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  • S. Karger AG  (23)
  • 2020-2024  (23)
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  • S. Karger AG  (23)
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  • 2020-2024  (23)
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  • 1
    Online Resource
    Online Resource
    Switching Monopolar No-Touch Radiofrequency Ablation Using Octopus Electrodes for Small Hepatocellular Carcinoma: A Randomized Clinical Trial
    S. Karger AG ; 2021
    In:  Liver Cancer Vol. 10, No. 1 ( 2021), p. 72-81
    Details
    In: Liver Cancer, S. Karger AG, Vol. 10, No. 1 ( 2021), p. 72-81
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 A switching monopolar no-touch radiofrequency ablation (RFA) technique is used for small hepatocellular carcinoma (HCC); however, there have not been any randomized clinical trials comparing this technique to the conventional RFA technique. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study aims to compare the results of two RFA techniques, and to comparatively identify more effective methods to reduce the progression of local tumors associated with small HCC (≤2.5 cm). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This prospective randomized clinical trial (NCT03375281) recruited a total of 116 participants (M:F, 93:23; 68.3 ± 8.4 years) between October 2016 and September 2017. The primary outcome was the cumulative incidence of local tumor progression (LTP) after RFA. Secondary outcomes included technical success rate, technique efficacy, and RFA procedure characteristics. Kaplan-Meier analysis and the Cox proportional hazard regression model were used. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The mean follow-up period was 24.1 months. A sufficient ablative margin was more frequently achieved in the no-touch RFA group (57/60 = 95%) than in the conventional RFA group (50/64 = 78.1%) on immediate follow-up CT ( 〈 i 〉 p 〈 /i 〉 = 0.01). The cumulative incidence of LTP in the no-touch RFA group was significantly lower than that in the conventional RFA group ( 〈 i 〉 p 〈 /i 〉 = 0.02). In multivariable analysis, no-touch RFA was the only predictive factor for LTP ( 〈 i 〉 p 〈 /i 〉 = 0.04, hazard ratio = 0.2, 95% confidence interval = 0.04–0.94). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 A switching monopolar no-touch RFA technique is a favorable treatment option and provides lower LTP after RFA compared with conventional RFA for small HCC.
    Type of Medium: Online Resource
    ISSN: 2235-1795 , 1664-5553
    URL: Article
    DOI: 10.1159/000512338
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 2666925-0
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  • 2
    Online Resource
    Online Resource
    Effects of Proton Pump Inhibitor on the Distribution of Helicobacter pylori and Associated Gastritis in Patients with Gastric Atrophy
    S. Karger AG ; 2020
    In:  Digestion Vol. 101, No. 3 ( 2020), p. 279-286
    Details
    In: Digestion, S. Karger AG, Vol. 101, No. 3 ( 2020), p. 279-286
    Abstract: Background/Aims: Acid suppression therapy is thought to be associated with the topography of Helicobacter pylori and associated gastritis, leading to corpus-predominant gastritis. This study was aimed to investigate the influence of proton pump inhibitor (PPI) treatment on the distribution of H. pylori and associated gastritis in patients with atrophic change. Methods: Patients who underwent endoscopic resection for gastric neoplasms and received PPI for 2 months were prospectively analyzed. Biopsy specimens were obtained from 5 areas in the stomach before, during, and after the treatment with PPI. Histological examination was ­performed using the updated Sydney system, and ­bacterial density of H. pylori was further graded by immunohistochemistry (ClinicalTrials.gov registration number NCT02449941). Results: A total of 15 patients were analyzed, of whom 7 had H. pylori infection. The degree of activity and inflammation were greater in patients with H. pylori infection than in those without H. pylori infection. During the PPI treatment, the density of H. pylori decreased not only in the antrum but also in the corpus. The degree of activity and inflammation improved significantly in the antrum, particularly in the presence of H. pylori infection, while the corpus gastritis was not affected by PPI use. Atrophy and intestinal metaplasia remained unchanged in both regions of the stomach. The observed changes reverted following the discontinuation of PPI treatment. Conclusion: PPI treatment decreased H. pylori both in the antrum and the corpus in patients with atrophic gastritis. Antral gastritis improved during PPI treatment, whereas no changes were found in the corpus.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000499424
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1482218-0
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  • 3
    Online Resource
    Online Resource
