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  • SAGE Publications  (77)
  • 2020-2024  (77)
  • 1
    Online Resource
    Online Resource
    The association between HER2-low expression and prognosis of breast cancer: a systematic review and meta-analysis
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Medical Oncology Vol. 15 ( 2023-01), p. 175883592311566-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 15 ( 2023-01), p. 175883592311566-
    Abstract: The use of antibody–drug conjugates for the treatment of advanced-stage human epidermal growth factor receptor 2 (HER2)-low expression in breast cancer (BC) has shown prominent curative effects, which has led to increased academic interest. However, the role of HER2-low expression in the prognosis of BC remains controversial. Methods: We conducted a systematic search of the PubMed, Embase, and Cochrane library databases and several oncology conferences until 20 September 2022. We used fixed- and random-effects models to calculate odds ratio (OR) or hazard ratio (HR) with 95% confidence interval (CI) for overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), and pathological complete response (pCR) rates. Results: Overall, 26 studies encompassing 677,248 patients were included in the meta-analysis. Patients with HER2-low BC showed significantly better OS than those with HER2-zero BC in the overall population (HR = 0.90; 95% CI: 0.85–0.97) and hormone receptor-positive population (HR = 0.98; 95% CI: 0.96–0.99), whereas no significant difference was observed in the OS of the hormone receptor-negative population ( p  〉  0.05). In addition, there was no significant difference in the DFS of the overall and hormone receptor-negative population ( p  〉  0.05), but better DFS than those with HER2-zero BC in the hormone receptor-negative population (HR = 0.96; 95% CI: 0.94–0.99). There was also no significant difference in the PFS of the overall population, hormone receptor-positive, and hormone receptor-negative population ( p  〉  0.05). Patients with HER2-low BC had a lower pCR rate after neoadjuvant treatment than those with HER2-zero BC. Conclusions: Compared to patients with HER2-zero BC, those with HER2-low BC had better OS in the overall population and hormone receptor-positive population, DFS in hormone receptor-positive population and lower pCR in the overall population. The biological differences between HER2-low and HER2-zero BCs, particularly in hormone receptor-positive patients, and the relationship between HER2-low expression status and prognosis need to be explored further.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359231156669
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2503443-1
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  • 2
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    Short-Term Effect of Lumbar Traction on Intervertebral Discs in Patients with Low Back Pain: Correlation between the T2 Value and ODI/VAS Score
    SAGE Publications ; 2021
    In:  CARTILAGE Vol. 13, No. 1_suppl ( 2021-12), p. 414S-423S
    Details
    In: CARTILAGE, SAGE Publications, Vol. 13, No. 1_suppl ( 2021-12), p. 414S-423S
    Abstract: The effect of lumbar traction on low back pain (LBP) patients is controversial. Our study aims to assess changes in the intervertebral disc water content after lumbar traction using T2 mapping and explore the correlation between changes in the T2 value and Oswestry Disability Index (ODI)/visual analogue scale (VAS) score. Design Lumbar spine magnetic resonance imaging was performed, and the ODI/VAS scores were recorded in all 48 patients. Midsagittal T2-weighted imaging and T2 mapping were performed to determine the Pfirrmann grade and T2 value. Then, the T2 values were compared between pre- and posttraction, and the correlation between changes in the T2 value and ODI/VAS scores were examined. Results In the traction group, the changes in the nucleus pulposus (NP) T2 values for Pfirrmann grades II-IV and the annulus fibrosus (AF) T2 values for Pfirrmann grade II were statistically significant after traction ( P 〈 0.05). Changes in the mean NP T2 value of 5 discs in each patient and in the ODI/VAS score showed a strong correlation ( r = 0.822, r = 0.793). Conclusion T2 mapping can be used to evaluate changes in the intervertebral disc water content. Ten sessions of traction resulted in a significant increase in quantitative T2 measurements of the NP in discs for Pfirrmann grade II-IV degeneration and remission of the patients’ clinical symptoms in the following 6 months. Changes in the mean NP T2 value of 5 discs in each patient were strongly correlated with changes in the ODI/VAS score.
