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  • Wiley  (17)
  • 2020-2024  (17)
  • 1
    Online Resource
    Online Resource
    Ibrutinib as monotherapy versus combination therapy in Chinese patients with relapsed/refractory mantle cell lymphoma: A multicenter study
    Wiley ; 2022
    In:  Cancer Medicine Vol. 11, No. 22 ( 2022-11), p. 4134-4145
    Details
    In: Cancer Medicine, Wiley, Vol. 11, No. 22 ( 2022-11), p. 4134-4145
    Abstract: Ibrutinib has revolutionized the treatment of mantle cell lymphoma (MCL). Both ibrutinib monotherapy and ibrutinib‐based combination therapy are important salvage options for patients with relapsed/refractory (R/R) MCL. The real‐world efficacy and safety profile of the two strategies in Chinese patients with R/R MCL remain unclarified. Methods In the present study, data of 121 R/R MCL patients who received either ibrutinib monotherapy ( N = 68) or ibrutinib combination therapy ( N = 53) in 13 medical centers in China were retrospectively reviewed. Results With a median follow‐up of 20.5 months, the overall response rate was 60.3% versus 84.9% ( p = 0.003), complete remission rate was 16.2% versus 43.4% ( p 〈  0.001), and median progression‐free survival (PFS) was 18.5 months (95% confidence interval [CI], 12.1–21.8) vs. 30.8 months (95% CI, 23.5‐NR) (hazard ratio, 0.53 [95% CI, 0.30–0.93] ; p = 0.025), with ibrutinib monotherapy and ibrutinib‐based combination therapy, respectively. Subgroup analysis showed that patients with male gender, no refractory disease, Ki67 〈 30%, previous line of therapy = 1, non‐blastoid subtype, and the number of extranodal sites involved 〈 2 might benefits more from the combination therapy. Treatment‐emergent adverse events were similar, except for a higher incidence of all grade neutropenia in the ibrutinib combination group (12.7% vs. 32.0%, p = 0.017). Conclusions Ibrutinib combination therapy demonstrated potentially superior efficacy and comparable tolerability to ibrutinib monotherapy. Ibrutinib‐based combination therapy could be one of the prominent treatment options for R/R MCL patients.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v11.22
    DOI: 10.1002/cam4.4765
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2659751-2
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  • 2
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    Online Resource
    Society‐level social axiom moderates the association between growth mindset and achievement across cultures
    Wiley ; 2021
    In:  British Journal of Educational Psychology Vol. 91, No. 4 ( 2021-12), p. 1166-1184
    Details
    In: British Journal of Educational Psychology, Wiley, Vol. 91, No. 4 ( 2021-12), p. 1166-1184
    Abstract: Meta‐analytic studies show that the benefits of the growth mindset on academic achievement are heterogenous. Past studies have explored how individual characteristics and proximal environmental factors could explain these variations, but the role of the broader sociocultural environment has seldom been explored. Aims We investigated society‐level social axioms to explain variations in growth mindset effects on achievement across cultures. We hypothesized that three society‐level social axioms (social complexity, fate control, and reward for application) imply social norms that would either support or obstruct the growth mindset effect. Sample and methods We conducted multilevel SEM with random slopes using data from 273,074 students nested within 39 countries/territories. Results We found weaker growth mindset effects in societies with stronger social complexity beliefs; societies believing that there are multiple solutions to problems have social norms that obstruct the growth mindset effects on achievement. No moderating effects were found with other social axioms. Conclusion Relevant cultural‐level normative beliefs should be considered to better assess the relevance of the growth mindset construct.
    Type of Medium: Online Resource
    ISSN: 0007-0998 , 2044-8279
    URL: Issue
    URL: Article
    DOI: 10.1111/bjep.v91.4
    DOI: 10.1111/bjep.12411
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 280391-4
    detail.hit.zdb_id: 1501130-6
    SSG: 5,2
    SSG: 5,3
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  • 3
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    Online Resource
    Why do girls do better in reading than boys? How parental emotional contagion explains gender differences in reading achievement
    Wiley ; 2020
    In:  Psychology in the Schools Vol. 57, No. 2 ( 2020-02), p. 310-319
    Details
    In: Psychology in the Schools, Wiley, Vol. 57, No. 2 ( 2020-02), p. 310-319
    Abstract: Previous studies that attempted to explain why girls often perform better than boys in reading have emphasized the role of values and beliefs, with little attention paid to the role of emotions. This study focused on the role of parent–child emotional contagion in explaining gender differences, by investigating how parents’ reading emotion predicts students’ reading emotion and subsequent reading achievement. The data that was used was from a subsample of students from the Program for International Students Assessment ( n  = 84,429) from 14 countries. Multi‐group structural equation modeling was conducted to assess a model of parents’ enjoyment of reading predicting reading achievement through students’ enjoyment of reading. Results provided support for a model of parents’ enjoyment of reading, predicting students 'enjoyment of reading, and subsequent reading achievement for both girls and boys. However, the indirect effect of parents’ enjoyment of reading on reading achievement through students’ enjoyment of reading was found to be stronger in girls than in boys. Findings emphasize the important role of parents’ emotions on student outcomes and how gender biases in a certain context can affect the extent to which parents’ emotions can influence student achievement.
