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  • Viet Nam National University Ho Chi Minh City  (11)
  • 2020-2024  (11)
  • 1
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    Online Resource
    Establishing pinostrobin reference standard for quantitative analysis of the rhizomes of Boesenbergia pandurata
    Viet Nam National University Ho Chi Minh City ; 2020
    In:  Science and Technology Development Journal - Natural Sciences Vol. 4, No. 4 ( 2020-12-16), p. first-
    Details
    In: Science and Technology Development Journal - Natural Sciences, Viet Nam National University Ho Chi Minh City, Vol. 4, No. 4 ( 2020-12-16), p. first-
    Abstract: Boesenbergia pandurata Roxb. Schlecht. (Zingiberaceae), called ``Ngai bun'' in Viet Nam, is one of the Southeast Asian medicinal plants and its rhizomes are used primarily as a spice. This is a perennial, short-stemmed plant, formed by leaf sheaths and can grow up to 50 cm. The leaves are 7-11 cm wide and 25-50 cm long. Its rhizome surfaces are light brown in color, the inner rhizome is yellow, oval-shaped, and has a very aromatic odor. In folklore, Boesenbergia pandurata rhizomes are used as a spice for food processing. This plant contains pinostrobin as the major constituents. Previously showed that pinostrobin compound is the main ingredient together with a variety of biological activities such as antibacterial, inhibition of free radicals, ... Pinostrobin is necessary composition for the screening, testing, and quality evaluation of the rhizomes of B. pandurata species and others in the Zingiberaceae family. This research had conducted a reference standard of pinostrobin isolated from the rhizomes of B. pandurata had 99.26 % purity, which is reliable in medicinal testing. An HPLC method for pinostrobin determination was conducted and The quantitative HPLC analysis was validated for system suitability, selectivity, linearity ranges, and precision. Application of the process to investigate the preparation of extract shown that reflux extraction with ethanol obtained the highest pinostrobin content with 22.05 % in extracts and 2.89 % in dried rhizomes of B. pandurata.
    Type of Medium: Online Resource
    ISSN: 2588-106X , 2588-106X
    URL: Article
    DOI: 10.32508/stdjns.v4i4.948
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2020
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  • 2
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    Chemical constituents and their alpha-glucosidase inhibitory activity from the stems of taxotrophis ilicifolius
    Viet Nam National University Ho Chi Minh City ; 2021
    In:  Science and Technology Development Journal - Natural Sciences Vol. 5, No. 3 ( 2021-06-27), p. 1334-1340
    Details
    In: Science and Technology Development Journal - Natural Sciences, Viet Nam National University Ho Chi Minh City, Vol. 5, No. 3 ( 2021-06-27), p. 1334-1340
    Abstract: Taxotrophis ilicifolius, called "Gai quít" in Vietnam, belonged to the family of Moraceae. The stems of T. ilicifolius are used in traditional medicine to cure pimples, anti-inflammatory, antibacterial... By column chromatography method together with thin layer chromatography on the ethyl acetate extract of its stems, six compounds were isolated including wogonin (1), 4-hydroxybenzoic acid (2), vanillic acid (3), vanillin (4), syringic acid (5), and syringaldehyde (6). Their chemical structures were elucidated by extensive NMR spectroscopic analysis and comparison with the literature data. The isolated compounds were tested fora-glucosidase inhibitory activity. All compounds showed more potent inhibitory activity with IC50 values 42–142 mM, than that of a positive control acarbose (IC50, 214.5 mM). Among all isolates, compounds 2, 4 and 6 exhibited significant a-glucosidase inhibitory activity with the IC50 values of 49.7, 42.6 and 55.9 mM, respectively. From the present investigation, all these compounds were isolated for the first time as well as their a-glucosidase inhibitoryactivity of T. ilicifolius. These results suggested that the traditional use of T. ilicifolius for the treatment of diabetes disease in Vietnam may be due to thea-glucosidase inhibitory activity of its phenolic constituents.
