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  • 1
    Online Resource
    Online Resource
    Projected climate change impact on a coastal sea—As significant as all current pressures combined
    Wiley ; 2022
    In:  Global Change Biology Vol. 28, No. 17 ( 2022-09), p. 5310-5319
    Details
    In: Global Change Biology, Wiley, Vol. 28, No. 17 ( 2022-09), p. 5310-5319
    Abstract: Climate change influences the ocean's physical and biogeochemical conditions, causing additional pressures on marine environments and ecosystems, now and in the future. Such changes occur in environments that already today suffer under pressures from, for example, eutrophication, pollution, shipping, and more. We demonstrate how to implement climate change into regional marine spatial planning by introducing data of future temperature, salinity, and sea ice cover from regional ocean climate model projections to an existing cumulative impact model. This makes it possible to assess climate change impact in relation to pre‐existing cumulative impact from current human activities. Results indicate that end‐of‐century projected climate change alone is a threat of the same magnitude as the combination of all current pressures to the marine environment. These findings give marine planners and policymakers forewarning on how future climate change may impact marine ecosystems, across space, emission scenarios, and in relation to other pressures.
    Type of Medium: Online Resource
    ISSN: 1354-1013 , 1365-2486
    URL: Issue
    URL: Article
    DOI: 10.1111/gcb.v28.17
    DOI: 10.1111/gcb.16312
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020313-5
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Impact of concomitant tricuspid regurgitation on outcome after edge‐to‐edge mitral valve repair
    Wiley ; 2023
    In:  Catheterization and Cardiovascular Interventions Vol. 102, No. 3 ( 2023-09), p. 528-537
    Details
    In: Catheterization and Cardiovascular Interventions, Wiley, Vol. 102, No. 3 ( 2023-09), p. 528-537
    Abstract: To evaluate the impact of tricuspid regurgitation (TR) on echocardiographic and functional outcome after mitral valve transcatheter edge‐to‐edge‐repair (M‐TEER). Methods and Results A total of 740 patients underwent M‐TEER at our center from 2010 to 2021. Patients were analyzed according to severity of concomitant TR at the time of M‐TEER procedure: low‐grade TR (grade ≤I [trace–mild], 279 patients [37.7%] ), moderate TR (grade II, 170 patients [23.0%]) and high‐grade TR (grade III‐V [severe–torrential] , 291 patients [39.3%]). Patients with moderate to high‐grade TR had higher morbidity. Procedural success of M‐TEER was achieved similarly in all groups (98.2% vs. 97.6% vs. 95.9%, p  = 0.22). TR severity decreased rapidly and consistently after M‐TEER to only 48.0% of high‐grade TR patients after 3 months ( p   〈  0.001) and to 46.8% after 12 months ( p  = 0.99). High‐grade TR patients had significantly higher mortality (21.5% vs. 18.2% vs. 11.1%,  p  = 0.003) up to 12 months after M‐TEER. However, high‐grade TR did not independently predict mortality (HR 1.302, 95% CI 0.937–1.810; p  = 0.116). Echocardiographic and functional outcome was similar in both secondary and primary MR patients. Conclusions High‐grade concomitant TR did not independently predict adverse outcome following M‐TEER. A wait‐and‐observe approach for these patients is reasonable.
    Type of Medium: Online Resource
    ISSN: 1522-1946 , 1522-726X
    URL: Issue
    URL: Article
    DOI: 10.1002/ccd.v102.3
    DOI: 10.1002/ccd.30787
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2001555-0
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  • 3
    Online Resource
    Online Resource
    Combined climate change and nutrient load impacts on future habitats and eutrophication indicators in a eutrophic coastal sea
    Wiley ; 2020
    In:  Limnology and Oceanography Vol. 65, No. 9 ( 2020-09), p. 2170-2187
    Details
    In: Limnology and Oceanography, Wiley, Vol. 65, No. 9 ( 2020-09), p. 2170-2187
    Abstract: Eutrophication and climate change will affect habitats of species and more generally, the structure and functioning of ecosystems. We used a three‐dimensional, coupled hydrodynamic‐biogeochemical model to investigate potential future changes in size and location of potential habitats of marine species during the 21 st century in a large, eutrophicated brackish sea (the Baltic Sea, northern Europe). We conducted scenario projections under the combined impact of nutrient load and climate change. Possible future changes of the eutrophication state of this sea were also assessed through two policy‐relevant indicators. The results imply a physiologically more stressful environment for marine species by the end of the 21 st century: volumes of higher salinity water become more hypoxic/anoxic and the volumes of low salinity, oxic water increase. For example, these results impact and reduce cod reproductive habitats. The decrease is mainly climate change induced in the Baltic basins less directly influenced by inflows of saline, oxic water to the Baltic Sea (E Gotland and Gdansk Basins). In basins more directly influenced by such inflows (Arkona and Bornholm Basins), the combined effect from climate change and nutrient loads is of importance. The results for the eutrophication state indicators clearly indicate a more eutrophic sea than at present without a rigorous nutrient reduction policy, that is, the necessity to implement the Baltic Sea Action Plan. The multidisciplinary, multiscenario assessment strategy presented here provides a useful concept for the evaluation of impacts from cumulative stresses of changing climate and socioeconomic pressures on future eutrophication indicators and habitats of marine species.