    Type of Medium: Online Resource
    ISSN: 0033-3085 , 1520-6807
    URL: Issue
    URL: Article
    DOI: 10.1002/pits.v57.2
    DOI: 10.1002/pits.22330
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2002070-3
    SSG: 5,2
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  • 4
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    RBM4 inhibits the growth of clear cell renal cell carcinoma by enhancing the stability of p53 mRNA
    Wiley ; 2023
    In:  Molecular Carcinogenesis Vol. 62, No. 4 ( 2023-04), p. 464-478
    Details
    In: Molecular Carcinogenesis, Wiley, Vol. 62, No. 4 ( 2023-04), p. 464-478
    Abstract: RBM4 has been reported as a tumor suppressor gene in cancers, including lung cancer, colon cancer and gastric cancer. However, the role of RBM4 in clear cell renal cell carcinoma (ccRCC) remains unclear. Therefore, the present study investigated the expression and biological function of RBM4 in ccRCC. Analysis of the differential expression of RBM4 and its relationship with clinicopathological features using ccRCC samples data from TCGA database deminstrated that RBM4 expression in tumor samples of ccRCC was lower than that in normal samples, and RBM4 expression was closely related to the survival time of patients. RBM4 overexpression (RBM4‐oe) cell lines were constructed to investigate the effect of RBM4 on biological function using CCK‐8, EdU, flow cytometry and wound‐healing assays. In addition, the regulatory effect of RBM4 on signaling pathways was investigated by GSEA and WB assays. RBM4‐oe significantly reduced the proliferation of ccRCC cells by controlling the p53 signaling pathway, inhibited cell cycle progression and promoted apoptosis. In addition, RBM4‐oe suppressed the migration and invasion of cells by EMT. Mechanistically, RBM4‐oe facilitated the activity of the p53 signaling pathway by enhancing the stability of p53 mRNA. Finally, RBM4‐oe markedly inhibited the growth of tumors formed with 786‐O cells in vivo. In summary, there findings suggeated that RBM4 inhibits the progression of ccRCC by promoting p53 signaling pathway activity by enhancing the stability of p53 mRNA, suggesting that RBM4 may be a potential target for the treatment of patients.
    Type of Medium: Online Resource
    ISSN: 0899-1987 , 1098-2744
    URL: Issue
    URL: Article
    DOI: 10.1002/mc.v62.4
    DOI: 10.1002/mc.23499
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2001984-1
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  • 5
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    Online Resource
    Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharide‐stimulated periodontitis in vitro and in vivo
    Wiley ; 2022
    In:  Oral Diseases
    Details
    In: Oral Diseases, Wiley
    Abstract: Ferroptosis is associated with multiple inflammatory diseases. Periodontitis is an inflammatory disease mainly caused by oral opportunistic pathogens. However, the ferroptosis–periodontitis relationship has not been thoroughly described. We here analyzed whether ferroptosis is involved in periodontitis. Materials and methods Human gingival fibroblasts (HGFs) were stimulated with P. gingivalis ‐LPS and ferrostatin‐1 (Fer‐1, a ferroptosis inhibitor), and changes in mitochondrial morphology, ferroptosis‐related factors, and inflammation levels were detected. After the rat experimental periodontitis model was established, changes in ferroptosis‐related factors and inflammation levels were re‐evaluated in the same manner. Results Porphyromonas gingivalis ‐LPS‐induced mitochondrial shrinkage, an increase in mitochondrial membrane density, and upregulation of reactive oxygen species in HGFs. The expression of prostaglandin‐endoperoxide synthase 2, transferrin receptor 1, and malondialdehyde and inflammation levels were upregulated, whereas the expression of solute carrier family seven member 11, glutathione peroxidase 4, superoxide dismutase, and glutathione were downregulated. Fer‐1 attenuated these aforementioned changes and inflammation levels induced by P. gingivalis ‐LPS. The in vivo experiment results were consistent with the in vitro experiment results. Conclusions Ferroptosis is involved in inflammatory processes in HGFs upon P. gingivalis ‐LPS stimulation. Ferroptosis is observed in the gingival tissue of periodontitis rats.
