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  • Wiley  (67)
  • 2020-2024  (67)
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  • Wiley  (67)
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  • 2020-2024  (67)
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  • 1
    Online Resource
    Online Resource
    The neutrophil‐to‐lymphocyte ratio represents a systemic inflammation marker and reflects the relationship with 90‐day mortality in non‐cirrhotic chronic severe hepatitis
    Wiley ; 2022
    In:  Journal of Digestive Diseases Vol. 23, No. 10 ( 2022-10), p. 587-596
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 23, No. 10 ( 2022-10), p. 587-596
    Abstract: To investigate the relationship between systemic inflammatory response and short‐term mortality in patients with non‐cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil‐to‐lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet‐to lymphocyte ratio (PLR), and monocyte‐to‐lymphocyte ratio (MLR). Methods Data were collected from two prospectively enrolled CATCH‐LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90‐day liver transplant (LT)‐free mortality. A generalized additive model (GAM) was used to illustrate the quantitative curve relationship between NLR and 90‐day LT‐free mortality. Kaplan–Meier method was used to estimate the 90‐year LT‐free survival. Results The prevalence of CSH was 20.5% (226/1103). The 28‐day and 90‐day LT‐free mortality rates were 17.7% and 26.1%, respectively, for patients with non‐cirrhotic CSH. Patients with no infection accounted for 75.0% of all CSH patients, and NLR was independently associated with 90‐day LT‐free mortality. NLR of 2.9 might be related to disease deterioration in CSH patients without infection. Conclusions NLR may be an independent risk factor for 90‐day LT‐free mortality in patients with non‐cirrhotic chronic liver disease. A NLR of 2.9 as the cut‐off value can be used to predict disease aggravation in CSH patients without infection.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v23.10
    DOI: 10.1111/1751-2980.13143
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2317117-0
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  • 2
    Online Resource
    Online Resource
    Magnetoencephalography for epileptic focus localization based on Tucker decomposition with ripple window
    Wiley ; 2021
    In:  CNS Neuroscience & Therapeutics Vol. 27, No. 7 ( 2021-07), p. 820-830
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 27, No. 7 ( 2021-07), p. 820-830
    Abstract: To improve the Magnetoencephalography (MEG) spatial localization precision of focal epileptic. Methods 306‐channel simulated or real clinical MEG is estimated as a lower‐dimensional tensor by Tucker decomposition based on Higher‐order orthogonal iteration (HOOI) before the inverse problem using linearly constraint minimum variance (LCMV). For simulated MEG data, the proposed method is compared with dynamic imaging of coherent sources (DICS), multiple signal classification (MUSIC), and LCMV. For clinical real MEG of 31 epileptic patients, the ripples (80–250 Hz) were detected to compare the source location precision with spikes using the proposed method or the dipole‐fitting method. Results The experimental results showed that the positional accuracy of the proposed method was higher than that of LCMV, DICS, and MUSIC for simulation data. For clinical real MEG data, the positional accuracy of the proposed method was higher than that of dipole‐fitting regardless of whether the time window was ripple window or spike window. Also, the positional accuracy of the ripple window was higher than that of the spike window regardless of whether the source location method was the proposed method or the dipole‐fitting method. For both shallow and deep sources, the proposed method provided effective performance. Conclusion Tucker estimation of MEG for source imaging by ripple window is a promising approach toward the presurgical evaluation of epileptics.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Issue
    URL: Article
    DOI: 10.1111/cns.v27.7
    DOI: 10.1111/cns.13643
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2423467-9
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  • 3
    Online Resource
    Online Resource
    N6‐methyladenosine reader YTHDF3 regulates melanoma metastasis via its ‘executor' LOXL3
    Wiley ; 2022
    In:  Clinical and Translational Medicine Vol. 12, No. 11 ( 2022-11)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 12, No. 11 ( 2022-11)
    Abstract: A number of studies have demonstrated that N6‐methyladenosine (m6A) plays a vital role in the pathological process of various tumours. Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma. However, the relationship between m6A readers such as YTH domain family (YTHDF) proteins and melanoma was still elusive. Methods RT‐qPCR, Western blot and immunohistochemistry were conducted to measure the expression level of YTH N6–methyladenosine RNA binding protein 3 (YTHDF3) and lysyl oxidase–like 3 (LOXL3) in melanoma tissues and cells. The effects of YTHDF3 and LOXL3 on melanoma were verified in vitro and in vivo. Multi‐omics analysis including RNA‐seq, MeRIP‐seq, RIP‐seq and mass spectrometry analyses was performed to identify the target. The interaction between YTHDF3 and LOXL3 was verified by RT‐PCR, Western blot, MeRIP‐qPCR, RIP‐qPCR and CRISPR‐Cas13b‐based epitranscriptome engineering. Results In this study, we found that m6A reader YTHDF3 could affect the metastasis of melanoma both in vitro and in vivo. The downstream targets of YTHDF3, such