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  • SAGE Publications  (2)
  • 2020-2024  (2)
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  • SAGE Publications  (2)
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  • 2020-2024  (2)
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  • 1
    In: Bioinformatics and Biology Insights, SAGE Publications, Vol. 16 ( 2022-01), p. 117793222211155-
    Abstract: LHPP gene encodes a phospholysine phosphohistidine inorganic pyrophosphate phosphatase, which functions as a tumor-suppressor protein. The tumor suppression by this protein has been confirmed in various cancers, including hepatocellular carcinoma (HCC). LHPP downregulation promotes cell growth and proliferation by modulating the PI3K/AKT signaling pathway. This study identifies potentially deleterious missense single nucleotide variants (SNVs) associated with the LHPP gene using multiple computational tools based on different algorithms. A total of 4 destabilizing mutants are identified as L22P, I212T, G227R, and G236R, from the conserved region of the phosphatase. The 3-dimensional (3D) modeling and structural comparison of variants with the native protein reveals significant structural and conformational variations after mutations, suggesting disruption in the function of phospholysine phosphohistidine inorganic pyrophosphate phosphatase. The identified mutations might, therefore, participate in the cause of HCC.
    Type of Medium: Online Resource
    ISSN: 1177-9322 , 1177-9322
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2423808-9
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2021
    In:  SAGE Open Vol. 11, No. 2 ( 2021-04), p. 215824402110071-
    In: SAGE Open, SAGE Publications, Vol. 11, No. 2 ( 2021-04), p. 215824402110071-
    Abstract: We explored the contribution and effectiveness of state and non-state institutions in rural development efforts in highlands (Khyber Pakhtunkhwa [KPK] province) of Pakistan. This study employed mixed-methods research design and data were collected from 300 household heads, randomly selected from six villages from two purposively selected districts Mansehra and Nowshehra. Findings showed people in KPK were deprived of due to conflicts, conspiracies and terrorism, poor governance, small landholdings and subsistence farming followed by sluggish marketing system, insufficient education and training for people, and inadequate employment opportunities. Regarding contribution, non-state institutions had more contribution as compared to state institutions. T-test analysis showed that the non-state institutions had an effective provision of agricultural extension and forestry advisory services, education, health services in remote areas, skill development, and provision of microcredit schemes. The results of F-test statistics showed highly significant difference among the perceived effectiveness of rural development activities of different types of non-state actors (localite, cosmopolite, and religious/faith-based) working in the research area. This study recommends state-owned rural development departments revisit their working mechanism and develop synergistic working relationship with the non-state institutions in discharging rural development efforts.
    Type of Medium: Online Resource
    ISSN: 2158-2440 , 2158-2440
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2628279-3
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