    Type of Medium: Online Resource
    ISSN: 1354-523X , 1601-0825
    URL: Article
    DOI: 10.1111/odi.14292
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2008428-6
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  • 6
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    Online Resource
    The role of nucleolar spindle‐associated protein 1 in human ovarian cancer
    Wiley ; 2020
    In:  Journal of Cellular Biochemistry Vol. 121, No. 11 ( 2020-11), p. 4397-4405
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 121, No. 11 ( 2020-11), p. 4397-4405
    Abstract: Ovarian cancer (OC) is one of the deadliest malignancies of the female reproductive system. The present study focused on the role of Nucleolar spindle‐associated protein 1 (NuSAP1) in OC. Relative expression of NuSAP1 was detected in OC tissues as well as cells. After knocking down NuSAP1 with lentivirus‐mediated shRNA and verifying the knockdown efficiency via quantitative real‐time polymerase chain reaction and Western blot assays, the cell proliferation, apoptosis, and cell cycle were determined using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, colony formation, and flow cytometry, respectively. Transwell assay was conducted to detect the migration and invasion of OC cells. It was showed that NuSAP1 was abundantly expressed in OC tissues and cell lines. After knocking down NuSAP1 in OC cells, in addition to significantly inhibiting proliferation and colony forming ability, it also promotes apoptosis and affects cell cycle distribution. Moreover, cells in the shNuSAP1 group showed significantly suppressed migration and invasion ability compared with that in the shCtrl group. In conclusion, NuSAP1 may act as an oncogenic factor in OC and therefore might serve as an indicator for prognosis and therapeutic target for OC treatment.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v121.11
    DOI: 10.1002/jcb.29661
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1479976-5
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  • 7
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    Societal‐level utility value strengthens the relationship between student‐level utility value and achievement: A person‐culture fit perspective
    Wiley ; 2021
    In:  British Journal of Educational Psychology Vol. 91, No. 1 ( 2021-03), p. 328-346
    Details
    In: British Journal of Educational Psychology, Wiley, Vol. 91, No. 1 ( 2021-03), p. 328-346
    Abstract: Expectancy–value theory posits that higher levels of utility‐value yield better achievement outcomes. Much of the existing research on utility value has focused on the individual as the unit of analysis. Person–culture fit theory, however, suggests that it is also important to consider the fit between the person and the broader society one is embedded in. The greater the fit, the more optimal outcomes ensue. However, to our knowledge past studies have not examined utility value from a person–culture fit perspective. Aims This study aimed to examine whether person–culture fit in utility value, defined as the match between the student’s and the society’s utility value perceptions, is associated with more optimal outcomes. More specifically, we examined (1) how utility value predicted achievement and (2) whether societal‐level utility value changed the magnitude of the relationship between student‐level utility value and achievement. Sample We used the Programme for International Student Assessment (PISA) 2009 data provided by 502,261 15‐year‐old students from 73 countries/societies. Methods Multilevel random‐slopes structural equation modelling was used. Results Across all societies, students with higher utility value had better achievement. Moreover, in societies where schooling is highly valued, students’ utility value was a stronger predictor of achievement in reading, math, and science confirming our person–culture fit hypothesis. Conclusion These findings signify the importance of person–culture fit in utility value. It also has important implications for motivation research by demonstrating the need to take the broader societal context into account and moving beyond an exclusive focus on the individual student as the unit of analysis.
    Type of Medium: Online Resource
    ISSN: 0007-0998 , 2044-8279
    URL: Issue
    URL: Article
    DOI: 10.1111/bjep.v91.1
    DOI: 10.1111/bjep.12354
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 280391-4
    detail.hit.zdb_id: 1501130-6
    SSG: 5,2
    SSG: 5,3
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  • 8
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    Ordered Heterostructured Aerogel with Broadband Electromagnetic Wave Absorption Based on Mesoscopic Magnetic Superposition Enhancement
    Wiley ; 2023
    In:  Advanced Science Vol. 10, No. 21 ( 2023-07)
    Details
    In: Advanced Science, Wiley, Vol. 10, No. 21 ( 2023-07)
    Abstract: Demand for lightweight and efficient electromagnetic wave (EW) absorbers continues to increase with technological advances in highly integrated electronics and military applications. Although MXene‐based EW absorbers have been extensively developed, more efficient electromagnetic coupling and thinner thickness are still essential. Recently, ordered heterogeneous materials have emerged as a novel design concept to address the bottleneck faced by current material development. Herein, an ordered heterostructured engineering to assemble Ti 3 CNT x MXenes/Aramid nanofibers/FeCo@SiO 2 nanobundles (FS) aerogel (AMFS‐O) is proposed, where the commonly disordered magnetic composition is transformed to ordered FS arrays that provide more powerful magnetic loss capacity. Experiments and simulations reveal that the anisotropy magnetic networks enhance the response to the magnetic field vector of EW, which effectively improves the impedance matching and makes the reflection loss (RL) peaks shift to lower frequencies, leading to the thinner matching thickness. Furthermore, the temperature stability and excellent compressibility of AMFS‐O expand functionalized applications. The synthesized AMFS‐O achieves full‐wave absorption in X and Ku‐band (8.2–18.0 GHz) at 3.0 mm with a RL min of −41 dB and a low density of 0.008 g cm −3 . These results suggest that ordered heterostructured engineering is an effective strategy for designing high‐performance multifunctional EW absorbers.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v10.21
    DOI: 10.1002/advs.202301599
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2808093-2
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  • 9
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    Is there a common latent cognitive construct for dementia estimation across two Chinese cohorts?