as LOXL3, phosphodiesterase 3A (PDE3A) and chromodomain helicase DNA‐binding protein 7 (CHD7) were identified by means of RNA‐seq, MeRIP‐seq, RIP‐seq and mass spectrometry analyses. Besides, RT‐qPCR, Western blot, RIP‐qPCR and MeRIP‐qPCR were performed for subsequent validation. Among various targets of YTHDF3, LOXL3 was found to be the optimal target of YTHDF3. With the application of CRISPR–Cas13b‐based epitranscriptome engineering, we further confirmed that the transcript of LOXL3 was captured and regulated by YTHDF3 via m6A binding sites. YTHDF3 augmented the protein expression of LOXL3 without affecting its mRNA level via the enrichment of eukaryotic translation initiation factor 3 subunit A (eIF3A) on the transcript of LOXL3. LOXL3 downregulation inhibited the metastatic ability of melanoma cells, and overexpression of LOXL3 ameliorated the inhibition of melanoma metastasis caused by YTHDF3 downregulation. Conclusions The YTHDF3‐LOXL3 axis could serve as a promising target to be interfered with to inhibit the metastasis of melanoma.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v12.11
    DOI: 10.1002/ctm2.1075
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2697013-2
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  • 4
    Online Resource
    Online Resource
    Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China
    Wiley ; 2022
    In:  Bipolar Disorders Vol. 24, No. 4 ( 2022-06), p. 400-411
    Details
    In: Bipolar Disorders, Wiley, Vol. 24, No. 4 ( 2022-06), p. 400-411
    Abstract: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting‐state functional magnetic resonance imaging (R‐fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18–60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel‐mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q  〈  0.002, z = −7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age‐related change in males instead of females. Besides, the reduction in MTG was found to be a male‐special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First‐episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
    Type of Medium: Online Resource
    ISSN: 1398-5647 , 1399-5618
    URL: Issue
    URL: Article
    DOI: 10.1111/bdi.v24.4
    DOI: 10.1111/bdi.13139
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001157-X
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  • 5
    Online Resource
    Online Resource
    Icarisid II promotes proliferation and neuronal differentiation of neural stem cells via activating Wnt/β‐catenin signaling pathway
    Wiley ; 2021
    In:  Phytotherapy Research Vol. 35, No. 5 ( 2021-05), p. 2773-2784
    Details
    In: Phytotherapy Research, Wiley, Vol. 35, No. 5 ( 2021-05), p. 2773-2784
    Abstract: Adult neurogenesis plays a vital role in maintaining cognitive functions in mammals and human beings. Mobilization of hippocampal neurogenesis has been regarded as a promising therapeutic approach to restore injured neurons in neurodegenerative diseases including Alzheimer's disease (AD). Icarisid II (ICS II), an active ingredient derived from Epimedii Folium , has been reported to exhibit multiple neuroprotective effects. In the present study, we investigated the effects of ICS II on the proliferation and differentiation of neural stem cells (NSCs) and amyloid precusor protein (APP)‐overexpressing NSCs (APP‐NSCs) in vitro. Our results demonstrated that ICS II dose‐dependently suppressed apoptosis and elevated viability of APP‐NSCs. ICS II (1 μM) potently promoted proliferation and neuronal differentiation of NSCs and APP‐NSCs. ICS II (1 μM) significantly upregulated Wnt‐3a expression, increased the phosphorylation of glycogen synthase kinase‐3β and enhanced the nuclear transfer of β‐catenin. Moreover, ICS II also promoted astrocytes to secrete Wnt‐3a, which positively modulates Wnt/β‐catenin signaling pathway. These findings demonstrate that ICS II promotes NSCs proliferation and neuronal differentiation partly by activating the Wnt/β‐catenin signaling pathway.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v35.5
    DOI: 10.1002/ptr.7022
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Projected impacts of climate change on snow leopard habitat in Qinghai Province, China
    Wiley ; 2021
    In:  Ecology and Evolution Vol. 11, No. 23 ( 2021-12), p. 17202-17218
    Details
    In: Ecology and Evolution, Wiley, Vol. 11, No. 23 ( 2021-12), p. 17202-17218
    Abstract: Assessing species’ vulnerability to climate change is a prerequisite for developing effective strategies to reduce emerging climate‐related threats. We used the maximum entropy algorithm (MaxEnt model) to assess potential changes in suitable snow leopard ( Panthera uncia ) habitat in Qinghai Province, China, under a mild climate change scenario. Our results showed that the area of suitable snow leopard habitat in Qinghai Province was 302,821 km 2 under current conditions and 228,997 km 2 under the 2050s climatic scenario, with a mean upward shift in elevation of 90 m. At present, nature reserves protect 38.78% of currently suitable habitat and will protect 42.56% of future suitable habitat. Current areas of climate refugia amounted to 212,341 km 2 and are mainly distributed in the Sanjiangyuan region, Qilian mountains, and surrounding areas. Our results provide valuable information for formulating strategies to meet future conservation challenges brought on by climate stress. We suggest that conservation efforts in Qinghai Province should focus on protecting areas of climate refugia and on maintaining or building corridors when planning for future species management.
