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  • Wiley  (23)
  • 2020-2024  (23)
  • 1
    Online Resource
    Online Resource
    Transport stress affects the fecal microbiota in healthy donkeys
    Wiley ; 2021
    In:  Journal of Veterinary Internal Medicine Vol. 35, No. 5 ( 2021-09), p. 2449-2457
    Details
    In: Journal of Veterinary Internal Medicine, Wiley, Vol. 35, No. 5 ( 2021-09), p. 2449-2457
    Abstract: With the development of large‐scale donkey farming in China, long‐distance transportation has become common practice, and the incidence of intestinal diseases after transportation has increased. The intestinal microbiota is important in health and disease, and whether or not transportation disturbs the intestinal microbiota in donkeys has not been investigated. Objectives To determine the effects of transportation on the fecal microbiota of healthy donkeys using 16S rRNA sequencing. Animals Fecal and blood samples were collected from 12 Dezhou donkeys before and after transportation. Methods Prospective controlled study. Cortisol, ACTH, and heat‐shock protein 90 (HSP90) concentrations were measured. Sequencing of 16S rRNA was used to assess the microbial composition. Alpha diversity and beta diversity were assessed. Results Results showed significant ( P   〈  .05) increases in cortisol (58.1 ± 14.6 to 71.1 ± 9.60 ng/mL), ACTH (163.8 ± 31.9 to 315.8 ± 27.9 pg/mL), and HSP90 (10.8 ± 1.67 to 14.6 ± 1.75 ng/mL) on the day of arrival. A significantly lower ( P  = .04) level of bacterial richness was found in fecal samples after transportation, compared with that before transportation without distinct changes in diversity. Most notably, donkeys had significant decreases in Atopostipes , Eubacterium , Streptococcus , and Coriobacteriaceae . Conclusions and Clinical Importance Transportation can induce stress in healthy donkeys and have some effect on the composition of the in fecal microbiota. Additional studies are required to understand the potential effect of these microbiota changes, especially significantly decreased bacteria, on the development intestinal diseases in donkeys during recovery from transportation.
    Type of Medium: Online Resource
    ISSN: 0891-6640 , 1939-1676
    URL: Issue
    URL: Article
    DOI: 10.1111/jvim.v35.5
    DOI: 10.1111/jvim.16235
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2177690-8
    SSG: 22
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  • 2
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    Design, Bio‐evaluation and Molecular Dynamics Simulation of Novel GSK‐3β Inhibitors
    Wiley ; 2021
    In:  Molecular Informatics Vol. 40, No. 12 ( 2021-12)
    Details
    In: Molecular Informatics, Wiley, Vol. 40, No. 12 ( 2021-12)
    Abstract: Glycogen synthase kinase 3 beta (GSK‐3β) is considered as a promising drug target for the treatment of Alzheimer's disease (AD). In the present study, two compound libraries were selected for virtual screening based on pharmacophore models of GSK‐3β to discover new inhibitors. Nine potential hits were retained for biological investigation and four of these compounds showed GSK‐3β inhibitory activity (with the IC 50 values in sub‐micromolar range on GSK‐3β). Compounds 6 and 9 have good safety. They do not have any significant in vitro cytotoxicity against PC12 and SH‐SY5Y neuroblastoma cells at concentrations up to 90 μM. Based on the inhibitory activity and druggability properties, compound 8 is the preferred molecule, and it is a promising lead for the development of the GSK‐3β inhibitors for reducing the abnormal hyperphosphorylation of tau protein and relieving AD.
