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  • 1
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    Online Resource
    Prevalence of iron deficiency and anemia in pediatric heart transplant recipients
    Wiley ; 2024
    In:  Clinical Transplantation Vol. 38, No. 6 ( 2024-06)
    Details
    In: Clinical Transplantation, Wiley, Vol. 38, No. 6 ( 2024-06)
    Abstract: The prevalence of iron deficiency and anemia in the setting of modern‐day maintenance immunosuppression in pediatric heart transplant (HTx) recipients is unclear. The primary aim was to determine the prevalence of iron deficiency (serum ferritin  〈  30 ng/mL ± transferrin saturation  〈  20%) and anemia per World Health Organization diagnostic criteria and associated risk factors. Methods Single‐center, cross‐sectional analysis of 200 consecutive pediatric HTx recipients ( 〈 21 years old) from 2005 to 2021. Data were collected at 1‐year post‐HTx at the time of annual protocol biopsy. Results Median age at transplant was 3 years (IQR .5–12.2). The median ferritin level was 32 ng/mL with 46% having ferritin  〈  30 ng/mL. Median transferrin saturation (TSAT) was 22% with 47% having TSAT  〈  20%. Median hemoglobin was 11 g/dL with 54% having anemia. Multivariable analysis revealed lower absolute lymphocyte count, TSAT  〈  20%, and estimated glomerular filtration rate  〈 75 mL/min/1.73 m 2 were independently associated with anemia. Ferritin  〈  30 ng/mL in isolation was not associated with anemia. Ferritin  〈  30 ng/mL may aid in detecting absolute iron deficiency while TSAT  〈  20% may be useful in identifying patients with functional iron deficiency ± anemia in pediatric HTx recipients. Conclusion Iron deficiency and anemia are highly prevalent in pediatric HTx recipients. Future studies are needed to assess the impact of iron deficiency, whether with or without anemia, on clinical outcomes in pediatric HTx recipients.
    Type of Medium: Online Resource
    ISSN: 0902-0063 , 1399-0012
    URL: Issue
    URL: Article
    DOI: 10.1111/ctr.v38.6
    DOI: 10.1111/ctr.15367
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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    detail.hit.zdb_id: 2004801-4
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  • 2
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    Online Resource
    Mycophenolic acid therapeutic drug monitoring using area under the curve in pediatric heart transplant recipients
    Wiley ; 2023
    In:  Clinical Transplantation
    Details
    In: Clinical Transplantation, Wiley
    Type of Medium: Online Resource
    ISSN: 0902-0063 , 1399-0012
    URL: Article
    DOI: 10.1111/ctr.15087
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2739458-X
    detail.hit.zdb_id: 2004801-4
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  • 3
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    Online Resource
    Molecular Weight Control via Cross Metathesis in Photo‐Redox Mediated Ring‐Opening Metathesis Polymerization
    Wiley ; 2020
    In:  Angewandte Chemie Vol. 132, No. 23 ( 2020-06-02), p. 9159-9164
    Details
    In: Angewandte Chemie, Wiley, Vol. 132, No. 23 ( 2020-06-02), p. 9159-9164
    Abstract: Photo‐redox mediated ring‐opening metathesis polymerization (photo‐ROMP) is an emerging ROMP technique that uses an organic redox mediator and a vinyl ether initiator, in contrast to metal‐based initiators traditionally used in ROMP. The reversibility of the redox‐mediated initiation and propagation steps enable spatiotemporal control over the polymerization. Herein, we explore a simple, inexpensive means of controlling molecular weight, using alpha olefins as chain transfer agents. This method enables access to low molecular weight oligomers, and molecular weights between 1 and 30 kDa can be targeted simply by altering the stoichiometry of the reaction. This method of molecular weight control was then used to synthesize a functionalized norbornene copolymer in a range of molecular weights for specific materials applications.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v132.23
    DOI: 10.1002/ange.202000434
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 4
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    Impact of aspirin on takotsubo syndrome: a propensity score‐based analysis of the InterTAK Registry
    Wiley ; 2020
    In:  European Journal of Heart Failure Vol. 22, No. 2 ( 2020-02), p. 330-337