    Type of Medium: Online Resource
    ISSN: 1947-6035 , 1947-6043
    URL: Article
    DOI: 10.1177/1947603521996793
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2515870-3
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  • 3
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    Distributed H ∞ consensus of multiagent systems with nonuniform time-varying communication delays
    SAGE Publications ; 2023
    In:  Transactions of the Institute of Measurement and Control
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications
    Abstract: This article addresses the distributed H ∞ consensus control problem of general linear multiagent systems with time-varying communication delays and external disturbances. The communication network is subject to arbitrarily bounded and nonuniform time-varying communication delays. Based on the leader-following control mode, a novel distributed state feedback control protocol is proposed to achieve state consensus over undirected fixed topology while guaranteeing a prescribed disturbance rejection objective. By means of Lyapunov analysis and some inequality techniques, admissible upper bounds of nonuniform time-varying delays and H ∞ consensus criteria are acquired. As opposed to the existing result for the similar problem, our result has its distinct advantages in that it can accommodate arbitrarily bounded nonuniform time-varying communication delays, and has greater delay margin and better consensus performance. Moreover, the consensus problem for the multiagent systems over connected undirected switching topology is discussed. Finally, a numerical example is provided to show the effectiveness and superiority of these obtained results.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/01423312231158841
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2025882-3
    SSG: 3,2
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  • 4
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    LncRNA HOXA-AS2 Promotes Oral Squamous Cell Proliferation, Migration, and Invasion via Upregulating EZH2 as an Oncogene
    SAGE Publications ; 2021
    In:  Technology in Cancer Research & Treatment Vol. 20 ( 2021-01), p. 153303382110391-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 20 ( 2021-01), p. 153303382110391-
    Abstract: Oral squamous cell carcinoma (OSCC) is one of the most common types of cancer worldwide. Accumulating evidence has shown that long noncoding RNAs (lncRNAs) serve important roles in the development of OSCC. The purpose of this study was to investigate the biological function and underlying regulatory mechanism of lncRNA homeobox A cluster antisense RNA2 (HOXA-AS2) in OSCC. RT-qPCR was performed to analyze the HOXA-AS2 expressions in human immortalized oral epithelial cell (HIOEC) line, human OSCC cell lines, and plasma. The expression of HOXA-AS2 and enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) in Tca-8113 cells were knocked down or overexpressed by transfection with shRNA-HOXA-AS2 or pcDNA-EZH2, respectively. The interaction between HOXA-AS2 and EZH2 was validated by RNA immunoprecipitation assay. In addition, cell proliferation was assessed by CCK-8 and EdU assays. Cell cycle distribution was analyzed by flow cytometry. Cell migration and invasion were detected using wound healing and Transwell assays, respectively. Apoptosis was detected by TUNEL staining. The protein expression levels of cell cycle and apoptosis-related proteins were measured by western blot analysis. Compared with HIOEC cells, HOXA-AS2 expression in OSCC cells was upregulated. HOXA-AS2 knockdown significantly inhibited Tca-8113 cell proliferation, blocked the cell cycle by arresting cells in the G0/G1 phase, promoted apoptosis, and suppressed migration and invasion. In addition, HOXA-AS2 was predicted to directly target EZH2 and positively regulate EZH2 expression. EZH2 overexpression could reverse the inhibitory effect of HOXA-AS2 knockdown on the proliferation, migration, and invasion of Tca-8113 cells. In summary, the findings suggested that HOXA-AS2 may inhibit cell proliferation, invasion, and migration, induce cell cycle arrest in the G0/G1 phase, and increase cell apoptosis by targeting EZH2. The research indicated that HOXA-AS2/EZH2 axis may play a key role in the development of OSCC.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/15330338211039109
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 5
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    Toward discourse involution within China’s Internet: Class, voice, and social media
    SAGE Publications ; 2022
    In:  New Media & Society Vol. 24, No. 5 ( 2022-05), p. 1033-1052
    Details
    In: New Media & Society, SAGE Publications, Vol. 24, No. 5 ( 2022-05), p. 1033-1052
    Abstract: Despite scholarly concern regarding the online discussion in China’s cyberspace, research tracing the trends in discourse expression on social media remains scant. Revolving around the concept of discursive power, this study explicates how the voices of different social classes have been represented and expressed in social media during the past decade. Employing longitudinal content analysis on class-based voice in 2009 ( n = 1374) and 2018 ( n = 25,330), the results demonstrate that online discussion in China’s social media has displayed a trend for “discourse involution,” where the increasing appropriation of the Internet among different social classes results in a continued divide of the discursive power in cyberspace. We argue that this discourse involution is achieved through the asymmetry of discursive expression, centralization of voice representation, and polarization in the emotional expression online. The study contributes to the current debate on the social effects of online discussions using a discursive and class-based approach.
