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  • Wiley  (24)
  • 2020-2024  (24)
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  • Wiley  (24)
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  • 2020-2024  (24)
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  • 1
    Online Resource
    Online Resource
    A serum lipidomics study for the identification of specific biomarkers for endometrial polyps to distinguish them from endometrial cancer or hyperplasia
    Wiley ; 2022
    In:  International Journal of Cancer Vol. 150, No. 9 ( 2022-05), p. 1549-1559
    Details
    In: International Journal of Cancer, Wiley, Vol. 150, No. 9 ( 2022-05), p. 1549-1559
    Abstract: Endometrial diseases, including endometrial polyps (EP), endometrial cancer (EC) and endometrial hyperplasia (EH), are common gynecological diseases that affect women of childbearing and perimenopausal age. Clinically, biopsy or imaging methods are usually used to screen and diagnose these diseases; however, due to the invasiveness and heterogeneity of these tests, a noninvasive, convenient, objective and accurate biomarker is needed for the differential diagnosis of EP, EC or EH. In the present study, serum samples from 326 patients with endometrial diseases and 225 healthy volunteers were analyzed using nontargeted lipidomics. A combination of multivariate and univariate analyses was used to identify and qualify six, eight and seven potential biomarkers in the sera from patients with EP, EC and EH, respectively. Using a logistic regression algorithm and receiver operating characteristic (ROC) curve analysis, a biomarker panel including four specific EP biomarkers, 6‐keto‐PGF1α, PA(37:4), LysoPC(20:1) and PS(36:0), showed good classification and diagnostic ability in distinguishing EP from EC or EH. The biomarker panel for distinguishing EP from EC yielded an area under the curve (AUC) of 0.915, sensitivity of 100% and specificity of 72.41%, while that for distinguishing EP from EH yielded an AUC of 1.000, sensitivity of 100% and specificity of 100%. The two diagnostic models also showed good diagnostic abilities in the validation set. Therefore, this biomarker panel can be used as a rapid diagnostic method to assist in imaging examinations and provide a reference for clinicians in the identification and diagnosis of endometrial diseases.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v150.9
    DOI: 10.1002/ijc.33943
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 2
    Online Resource
    Online Resource
    Impact of individual factors on DNA methylation of drug metabolism genes: A systematic review
    Wiley ; 2023
    In:  Environmental and Molecular Mutagenesis Vol. 64, No. 7 ( 2023-08), p. 401-415
    Details
    In: Environmental and Molecular Mutagenesis, Wiley, Vol. 64, No. 7 ( 2023-08), p. 401-415
    Abstract: Individual differences in drug response have always existed in clinical treatment. Many non‐genetic factors show non‐negligible impacts on personalized medicine. Emerging studies have demonstrated epigenetic could connect non‐genetic factors and individual treatment differences. We used systematic retrieval methods and reviewed studies that showed individual factors’ impact on DNA methylation of drug metabolism genes. In total, 68 studies were included, and half ( n  = 36) were cohort studies. Six aspects of individual factors were summarized from the perspective of personalized medicine: parental exposure, environmental pollutants exposure, obesity and diet, drugs, gender and others. The most research ( n  = 11) focused on ABCG1 methylation. The majority of studies showed non‐genetic factors could result in a significant DNA methylation alteration in drug metabolism genes, which subsequently affects the pharmacokinetic processes. However, the underlying mechanism remained unknown. Finally, some viewpoints were presented for future research.