    Wiley ; 2022
    In:  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Vol. 14, No. 1 ( 2022-01)
    Details
    In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, Vol. 14, No. 1 ( 2022-01)
    Abstract: It is valuable to identify common latent cognitive constructs for dementia prevalence estimation across Chinese aging cohorts. Methods Based on cognitive measures of 12015 Chinese Longitudinal Healthy Longevity Survey (CLHLS; 13 items) and 6623 China Health and Retirement Longitudinal Study (CHARLS; 9 items) participants aged 65 to 99 in 2018, confirmatory factor analysis was applied to identify latent cognitive constructs, and to estimate dementia prevalence compared to Mini‐Mental State Examination (MMSE) and nationwide estimates of the literature. Results A common three‐factor cognitive construct of orientation, memory, and executive function and language was found for both cohorts with adequate model fits. Crude dementia prevalence estimated by factor scores was similar to MMSE in CLHLS, and was more reliable in CHARLS. Age‐standardized dementia estimates of CLHLS were lower than CHARLS among those aged 70+, which were close to the nationwide prevalence reported by the COAST study and Global Burden of Disease. Discussion We verified common three‐factor cognitive constructs for both cohorts, providing an approach to estimate dementia prevalence at the national level. Highlights Common three‐factor cognitive constructs were identified in Chinese Longitudinal Healthy Longevity Survey (CLHLS) and China Health and Retirement Longitudinal Study (CHARLS). Crude dementia estimates using factor scores were reliable in both cohorts. Estimates of CHARLS were close to current evidence, but higher than that of CLHLS.
    Type of Medium: Online Resource
    ISSN: 2352-8729 , 2352-8729
    URL: Issue
    URL: Article
    DOI: 10.1002/dad2.v14.1
    DOI: 10.1002/dad2.12356
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2832898-X
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  • 10
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    Glucose‐Sensing Photonic Nanochain Probes with Color Change in Seconds
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 9 ( 2022-03)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 9 ( 2022-03)
    Abstract: Glucose‐sensing photonic crystals are promising for the significant advance of continuous glucose monitoring systems due to the naked‐eye colorimetric readouts and noninvasive detection of diabetes, but the long response time hampers their practical applications. Here, for the first time probes of photonic nanochains (PNCs) are demonstrated that are capable of continuously and reversibly sensing glucose concentration ([glucose]) variation within seconds by color change without power consumption, much faster by 2–3 orders of magnitude than previous ones. They are comprised of 1D equidistant arrays of magnetic nanoparticles enveloped by tens‐of‐nanometer‐thick phenylboronic acid‐functionalized hydrogels, and fabricated by developing selective concentration polymerization of monomers in binary microheterogeneous solvents of dimethyl sulfoxide (DMSO) and H 2 O. In this process, both 3‐acrylamido phenylboronic acid (AAPBA) and N ‐2‐hydroxyethyl acrylamide (HEAAm) are preferentially dissolved in the small volume of free DMSO concentrated in the vicinity of poly vinylpyrrolidone coated Fe 3 O 4 colloidal nanoparticles (Fe 3 O 4 @PVP), yielding Fe 3 O 4 @PVP@poly(AAPBA‐ co ‐HEAAm) PNCs after UV irradiation under magnetic field. The PNCs in phosphate buffered solution have a wavelength‐shift range up to 130 nm when [glucose] changes from 0 to 20 × 10 −3 m . The results can facilitate real‐time glucose monitoring and provide an alternative to produce functional organic–inorganic nanostructures.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.9
    DOI: 10.1002/advs.202105239
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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