    Type of Medium: Online Resource
    ISSN: 1868-1743 , 1868-1751
    URL: Issue
    URL: Article
    DOI: 10.1002/minf.v40.12
    DOI: 10.1002/minf.202060031
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2537668-8
    SSG: 15,3
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  • 3
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    Boron Nitride‐Based Release Agent Coating Stabilizes Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 /Li Interface with Superior Lean‐Lithium Electrochemical Performance and Thermal Stability
    Wiley ; 2022
    In:  Advanced Functional Materials Vol. 32, No. 29 ( 2022-07)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 32, No. 29 ( 2022-07)
    Abstract: Sodium super ionic conductor (NASICON)‐type Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP) is one of the most promising solid‐state electrolytes (SSEs) owing to its high Li‐ion conductivity, high stability with air, and low cost. However, LATP is less widely deployed due to its high incompatibility with lithium metal. Herein, a facile and inexpensive spray‐coating approach is proposed to construct a thin 3D organic/inorganic composite layer of a commercial boron nitride‐based release agent (BNRA) onto LATP. Apart from protecting LATP, this interfacial BNRA layer enables Li‐ion migration through BN defects and affords low resistance at BNRA/Li interface due to in situ formation of Li–N. Compared to bare LATP, which fails to support Li stripping–plating process in a lean‐lithium Li/Li symmetric cell (2 µm), BNRA‐LATP runs for ≈1800 h. The assembled lean‐lithium LiFePO 4 (LFP)/BNRA‐LATP/Li solid state batteries (SSBs) deliver a specific capacity of 150.9 mA h g –1 at 0.5 C with minor capacity decay after 500 cycles. Besides, the BNRA layer eliminates thermal runaway risks of LATP‐based SSBs by fast in‐plane thermal dispersion. This work demonstrates a facile LATP‐protection strategy regarding Li incompatibility and thermal runway issues, and pinpoints the interfacial formation mechanism, fulfilling the pursuit of high‐performance low‐cost SSEs.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v32.29
    DOI: 10.1002/adfm.202201136
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 4
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    Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR‐4492/ROMO1 axis
    Wiley ; 2020
    In:  Journal of Cellular Physiology Vol. 235, No. 4 ( 2020-04), p. 3768-3775
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 235, No. 4 ( 2020-04), p. 3768-3775
    Abstract: Growing reports indicate that long noncoding RNA (lncRNA) are involved in the regulation of various biological processes of cancer cells. LINC00319 is an ill investigated lncRNA and has been shown to regulate lung cancer, nasopharyngeal carcinoma and ovarian cancer. Nevertheless, its roles in bladder cancer (BCa) remain unclear. In our research, LINC00319 was shown to be an upregulated lncRNA in BCa tissues. LINC00319 expression is negatively correlated with the patient's prognosis. Silencing of LINC00319 suppressed BCa proliferation and invasiveness. In addition, the data indicated LINC00319 was a sponge for miR‐4492 and miR‐4492 suppressed ROMO1 expression in BCa. Furthermore, our results illustrated miR‐4492/ROMO1 axis regulates proliferation, migration, and invasion and LINC00319 exerts oncogenic roles through modulating miR‐4492/ROMO1 axis. In sum, this study suggested that LINC00319 acts as oncogenic roles in BCa progression.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v235.4
    DOI: 10.1002/jcp.29271
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 5
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    Tillandsia‐Inspired Hygroscopic Photothermal Organogels for Efficient Atmospheric Water Harvesting
    Wiley ; 2020
    In:  Angewandte Chemie International Edition Vol. 59, No. 43 ( 2020-10-19), p. 19237-19246
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 59, No. 43 ( 2020-10-19), p. 19237-19246
    Abstract: Tillandsia species with degenerated roots have evolved into hygroscopic leaves that absorb moisture from air. This interesting biological adaptability has inspired us to develop an integrated hygroscopic photothermal organogel (POG) to achieve a solar‐powered atmospheric water harvesting (AWH). The well‐designed hydrophilic co‐polymeric skeleton is fabricated to accommodate hygroscopic glycerin medium, which enables the POG self‐contained property, mechanically flexibility and synergistic enhancement of moisture sorption. The integration of interpenetrated photothermal component of poly‐pyrrole‐dopamine (P‐Py‐DA) can endow the POG an efficient solar‐to‐thermal property for controllable solar‐driven interfacial water releasing. The integrated POG has an equilibrium moisture sorption of 16.01 kg m −2 at the RH of 90 %, and daily water production as high as 2.43 kg m −2  day −1 is achieved in actual outdoor experiments.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v59.43
    DOI: 10.1002/anie.202007885
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 6