    Type of Medium: Online Resource
    ISSN: 2588-106X , 2588-106X
    URL: Article
    DOI: 10.32508/stdjns.v5i3.1028
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2021
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  • 3
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    Chemical constituents and their alpha-glucosidase inhibitory activity of Solanum procumbens
    Viet Nam National University Ho Chi Minh City ; 2021
    In:  Science and Technology Development Journal - Natural Sciences Vol. 5, No. 3 ( 2021-06-23), p. 1326-1333
    Details
    In: Science and Technology Development Journal - Natural Sciences, Viet Nam National University Ho Chi Minh City, Vol. 5, No. 3 ( 2021-06-23), p. 1326-1333
    Abstract: Solanum procumbens called ``Cà gai leo'' in Vietnam, belonged to the family of Solanaceae, which is a prickly diffuse, bright green perennial shrub, woody at the base. This plant has been sought for plenty of Vietnamese folk remedies for diseases such as rheumatism, back pain, detoxification, cough, pain relief, hemostasis, hepatitis, and cirrhosis. Chemical reports revealed the presence of lots of secondary metabolites such as steroids, triterpenoids, alkaloids, and phenolic compounds that have good biological activities such as antibacterial, antidiabetic, antioxidant, and antimicrobial... By column chromatography method together with thin layer normal-phase chromatography on the ethyl acetate extract of its entire plant, we isolated four compounds including dioscin (1), b -sitosterol (2), daucosterol (3) and 6'-O-acetyl-b -daucosterol (4). The result of theira-glucosidase inhibitory activity showed that compounds 2 and 4 had strong inhibition with IC50 values of 35.2 and 209.5 mM, comparing to the positive control, acarbose with an IC50 value of 214.5 mM. The results of this study have contributed to the scientific data of chemical compositions of Vietnamese medicinal plants, among them S. procumbens would potentially be developed as a plant-based drug to decrease the blood glucose level.
    Type of Medium: Online Resource
    ISSN: 2588-106X , 2588-106X
    URL: Article
    DOI: 10.32508/stdjns.v5i3.1027
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2021
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  • 4
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    Chemical constituents and theira-glucosidase inhibitory activity of the stem of Salacia chinensis L.
    Viet Nam National University Ho Chi Minh City ; 2021
    In:  Science and Technology Development Journal - Natural Sciences Vol. 5, No. 3 ( 2021-07-05), p. first-
    Details
    In: Science and Technology Development Journal - Natural Sciences, Viet Nam National University Ho Chi Minh City, Vol. 5, No. 3 ( 2021-07-05), p. first-
    Abstract: Salacia chinensis L., known as “Chop mao” in Vietnam, is a climbing shrub that belongs to the Celastraceae family. The stem of S. chinensis L. is used as a traditional medicine for the treatment of diabetes, rheumatoid arthritis, back pain, … The dried powdered stem of S. chinensis L. was collected in Phu Yen province and was extracted with methanol to yield methanol extract. The methanol extract was suspended in H2O and partitioned successively with n-hexane, CHCl3, EtOAc to obtain n-hexane, CHCl3, EtOAc, and H2O fractions, respectively. The CHCl3 fraction was subjected to a series of chromatographic separation to afford four purified compounds including 3-oxolup-20(29)-en-30-al (1), betulin-3-caffeate (2), 2-(4-hydroxy-3,5-dimethoxylphenyl)ethanol (3), and acetosyringone (4). Their structures were elucidated on the basis of the spectroscopic analysis and comparison with literature data. The isolated compounds were tested for their α-glucosidase inhibitory activity. The result indicated that all compounds (1-4) possessed significant α-glucosidase at the testing concentration of 100 µM with the percent inhibition values of 9.5 ± 1.3, 70.89 ± 0.25, 44.2 ± 1.6, and 6.7 ± 1.7 %, respectively. In addition, betulin-3-caffeate (2) and 2-(4-hydroxy-3,5-dimethoxylphenyl)ethanol (3) show more potent α-glucosidase inhibitory activity, with IC50 values of 69.7 and 152.0 µM, respectively, than that of positive control acarbose (IC50 = 214.5 µM).