    A Comparison of Biannual Two-Phase Low-Dose Liver CT and US for HCC Surveillance in a Group at High Risk of HCC Development
    S. Karger AG ; 2020
    In:  Liver Cancer Vol. 9, No. 5 ( 2020), p. 503-517
    Details
    In: Liver Cancer, S. Karger AG, Vol. 9, No. 5 ( 2020), p. 503-517
    Abstract: 〈 b 〉 〈 i 〉 Background and Aims: 〈 /i 〉 〈 /b 〉 Biannual ultrasonography (US) is a current recommendation for hepatocellular carcinoma (HCC) surveillance in a high-risk group. The sensitivity of US, however, has been low in patients with a high risk of developing HCC. We aimed to compare sensitivity for HCC of biannual US and two-phase low-dose computed tomography (LDCT) in patients with a high risk of HCC. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In this prospective single-arm study, participants with an annual risk of HCC greater than 5% (based on a risk index of ≥2.33) and who did not have a history of HCC were enrolled from November 2014 to July 2016. Participants underwent paired biannual US and two-phase LDCT 1–3 times. Two-phase LDCT included arterial and 3-min delayed phases. The sensitivity, specificity, and positive predictive value of HCC detection using US and two-phase LDCT were compared using a composite algorithm as a standard of reference. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of the 139 enrolled participants, 137 underwent both the biannual US and two-phase LDCT at least once and had follow-up images. Among them, 27 cases of HCC (mean size: 14 ± 4 mm) developed in 24 participants over 1.5 years. Two-phase LDCT showed a significantly higher sensitivity (83.3% [20/24] vs. 29.2% [7/24] , 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) and specificity (95.6% [108/113] vs. 87.7% [99/113] , 〈 i 〉 p 〈 /i 〉 = 〈 i 〉 〈 /i 〉 0.03) than US. A false-positive result was reported in 14 participants at US and 5 participants at two-phase LDCT, resulting in a significantly higher positive predictive value of two-phase LDCT (33.3% [7/21] vs. 80% [20/25] , 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Patients with a risk index ≥2.33 showed a high annual incidence of HCC development in our study, and two-phase LDCT showed significantly higher sensitivity and specificity for HCC detection than US.
    Type of Medium: Online Resource
    ISSN: 2235-1795 , 1664-5553
    URL: Article
    DOI: 10.1159/000506834
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 2666925-0
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  • 4
    Online Resource
    Online Resource
    How to Best Detect Portal Vein Tumor Thrombosis in Patients with Hepatocellular Carcinoma Meeting the Milan Criteria: Gadoxetic Acid-Enhanced MRI versus Contrast-Enhanced CT
    S. Karger AG ; 2020
    In:  Liver Cancer Vol. 9, No. 3 ( 2020), p. 293-307
    Details
    In: Liver Cancer, S. Karger AG, Vol. 9, No. 3 ( 2020), p. 293-307
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The detection of portal vein tumor thrombosis (PVTT) in patients with hepatocellular carcinoma (HCC) meeting the Milan criteria is of critical importance as PVTT is known to be a contraindication to transplantation and an indicator of a dismal prognosis. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To determine which modality may best detect PVTT, we compared the diagnostic performance of gadoxetic acid-enhanced MRI (GA-MRI) and contrast-enhanced CT (CECT) in HCC patients meeting the Milan criteria. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively enrolled 310 patients with HCCs meeting the Milan criteria who underwent both GA-MRI and CECT between June 2007 and May 2017. Among them, 44 patients were demonstrated to have PVTT while 266 patients had no PVTT. Two radiologists then assessed GA-MRI and CECT images for the presence of PVTT on a 5-point scale as well as vessel expansion, continuity with tumors, and enhancement on both modalities, as well as T2 hyperintensity and diffusion restriction on GA-MRI. The McNemar test was used to compare sensitivity and specificity of GA-MRI and CECT for the detection of PVTT, and Fisher’s exact test was used to compare their imaging features. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 GA-MRI showed higher sensitivity values than CECT in detecting PVTT (reviewer 1, 93.2% [41/44] vs. 77.3% [34/44] ; reviewer 2, 88.6% [39/44] vs. 70.5% [31/44] ) (both 〈 i 〉 p 〈 /i 〉 = 0.039). Specificity of GA-MRI and CECT demonstrated no difference (reviewer 1, 95.5% [254/266] vs. 95.1% [253/266] ; reviewer 2, 97.0% [258/266] vs. 97.4% [259/266] ) (both 〈 i 〉 p 〈 /i 〉 & #x3e; 0.999). Continuity with tumors and enhancement were more frequently observed on GA-MRI than on CECT ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.050, both reviewers). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 GA-MRI detected PVTT more often than CECT in HCC patients meeting the Milan criteria and better depicted PVTT in continuity with tumors and those showing enhancement than CECT.