    Details
    In: European Journal of Heart Failure, Wiley, Vol. 22, No. 2 ( 2020-02), p. 330-337
    Abstract: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30‐day and 5‐year follow‐up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30‐day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50–3.04, P  = 0.64] or 5‐year follow‐up (HR 1.11, 95% CI 0.78–1.58, P  = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS‐based methods, i.e. covariate adjustment and inverse probability of treatment weighting. Conclusion In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30‐day and 5‐year follow‐up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
    Type of Medium: Online Resource
    ISSN: 1388-9842 , 1879-0844
    URL: Issue
    URL: Article
    DOI: 10.1002/ejhf.v22.2
    DOI: 10.1002/ejhf.1698
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1500332-2
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  • 5
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    Online Resource
    Molecular Weight Control via Cross Metathesis in Photo‐Redox Mediated Ring‐Opening Metathesis Polymerization
    Wiley ; 2020
    In:  Angewandte Chemie International Edition Vol. 59, No. 23 ( 2020-06-02), p. 9074-9079
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 59, No. 23 ( 2020-06-02), p. 9074-9079
    Abstract: Photo‐redox mediated ring‐opening metathesis polymerization (photo‐ROMP) is an emerging ROMP technique that uses an organic redox mediator and a vinyl ether initiator, in contrast to metal‐based initiators traditionally used in ROMP. The reversibility of the redox‐mediated initiation and propagation steps enable spatiotemporal control over the polymerization. Herein, we explore a simple, inexpensive means of controlling molecular weight, using alpha olefins as chain transfer agents. This method enables access to low molecular weight oligomers, and molecular weights between 1 and 30 kDa can be targeted simply by altering the stoichiometry of the reaction. This method of molecular weight control was then used to synthesize a functionalized norbornene copolymer in a range of molecular weights for specific materials applications.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v59.23
    DOI: 10.1002/anie.202000434
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 6
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    Substrate availability and not thermal acclimation controls microbial temperature sensitivity response to long‐term warming
    Wiley ; 2023
    In:  Global Change Biology Vol. 29, No. 6 ( 2023-03), p. 1574-1590
    Details
    In: Global Change Biology, Wiley, Vol. 29, No. 6 ( 2023-03), p. 1574-1590
    Abstract: Microbes are responsible for cycling carbon (C) through soils, and predicted changes in soil C stocks under climate change are highly sensitive to shifts in the mechanisms assumed to control the microbial physiological response to warming. Two mechanisms have been suggested to explain the long‐term warming impact on microbial physiology: microbial thermal acclimation and changes in the quantity and quality of substrates available for microbial metabolism. Yet studies disentangling these two mechanisms are lacking. To resolve the drivers of changes in microbial physiology in response to long‐term warming, we sampled soils from 13‐ and 28‐year‐old soil warming experiments in different seasons. We performed short‐term laboratory incubations across a range of temperatures to measure the relationships between temperature sensitivity of physiology (growth, respiration, carbon use efficiency, and extracellular enzyme activity) and the chemical composition of soil organic matter. We observed apparent thermal acclimation of microbial respiration, but only in summer, when warming had exacerbated the seasonally‐induced, already small dissolved organic matter pools. Irrespective of warming, greater quantity and quality of soil carbon increased the extracellular enzymatic pool and its temperature sensitivity. We propose that fresh litter input into the system seasonally cancels apparent thermal acclimation of C‐cycling processes to decadal warming. Our findings reveal that long‐term warming has indirectly affected microbial physiology via reduced C availability in this system, implying that earth system models including these negative feedbacks may be best suited to describe long‐term warming effects on these soils.