    Type of Medium: Online Resource
    ISSN: 2588-106X , 2588-106X
    URL: Article
    DOI: 10.32508/stdjns.v5i3.1031
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2021
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  • 5
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    Chemical constituents of the Rhizomes of Curcuma zedoaria
    Viet Nam National University Ho Chi Minh City ; 2021
    In:  Science and Technology Development Journal - Natural Sciences Vol. 5, No. 2 ( 2021-04-16), p. first-
    Details
    In: Science and Technology Development Journal - Natural Sciences, Viet Nam National University Ho Chi Minh City, Vol. 5, No. 2 ( 2021-04-16), p. first-
    Abstract: Curcuma zedoaria (Berg.), belongs to the Zingiberaceae family, is one of the medicinal plants that is found in Southeast Asia. This plant is known as “Nghe tim” in Vietnam; and a decoction of its rhizomes has been used traditionally for the cure flatulence, fatigue, and hepatitis. Previously, some studies on the chemical constituent of the rhizomes of C. zedoaria have reported plenty of curcuminoids and sesquiterpenoids together with their derivatives, which have shown a lot of various bioactivities such as antiproliferative characteristic, anti-ulcer, antioxidant and antibacterial potential. By chromatography column method along with preparative thin layer chromatography on a normal phase silica gel on the EtOAc extract of the rhizomes of Curcuma zedoaria, we have isolated five pure compounds. Their chemical structures have been elucidated by NMR techniques and comparison with publishing data that have determined to be gajustulactone A (1), isozedoarondiol (2), neolitacumone (3), β-sitosterol (4), and β-stigmasterol (5). The results of this study have contributed to the scientific data system on the chemical composition of Vietnamese medicinal plants, especially the rhizomes of Curcuma zedoaria grown in Tinh Bien, An Giang. Therefore, there is more evidence to continue screening studies to detect interesting biological activities from this species.
    Type of Medium: Online Resource
    ISSN: 2588-106X , 2588-106X
    URL: Article
    DOI: 10.32508/stdjns.v5i2.950
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2021
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  • 6
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    Chemical constituents of the leave of Gnetum gnemon L.
    Viet Nam National University Ho Chi Minh City ; 2020
    In:  Science and Technology Development Journal - Natural Sciences Vol. 3, No. 3 ( 2020-02-13), p. 188-194
    Details
    In: Science and Technology Development Journal - Natural Sciences, Viet Nam National University Ho Chi Minh City, Vol. 3, No. 3 ( 2020-02-13), p. 188-194
    Abstract: (Vietnamese name; L.), which belongs to the family, is an evergreen and perennial tree that is widely cultivated in Southeast Asia. In Vietnam, leaves of the species are used as an ordinary vegetable in many regions. The aim of this research is to investigate the chemical constituents of G. leaves collected from Lam Dong province, Vietnam. The fresh leaves were collected, dried, cut into small species, and extracted with ethanol to the extract. By using the column chromatography method together with thin layer chromatography on a normal phase silica gel with different solvent systems on the extract of the dried leaves of G. L., we isolated five pure compounds. The structures of 1-5 were elucidated by analyzing nuclear magnetic resonance (NMR) data. The result was confirmed by comparison with publish data including (1), acid (2), acid (3), (4), and (5). To the best of our knowledge, compounds 1-3were isolated from this plant for the first time. This study is to provide a comprehensive overview of of G. , and possibly make recommendations for further research.