    Type of Medium: Online Resource
    ISSN: 2235-1795 , 1664-5553
    URL: Article
    DOI: 10.1159/000505191
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 2666925-0
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  • 5
    Online Resource
    Online Resource
    Clinical Outcomes following Endoscopic Treatment for Sporadic Nonampullary Duodenal Adenoma
    S. Karger AG ; 2020
    In:  Digestive Diseases Vol. 38, No. 5 ( 2020), p. 364-372
    Details
    In: Digestive Diseases, S. Karger AG, Vol. 38, No. 5 ( 2020), p. 364-372
    Abstract: 〈 b 〉 〈 i 〉 Background and Aims: 〈 /i 〉 〈 /b 〉 Endoscopic treatment for duodenal neoplasms is associated with a high risk of perforation. This study aimed to determine the feasibility of endoscopic treatment for sporadic nonampullary duodenal adenoma (SNDA). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Consecutive patients undergoing endoscopic treatment for SNDA between January 2005 and December 2015 were included in the study. Clinical characteristics and endoscopic outcomes were analyzed using medical records. Long-term outcome was assessed in patients whose follow-up period was & #x3e;12 months & #x3e;1 year. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 95 lesions (92 patients) were treated with argon plasma coagulation (APC) ablation ( 〈 i 〉 n 〈 /i 〉 = 25), endoscopic mucosal resection (EMR, 〈 i 〉 n 〈 /i 〉 = 59), or endoscopic submucosal dissection (ESD, 〈 i 〉 n 〈 /i 〉 = 11). The median age was 54.9 years, and 63% were male. In patients who underwent EMR and ESD, the en bloc resection rate was 83.1 and 90.0% ( 〈 i 〉 p 〈 /i 〉 & #x3e; 0.99); and the complete resection rate was 81.4 and 80% ( 〈 i 〉 p 〈 /i 〉 & #x3e; 0.99), respectively. Perforation occurred in 8 patients (8.7%), 4 of whom required surgery. The ESD group showed a significantly higher perforation rate than APC or EMR group (45.5 vs. 0 and 5.1%; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). During the median follow-up period of 19 months (range 12–137 months), one patient in the APC ablation group experienced recurrence; no recurrences were seen among EMR and ESD groups. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Favorable long-term outcomes indicate that endoscopic treatment is an effective approach for the treatment of SNDA. Considering the high risk of perforation associated with ESD, APC, or EMR may be an acceptable alternative.