    Type of Medium: Online Resource
    ISSN: 1354-1013 , 1365-2486
    URL: Issue
    URL: Article
    DOI: 10.1111/gcb.v29.6
    DOI: 10.1111/gcb.16544
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020313-5
    SSG: 12
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  • 7
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    Fungal community response to long‐term soil warming with potential implications for soil carbon dynamics
    Wiley ; 2021
    In:  Ecosphere Vol. 12, No. 5 ( 2021-05)
    Details
    In: Ecosphere, Wiley, Vol. 12, No. 5 ( 2021-05)
    Abstract: The direction and magnitude of climate warming effects on ecosystem processes such as carbon cycling remain uncertain. Soil fungi are central to these processes due to their roles as decomposers of soil organic matter, as mycorrhizal symbionts, and as determinants of plant diversity. Yet despite their importance to ecosystem functioning, we lack a clear understanding of the long‐term response of soil fungal communities to warming. Toward this goal, we characterized soil fungal communities in two replicated soil warming experiments at the Harvard Forest (Petersham, Massachusetts, USA) which had experienced 5°C above ambient soil temperatures for 5 and 20 yr at the time of sampling. We assessed fungal diversity and community composition by sequencing the ITS2 region of rDNA using Illumina technology, along with soil C concentrations and chemistry. Three main findings emerged: (1) long‐, but not short‐term warming resulted in compositional shifts in the soil fungal community, particularly in the saprotrophic and unknown components of the community; (2) soil C concentrations and the total C stored in the organic horizon declined in response to both short‐ (5 yr) and long‐term (20 yr) warming; and (3) following long‐term warming, shifts in fungal guild relative abundances were associated with substantial changes in soil organic matter chemistry, particularly the relative abundance of lignin. Taken together, our results suggest that shifts with warming in the relative abundance of fungal functional groups and dominant fungal taxa are related to observed losses in total soil C.
    Type of Medium: Online Resource
    ISSN: 2150-8925 , 2150-8925
    URL: Issue
    URL: Article
    DOI: 10.1002/ecs2.v12.5
    DOI: 10.1002/ecs2.3460
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2572257-8
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  • 8
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    Online Resource
    How prenatal cortisol levels relate to grandmother‐mother relationships among a cohort of Latina women
    Wiley ; 2023
    In:  American Journal of Human Biology Vol. 35, No. 7 ( 2023-07)
    Details
    In: American Journal of Human Biology, Wiley, Vol. 35, No. 7 ( 2023-07)
    Abstract: As part of the human reproductive strategy, mothers receive childcare assistance from others. For kin, allomothers are adaptively incentivized to provide assistance due to inclusive fitness benefits. Previous studies across a broad range of populations identify grandmothers as particularly consistent allomothers. Minimal attention has been paid to the possibility that allomothers may begin investing in offspring quality during the prenatal stage of life. Here, we innovate within the area of grandmother allocare research by examining the prenatal stage of life and biopsychosocial mechanisms by which prenatal grandmother effects may be enacted. Methods Data derive from the Mothers' Cultural Experiences study, a cohort of 107 pregnant Latina women in Southern California. At 〈 16 weeks' gestation, we administered questionnaires, collected morning urine samples, and measured cortisol by enzyme‐linked immunosorbent assay, correcting for specific gravity. We measured the soon‐to‐be maternal and paternal grandmothers' relationship quality, social support, frequency of seeing each other, communicating, and geographic proximity to pregnant mothers, that is, their daughters and daughters‐in‐law. These measures were self‐reported by the pregnant mothers. We assessed how grandmother constructs related to the pregnant women's depression, stress, anxiety, and cortisol levels. Results We observed benefits conferred by maternal grandmothers for mothers' prenatal mental health and lower cortisol levels. Paternal grandmothers also conferred mental health benefits to pregnant daughters‐in‐law, but higher cortisol levels. Conclusion Our results suggest that grandmothers, especially maternal grandmothers, are able to improve their inclusive fitness by caring for pregnant daughters, and allomother support may positively impact prenatal health. This work extends the traditional cooperative breeding model by identifying a prenatal grandmother effect, and, by examining a maternal biomarker.
