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  • Wiley-Blackwell  (3)
  • 2020-2024
  • 2010-2014  (3)
  • 1
    Publication Date: 2013-01-16
    Description: Patients dually infected with hepatitis C virus (HCV)/hepatitis B virus (HBV) have a higher risk of developing advanced liver disease or hepatocellular carcinoma compared to monoinfected patients. Our previous study showed a similar rate of sustained virologic response (SVR) after peginterferon alfa-2a and ribavirin combination therapy in these patients compared to HCV monoinfected patients, and a high hepatitis B surface antigen (HBsAg) seroclearance rate. The durability of hepatitis C and B clearance in dually infected patients was investigated by a 5-year follow-up study. Patients with active HCV genotype 1, both HBV coinfected (n=97) and monoinfected (n=110), received a 48-week combination therapy with peginterferon alfa-2a plus ribavirin. Patients with active HCV genotype 2/3, both HBV coinfected (n=64) and monoinfected (n=50) patients received a 24-week combination therapy. A total of 295 (91.9%) patients completed treatment and 24 weeks post-treatment follow-up; 264 (89.5%) agreed to receive additional follow-up for up to 5 years after the end of treatment. After a median follow-up of 4.6 + 1.0 years, 6 of the 232 patients achieving SVR developed HCV RNA reappearance, including 5 HCV genotype 1/HBV coinfected patients and 1 HCV genotype 2/3 monoinfected patient. Subgenomic analysis of the HCV core gene suggested that 5 patients developed delayed recurrence of HCV infection. Overall, the cumulative recurrence rate of HCV infection was 2.3% (0.4%/year; 95% confidence interval [CI]=0.9%∼5.5%). The cumulative HBsAg seroclearance rate was 30.0% (95% CI=21.5%∼42.0%); with 33.1% (95% CI=21.8%∼50.1%) in 48-week combination therapy group and 24.3% (95% CI=13.7%∼42.9%) in 24-week therapy group. Conclusion: Peginterferon alfa-2a and ribavirin therapy provides a good durability of HCV SVR and a high accumulative HBsAg seroclearance rate in patients dually infected with HCV and HBV. (H EPATOLOGY 2013.)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
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  • 2
    Publication Date: 2013-03-09
    Description: The Gulf of Mexico (GOM) is facing large pressures from environmental changes since the beginning of last century. However, the magnitude and long-term trend of total water discharge to the GOM and the underlying processes are not well understood. In this study, the Dynamic Land Ecosystem Model (DLEM) has been improved and applied to investigate spatial and temporal variations of evapotranspiration (ET) and runoff (R) over drainage basins of the GOM during 1901-2008. Modeled ET and discharge were evaluated against up-scaled data sets and gauge observations. Simulated results demonstrated a significant decrease in ET at a rate of 15 mm yr -1 century -1 and an insignificant trend in runoff/precipitation (R/P) and river discharge over the whole region during 1901-2008. However, the trends in estimated water fluxes show substantial spatial and temporal heterogeneities across the study region. Generally, in the west arid area, ET, R, and R/P decreased; while they increased in the eastern part of the study area during the last 108 years. In the resent 30 years this region experienced substantial decrease in R. Factorial simulation experiments indicate that climate change, particularly P, was the dominant factor controlling interannual variations of ET and R; while land use change had the same magnitude of effects on long-term trends in water fluxes as climate change did. To eliminate modeling uncertainties, high-resolution historical meteorological data sets and model parameterizations on anthropogenic effects such as water use and dam constructions should be developed.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
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  • 3
    Publication Date: 2013-03-09
    Description: A one-dimensional Ag I coordination complex, catena -poly[[silver(I)-μ-{2-[2-(pyridin-4-yl)-1 H -benzimidazol-1-ylmethyl]phenol-κ 2 N 2 : N 3 }] perchlorate monohydrate], {[Ag(C 19 H 15 N 3 O)]ClO 4 ·H 2 O} n , was synthesized by the reaction of 2-[2-(pyridin-4-yl)-1 H -benzimidazol-1-ylmethyl]phenol ( L ) with silver perchlorate. In the complex, the L ligands are arranged alternately and link Ag I cations through one benzimidazole N atom and the N atom of the pyridine ring, leading to an extended zigzag chain structure. In addition, the one-dimensional chains are extended into a three-dimensional supramolecular architecture via O—H...O hydrogen-bond interactions and π–π stacking interactions. The complex exhibits photoluminescence in acetonitrile solution, with an emission maximum at 390 nm, and investigation of the thermal stability reveals that the network structure is stable up to 650 K.
    Print ISSN: 0108-2701
    Electronic ISSN: 1600-5759
    Topics: Chemistry and Pharmacology , Geosciences , Physics
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