    Type of Medium: Online Resource
    ISSN: 0257-2753 , 1421-9875
    URL: Article
    DOI: 10.1159/000504249
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1482221-0
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  • 6
    Online Resource
    Online Resource
    Outcomes of Remote Patient Monitoring for Automated Peritoneal Dialysis: A Randomized Controlled Trial
    S. Karger AG ; 2021
    In:  Nephron Vol. 145, No. 6 ( 2021), p. 702-710
    Details
    In: Nephron, S. Karger AG, Vol. 145, No. 6 ( 2021), p. 702-710
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 We hypothesize that remote patient monitoring (RPM) for automated peritoneal dialysis (APD) and feedback could enhance patient self-management and improve outcomes. The aim of this study was to evaluate the efficacy of RPM-APD compared to traditional APD (T-APD) without RPM. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In this multicenter, randomized controlled trial, patients on APD were randomized to T-APD ( 〈 i 〉 n 〈 /i 〉 = 29) or RPM-APD ( 〈 i 〉 n 〈 /i 〉 = 28) at 12 weeks and followed until 25 weeks. Health-related quality of life (HRQOL), patient and medical staff satisfaction with RPM-APD, and dialysis-related outcomes were compared between the 2 groups. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 We found no significant differences in HRQOL scores at the time of enrollment and randomization between RPM-APD and T-APD. At the end of the study, the RPM-APD group showed better HRQOL for the sleep domain ( 〈 i 〉 p 〈 /i 〉 = 0.049) than the T-APD group and the T-APD group showed better HRQOL for the sexual function domain ( 〈 i 〉 p 〈 /i 〉 = 0.030) than the RPM-APD group. However, we found no significant interactions between the time and groups in terms of HRQOL. Different HRQOL domains significantly improved over time in patients undergoing RPM-APD (effects of kidney disease, 〈 i 〉 p 〈 /i 〉 = 0.025) and T-APD (burden of kidney disease, 〈 i 〉 p 〈 /i 〉 = 0.029; physical component summary, 〈 i 〉 p 〈 /i 〉 = 0.048). Though medical staff satisfaction with RPM-APD was neutral, most patients were quite satisfied with RPM-APD (median score 82; possible total score 105 on 21 5-item scales) and the rating scores were maintained during the study period. We found no significant differences in dialysis adherence, accuracy, adequacy, overhydration status, blood pressure, or the number of unplanned visits between the 2 groups. 〈 b 〉 〈 i 〉 Discussion/Conclusion: 〈 /i 〉 〈 /b 〉 Although HRQOL and dialysis-related outcomes were comparable between RPM-APD and T-APD, RPM-APD was positive in terms of patient satisfaction. Further long-term and large-scale studies will be required to determine the efficacy of RPM-APD. 〈 b 〉 〈 i 〉 Trial Registration: 〈 /i 〉 〈 /b 〉 CRIS identifier: KCT0003390, registered on December 14, 2018 – retrospectively registered, https://cris.nih.go.kr/cris/search/search_result_st01.jsp?seq=12348.
    Type of Medium: Online Resource
    ISSN: 1660-8151 , 2235-3186
    URL: Article
    DOI: 10.1159/000518364
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 2810853-X
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  • 7
    Online Resource
    Online Resource
    A Scoring Model with Simple Clinical Parameters to Predict Successful Discontinuation of Continuous Renal Replacement Therapy
    S. Karger AG ; 2021
    In:  Blood Purification Vol. 50, No. 6 ( 2021), p. 779-789
    Details
    In: Blood Purification, S. Karger AG, Vol. 50, No. 6 ( 2021), p. 779-789
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Continuous renal replacement therapy (CRRT) is the standard treatment for severe acute kidney injury in critically ill patients. However, a practical consensus for discontinuing CRRT is lacking. We aimed to develop a prediction model with simple clinical parameters for successful discontinuation of CRRT. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Adult patients who received CRRT at Samsung Medical Center from 2007 to 2017 were included. Patients with preexisting ESRD and patients who progressed to ESRD within 1 year or died within 7 days after CRRT were excluded. Successful discontinuation of CRRT was defined as no requirement for renal replacement therapy for 7 days after discontinuing CRRT. Patients were assigned to either a success group or failure group according to whether discontinuation of CRRT was successful or not. