
    Abstract: We evaluated the outcome of esophageal reconstructions using tissue‐engineered scaffolds. Method Partial esophageal defects were reconstructed with the following scaffolds; animals were grouped (n = 7 per group) as follows: (a) normal rats; (b) rats implanted with three‐dimensional printing (3DP) polycaprolactone (PCL) scaffolds; (c) with human adipose‐derived mesenchymal stem cell (ADSC)‐seeded 3DP PCL scaffolds; (d) with polyurethane (PU)‐nanofiber(Nf) scaffolds; and (e) with ADSC‐seeded PU‐Nf scaffolds. Results The esophageal defects were successfully repaired; however, muscle regeneration was greater in the 3DP PCL + ADSC groups than in the PU‐Nf + ADSC groups ( P   〈  .001). Regeneration of the epithelium was greater in PU‐Nf and PU‐Nf + ADSC groups than in the 3DP PCL and 3DP PCL + ADSC groups ( P   〈  .001). Conclusion A tendency for more re‐epithelization was observed with the PU‐Nf scaffolds, while more muscle regeneration was achieved with the 3DP PCL scaffolds.
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v43.3
    DOI: 10.1002/hed.26540
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2001440-5
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  • 4
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    New Acetohydrazides Incorporating 2‐Oxoindoline and 4‐Oxoquinazoline: Synthesis and Evaluation of Cytotoxicity and Caspase Activation Activity
    Wiley ; 2020
    In:  Chemistry & Biodiversity Vol. 17, No. 3 ( 2020-03)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 17, No. 3 ( 2020-03)
    Abstract: In our search for new small molecules activating procaspase‐3, we have designed and synthesized a series of new acetohydrazides incorporating both 2‐oxoindoline and 4‐oxoquinazoline scaffolds. Biological evaluation showed that a number of these acetohydrazides were comparably or even more cytotoxic against three human cancer cell lines (SW620, colon cancer; PC‐3, prostate cancer; NCI−H23, lung cancer) in comparison to PAC‐1, a first procaspase‐3 activating compound, which was used as a positive control. One of those new compounds, 2‐(6‐chloro‐4‐oxoquinazolin‐3(4 H )‐yl)‐ N ′‐[(3 Z )‐5‐methyl‐2‐oxo‐1,2‐dihydro‐3 H ‐indol‐3‐ylidene]acetohydrazide activated the caspase‐3 activity in U937 human lymphoma cells by 5‐fold higher than the untreated control. Three of the new compounds significantly induced necrosis and apoptosis in U937 cells.
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v17.3
    DOI: 10.1002/cbdv.201900670
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2139001-0
    SSG: 12
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  • 5
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    Thyroid nodules in childhood‐onset Hashimoto's thyroiditis: Frequency, risk factors, follow‐up course and genetic alterations of thyroid cancer
    Wiley ; 2021
    In:  Clinical Endocrinology Vol. 95, No. 4 ( 2021-10), p. 638-648
    Details
    In: Clinical Endocrinology, Wiley, Vol. 95, No. 4 ( 2021-10), p. 638-648
    Abstract: We evaluated the frequency, risk factors and the follow‐up outcomes of thyroid nodules, and genetic alterations in thyroid cancer, in youth with childhood‐onset Hashimoto thyroiditis (HT) residing in an iodine‐sufficient country. Design A retrospective cohort study. Patients and measurements A total of 213 patients (194 females, mean age 10.6 years at the time of HT diagnosis) were ultrasonographically evaluated. Thyroid nodules were categorized using the Korean Thyroid Imaging Reporting and Data System (K‐TIRADS) and the American College of Radiology Thyroid Imaging Reporting and Data System (ACR‐TI‐RADS). Results Thyroid nodules were detected in 40 (18.8%) patients over a median follow‐up period of 3.4 years, usually after the onset of puberty. A family history of thyroid disease (hazard ratio 2.1, p  = .031) was predictive of thyroid nodule detection. Papillary thyroid carcinoma (PTC) was diagnosed in 9 (4.2% of all and 22.5% of nodule‐positive patients). The malignant nodules had a higher K‐TIRADS or ACR‐TI‐RADS risk level compared with benign nodules ( p   〈  .01 for both). Genetic alterations were revealed in 7 ( BRAF V600E in 6 and RET‐ERC1 fusion in 1) of the eight available tumour tissue samples. None showed evidence of disease over a median follow‐up period of 3.4 years. Conclusions The nodule detection rate was 18.8%, with a 22.5% risk of malignancy among the detected nodules in childhood‐onset HT patients, showing increased risk in those with a family history. Additional large‐scale studies are required to evaluate the usefulness of K‐TIRADS or ACR‐TI‐RADS risk level for the differentiation of paediatric thyroid nodules.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.v95.4
    DOI: 10.1111/cen.14490
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2004597-9
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  • 6
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    Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE‐TPA): A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Study
    Wiley ; 2020
    In:  Annals of Neurology Vol. 87, No. 2 ( 2020-02), p. 233-245
    Details
    In: Annals of Neurology, Wiley, Vol. 87, No. 2 ( 2020-02), p. 233-245