    Type of Medium: Online Resource
    ISSN: 2045-7758 , 2045-7758
    URL: Issue
    URL: Article
    DOI: 10.1002/ece3.v11.23
    DOI: 10.1002/ece3.8358
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2635675-2
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  • 7
    Online Resource
    Online Resource
    Residual circulating tumor DNA after adjuvant chemotherapy effectively predicts recurrence of stage II‐III gastric cancer
    Wiley ; 2023
    In:  Cancer Communications Vol. 43, No. 12 ( 2023-12), p. 1312-1325
    Details
    In: Cancer Communications, Wiley, Vol. 43, No. 12 ( 2023-12), p. 1312-1325
    Abstract: Circulating tumor DNA (ctDNA) is a promising biomarker for predicting relapse in multiple solid cancers. However, the predictive value of ctDNA for disease recurrence remains indefinite in locoregional gastric cancer (GC). Here, we aimed to evaluate the predictive value of ctDNA in this context. Methods From 2016 to 2019, 100 patients with stage II/III resectable GC were recruited in this prospective cohort study (NCT02887612). Primary tumors were collected during surgical resection, and plasma samples were collected perioperatively and within 3 months after adjuvant chemotherapy (ACT). Somatic variants were captured via a targeted sequencing panel of 425 cancer‐related genes. The plasma was defined as ctDNA‐positive only if one or more variants detected in the plasma were presented in at least 2% of the primary tumors. Results Compared with ctDNA‐negative patients, patients with positive postoperative ctDNA had moderately higher risk of recurrence [hazard ratio (HR) = 2.74, 95% confidence interval (CI) = 1.37–5.48; P = 0.003], while patients with positive post‐ACT ctDNA showed remarkably higher risk (HR = 14.99, 95% CI = 3.08‐72.96; P 〈 0.001). Multivariate analyses indicated that both postoperative and post‐ACT ctDNA positivity were independent predictors of recurrence‐free survival (RFS). Moreover, post‐ACT ctDNA achieved better predictive performance (sensitivity, 77.8%; specificity, 90.6%) than both postoperative ctDNA and serial cancer antigen. A comprehensive model incorporating ctDNA for recurrence risk prediction showed a higher C‐index (0.78; 95% CI = 0.71–0.84) than the model without ctDNA (0.71; 95% CI = 0.64–0.79; P = 0.009). Conclusions Residual ctDNA after ACT effectively predicts high recurrence risk in stage II/III GC, and the combination of tissue‐based and circulating tumor features could achieve better risk prediction.
