In:
Tạp chí Y học Dự phòng, Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM), Vol. 32, No. 4 ( 2022-08-01), p. 74-81
Abstract:
Rotavirus (RV), Norovirus (NV), Sapovirus (SaV) and Astrovirus (Ast) are the leading causes of gastroenteritis and mortality in children worldwide. RV vaccines help to reduce the burden of diarrhea while the importance of other viruses is increasing. Therefore, we conducted a cross-sectional descriptive study to determine prevalence of these viruses in hospitalized children under 5 years old in Nam Dinh province with approximately 80% of RV vaccine coverage. We randomly selected 579 (25%) among diarrheal samples collected in 4 district hospitals from Dec. 2017 to Nov. 2019. An ELISA kit was employed to detect RV and the multiplex real-time RT-PCR with specific primers to detect NV, SaV and Ast. These viruses were found among 64.3% of hospitalized children, of which NV and RV were present in 28.5% and 21.4%, respectively, while SaV and Ast were detected in 3.3% and 2.6%, respectively. Co-infections accounted for 8.5%, mainly among RV and 3 other viruses. There is a significant difference in RV and NV positive rates between vaccinated and unvaccinated groups (p 〈 0.001 and p = 0.008, respectively). This study contributed to the understanding of the potential impact of rotavirus vaccine on other diarheal pathogens and emphasize the need for further epidemiological studies when the nationwide RV vaccination in Vietnam is implementing.
Type of Medium:
Online Resource
ISSN:
0868-2836
DOI:
10.51403/0868-2836/2022/686
Language:
Unknown
Publisher:
Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM)
Publication Date:
2022
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