    Abstract: Otaplimastat is a neuroprotectant that inhibits matrix metalloprotease pathway, and reduces edema and intracerebral hemorrhage induced by recombinant tissue plasminogen activator (rtPA) in animal stroke models. We aimed to assess the safety and efficacy of otaplimastat in patients receiving rtPA. Methods This was a phase 2, 2‐part, multicenter trial in stroke patients (19–80 years old) receiving rtPA. Intravenous otaplimastat was administered 〈 30 minutes after rtPA. Stage 1 was a single‐arm, open‐label safety study in 11 patients. Otaplimastat 80 mg was administered twice daily for 3 days. Stage 2 was a randomized, double‐blind, placebo‐controlled study involving 69 patients, assigned (1:1:1) to otaplimastat 40 mg, otaplimastat 80 mg, or a placebo. The primary endpoint was the occurrence of parenchymal hematoma (PH) on day 1. Secondary endpoints included serious adverse events (SAEs), mortality, and modified Rankin scale (mRS) distribution at 90 days ( clinicaltrials.gov identifier: NCT02787278). Results No safety issues were encountered in stage 1. The incidence of PH during stage 2 was comparable: 0 of 22 with the placebo, 0 of 22 with otaplimastat 40 mg, and 1 of 21 with the 80 mg dose. No differences in SAEs (13%, 17%, 14%) or death (8.3%, 4.2%, 4.8%) were observed among the 3 groups. Three adverse events (chills, muscle rigidity, hepatotoxicity) were judged to be related to otaplimastat. Interpretation Intravenous otaplimastat adjunctive therapy in patients receiving rtPA is feasible and generally safe. The functional efficacy of otaplimastat needs to be investigated with further large trials. ANN NEUROL 2020;87:233–245
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v87.2
    DOI: 10.1002/ana.25644
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2037912-2
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  • 7
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    Design, Synthesis and Bioevaluation of Two Series of 3‐[(1‐Benzyl‐1 H ‐1,2,3‐triazol‐4‐yl)methyl]quinazolin‐4(3 H )‐ones and N ‐(1‐Benzylpiperidin‐4‐yl)quinazolin‐4‐amines
    Wiley ; 2020
    In:  Chemistry & Biodiversity Vol. 17, No. 7 ( 2020-07)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 17, No. 7 ( 2020-07)
    Abstract: Two series of 3‐[(1‐benzyl‐1 H ‐1,2,3‐triazol‐4‐yl)methyl]quinazolin‐4(3 H )‐ones and N ‐(1‐benzylpiperidin‐4‐yl)quinazolin‐4‐amines were designed initially as potential acetylcholine esterase inhibitors. Biological evaluation demonstrated that N ‐(1‐benzylpiperidin‐4‐yl)quinazolin‐4‐amines significantly inhibited AChE activity. Especially, two compounds of them were found to be the most potent with relative AChE inhibition percentages of 87 % in comparison to donepezil. The docking studies with AChE showed similar interactions between donepezil and four derivatives. N ‐(1‐Benzylpiperidin‐4‐yl)quinazolin‐4‐amines also exhibited significant DPPH scavenging effects. The two series of compound also exerted moderate to good cytotoxicity against three human cancer cell lines, including SW620 (human colon cancer), PC‐3 (prostate cancer), and NCI−H23 (lung cancer), with 3‐[(1‐benzyl‐1 H ‐1,2,3‐triazol‐4‐yl)methyl]quinazolin‐4(3 H )‐one being the most cytotoxic agent. 3‐[(1‐Benzyl‐1 H ‐1,2,3‐triazol‐4‐yl)methyl]quinazolin‐4(3 H )‐one significantly induced early apoptosis and arrested the SW620 cells at G2/M phase. From this study, two compounds of N ‐(1‐benzylpiperidin‐4‐yl)quinazolin‐4‐amines could serve as new leads for further design and AChE inhibitors, while 3‐[(1‐benzyl‐1 H ‐1,2,3‐triazol‐4‐yl)methyl]quinazolin‐4(3 H )‐one could serve as a new lead for the design and development of more potent anticancer agents.
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v17.7
    DOI: 10.1002/cbdv.202000290
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2139001-0
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  • 8
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    Analysis of hybrid discontinuous Galerkin methods for linearized Navier–Stokes equations
    Wiley ; 2023
    In:  Numerical Methods for Partial Differential Equations Vol. 39, No. 1 ( 2023-01), p. 304-328
    Details
    In: Numerical Methods for Partial Differential Equations, Wiley, Vol. 39, No. 1 ( 2023-01), p. 304-328
    Abstract: In this article, we introduce and analyze arbitrary‐order, locally conservative hybrid discontinuous Galkerin methods for linearized Navier–Stokes equations. The unknowns of the global system are reduced to trace variables on the skeleton of a triangulation and the average of pressure on each cell via embedded static condensation. We prove that the lifting operator associated with trace variables is injective for any polynomial degree. This generalizes the result in (Y. Jeon and E.‐J. Park, Numerische Mathematik 123 [2013], no. 1, pp. 97–119), where quadratic and cubic rectangular elements are analyzed. Moreover, optimal error estimates in the energy norm are obtained by introducing nonstandard projection operators for the hybrid DG method. Several numerical results are presented to show the performance of the algorithm and to validate the theory developed in the article.
