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  • Medknow  (2)
  • 2020-2024  (2)
  • 1
    In: Journal of Pharmacy and Bioallied Sciences, Medknow, Vol. 13, No. Suppl 1 ( 2021-06), p. S549-S554
    Abstract: Maxillofacial radiologists play a significant role in detecting airway changes using radiographic tools. Clinical examination parameters and lateral cephalogram parameters play a vital role in diagnosing obstructive sleep apnea (OSA) and dreadful consequences. Aim and Objectives: This study aims to evaluate central obesity, increased body mass index (BMI), and its relation to oropharyngeal airway space using lateral cephalogram in risk prediction of OSA. Objectives are to measure central obesity and BMI. Methodology: BMI is measured using World Health Organization guidelines to measure oropharyngeal airway space and the tongue and soft palate area using lateral cephalogram to predict OSA's risk using Berlin's questionnaire. Age group between 18 and 60 years with 20 individuals in each group will be present in the study. Conclusion: Cephalometric upper airway space and soft-tissue variables in different BMI groups were compared, and it was found that there was a decrease in SPAS, MAS with an increase in BMI, and in patients with BMI 〈 24, there was narrower nasopharynx and oropharynx.
    Type of Medium: Online Resource
    ISSN: 0976-4879 , 0975-7406
    Language: English
    Publisher: Medknow
    Publication Date: 2021
    detail.hit.zdb_id: 2573569-X
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  • 2
    In: Journal of Anaesthesiology Clinical Pharmacology, Medknow
    Abstract: Sedative effects of melatonin may have an additive effect on general anesthesia (GA). We compared hemodynamic response to intubation following oral premedication with melatonin versus placebo. Induction dose of propofol, isoflurane and fentanyl consumption were also compared. Material and Methods: This prospective, double-blinded study was conducted in fifty patients randomized into two equal groups. Group M received oral melatonin 6 mg and group P a placebo two hours before surgery. All patients were induced with intravenous propofol of 1.5–2.5mg/kg till loss of response to verbal commands, three minutes after vecuronium, laryngoscopy was done and trachea was intubated. Heart rate (HR) and mean arterial pressures (MAP) were recorded before premedication, before induction, immediately after induction and then at 1,3,5 and 10 minutes after intubation. Results: Mean HR was comparable in both groups throughout the study period. Group M had significantly lower MAP before induction and immediately after induction ( P 〈 0.05). At all other time points MAP remained comparable in both groups. Mean isoflurane consumption was significantly lower in group M compared to group P (14.8 ± 4.2 vs 19.7 ± 3.2 mL). Propofol requirement for induction was also significantly lower in group M (102.4 ± 19.6 vs 122.4 ± 26.3mg). Intraoperative fentanyl consumption was comparable. Conclusion: Oral premedication with melatonin 6mg administered two hours before surgery significantly reduced MAP before and after induction of GA with a significant reduction in dose of propofol requirement.Titrating induction dose of propofol till loss of response to verbal commands did not effectively attenuate responses to laryngoscopy and intubation following melatonin oral premedication.
    Type of Medium: Online Resource
    ISSN: 2231-2730 , 0970-9185
    Language: English
    Publisher: Medknow
    Publication Date: 2023
    detail.hit.zdb_id: 2253976-1
    SSG: 15,3
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