    Type of Medium: Online Resource
    ISSN: 0893-6692 , 1098-2280
    URL: Issue
    URL: Article
    DOI: 10.1002/em.v64.7
    DOI: 10.1002/em.22567
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1497682-1
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Hepatobiliary Tumor Organoids Reveal HLA Class I Neoantigen Landscape and Antitumoral Activity of Neoantigen Peptide Enhanced with Immune Checkpoint Inhibitors
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 22 ( 2022-08)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 22 ( 2022-08)
    Abstract: Neoantigen‐directed therapy lacks preclinical models recapitulating neoantigen characteristics of original tumors. It is urgent to develop a platform to assess T cell response for neoantigen screening. Here, immunogenic potential of neoantigen‐peptides of tumor tissues and matched organoids ( n = 27 pairs) are analyzed by Score tools with whole genome sequencing (WGS)‐based human leukocyte antigen (HLA)‐class‐I algorithms. The comparisons between 9203 predicted neoantigen‐peptides from 2449 mutations of tumor tissues and 9991 ones from 2637 mutations of matched organoids demonstrate that organoids preserved majority of genetic features, HLA alleles, and similar neoantigen landscape of original tumors. Higher neoantigen load is observed in tumors with early stage. Multiomics analysis combining WGS, RNA‐seq, single‐cell RNA‐seq, mass spectrometry filters out 93 candidate neoantigen‐peptides with strong immunogenic potential for functional validation in five organoids. Immunogenic peptides are defined by inducing increased CD107aCD137IFN‐ γ expressions and IFN‐ γ secretion of CD8 cells in flow cytometry and enzyme‐linked immunosorbent assay assays. Nine immunogenic peptides shared by at least two individuals are validated, including peptide from TP53 R90S . Organoid killing assay confirms the antitumor activity of validated immunogenic peptide‐reactive CD8 cells, which is further enhanced in the presence of immune checkpoint inhibitors. The study characterizes HLA‐class‐I neoantigen landscape in hepatobiliary tumor, providing practical strategy with tumor organoid model for neoantigen‐peptide identification in personalized immunotherapy.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.22
    DOI: 10.1002/advs.202105810
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 4
    Online Resource
    Online Resource
    Individualized treatment with voriconazole in the Chinese population: inflammation level as a novel marker for dose optimization
    Wiley ; 2023
    In:  British Journal of Clinical Pharmacology
    Details
    In: British Journal of Clinical Pharmacology, Wiley
    Abstract: The aim of this study was to explore the influence and possible mechanisms of pharmacokinetics‐related genes polymorphisms, especially CYP2C19 polymorphisms, and non‐genetic factors combined with the inflammatory status on the voriconazole (VRC) metabolism of the Chinese population. In clinical studies, it was performed with collecting more than one VRC trough concentration and C‐reactive protein (CRP) level. A total of 265 blood samples were collected from 120 patients. Results of multiple regression analyses demonstrated that CYP2C19 genotypes and albumin (Alb) level were remained predictors of C min ss/D in patients with no to mild inflammation ( R 2 = 0.12, P 〈 0.001). In addition, in patients with moderate to severe inflammation, it resulted in a significant model containing factors of CRP and total bilirubin (T‐Bil) levels ( R 2 = 0.19, P 〈 0.001). In non‐clinical studies, 32 rats were divided into control group and inflammatory group, and it was found that the mean residence time (MRT (0‐t) ) of VRC in inflammatory group was significantly longer than that in control group ( P 〈 0.001), which may be due to down‐regulation of mRNA and protein expression of CYP2C19 ( CYP2C6 in rats) through Interleukin (IL)‐6/signal transducer and activator of transcription (STAT) 3 pathway. Therefore, the effect of CYP2C19 polymorphisms on VRC metabolism may be masked by inflammatory status, which should be of more concern than CYP2C19 polymorphisms in patients with moderate to severe inflammation. Additionally, the impact of Alb and T‐Bil on VRC metabolism should not be disregarded.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Article
    DOI: 10.1111/bcp.15916
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1498142-7
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Establishment of a new protein C detection system based on chromogenic substrate assay and its clinical diagnostic value for deep vein thrombosis
    Wiley ; 2021
    In:  Journal of Clinical Laboratory Analysis Vol. 35, No. 12 ( 2021-12)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 35, No. 12 ( 2021-12)
    Abstract: Deficiency of protein C (PC) affects the balance between blood coagulation and fibrinolysis in the human body. Chromogenic‐based assay is recommended as the preferred screening method for detecting PC deficiency. We established a PC detection system based on the chromogenic substrate assay. Methods First, a kit for the determination of PC activity in plasma was elaborately developed and its reaction parameters on XL‐3200c were explored. Then, we evaluated its performance and collected specimens to compare the test results obtained with those of the Siemens detection system. Finally, the clinical diagnostic efficacy of this detection system for deep vein thrombosis (DVT) was assessed. Results Optimum conditions for PC detection were 0.25–0.1 U/ml protein C activator Protac ® and 2.5–1 mM Pefachrome ® PCa5297. The composition and concentration ranges of buffer substances and stabilizers in the kit were also explored. Satisfactory results were observed in performance evaluation. The test results of the newly built detection system were highly correlated with those of the Siemens detection system ( R 2  = 0.9771 in the control group and R 2  = 0.9776 in the DVT group), and Bland‐Altman plots also showed high consistency between the two detection systems. In addition, the area under the curve (AUC) of the newly built PC detection system for DVT was 0.888, indicating this system could effectively improve the diagnostic sensitivity and specificity for DVT. Conclusion In this study, a sensitive, wide linear range and reliable PC activity detection system were established.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v35.12
    DOI: 10.1002/jcla.24109
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2001635-9
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  • 6
    Online Resource
    Online Resource
    Indium oxide nanoparticles induce lung intercellular toxicity between bronchial epithelial cells and macrophages
    Wiley ; 2020
    In:  Journal of Applied Toxicology Vol. 40, No. 12 ( 2020-12), p. 1636-1646
    Details
    In: Journal of Applied Toxicology, Wiley, Vol. 40, No. 12 ( 2020-12), p. 1636-1646
    Abstract: The effects of indium oxide nanoparticles (IO‐NPs) on lung cells associated with respiratory and immune barriers and the toxic effects of intercellular cascades were studied. We found IO‐NPs could directly damage pulmonary epithelial cells. Indium ions released by epithelial cells affect the phagocytosis and migration of macrophages, which may be a new point for the decrease in the clearance of alveolar surfactants and the development of IO‐related pulmonary alveolar proteinosis.