    Type of Medium: Online Resource
    ISSN: 0749-159X , 1098-2426
    URL: Issue
    URL: Article
    DOI: 10.1002/num.v39.1
    DOI: 10.1002/num.22880
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2012605-0
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  • 9
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    Efficacy of health coaching and a web‐based program on physical activity, weight, and distress management among cancer survivors: A multi‐centered randomised controlled trial
    Wiley ; 2020
    In:  Psycho-Oncology Vol. 29, No. 7 ( 2020-07), p. 1105-1114
    Details
    In: Psycho-Oncology, Wiley, Vol. 29, No. 7 ( 2020-07), p. 1105-1114
    Abstract: To investigate the efficacy of health coaching and a web‐based program on survivor physical activity (PA), weight, and distress management among stomach, colon, lung and breast cancer patients. Methods This randomised, controlled, 1‐year trial conducted in five hospitals recruited cancer survivors within 2 months of completing primary cancer treatment who had not met ≥1 of these behavioural goals: (i) conducting moderate PA for at least 150 minutes/week or strenuous exercise for over 75 minutes per week or, in the case of lung cancer patients, low or moderate intensity exercise for over 12.5 MET per week, (ii) maintaining normal weight, and (iii) attaining a score  〉 72 in the Post Traumatic Growth Inventory (PTGI). Participants were randomly assigned to one of three groups: the control group, a web‐only group, or a health coaching + web group. The primary endpoint was based on a composite of PA, weight, and PTGI score at 12 months. Results Patients in the health coaching + web group (difference = 6.6%, P = .010) and the web‐only group (difference = 5.9%, P = .031) had greater overall improvements across the three‐outcome composite than the control group. The health coaching + web group had greater overall improvement in PTGI (difference = 12.6%; P   〈  .001) than the control group, but not in PA and weight. Conclusion The web‐based program, with or without health coaching, may improve health behaviours including PA, weight, and distress management among cancer survivors within 2 months of completing primary cancer treatment. The web‐based program with health coaching was mainly effective for reducing psychological distress.
    Type of Medium: Online Resource
    ISSN: 1057-9249 , 1099-1611
    URL: Issue
    URL: Article
    DOI: 10.1002/pon.v29.7
    DOI: 10.1002/pon.5394
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1495115-0
    SSG: 5,2
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  • 10
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    Nationwide validation study of diagnostic algorithms for inflammatory bowel disease in Korean National Health Insurance Service database
    Wiley ; 2020
    In:  Journal of Gastroenterology and Hepatology Vol. 35, No. 5 ( 2020-05), p. 760-768
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 35, No. 5 ( 2020-05), p. 760-768
    Abstract: We conducted a nationwide validation study of diagnostic algorithms to identify cases of inflammatory bowel disease (IBD) within the Korea National Health Insurance System (NHIS) database. Method Using the NHIS dataset, we developed 44 algorithms combining the International Classification of Diseases (ICD)‐10 codes, codes for Rare and Intractable Diseases (RID) registration and claims data for health care encounters, and pharmaceutical prescriptions for IBD‐specific drugs. For each algorithm, we compared the case identification results from electronic medical records data with the gold standard (chart‐based diagnosis). A multiple sampling test verified the validation results from the entire study population. Results A random nationwide sample of 1697 patients (848 potential cases and 849 negative control cases) from 17 hospitals were included for validation. A combination of the ICD‐10 code, ≥ 1 claims for health care encounters, and ≥ 1 prescription claims (reference algorithm) achieved excellent performance (sensitivity, 93.1% [95% confidence interval 91–94.7]; specificity, 98.1% [96.9–98.8] ; positive predictive value, 97.5% [96.1–98.5]; negative predictive value, 94.5% [92.8–95.8] ) with the lowest error rate (4.2% [3.3–5.3]). The multiple sampling test confirmed that the reference algorithm achieves the best performance regarding IBD diagnosis. Algorithms including the RID registration codes exhibited poorer performance compared with that of the reference algorithm, particularly for the diagnosis of patients affiliated with secondary hospitals. The performance of the reference algorithm showed no statistical difference depending on the hospital volume or IBD type, with P ‐value  〈  0.05. Conclusions We strongly recommend the reference algorithm as a uniform standard operational definition for future studies using the NHIS database.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.v35.5
    DOI: 10.1111/jgh.14855
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2006782-3
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