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  • 1
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962210743-
    Abstract: To evaluate the efficacy and safety of a plasma-derived factor VIII concentrate containing von Willebrand Factor (pdVWF/FVIII) in standard clinical practice in von Willebrand Disease (VWD) patients. Methods A retrospective, multicentric, observational study of VWD patients treated with Fanhdi ® , a pdVWF/FVIII concentrate, from January 2011 to December 2017 was conducted at 14 centers in Spain. Efficacy and safety were evaluated for acute bleeding episodes, for prevention of bleeding in surgeries, and for secondary long-term prophylaxis. Results Seventy-two eligible patients, type 1, 2, 3 VWD (25%/38.9%/36.1%) were treated for spontaneous and traumatic bleeding (140 episodes, n = 41 patients), to prevent surgical bleeding (69 episodes, n = 43 patients); and for secondary long-term prophylaxis (18 programs, n = 13 patients). Replacement therapy with pdVWF/FVIII showed an excellent to good clinical efficacy in 96.7% of the bleeding episodes, 100% during surgical procedures and 100% during prophylaxis. No adverse events (AEs), nor serious AEs related to the product were observed. Conclusions Fanhdi ® was effective, safe and well tolerated in the management of bleeding episodes, the prevention of bleeding during surgeries, and for secondary long-term prophylaxis in VWD patients.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2230591-9
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  • 2
    In: Laboratory Animals, SAGE Publications, Vol. 55, No. 1 ( 2021-02), p. 30-42
    Abstract: Changes in bone mineral content of calcium (Ca), phosphorous (P), magnesium and potassium for male and female Wistar rats during their development from 3 weeks old to adulthood (27 weeks old) were measured. Bone mineral content was related to areal bone mineral density (BMD) which was measured in vivo at the femoral neck using a calibrated X-ray transmission system to obtain basal curves as a function of the age of the specimen. Diagnostic curves were built to determine low BMD (osteopaenia) and osteoporosis in female rats fed a Ca-depleted diet (50%) based on the obtained data and the criteria established by the World Health Organization. Bone mineral content is directly related to sex and age, but P did not change throughout the experimental period. P content did not exhibit significant changes with growing, while Ca was greatest in male rats, producing significant differences in the Ca:P ratio. Male rats reach the Ca:P ratio peak before female rats. However, areal BMD does not follow the same trend. On the other hand, osteoporosis produced a 45% decrease in this parameter for young and mature adults. These results make Z-score values available to diagnose bone-mass losses and hence the possibility of improving the conditions of non-contact measurement of BMD in vivo. This technique can be used for future experiments with Wistar rats.
    Type of Medium: Online Resource
    ISSN: 0023-6772 , 1758-1117
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2036511-1
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  • 3
    In: Clinical Rehabilitation, SAGE Publications, Vol. 36, No. 4 ( 2022-04), p. 486-497
    Abstract: To compare the effectiveness of two different exercise-based programs through telerehabilitation in patients with coronavirus disease 2019. Design Randomized, controlled, parallel, double-blinded, three-arm clinical trial. Setting Patients’ homes through telerehabilitation devices. Subjects Subjects with coronavirus disease 2019 in the acute phase. Interventions Subjects were divided into three groups: breathing exercises group, strength exercises group or no treatment/control group. Main measures We analysed visual analogue scale for fatigue, 6-minute walking test, 30-seconds sit-to-stand test, multidimensional dyspnoea-12 questionnaire and Borg scale at baseline and 14 days later. Results From 93 subjects recruited, 88 were enrolled, and 77 patients (mean [SD] age 39.40 [11.71] ) completed the 14-days intervention and were included in the analysis: 26 in strength exercises group, 29 in breathing exercises group and 22 in control group. The intergroup analysis shows significant differences between the study groups and control group in all variables ( p  〈  0.05); Borg scale, multidimensional dyspnoea-12 questionnaire (pre–post intervention score: strength exercises group: 7.85 [6.82] – 4.54[4.82] , breathing exercises group: 11.04 [6.49] – 5.32 [3.63] , control group: 10.27 [6.49] – 10.59[6.58] ), visual analogue scale for fatigue, 6-minute walking test and 30-seconds sit-to-stand test (pre–post intervention score: strength exercises group: 12.19 [4.42] – 13.58 [5.37] , breathing exercises group: 11.18 [3.42] – 12.79 [4.00] , control group: 10.45 [2.15] – 9.86[1.88] ). The greatest effect sizes were found in the variables Borg Scale ( R 2  = 0.548) and multidimensional dyspnoea-12 questionnaire ( R 2  = 0.475). Conclusions Strength exercises group and breathing exercises group obtained significant improvements in fatigue, dyspnoea, perceived effort, and physical state, compared to control group, although the greatest benefits were found for dyspnoea and aerobic capacity in breathing exercises group.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2028323-4
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Social Science Computer Review Vol. 40, No. 6 ( 2022-12), p. 1376-1392
    In: Social Science Computer Review, SAGE Publications, Vol. 40, No. 6 ( 2022-12), p. 1376-1392
    Abstract: This article analyzes the influence of Spanish citizens’ computer knowledge and level of education on their tolerance of, or aversion to, risk in the online purchase of goods and services. To this end, annual survey data from Spain’s National Statistics Institute were used to know the incidence in e-commerce of the following variables: “computer knowledge,” “electronic commerce,” and “socioeconomic characteristics.” A method based on the design of a computer knowledge indicator was used, followed by a bivariate logistic regression to determine computer knowledge and level of education. The results show that the higher the level of computer knowledge, the greater the impulse to buy online and the higher the tolerance of risk. There was also a positive relation between level of education and propensity to buy; the higher the level of education, the greater the propensity.