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    Lewis Acid‐Free Ynoate‐Mediated Chemoselective Reduction of Carboxylic Acids to Primary Alcohols
    Wiley ; 2020
    In:  ChemistrySelect Vol. 5, No. 28 ( 2020-07-31), p. 8687-8690
    Details
    In: ChemistrySelect, Wiley, Vol. 5, No. 28 ( 2020-07-31), p. 8687-8690
    Abstract: We present an economical and facile catalytic reduction process of carboxylic acids for the synthesis of alcohols. This pyridine‐catalyzed strategy operates through addition of carboxylic acids with methyl propiolate followed by NaBH 4 reduction or unexpected ester exchange, providing the corresponding primary alcohols and esters, respectively. A range of carboxylic acids bearing other reductive groups (e. g., halogen, cyano, nitro, ester and double bond) are accessed with uniformly high chemoselectivity. The use of environmentally benign, convenient and safe procedure also makes this catalytic protocol attractive for practical application.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v5.28
    DOI: 10.1002/slct.202002728
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2844262-3
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  • 7
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    Multiplexing Vectorial Holographic Images with Arbitrary Metaholograms
    Wiley ; 2021
    In:  Advanced Optical Materials Vol. 9, No. 20 ( 2021-10)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 9, No. 20 ( 2021-10)
    Abstract: Metasurfaces achieving arbitrary phase profiles within ultrathin thickness, emerge as miniaturized, ultracompact, and kaleidoscopic nanophotonic platforms. However, it is often required to segment or interleave independent subarray metasurfaces to multiplex holograms in a single nanodevice, which in turn affects the device's compactness and channel capacity. Here, a flexible strategy is proposed for multiplexing vectorial holographic images by controlling the phase distributions of holographic images in far field. Benefitting from precisely controlling the phase difference of reconstructed images through the modified Gerchberg–Saxton algorithm, two different holographic images are independently designed for the circular light by two interleaved metasurfaces and an extra vectorial hologram is flexibly encrypted in far field without additional set of structures on the metasurface plane. An unlimited number of polarization can be achieved in the holographic image and additional information can be decrypted when different polarization‐dependent holographic images overlap. By continually varying phase difference between the incident right and left circular polarized light, the image within the overlap area can be modulated. The silicon dielectric metahologram with record absolute multiplexed efficiency ( 〉 25%) is achieved in the experiment. This technique, as far as it is known, promises an enormous data capacity as well as a high level of information security.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v9.20
    DOI: 10.1002/adom.202100626
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2708158-8
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  • 8
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    SNPs in PRKCA‐HIF1A‐GLUT1 are associated with diabetic kidney disease in a Chinese Han population with type 2 diabetes
    Wiley ; 2020
    In:  European Journal of Clinical Investigation Vol. 50, No. 9 ( 2020-09)
    Details
    In: European Journal of Clinical Investigation, Wiley, Vol. 50, No. 9 ( 2020-09)
    Abstract: To explore the relationship between SNPs in PRKCA‐HIF1A‐GLUT1 and diabetic kidney disease in Chinese Han people. Materials and methods A total of 2552 participants from Shanghai Diabetes Institute Inpatient Database of Shanghai Jiao Tong University Affiliated Sixth People's Hospital were involved in the stage 1 cross‐sectional population. A total of 6015 subjects from the Hong Kong Diabetes Register were included for validation. Genotyping of participants was conducted by the MassARRAY Compact Analyzer (Agena Bioscience). The data were analysed by plink, SAS, Haploview. Results We identified variants associated with diabetic kidney disease in stage 1. Rs1681851 ( P  = .0105, OR = 1.331) in GLUT1 as well as rs2301108 ( P  = .0085, OR = 1.289) and rs79865957 ( P  = .0204, OR = 1.263) in HIF1A were significantly associated with diabetic kidney disease. Regarding DKD‐related traits, rs1681851 was associated with plasma creatinine levels ( P  = .0169, β  = 4.822) and eGFR ( P  = .0457, β  = −6.956). Moreover, the results showed the interactions between PRKCA‐GLUT1 in the occurrence of DKD. We further sought validation of the 17 SNPs in a prospective cohort and found that rs900836 and rs844501 were associated with the percentage change in eGFR slope. We performed a meta‐analysis of case‐control analysis data from the Hong Kong samples together with the stage 1 data from Shanghai. Rs9894851 showed significant correlation with the serum creatinine level as well as eGFR and no SNP showed association with DKD after meta‐analysis. Conclusions Our results suggest potential association between SNPs in PRKCA‐HIF1A‐GLUT1 and diabetic kidney disease in Chinese Han people.