    Type of Medium: Online Resource
    ISSN: 2588-106X , 2588-106X
    URL: Article
    DOI: 10.32508/stdjns.v3i3.572
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2020
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  • 7
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    Establishing murine models of hepatocellular carcinoma using NOD/SCID, nude and Balb/c mice: An initial comparative study
    Viet Nam National University Ho Chi Minh City ; 2020
    In:  Science and Technology Development Journal Vol. 23, No. 1 ( 2020-03-19), p. 454-460
    Details
    In: Science and Technology Development Journal, Viet Nam National University Ho Chi Minh City, Vol. 23, No. 1 ( 2020-03-19), p. 454-460
    Abstract: Introduction: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality in the world. Therefore, more and more studies are developing novel therapies to treat this disease. The pre-clinical trials on animals are a vital step to evaluate the efficacy as well as side effects of these novel therapies. Hence, this study aimed to develop the murine model of HCC using 3 kinds of mice: NOD/SCID, nude and Balb/c mice. Methods: HCC cell line HepG2 was used in this study. They were injected into 3 kinds of mice: NOD/SCID, nude and Balb/c mice at three doses: 5 x 106, 2.5 x 106, and 1.25 x 106 cells. Tumor size and body weight of the mice were recorded daily. To confirm these tumors in mice as malignant tumors, they were removed and analyzed by histopathology. Results: The results showed that in nude mice, the tumors appeared after 1 day of injection and could be detected by the naked eye; they continuously developed until the end of the study. In NOD/SCID mice, the tumors could be detected by the naked eye after 3 days of injection; their sizes also increased until the end of the experimental study. Meanwhile, in Balb/c mice, although the tumors could be observed by the naked eye on the 3rd day after cell injection, they regressed and markedly disappeared after 30 days. The dose of 5 x 106 cells per mouse induced the largest tumors (1.2 cm in diameter) in NOD/SCID mice. The histopathological analysis showed that the tumors collected from nude and NOD/SCID mice also displayed the poorly differentiated malignant carcinoma with muscle tissue invasion. Conclusion: Both nude and NOD/SCID mice are appropriate for future studies to establish HCC murine models using HepG2 injection.
    Type of Medium: Online Resource
    ISSN: 1859-0128
    URL: Article
    DOI: 10.32508/stdj.v23i1.1767
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2020
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  • 8
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    Xao tam phan (Paramignya trimera) methanol extract induced apoptosis in hepatocellular carcinoma HepG2 cell line in vitro
    Viet Nam National University Ho Chi Minh City ; 2020
    In:  Science and Technology Development Journal Vol. 23, No. 1 ( 2020-03-31), p. 484-489
    Details
    In: Science and Technology Development Journal, Viet Nam National University Ho Chi Minh City, Vol. 23, No. 1 ( 2020-03-31), p. 484-489
    Abstract: Introduction: Xao Tam Phan (Paramignya trimera) has long been used in Viet Nam as an herbal medicine for the treatment of Hepatitis, hepatocellular carcinoma, and diabetes. This study aimed to determine the anti-proliferation effect of Paramignya trimera extract (P. trimera extract) on HepG2 hepatocellular carcinoma cells. Methods: AlamarBlue assay was used to determine the IC50 values of P. trimera extract on HepG2 cells. Adipose-derived stem cells (ADSCs) was used as normal cell control. For apoptosis examination, P. trimera extract-treated HepG2 cells were incubated with Annexin V/Propidium iodide (PI). Then they have been analyzed their expression of Annexin-V and PI by flow cytometry. The cell nuclear degradation also was evaluated by PI/Hoechst 33342 staining assay. Results: Doxorubicin and P. trimera extract IC50 values on HepG2 cells were 55.13 +/- 2.028 ng/ml and 582.533 +/- 16.521 mg/ml, respectively. Those on ADSCs were 5.96 +/- 0.56 ng/ml and 268.976 +/- 19.325 mg/ml, respectively. Side effect index value (SEI) of P. trimera extract was 2.175 +/- 0.12, and the SEI of doxorubicin was 8.71 +/- 0.36. Flow cytometry analysis indicated significant apoptosis on P. trimera extract-treated HepG2 cells at a dose of 500 mg/ml (32.39 +/- 2.28% apoptotic cells, and 14.63 +/- 1.59% necrotic cells). Nuclear aggregation and degradation was seen on 500 mg/ml P. trimera treated HepG2 cells. Conclusion: P. trimera extract could inhibit HepG2 hepatocellular carcinoma cell proliferation by inducing apoptosis.  