    Type of Medium: Online Resource
    ISSN: 1042-0533 , 1520-6300
    URL: Issue
    URL: Article
    DOI: 10.1002/ajhb.v35.7
    DOI: 10.1002/ajhb.23883
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2001218-4
    SSG: 12
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  • 9
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    Sociopolitical stressors are associated with psychological distress in a cohort of Latina women during early pregnancy
    Wiley ; 2023
    In:  Journal of Community Psychology Vol. 51, No. 7 ( 2023-09), p. 3044-3059
    Details
    In: Journal of Community Psychology, Wiley, Vol. 51, No. 7 ( 2023-09), p. 3044-3059
    Abstract: Research suggests that the 2016 US election was a potential stressor among Latinos residing in the United States. Sociopolitical stressors targeted toward ethnic minority communities and become embodied through psychosocial distress. The current study investigates if and how sociopolitical stressors related to the 45th President, Donald Trump, and his administration are associated with psychological distress in early pregnancy of Latina women living in Southern California during the second half of his term. This cross‐sectional analysis uses data from the Mothers' Cultural Experiences study ( n  = 90) collected from December 2018 to March 2020. Psychological distress was assessed in three domains: depression, state anxiety, and pregnancy‐related anxiety. Sociopolitical stressors were measured through questionnaires about sociopolitical feelings and concerns. Multiple linear regression models examined the relationship between sociopolitical stressors and mental health scores, adjusting for multiple testing. Negative feelings and a greater number of sociopolitical concerns were associated with elevated pregnancy‐related anxiety and depressive symptoms. The most frequently endorsed concern was about issues of racism (72.3%) and women's rights (62.4%); women endorsing these particular concerns also had higher scores on depression and pregnancy‐related anxiety. No significant associations were detected with state anxiety after correction for multiple testing. This analysis is cross‐sectional and cannot assess causality in the associations between sociopolitical stressors and distress. These results are consistent with the hypothesis that the 2016 election, the subsequent political environment, and the anti‐immigrant rhetoric and policies of former President Trump and his administration were sources of stress for Latinos residing in the United States.
    Type of Medium: Online Resource
    ISSN: 0090-4392 , 1520-6629
    URL: Issue
    URL: Article
    DOI: 10.1002/jcop.v51.7
    DOI: 10.1002/jcop.23065
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1491194-2
    SSG: 5,2
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  • 10
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    Apolipoprotein D and transthyretin are reduced in female adolescent offspring of women with type 1 diabetes: The EPICOM study
    Wiley ; 2022
    In:  Diabetic Medicine Vol. 39, No. 7 ( 2022-07)
    Details
    In: Diabetic Medicine, Wiley, Vol. 39, No. 7 ( 2022-07)
    Abstract: Adolescent offspring exposed to maternal diabetes during intrauterine life show a less favourable metabolic profile than the background population. Here, we hypothesize that offspring of women with type 1 diabetes (T1D), possess sex‐specific alterations in the serum profile of proteins involved in lipid, metabolic and transport processes and that these alterations are associated with lipid profile and indices of insulin sensitivity and secretion. Methods A prospective nationwide follow‐up study (EPICOM) in a Danish population. Blood samples were assessed from offspring of women with T1D (index offspring, n  = 267, 13–20 years), and matched control offspring ( n  = 290). Serum proteins were analysed using a 25‐plex cardio‐metabolic targeted proteomics assay, which includes 12 apolipoproteins and 13 transport and inflammatory proteins. Results Apolipoprotein D (ApoD) and transthyretin (TTR) were reduced in index females as compared to female controls (−8.1%, p  〈  0.001 and −6.1%, p  = 0.006 respectively), but not in index males (2.2%, p  = 0.476 and −2.4%, p  = 0.731 respectively). Sex‐dependent inverse associations between exposure to maternal T1D in utero and ApoD and TTR were significant after adjusting for age, BMI‐SDS and Tanner stage (OR = 0.252 [95% CI 0.085, 0.745], p  = 0.013 and OR = 0.149 [95% CI 0.040, 0.553], p  = 0.004). ApoD correlated to indices of insulin sensitivity and secretion in a similar sex‐specific pattern in crude and adjusted analyses. Conclusions Low ApoD may be regarded as an early risk marker of metabolic syndrome. A possible link between ApoD and cardiovascular disease needs further investigation.
    Type of Medium: Online Resource
    ISSN: 0742-3071 , 1464-5491
    URL: Issue
    URL: Article
    DOI: 10.1111/dme.v39.7
    DOI: 10.1111/dme.14776
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2019647-7
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