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  • European Respiratory Society (ERS)  (2)
  • 2020-2024  (2)
  • 1
    Online Resource
    Online Resource
    Endoscopic lung volume reduction with endobronchial valves in very low D LCO patients: results from the German Registry – Lungenemphysemregister e.V.
    European Respiratory Society (ERS) ; 2021
    In:  ERJ Open Research Vol. 7, No. 1 ( 2021-01), p. 00449-2020-
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    In: ERJ Open Research, European Respiratory Society (ERS), Vol. 7, No. 1 ( 2021-01), p. 00449-2020-
    Abstract: Endoscopic lung volume reduction (ELVR) with valves has been suggested to be the key strategy for patients with severe emphysema and concomitant low diffusing capacity of the lung for carbon monoxide ( D LCO ). However, robust evidence is still missing. We therefore aim to compare clinical outcomes in relation to D LCO for patients treated with ELVR. Methods We assessed D LCO at baseline and 3 months follow-up and compared pre- and postprocedural pulmonary function test, quality of life, exercise capacity and adverse events. This is a retrospective subanalysis of prospectively collected data from the German Lung Emphysema Registry. Results In total, 121 patients treated with ELVR were analysed. Thirty-four patients with a D LCO ≤20% and 87 patients with a D LCO 〉 20% showed similar baseline characteristics. After ELVR, there was a decrease of residual volume (both p 〈 0.001 to baseline) in both groups, and both demonstrated better quality of life (p 〈 0.01 to baseline). Forced expiratory volume in 1 s (FEV 1 ) improved significantly only in patients with a D LCO 〉 20% (p 〈 0.001 to baseline). Exercise capacity remained almost unchanged in both groups (p=0.3). The most frequent complication for both groups was a pneumothorax ( D LCO ≤20%: 17.6% versus D LCO 〉 20%: 16.1%; p=0.728). However, there were no significant differences in other adverse events between both groups. Conclusions ELVR improves lung function as well as quality of life in patients with D LCO 〉 20% and D LCO ≤20%. Adverse events did not differ between groups. Therefore, ELVR should be considered as a treatment option, even in patients with a very low D LCO .
    Type of Medium: Online Resource
    ISSN: 2312-0541
    URL: Article
    DOI: 10.1183/23120541.00449-2020
    Language: English
    Publisher: European Respiratory Society (ERS)
    Publication Date: 2021
    detail.hit.zdb_id: 2827830-6
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  • 2
    Online Resource
    Online Resource
    Assessment of efficacy and safety of endoscopic lung volume reduction with one-way valves in patients with a very low FEV 1
    European Respiratory Society (ERS) ; 2023
    In:  ERJ Open Research Vol. 9, No. 4 ( 2023-07), p. 00190-2023-
    Details
    In: ERJ Open Research, European Respiratory Society (ERS), Vol. 9, No. 4 ( 2023-07), p. 00190-2023-
    Abstract: Endoscopic lung volume reduction (ELVR) with one-way valves produces beneficial outcomes in patients with severe emphysema. Evidence on the efficacy remains unclear in patients with a very low forced expiratory volume in 1 s (FEV 1 ) (≤20% predicted). We aim to compare clinical outcomes of ELVR, in relation to the FEV 1 restriction. Methods All data originated from the German Lung Emphysema Registry (Lungenemphysem Register), which is a prospective multicentric observational study for patients with severe emphysema after lung volume reduction. Two groups were formed at baseline: FEV 1 ≤20% pred and FEV 1 21–45% pred. Pulmonary function tests (FEV 1 , residual volume, partial pressure of carbon dioxide), training capacity (6-min walk distance (6MWD)), quality of life (modified Medical Research Council dyspnoea scale (mMRC), COPD Assessment Test (CAT), St George's Respiratory Questionnaire (SGRQ)) and adverse events were assessed and compared at baseline and after 3 and 6 months. Results 33 patients with FEV 1 ≤20% pred and 265 patients with FEV 1 21–45% pred were analysed. After ELVR, an increase in FEV 1 was observed in both groups (both p 〈 0.001). The mMRC and CAT scores, and 6MWD improved in both groups (all p 〈 0.05). The SGRQ score improved significantly in the FEV 1 21–45% pred group, and by trend in the FEV 1 ≤20% pred group. Pneumothorax was the most frequent complication within the first 90 days in both groups (FEV 1 ≤20% pred: 7.7% versus FEV 1 21–45% pred: 22.1%; p=0.624). No deaths occurred in the FEV 1 ≤20% pred group up to 6 months. Conclusion Our study highlights the potential efficacy of one-way valves, even in patients with very low FEV 1 , as these patients experienced significant improvements in FEV 1 , 6MWD and quality of life. No death was reported, suggesting a good safety profile, even in these high-risk patients.
    Type of Medium: Online Resource
    ISSN: 2312-0541
    URL: Article
    DOI: 10.1183/23120541.00190-2023
    Language: English
    Publisher: European Respiratory Society (ERS)
    Publication Date: 2023
    detail.hit.zdb_id: 2827830-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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