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 1,158 patients were included in the final analyses. The success group showed greater urine output on the day before CRRT discontinuation (D-1) and the discontinuation day (D0). Multivariable analysis identified that urine output ≥300 mL on D-1, and mean arterial pressure 50∼78 mm Hg, serum potassium & #x3c;4.1 mmol/L, and BUN & #x3c;35 mg/dL (12.5 mmol/L) on D0 were predictive factors for successful discontinuation of CRRT. A scoring system using the 4 variables above (area under the receiver operating curve: 0.731) was developed. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Scoring system composed of urine output ≥300 mL/day on D-1, and adequate blood pressure, serum potassium & #x3c;4.1 mmol/L, and BUN & #x3c;35 mg/dL (12.5 mmol/L) on D0 was developed to predict successful discontinuation of CRRT.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000512350
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1482025-0
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  • 8
    Online Resource
    Online Resource
    Genetic Polymorphisms in Activating Transcription Factor 3 Binding Site and the Prognosis of Early-Stage Non-Small Cell Lung Cancer
    S. Karger AG ; 2021
    In:  Oncology Vol. 99, No. 5 ( 2021), p. 336-344
    Details
    In: Oncology, S. Karger AG, Vol. 99, No. 5 ( 2021), p. 336-344
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Activating transcription factor 3 (ATF3) plays a significant role in cancer development and progression. We investigated the association between variants in expression quantitative trait loci (eQTLs) within ATF3 binding regions and the prognosis of non-small cell lung cancer (NSCLC) after surgery. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 772 patients with NSCLC who underwent curative surgery were enrolled. Using a public database (http://galaxyproject.org), we selected 104 single nucleotide polymorphisms (SNPs) in eQTLs in the ATF3 binding regions. The association of those SNPs with disease-free survival (DFS) was evaluated. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among those SNPs, 〈 i 〉 HAX1 〈 /i 〉 rs11265425T & #x3e;G was associated with significantly worse DFS (aHR = 1.30, 95% CI = 1.00–1.69, 〈 i 〉 p 〈 /i 〉 = 0.05), and 〈 i 〉 ME3 〈 /i 〉 rs10400291C & #x3e;A was associated with significantly better DFS (aHR = 0.66, 95% CI = 0.46–0.95, 〈 i 〉 p 〈 /i 〉 = 0.03). Regarding 〈 i 〉 HAX1 〈 /i 〉 rs11265425T & #x3e;G, the significant association remained only in adenocarcinoma, and the association was significant only in squamous cell carcinoma regarding 〈 i 〉 ME3 〈 /i 〉 rs10400291C & #x3e;A. ChIP-qPCR assays showed that the two variants reside in active enhancers where H3K27Ac and ATF3 binding occurs. Promoter assays showed that rs11265425 G allele had significantly higher 〈 i 〉 HAX1 〈 /i 〉 promoter activity than T allele. 〈 i 〉 HAX1 〈 /i 〉 RNA expression was significantly higher in tumor than in normal lung, and higher in rs11265425 TG+GG genotypes than in TT genotype. Conversely, 〈 i 〉 ME3 〈 /i 〉 expression was significantly lower in tumor than in normal lung, and higher in rs10400291 AA genotype than in CC+CA genotypes. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In conclusion, this study shows that the functional polymorphisms in ATF3 binding sites, 〈 i 〉 HAX1 〈 /i 〉 rs11265425T & #x3e;G and 〈 i 〉 ME3 〈 /i 〉 rs10400291C & #x3e;A are associated with the clinical outcomes of patients in surgically resected NSCLC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000514131
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 9
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    Genetic Variants in One-Carbon Metabolism Pathway Predict Survival Outcomes of Early-Stage Non-Small Cell Lung Cancer
    S. Karger AG ; 2020
    In:  Oncology Vol. 98, No. 12 ( 2020), p. 897-904
    Details
    In: Oncology, S. Karger AG, Vol. 98, No. 12 ( 2020), p. 897-904