    Type of Medium: Online Resource
    ISSN: 0260-437X , 1099-1263
    URL: Issue
    URL: Article
    DOI: 10.1002/jat.v40.12
    DOI: 10.1002/jat.4023
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1475015-6
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  • 7
    Online Resource
    Online Resource
    A spatial and cellular distribution of rabies virus infection in the mouse brain revealed by fMOST and single‐cell RNA sequencing
    Wiley ; 2022
    In:  Clinical and Translational Medicine Vol. 12, No. 1 ( 2022-01)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 12, No. 1 ( 2022-01)
    Abstract: Neurotropic virus infection can cause serious damage to the central nervous system (CNS) in both humans and animals. The complexity of the CNS poses unique challenges to investigate the infection of these viruses in the brain using traditional techniques. Methods In this study, we explore the use of fluorescence micro‐optical sectioning tomography (fMOST) and single‐cell RNA sequencing (scRNA‐seq) to map the spatial and cellular distribution of a representative neurotropic virus, rabies virus (RABV), in the whole brain. Mice were inoculated with a lethal dose of a recombinant RABV encoding enhanced green fluorescent protein (EGFP) under different infection routes, and a three‐dimensional (3D) view of RABV distribution in the whole mouse brain was obtained using fMOST. Meanwhile, we pinpointed the cellular distribution of RABV by utilizing scRNA‐seq. Results Our fMOST data provided the 3D view of a neurotropic virus in the whole mouse brain, which indicated that the spatial distribution of RABV in the brain was influenced by the infection route. Interestingly, we provided evidence that RABV could infect multiple nuclei related to fear independent of different infection routes. More surprisingly, our scRNA‐seq data revealed that besides neurons RABV could infect macrophages and the infiltrating macrophages played at least three different antiviral roles during RABV infection. Conclusion This study draws a comprehensively spatial and cellular map of typical neurotropic virus infection in the mouse brain, providing a novel and insightful strategy to investigate the pathogenesis of RABV and other neurotropic viruses.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v12.1
    DOI: 10.1002/ctm2.700
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2697013-2
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  • 8
    Online Resource
    Online Resource
    Experience in the development of nurses' personal resilience: A meta‐synthesis
    Wiley ; 2023
    In:  Nursing Open Vol. 10, No. 5 ( 2023-05), p. 2780-2792
    Details
    In: Nursing Open, Wiley, Vol. 10, No. 5 ( 2023-05), p. 2780-2792
    Abstract: Nurses play roles in hospitals, families, society and other aspects and often face stress sources, such as heavy workload, doctor–patient conflict and medical accidents. Resilience can help the nurses to avoid or reduce various adverse consequences caused by stress sources; however, this phenomenon remains ill‐defined and under‐researched. The aim of this review was to summarize the experiences of development of nurses' resilience and explore the reasons for the formation of resilience by examining the findings of the existing qualitative studies. Design The review is a systematic review and meta‐synthesis of qualitative studies. Data Sources PubMed, Cochrane Library, CINAHL, Web of Science, Embase, and Ovid and Chinese databases include the following: Chinese National Knowledge Infrastructure (CNKI), Wanfang Database (CECDB), VIP Database and China Biomedical Database (CBM). Review Methods Relevant publications were identified by systematic searches across 11 databases in June 2021. All qualitative and mixed‐method studies in English and Chinese that explored the experiences of development of nurses' resilience were included. The qualitative meta‐synthesis followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) recommendations. Two independent reviewers selected the studies and assessed the quality of each study. Meta‐synthesis was performed to integrate the results. Results A total of nine studies revealed 10 sub‐themes and three descriptive themes: being psychologically strong, physical positive coping and adoption of external support. Conclusion Several factors contributed to the development of nurses' resilience, and various supporting strategies in the nursing management and education are helpful to their adaption ability. However, it is necessary to focus on the cultivation of nurses' resilience to improve the quality of clinical nursing. Leaders or organizations are required to establish and sustain multifaceted strategies to improve nurse’ resilience through scientific resilience training programmes and improved organizational support.