    Type of Medium: Online Resource
    ISSN: 2523-3548 , 2523-3548
    URL: Issue
    URL: Article
    DOI: 10.1002/cac2.v43.12
    DOI: 10.1002/cac2.12494
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2922913-3
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  • 8
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    Online Resource
    Icarisid II rescues cognitive dysfunction via activation of Wnt/β‐catenin signaling pathway promoting hippocampal neurogenesis in APP / PS1 transgenic mice
    Wiley ; 2022
    In:  Phytotherapy Research Vol. 36, No. 5 ( 2022-05), p. 2095-2108
    Details
    In: Phytotherapy Research, Wiley, Vol. 36, No. 5 ( 2022-05), p. 2095-2108
    Abstract: Restoring the compromised neurogenesis has been served as a potential strategy to rescue cognitive dysfunction of Alzheimer's disease (AD). In this study, we explored whether icarisid II (ICS II), a natural product possessing powerful neuroprotection, could recover the neurogenesis dysfunction of APP/PS1 mice, and investigated its underlying mechanisms. Our results showed that oral administration of ICS II could alleviate cognitive injuries of APP/PS1 mice, promote hippocampal neurogenesis, as well as stimulate Wnt/β‐catenin signal pathway confirmed by upregulated Wnt‐3a, phosphorylated glycogen synthase kinase‐3β (p‐GSK‐3β), and β‐catenin. ICS II also depressed mitochondrial fission evidenced by upregulated Mitofusin 1 (Mfn 1) and Mitofusin 2 (Mfn 2), and downregulated mitochondrial fission 1 protein (Fis 1), mitochondrial fission factor (Mff), and phosphorylated dynamin‐related protein 1 (p‐Drp 1). However, these effects of ICS II were blunted by XAV‐939, an inhibitor of Wnt/β‐catenin signaling pathway. In summary, our findings revealed that ICS II could improve neurogenesis and inhibit mitochondrial fission via activation of the Wnt/β‐catenin signaling pathway, which contributed to cognitive function restoration of APP/PS1 mice. This study discovered a novel mechanism involving neurogenesis regulation underlying the therapeutic effects of ICS II against AD.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v36.5
    DOI: 10.1002/ptr.7430
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 9
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    Elliptic‐ and hyperbolic‐function solutions of the nonlocal reverse‐time and reverse‐space‐time nonlinear Schrödinger equations
    Wiley ; 2022
    In:  Mathematical Methods in the Applied Sciences Vol. 45, No. 17 ( 2022-11-30), p. 10877-10890
    Details
    In: Mathematical Methods in the Applied Sciences, Wiley, Vol. 45, No. 17 ( 2022-11-30), p. 10877-10890
    Abstract: In this paper, we obtain the stationary elliptic‐ and hyperbolic‐function solutions of the nonlocal reverse‐time and reverse‐space‐time nonlinear Schrödinger (NLS) equations based on their connection with the standard Weierstrass elliptic equation. The reverse‐time NLS equation possesses the bounded ‐, ‐, ‐, ‐, and ‐function solutions. Of special interest, the ‐function solution can display both the dark‐ and antidark‐soliton profiles. The reverse‐space‐time NLS equation admits the general Jacobian elliptic‐function solutions (which are exponentially growing at one infinity or display the periodical oscillation in ), the bounded ‐ and ‐function solutions, as well as the ‐shifted ‐ and function solutions. In addition, the hyperbolic‐function solutions may exhibit an exponential growth behavior at one infinity, or show the gray/bright‐soliton profiles.
    Type of Medium: Online Resource
    ISSN: 0170-4214 , 1099-1476
    URL: Issue
    URL: Article
    DOI: 10.1002/mma.v45.17
    DOI: 10.1002/mma.8422
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1478610-2
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  • 10
    Online Resource
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    Individual variation in parental tradeoffs between the number and size of offspring at the pre‐ and post‐natal stages
    Wiley ; 2020
    In:  Ibis Vol. 162, No. 4 ( 2020-10), p. 1186-1197
    Details
    In: Ibis, Wiley, Vol. 162, No. 4 ( 2020-10), p. 1186-1197
    Abstract: Life‐history theory predicts that parents refer to the resources they hold to determine their breeding strategy. In multi‐brooded species, it is hypothesized that single‐brooded parents produce larger clutches and raise offspring with a brood survival strategy, whereas multi‐brooded parents only do this under good breeding conditions. Under poor conditions, they produce smaller clutches and raise offspring with a brood reduction strategy. We tested this hypothesis in the Brown‐cheeked Laughing Thrush Trochalopteron henrici , which can breed twice a year on the Tibetan Plateau, by investigating the life‐history traits and provisioning behaviours of single‐ and double‐brooded parents. Single‐brooded parents laid larger clutches of smaller eggs and produced more and larger fledglings than double‐brooded parents in their first brood. Double‐brooded parents produced smaller clutches of larger eggs but fledged larger nestlings in their first brood than in their second brood. As single‐brooded parents only need to raise one brood a year, then producing and raising as many offspring as possible (i.e. the brood survival strategy in a large brood) can maximize their reproductive success. For double‐brooded parents, producing and raising fewer offspring in the first brood (i.e. the brood survival strategy in a small brood) can ensure their nesting success during a short breeding cycle. Additionally, producing more offspring but raising larger nestlings in the second brood (i.e. the brood reduction strategy in a large brood) can select for offspring of higher quality within the brood. Our findings indicate that different tradeoffs between single‐ and double‐brooded parents in egg‐laying and nestling‐raising may be an adaptation to the seasonal variation in environmental conditions.
    Type of Medium: Online Resource
    ISSN: 0019-1019 , 1474-919X
    URL: Issue
    URL: Article
    DOI: 10.1111/ibi.v162.4
    DOI: 10.1111/ibi.12831
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2071870-6
    detail.hit.zdb_id: 2485031-7
    detail.hit.zdb_id: 2807-1
    SSG: 12
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