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 This study was conducted to investigate the association between genetic variants in one-carbon metabolism and survival outcomes of surgically resected non-small cell lung cancer (NSCLC). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We genotyped 41 potentially functional variants of 19 key genes in the one-carbon metabolism pathway among 750 NSCLC patients who underwent curative surgery. The association between genetic variants and overall survival (OS)/disease-free survival (DFS) were analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 41 single-nucleotide polymorphisms (SNPs) analyzed, 4 SNPs ( 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and rs3849794T & #x3e;C, 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A, and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T) were significantly associated with survival outcomes. 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A were significantly associated with better OS (adjusted hazard ratio [aHR] = 0.73, 95% confidence interval [CI] = 0.54–0.99, 〈 i 〉 p 〈 /i 〉 = 0.04) and worse OS (aHR = 2.14, 95% CI = 1.13–4.07, 〈 i 〉 p 〈 /i 〉 = 0.02), respectively. 〈 i 〉 MTHFD1L 〈 /i 〉 rs3849794T & #x3e;C and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T were significantly associated with worse DFS (aHR = 1.41, 95% CI = 1.08–1.83, 〈 i 〉 p 〈 /i 〉 = 0.01; and aHR = 1.97, 95% CI = 1.10–3.53, 〈 i 〉 p 〈 /i 〉 = 0.02, respectively). When the patients were divided according to histology, the associations were significant only in squamous cell carcinoma (SCC), but not in adenocarcinoma (AC). In SCC, 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A were significantly associated with better OS (aHR = 0.64, 95% CI = 0.41–1.00, 〈 i 〉 p 〈 /i 〉 = 0.05) and worse OS (aHR = 2.77, 95% CI = 1.11–6.91, 〈 i 〉 p 〈 /i 〉 = 0.03), respectively, and 〈 i 〉 MTHFD1L 〈 /i 〉 rs3849794T & #x3e;C and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T were significantly associated with worse DFS (aHR = 1.73, 95% CI = 1.17–2.56, 〈 i 〉 p 〈 /i 〉 = 0.01; and aHR = 2.78, 95% CI = 1.12–6.88, 〈 i 〉 p 〈 /i 〉 = 0.03, respectively). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our results suggest that the genetic variants in the one-carbon metabolism pathway could be used as biomarkers for predicting the clinical outcomes of patients with early-stage NSCLC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000509658
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 10
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    Genetic Variants in Histone Modification Regions Predict Clinical Outcomes of Pemetrexed Chemotherapy in Lung Adenocarcinoma
    S. Karger AG ; 2023
    In:  Oncology Vol. 101, No. 2 ( 2023), p. 96-104
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    In: Oncology, S. Karger AG, Vol. 101, No. 2 ( 2023), p. 96-104
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study was conducted to investigate the association between genetic variants in histone modification regions and clinical outcomes of PEM chemotherapy in patients with lung adenocarcinoma. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Potentially functional SNPs were selected using integrated analysis of ChIP-seq and RNA-seq. The associations of 279 SNPs with chemotherapy response and overall survival (OS) were analyzed in 314 lung adenocarcinoma patients who underwent PEM chemotherapy. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the SNPs investigated, 18 were significantly associated with response to chemotherapy, while 28 with OS. Of these SNPs, rs549794A & #x3e;G in an enhancer which is expected to regulate the expression of 〈 i 〉 ribosomal protein S3 〈 /i 〉 ( 〈 i 〉 RPS3 〈 /i 〉 ) gene was significantly associated with both worse response to chemotherapy and worse OS (adjusted odds ratio = 0.59, 95% CI = 0.36–0.97, 〈 i 〉 p 〈 /i 〉 = 0.04; adjusted hazard ratio = 1.44, 95% CI = 1.09–1.91, 〈 i 〉 p 〈 /i 〉 = 0.01, respectively). Previous studies suggested that RPS3, a multi-functional protein with various extraribosomal activities, may play a role in chemotherapy resistance. Therefore, it is postulated that rs549794-induced change in the expression level of RPS3 may affect the response to PEM chemotherapy and consequently the survival outcomes in lung adenocarcinoma patients. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This study suggests that genetic variants in the histone modification regions may be useful for the prediction of clinical outcomes of PEM chemotherapy in advanced lung adenocarcinoma.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000527492
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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