    Type of Medium: Online Resource
    ISSN: 0894-4393 , 1552-8286
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2021894-1
    SSG: 3,4
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  • 5
    In: Hispanic Health Care International, SAGE Publications, Vol. 18, No. 1 ( 2020-03), p. 27-31
    Abstract: One of the greatest challenges that health professionals face is providing humanized care, especially when technological advancements contribute to the depersonalization of care delivery. In this sense, nursing care not only requires the nurse to be scientific, academic, and clinical but also a humanitarian and moral agent, as a partner in human transactions. Method: Quantitative, descriptive, and transversal study. In a nonprobabilistic sampling for convenience, in 150 surgical patients, with more than 3 days of hospital stay, the instrument “Perception of Behaviors of Humanized Nursing Care” was used (third version). The study adhered to the legal and ethical research guidelines in Mexico. Results: According to the general objective of the study, the findings determined were that 67% of the participants perceived humanized nursing care as favorable Conclusion: More than half of the patients always perceived behaviors of humanized care, provided by nurses, during their hospitalization in surgical services.
    Type of Medium: Online Resource
    ISSN: 1540-4153 , 1938-8993
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2712088-0
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  • 6
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 35 ( 2021-01), p. 205873842110384-
    Abstract: There are few reports in oral squamous cell carcinoma (OSCC) that indicate the expression of macrophage migration inhibitory factor (MIF) in tissues, serum, or saliva of patients with OSCC. The aim of this study was to evaluate the mRNA expression and protein of MIF in tissues and serum, respectively, in OSCC patients and its association with the TNM stage. A cross-sectional study was performed. Serum and tissues of 25 patients with OSCC and 25 healthy control subjects (HCS) were included to evaluate the MIF mRNA expression and protein serum levels by real-time PCR and ELISA, respectively. Serum MIF levels were significantly higher in OSCC compared with control subjects. Furthermore, in the OSCC group, MIF was significantly increased in accordance with tumor disease stage (TNM III–IV), as well as in poorly differentiated tumors. The mRNA showed significantly higher levels in HCS, as well as in more differentiated tumors. The results of this study suggest that MIF could be an indicator of severity and progression of OSCC. Further studies are required to explore the role of MIF as a serological biomarker for OSCC.
    Type of Medium: Online Resource
    ISSN: 2058-7384 , 2058-7384
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2505963-4
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Visual Communication
    In: Visual Communication, SAGE Publications
    Abstract: The representation of women in advertising is based on constructs that have become consolidated in Western culture, giving rise to different archetypes that express the values and ways of thinking of each age. As in other media discourses, advertising resorts to elements, such as archetypes and myths, which shape the collective imaginary and are very effective devices, for they are recognizable to viewers and help to engage them. Specifically, this article focuses on car advertising, whose significance lies in the fact that it has traditionally been a sphere of male domination. In recent years, there has been a positive evolution towards more independent and autonomous female characters. Accordingly, this article analyses two of Audi’s most recent campaigns from 2016 and 2017 in order to observe how women are represented in car ads according to three fundamental aspects: visual semiotics (Arnheim’s Arte y percepción visual. Psicología del ojo creador, 2008; Casetti and Di Chio’s Cómo analizar un film, 1994; Van Leeuwen’s ‘Semiotics and iconography’, 2001), iconography (Cassirer’s Filosofía de las formas simbólicas, 1998); Panofsky’s ‘Iconografía e iconología: introducción al estudio del arte del Renacimiento, 1987) and symbolism grounded in a myth analysis of advertising (León’s Mitoanálisis de la publicidad, 2001).