    Type of Medium: Online Resource
    ISSN: 1859-0128
    URL: Article
    DOI: 10.32508/stdj.v23i1.2013
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2020
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  • 9
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    Determining facies distribution trend in order to update geological modeling ILBH 5.2 reservoir, lower miocene, Rong Trang Field, Block 16-1 Cuu Long Basin
    Viet Nam National University Ho Chi Minh City ; 2020
    In:  Science and Technology Development Journal - Natural Sciences Vol. 4, No. 3 ( 2020-09-06), p. First-
    Details
    In: Science and Technology Development Journal - Natural Sciences, Viet Nam National University Ho Chi Minh City, Vol. 4, No. 3 ( 2020-09-06), p. First-
    Abstract: Dòng dầu khí thương mại được phát hiện tại tập cát kết 5.2U, mỏ Rồng Trắng lô 16-1 trầm tích Miocen hạ bể Cửu Long. Tuy nhiên tầng chứa thường là tập hợp các vỉa mỏng, bất đồng nhất. Trên cơ sở xác định nguồn gốc của vật liệu, điều kiện biến đổi của môi trường, chế độ động lực của quá trình vận chuyển, bối cảnh địa hóa môi trường lắng đọng và tạo đá, công trình làm sáng tỏ quy luật phân bố tướng đá tầng chứa. Việc áp dụng phương thức tiếp cận tổng hợp địa chấn, tài liệu thạch học, mẫu lõi và địa vật lý giếng khoan kết hợp với ứng dụng mô hình địa chất phân giải cao cho phép chính xác hoá quy luật phân bố tướng đá của tập ILBH 5.2. Kết quả nghiên cứu tập đã phân loại thành công tướng đá chủ yếu ứng với môi trường thành tạo: Môi trường sông gồm tướng tướng trầm tích lòng sông, trầm tích vỡ đê và trầm tích ven sông phân bố theo phương từ Tây – Đông đến Bắc Tây Bắc – Nam Đông Nam, trong đó vùng Bắc – Tây Bắc đá chứa có chất lượng tốt nhất, theo phương Đông Nam là các tướng trầm tích lòng hồ, trầm tích cát ven bờ và trầm tích cát xa bờ được hình thành trong môi trường hồ và tại ranh giới giữa 2 môi trường đá chứa có chất lượng cao hơn cả. Cơ chế hình thành thành hệ trầm tích chứa dầu khí tuổi Miocen của lô 16-1 nói riêng, khu vực Trung Bộ phức tạp, để có thể dự đoán xu thế phân bố tiềm năng của thành hệ này, cần tiến hành đánh giá vai trò của phức hệ macma trong quá trình thành tạo thành hệ chứa dầu khí tuổi Miocen.
    Type of Medium: Online Resource
    ISSN: 2588-106X , 2588-106X
    URL: Article
    DOI: 10.32508/stdjns.v4i3.895
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2020
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  • 10
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    Investigate the mechanical properties of Si/Ge (Ge/Si) core-shell nanowires: A molecular dynamics study
    Viet Nam National University Ho Chi Minh City ; 2020
    In:  Science & Technology Development Journal - Engineering and Technology Vol. 3, No. 4 ( 2020-12-27), p. first-
    Details
    In: Science & Technology Development Journal - Engineering and Technology, Viet Nam National University Ho Chi Minh City, Vol. 3, No. 4 ( 2020-12-27), p. first-
    Abstract: Nanowires (NWs) have been used increasingly in practice due to their outstanding mechanical, physical, and chemical properties. In this paper, we use the molecular dynamics (MD) method to investigate the mechanical properties of NWs (Si/Ge, Ge/Si) with a core-shell structure under the axial tensile strain along the 〈 100 〉 /{100} direction. Our results show that the strength and elastic modulus of Ge/Si and Si/Ge NWs depend on the composition and size of the core/shell crosssection. The strength and strain of Ge/Si NW decrease with increasing the size of the core crosssection because of the lattice mismatch between two layers of core/shell materials. The elastic modulus of Ge/Si NWs increases with the increasing the size of the core cross-section, while the elastic modulus of the Si/Ge NW decreases. In addition, the theoretical strength and elastic modulus of Ge/Si NWs reduce with the growth of the temperature. Furthermore, we also investigate the effect of strain rate on the mechanical properties of the Ge/Si NWs. The obtained results of the study provide the intrinsic properties of the core-shell NWs and also help in the design and fabrication of electronic and optical devices based on the Ge/Si NWs.
    Type of Medium: Online Resource
    ISSN: 2615-9872 , 2615-9872
    URL: Article
    DOI: 10.32508/stdjet.v3i4.800
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2020
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