    Type of Medium: Online Resource
    ISSN: 0014-2972 , 1365-2362
    URL: Issue
    URL: Article
    DOI: 10.1111/eci.v50.9
    DOI: 10.1111/eci.13264
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2004971-7
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  • 9
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    Persistent chronic immune activation in HIV/HBV‐coinfected patients after antiretroviral therapy
    Wiley ; 2021
    In:  Journal of Viral Hepatitis Vol. 28, No. 10 ( 2021-10), p. 1355-1361
    Details
    In: Journal of Viral Hepatitis, Wiley, Vol. 28, No. 10 ( 2021-10), p. 1355-1361
    Abstract: We studied the characteristics of immune activation and investigated the underlying mechanisms in patients with human immunodeficiency virus‐1/hepatitis B virus (HIV/HBV) coinfection after receiving HBV‐active antiretroviral therapy. Forty patients with HIV/HBV coinfection, 38 patients with HIV monoinfection and 20 healthy controls were enrolled. CD4 + count, HIV load, HBV load, markers of immune activation and regulatory T‐cell (Treg cell) frequency were assessed and compared between HIV‐monoinfected and HIV/HBV‐coinfected patients at week 0 (baseline), 12, 24, 36 and 48 after the onset of HBV‐active antiretroviral therapy. Before antiretroviral therapy, frequencies of CD4 + HLADR + CD38 + , CD8 + HLADR + CD38 + , and Treg cells, and sCD163 and sCD14 levels were significantly higher in both HIV/HBV‐coinfected patients and HIV‐monoinfected patients, compared with healthy controls. Frequencies of CD4 + HLADR + CD38 + and CD8 + HLADR + CD38 + cells decreased following antiretroviral therapy in both groups. sCD163 levels did not change significantly in both groups and no significant difference was observed between the two groups at each time point during the 48‐week antiretroviral therapy. In week 24, levels of sCD14 and frequencies of Treg cells appeared significantly higher in HIV/HBV‐coinfected patients than in HIV‐monoinfected patients, in which sCD14 levels and Treg cell frequencies declined to those in healthy controls. The Treg cell frequency was consistent with that of sCD14 levels in HIV/HBV‐coinfected patients. Coinfection with HBV significantly increases sCD14 levels in HIV‐infected patients during HBV‐active antiretroviral therapy, which may potentially contribute to liver inflammation.
    Type of Medium: Online Resource
    ISSN: 1352-0504 , 1365-2893
    URL: Issue
    URL: Article
    DOI: 10.1111/jvh.v28.10
    DOI: 10.1111/jvh.13559
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2007924-2
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  • 10
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    Association between detectable SARS‐COV‐2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019
    Wiley ; 2021
    In:  Journal of Medical Virology Vol. 93, No. 2 ( 2021-02), p. 794-802
    Details
    In: Journal of Medical Virology, Wiley, Vol. 93, No. 2 ( 2021-02), p. 794-802
    Abstract: We longitudinally detected the SARS‐CoV‐2 RNA in anal swabs and throat swabs, and explored the association with disease severity of COVID‐19. 21.2% of COVID‐19 patients were detectable for SARS‐CoV‐2 RNA in annal swabs. The duration of virus was longer, but the viral load was lower in anal swabs than throat swabs. Patients with detectable viral RNA in anal swabs had a 2.5‐fold higher risk of ICU admission (26.3% vs. 10.7%, P  = 0.006). Detectable SARS‐CoV‐2 RNA in the digestive tract was a potential warning indicator of severe disease. Screening the virus in digestive tract, close monitoring and early intervention of patients with detectable virus are needed.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v93.2
    DOI: 10.1002/jmv.26307
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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