    Type of Medium: Online Resource
    ISSN: 1470-3572 , 1741-3214
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2077485-0
    SSG: 3,5
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2024
    In:  Journal of Family Issues Vol. 45, No. 2 ( 2024-02), p. 285-302
    In: Journal of Family Issues, SAGE Publications, Vol. 45, No. 2 ( 2024-02), p. 285-302
    Abstract: Leisure has been acquiring a leading role in families to the point of being represented in different areas of society. In fact, a diversified practice is necessary to obtain maximum benefit. Thus, the purpose of this study was to examine which are the types of family leisure activities most exercised. The degree of frequency of 11 types of family leisure activities was measured on a four-point Likert scale. The same consisted of 1054 Compulsory Secondary Education students from the southeast of Spain. Results revealed that gastronomic, digital, and commercial leisure are the most frequently practiced, while solidarity and spiritual leisure are the least practiced by adolescents with their families. In addition, age, academic performance, and parents' level of studies were variables significantly associated with the types of family leisure activities. In this way, there is a need to offer a more diversified model of family leisure activities.
    Type of Medium: Online Resource
    ISSN: 0192-513X , 1552-5481
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 1494068-1
    SSG: 3,4
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  • 9
    In: Plastic Surgery, SAGE Publications, Vol. 30, No. 2 ( 2022-05), p. 117-121
    Abstract: Mallet injuries are common and usually treated conservatively. Various systematic reviews have found a lack of evidence regarding the best management, and it is still unclear. Objective: To evaluate the treatment efficacy of Stack Splinting compared to a Kirschner wire immobilization of acute closed mallet finger Doyle I. Methods: From March 2019 to February 2020, 41 patients with acute close mallet finger Doyle I were treated; 19 patients were treated with Kirschner wire and 22 with Stack splinting for a mean of 6 weeks. The average patient age at the time of the injury was 43 years. Results: Twenty-eight males and 13 females were in this study. Among them, 17 patients were injured in the little finger, 15 in the middle finger, and 9 in the ring finger. Twenty-seven of injuries suffered an aggression, 11 from falling, and 3 from sports injuries. All the fingers had typical mallet malformation. Seventeen patients treated with Kirschner wire completed the treatment with full recovery, only 7 patients treated with Stack splint completed the treatment and 15 treated with Stack splint had relapse on mallet injury. Conclusion: Kirschner wire treatment is a simple procedure, and proves in this study that has better results in patients with acute closed mallet finger Doyle I compared to Stack splint.
    Type of Medium: Online Resource
    ISSN: 2292-5503 , 2292-5511
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2869727-3
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  • 10
    In: Journal of Intensive Care Medicine, SAGE Publications
    Abstract: The occurrence of pneumomediastinum (PM) and/or pneumothorax (PTX) in patients with severe pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was evaluated. Methods This was a prospective observational study conducted in patients admitted to the intermediate respiratory care unit (IRCU) of a COVID-19 monographic hospital in Madrid (Spain) between December 14, 2020 and September 28, 2021. All patients had a diagnosis of severe SARS-CoV-2 pneumonia and required noninvasive respiratory support (NIRS): high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP). The incidences of PM and/or PTX, overall and by NIRS, and their impact on the probabilities of invasive mechanical ventilation (IMV) and death were studied. Results A total of 1306 patients were included. 4.3% (56/1306) developed PM/PTX, 3.8% (50/1306) PM, 1.6% (21/1306) PTX, and 1.1% (15/1306) PM + PTX. 16.1% (9/56) of patients with PM/PTX had HFNC alone, while 83.9% (47/56) had HFNC + CPAP/BiPAP. In comparison, 41.7% (521/1250) of patients without PM and PTX had HFNC alone (odds ratio [OR] 0.27; 95% confidence interval [95% CI] 0.13-0.55; p  〈  .001), while 58.3% (729/1250) had HFNC + CPAP/BiPAP (OR 3.73; 95% CI 1.81-7.68; p  〈  .001). The probability of needing IMV among patients with PM/PTX was 67.9% (36/53) (OR 7.46; 95% CI 4.12-13.50; p  〈  .001), while it was 22.1% (262/1185) among patients without PM and PTX. Mortality among patients with PM/PTX was 33.9% (19/56) (OR 4.39; 95% CI 2.45-7.85; p  〈  .001), while it was 10.5% (131/1250) among patients without PM and PTX. Conclusions In patients admitted to the IRCU for severe SARS-CoV-2 pneumonia requiring NIRS, incidences of PM/PTX, PM, PTX, and PM + PTX were observed to be 4.3%, 3.8%, 1.6%, and 1.1%, respectively. Most patients with PM/PTX had HFNC + CPAP/BiPAP as the NIRS device, much more frequently than patients without PM and PTX. The probabilities of IMV and death among patients with PM/PTX were 64.3% and 33.9%, respectively, higher than those observed in patients without PM and PTX, which were 21.0% and 10.5%, respectively.
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2001472-7
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