In:
Chemistry & Biodiversity, Wiley, Vol. 20, No. 11 ( 2023-11)
Abstract:
From marine sponge‐associated fungus Hamigera avellanea , thirteen secondary metabolites including a pair of undescribed alkaloid enantiomers (+)‐hamiavemin A (4 S ) (+)‐ 1 and (−)‐hamiavemin A (4 R ) (−)‐ 1 . Compound 1 was enantiomers resolved by the Chiralpak AS‐3 column, using a hexane/isopropanol mobile phase. Their structures were determined based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR spectra. The absolute configuration of (+)‐ 1 and (−)‐ 1 were assigned tentatively by ECD calculations. Among the isolates, compound 6 showed strongest antibacterial activity against Enterococcus faecalis , Staphylococcus aureus , Bacillus cereus , Escherichia coli , Salmonella enterica , and Candida albicans with the MIC values of 2, 2, 16, 32, 64, and 16 μg/mL, respectively, which were stronger than that of the positive control compound, kanamycin (MIC values ranging from 4 to 128 μg/mL). In addition, compounds 1 , 2 , and 9 showed moderate cytotoxic activity against three cancer cell lines, HepG2, A549, and MCF‐7 with the IC50 values ranging from 55.35±1.70 to 83.02±2.85 μg/mL.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202301425
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2139001-0
SSG:
12
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