    Type of Medium: Online Resource
    ISSN: 1461-4448 , 1461-7315
    URL: Article
    DOI: 10.1177/1461444820966753
    RVK:
    MN 1000
    RVK:
    AP 10792.2
    RVK:
    AP 10790.6
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1476527-5
    detail.hit.zdb_id: 2684519-2
    detail.hit.zdb_id: 2016312-5
    detail.hit.zdb_id: 2686704-7
    SSG: 24,1
    SSG: 3,4
    SSG: 3,5
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  • 6
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    Multiple ballistic impacts of thin metallic plates: Numerical simulation
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 236, No. 14 ( 2022-07), p. 7962-7973
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 236, No. 14 ( 2022-07), p. 7962-7973
    Abstract: The ballistic performance of protective structures under multiple projectile impacts attracts increasing attention due to its practical importance, and existing studies were seldomly devoted to exploring how the structure would deform and fail when subjected to such loads. This study aimed to characterize the multi-hit ballistic resistance of fully-clamped thin plates made of 304 stainless steel using finite element method, with the equivalent plastic strain employed to define material damage and failure/fracture. The numerical model was validated against existing experimental results of double impacts at the same location, with good agreement achieved. The model was subsequently employed to quantify the effects of impact position, interval time between successive hits, projectile nose shape (e.g., spherical, flat, and conical), and boundary condition of target plate on ballistic limit and deformation/failure modes. Further, ballistic limit boundaries were constructed for both double and triple impacts of projectiles. Obtained results are helpful for designing high-performance protective structures against multiple projectile impacts.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/09544062221080139
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2024890-8
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  • 7
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    Agricultural adaptations to topography and climate changes in Central China during the mid- to late-Holocene
    SAGE Publications ; 2021
    In:  The Holocene Vol. 31, No. 11-12 ( 2021-12), p. 1705-1715
    Details
    In: The Holocene, SAGE Publications, Vol. 31, No. 11-12 ( 2021-12), p. 1705-1715
    Abstract: The development of pre-historic agriculture and its determining factors have been extensively investigated in recent years. Based on the identification of charred seeds and radiocarbon dating, we found that foxtail millet-based agriculture dominated Neixiang County in Central China during the mid-late-Holocene. There were three different farming patterns in the Nanyang Basin, including rice cultivation in the plains, foxtail millet cultivation in the pediment plains, and broomcorn millet cultivation in the valleys. In addition, during the Neolithic-Bronze Age, the distribution of human settlements with rice cultivation matched with the climate pattern at 31.0–36.5° N in China. The emergence of rice cultivation had been facilitated by a significant increase in East Asian summer monsoon and increased precipitation in Central China since 8500 BP and gradually flourished during the Peiligang (8500–7000 BP) and Yangshao (7000–4500 BP) Period, corresponding to a relatively warm and wet climate. However, the average latitude of the human settlements with rice cultivation shifted southward to 33.29° N during the Longshan Period (4500–4000 BP) due to the cold climate brought by the “4.2 ka event.” Afterward, rice cultivation was basically not constrained by climate change, probably owing to the improved farming methods in the Bronze Age.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/09596836211033201
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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  • 8
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    Adaptive fault-tolerant tracking control of flying-wing unmanned aerial vehicle with system input saturation and state constraints
    SAGE Publications ; 2022
    In:  Transactions of the Institute of Measurement and Control Vol. 44, No. 4 ( 2022-02), p. 880-891
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 44, No. 4 ( 2022-02), p. 880-891