    Type of Medium: Online Resource
    ISSN: 0024-3590 , 1939-5590
    URL: Issue
    URL: Article
    DOI: 10.1002/lno.v65.9
    DOI: 10.1002/lno.11446
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2033191-5
    detail.hit.zdb_id: 412737-7
    SSG: 12
    SSG: 14
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  • 4
    Online Resource
    Online Resource
    Percutaneous edge‐to‐edge mitral valve repair for mitral regurgitation improves heart failure symptoms in heart failure with preserved ejection fraction patients
    Wiley ; 2021
    In:  ESC Heart Failure Vol. 8, No. 6 ( 2021-12), p. 5010-5021
    Details
    In: ESC Heart Failure, Wiley, Vol. 8, No. 6 ( 2021-12), p. 5010-5021
    Abstract: Therapeutic options for patients with heart failure with preserved ejection fraction (HFpEF) are sparse. Mitral regurgitation (MR) is a common feature of HFpEF and worsens heart failure symptoms and prognosis. Our study examines the outcome of patients with preserved left ventricular ejection fraction (LVEF) and elevated left atrial (LAP) or left ventricular filling pressures (LVEDP), indicative of HFpEF, after undergoing percutaneous edge‐to‐edge mitral valve repair (pMVR) for moderate–severe MR. Methods and results Two hundred eleven patients with preserved LVEF ( 〉 50%), who underwent pMVR, were dichotomized by LAP ( 〈  / ≥15 mmHg) and LVEDP ( 〈  / ≥16 mmHg). Forty‐nine per cent of patients showed elevated LAP, and LVEDP was elevated in 55%, both indicating HFpEF. Patients with elevated filling pressures featured typical clinical characteristics of HFpEF, higher N‐terminal pro‐brain natriuretic peptide levels (5544.9 pg/mL in high LAP group vs. 3071.7 pg/mL in normal LAP group, P  = 0.06; 5061.0 pg/mL in high LVEDP group vs. 3230.3 pg/mL in normal LVEDP group, P  = 0.08), and higher prevalence of pulmonary hypertension (mean pulmonary artery pressure 36.4 mmHg in high LAP group vs. 26.3 mmHg in normal LAP group, P   〈  0.001; 35.2 mmHg in high LVEDP group vs. 29.7 mmHg in normal LVEDP group, P  = 0.004) and atrial fibrillation (78.8% in normal LAP group vs. 61.0% in high LAP group, P  = 0.04; 75.3% in high LVEDP group vs. 67.5% in normal LVEDP group, P  = 0.25). Pre‐treatment MR grade and New York Heart Association (NYHA) class were similar in both normal filling pressure and HFpEF groups. pMVR in HFpEF patients achieved effective heart failure symptom relief comparable with patients with normal filling pressures: significant decrease of MR grade and NYHA class, as well as significant reduction of heart failure hospitalizations 12 months after compared with 12 months before MitraClip. Conclusion Percutaneous edge‐to‐edge mitral valve repair for moderate–severe MR is an effective treatment option for symptom relief in HFpEF patients.
    Type of Medium: Online Resource
    ISSN: 2055-5822 , 2055-5822
    URL: Issue
    URL: Article
    DOI: 10.1002/ehf2.v8.6
    DOI: 10.1002/ehf2.13561
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2814355-3
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