    Type of Medium: Online Resource
    ISSN: 2054-1058 , 2054-1058
    URL: Issue
    URL: Article
    DOI: 10.1002/nop2.v10.5
    DOI: 10.1002/nop2.1556
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2809556-X
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  • 9
    Online Resource
    Online Resource
    Surface‐Anchored Nanogel Coating Endows Stem Cells with Stress Resistance and Reparative Potency via Turning Down the Cytokine‐Receptor Binding Pathways
    Wiley ; 2021
    In:  Advanced Science Vol. 8, No. 3 ( 2021-02)
    Details
    In: Advanced Science, Wiley, Vol. 8, No. 3 ( 2021-02)
    Abstract: Stem cell‐based therapy has great potential in regenerative medicine. However, the survival and engraftment rates of transplanted stem cells in disease regions are poor and limit the effectiveness of cell therapy due to the fragility of stem cells. Here, an approach involving a single‐cell coating of surface‐anchored nanogel to regulate stem cell fate with anti‐apoptosis capacity in the hypoxic and ischemic environment of infarcted hearts is developed for the first time. A polysialic acid‐based system is used to anchor microbial transglutaminase to the external surface of the cell membrane, where it catalyzes the crosslinking of gelatin. The single‐cell coating with surface‐anchored nanogel endows mesenchymal stem cells (MSCs) with stress resistance by blocking the activity of apoptotic cytokines including the binding of tumor necrosis factor α (TNFα) to tumor necrosis factor receptor, which in turn maintains mitochondrial integrity, function and protects MSCs from TNF α ‐induces apoptosis. The administration of surface engineered MSCs to hearts results in significant improvements in engraftment, cardiac function, infarct size, and vascularity compared with using uncoated MSCs in treating myocardial infarction. The surface‐anchored, biocompatible cell surface engineering with nanogel armor provides a new way to produce robust therapeutic stem cells and may explore immense potentials in cell‐based therapy.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v8.3
    DOI: 10.1002/advs.202003348
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2808093-2
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  • 10
    Online Resource
    Online Resource
    What caregivers believe affected the quality of implementation of asthma‐related family management models (AFMM) during COVID‐19: A phenomenological qualitative study
    Wiley ; 2022
    In:  Pediatric Pulmonology Vol. 57, No. 11 ( 2022-11), p. 2815-2823
    Details
    In: Pediatric Pulmonology, Wiley, Vol. 57, No. 11 ( 2022-11), p. 2815-2823
    Abstract: The recurrent COVID‐19 epidemic in China has disrupted many aspects of daily life for children with asthma and their caregivers, while negatively impacting their asthma family management models (AFMM). This phenomenological qualitative study identifies what affects the quality of implementation of AFMM in this population and outlines potential coping strategies for the caregivers. Methods We used purposive sampling to conduct semistructured interviews with primary caregivers of school‐age children with asthma from community healthcare centers (CHCs), which focused on understanding what factors influenced caregivers' implementation of AFMM during quarantine. The Colaizzi seven‐step method was used to independently code and categorize the transcript and to generate themes and identify associated key subthemes. Results Twenty‐four caregivers were interviewed, and they provided greater insight into barriers and motivators to implement AFMM. The three themes and nine relevant subthemes generated, (a) the “individual‐family” internal‐level factors: weak health literacy and beliefs, quietly changing family relationships, the dramatic increase in the care burden, gradual adjustment of negative psychology; (b) the “hospital‐community” external‐level factors: the endless power of peer support, strict community quarantine policy; and (c) the “health system‐public” social‐level factors: the enormous potential of internet‐based telemedicine, improved public awareness of prevention, government's prompt assistance. Conclusions This qualitative study reveals that the quality of AFMM implementation during pandemic is impacted by three different levels. Therefore, a targeted and comprehensive caring model that provides caregivers with the necessary coping strategies around these three levels is needed to achieve better asthma control outcomes.
    Type of Medium: Online Resource
    ISSN: 8755-6863 , 1099-0496
    URL: Issue
    URL: Article
    DOI: 10.1002/ppul.v57.11
    DOI: 10.1002/ppul.26107
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1491904-7
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