    Abstract: In this paper, an adaptive fault-tolerant attitude tracking controller based on reinforcement learning is developed for flying-wing unmanned aerial vehicle subjected to actuator faults and saturation. At first, the attitude dynamic model is separated into two dynamic subsystems as slow and fast dynamic subsystems based on the principle of time scale separation. Secondly, backstepping technique is adopted to design the controller. For the purpose of attitude angle constraints, the control technique based on Barrier Lyapunov is used to design controller of slow dynamic subsystem. Considering the optimization of the fast dynamic subsystem, this paper introduces an adaptive reinforcement learning control method in which neural network is used to approximate the long-term performance index and lumped fault dynamic. It is shown that this control algorithm can satisfy the requirements of attitude tracking subjected to the control constraints and the stability of the system is proved from Lyapunov stability theory. The simulation results demonstrate that the developed fault-tolerant scheme is useful and has more smooth control effect compared with fault-tolerant controller based on sliding mode theory.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/01423312211027037
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2025882-3
    SSG: 3,2
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  • 9
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    Earthquake-induced building damage recognition from unmanned aerial vehicle remote sensing using scale-invariant feature transform characteristics and support vector machine classification
    SAGE Publications ; 2023
    In:  Earthquake Spectra Vol. 39, No. 2 ( 2023-05), p. 962-984
    Details
    In: Earthquake Spectra, SAGE Publications, Vol. 39, No. 2 ( 2023-05), p. 962-984
    Abstract: Building damage is the main cause of casualties and economic losses from earthquakes. Therefore, understanding building damage is critical for emergency handling. Current information acquisition methods for assessing earthquake damage using unmanned aerial vehicle (UAV) remote sensing systems offer great flexibility and high efficiency with the capability to obtain high-resolution images, which can reflect actual damage to affected areas intuitively. Consequently, UAV remote sensing has become a convenient and important means to acquire earthquake-induced building damage information. Although manual visual interpretation can achieve high recognition accuracy, it is extremely time-consuming. In contrast, although current automatic recognition methods require less time, they have relatively poor recognition accuracy. Neither approach can satisfactorily simultaneously meet efficiency and accuracy requirements for earthquake emergency handling. This article applies image classification algorithms based on the support vector machine (SVM) to earthquake-induced building damage recognition, and proposes a recognition method based on scale-invariant feature transform (SIFT) characteristics and SVM classification. We use the magnitude 6.4 earthquake at Yangbi (2021) as an example to validate the proposed method. Results verify that the proposed method can recognize earthquake damage quickly and accurately, providing effective support for decision-making regarding rescue actions.
    Type of Medium: Online Resource
    ISSN: 8755-2930 , 1944-8201
    URL: Article
    DOI: 10.1177/87552930231157549
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2183411-8
    SSG: 16,13
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  • 10
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    A multifunctional coaxial fiber membrane loaded with dual drugs for guided tissue regeneration
    SAGE Publications ; 2020
    In:  Journal of Biomaterials Applications Vol. 34, No. 8 ( 2020-03), p. 1041-1051
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 34, No. 8 ( 2020-03), p. 1041-1051
    Abstract: Guided tissue regeneration is a standard surgical treatment for periodontal regeneration. For the purpose of producing a novel guided tissue regeneration membrane with antibacterial activity and osteogenesis, coaxial electrospinning was utilized to manufacture core/shell structure fiber mats. Polyvinylpyrrolidone loaded with naringin was worked as the core of the fiber to enrich osteogenesis and poly(lactic-co-glycolic acid)–Poly-l-lactic acid–Poly-dl-lactic acid loaded with metronidazole was designed as the shell of the fiber to prevent or treat infections caused by bacteria. The loaded metronidazole with an initial short-term release and the loaded naringin with a long-term sustainable release allowed the membranes with multifunction of antibacterial activity and boosting the proliferation of osteoblast with improved osteogenesis, respectively. The fibrous membrane also shielded osteoblast and fibroblasts from ingrowth. The study provided a simple coaxial electrospinning crafts for fabricating multifunctional guided tissue regeneration membranes. A graphical abstract is available online as a supplementary material.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328219894001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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