Note: Front Cover -- Recent Advances in Medicinal Chemistry, Volume 1 -- Copyright -- Contents -- Foreword -- Preface -- List of Contributors -- Chapter 1: New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs -- Abstract -- 1. Introduction -- 2. Principal Functions of Nsaids and Aureolic Acid Anticancer Antibiotics and Their Mechanism of Action -- 3. Other Functions of These Drugs and Mechanism of Actions -- 4. Chemical Dissection of the Drugs to Understand Alternate Functions -- 5. Conclusion -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 2: Updated Report on a Novel Mercaptopyruvate Sulfurtransferase Thioredoxin-Dependent Redox-Sensing Molecular Switch: A Mechanism for the Maintenance of Cellular Redox Equilibrium -- Abstract -- Introduction -- A Redox-sensing Molecular Switch Formed Via an Intermolecular Disulfide Bond -- Low Redox Potential Sulfenate Formation at a Catalytic Site Cysteine: Another Mechanism by Which MST Serves as an Anti-oxidant Protein -- Conclusions -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 3: Characterization of Inorganic Nanomaterials as Therapeutic Vehicles -- Abstract -- Introduction -- Concluding Remarks -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 4: Aromatase Inhibitors: A New Reality for the Adjuvant Endocrine Treatment of Early-Stage Breast Cancer in Postmenopausal Women -- Abstract -- Introduction -- Conclusions -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 5: Bacterial FabH: Towards the Discovery of New Broad-Spectrum Antibiotics -- Abstract -- Introduction -- Bacterial Type II Fas the Biological Process -- Three Dimensional Structure of FabH -- Substrate Binding and Specificity. , Catalytic Mechanism and Substrate Binding -- Molecular Modeling Studies of FabH -- Concluding Remarks -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 6: Tannins and Their Influence on Health -- Abstract -- 1. Introduction -- 2. Classification of Tannins -- 3. Absorption and Metabolism of Tannins -- 4. Biological Activity -- 5. Human Intervention Studies -- 6. Adverse and Undesirable Effects -- 7. Conclusions -- Acknowledgements -- Conflict of Interest -- Disclosure -- Abbreviations -- References -- Chapter 7: Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors? -- Abstract -- Introduction -- Role of RhoA in Normal and Tumor Cells -- Statins Inhibit RhoA Activity -- Statins and Tumor Growth/apoptosis -- Statins and Angiogenesis -- Statins and Metastasis -- Statins, Chemotherapy Efficacy and Multidrug Resistance -- Statins and Chemoprevention of Tumors -- Statins in Cancer Treatment -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 8: Carotenoids that are Involved in Prostate Cancer Risk -- Abstract -- Introduction -- Types of Carotenoids and Their Distribution in Diets -- Conclusions -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 9: Preclinical Studies of Saponins for Tumor Therapy -- Abstract -- Diverse Structures and Functions of Saponins -- Saponins as Anti-Cancer Agents -- Dioscins -- Saikosaponins -- Julibrosides -- Soy Saponins -- Ginseng Saponins -- Avicins -- Knowledge, Gaps and Future -- Combinations of Saponins and Other Anti-Cancer Agents -- Conclusions -- Acknowledgements -- Conflict of Interest -- Disclosure -- Abbreviations -- References -- Chapter 10: Pharmacological Neuroprotection for Acute Spinal Cord Injury -- Abstract -- 1. Introduction -- 2. Epidemiology -- 3. Pathophysiology. , 4. Search Criteria -- 5. Current Treatment of Acute Spinal Cord Injuries -- 6. Promising Future Pharmacological Therapies -- Conclusions -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 11: HPLC and its Essential Role in the Analysis of Tricyclic Antidepressants in Biological Samples -- Abstract -- 1. Introduction -- 2. Chemistry and Activity -- 3. Analytical Methods -- 4. Conclusions -- Acknowledgements -- Conflict of Interest -- Disclosure -- Abbreviations -- References -- Chapter 12: Gene Expression Profiles in Breast Cancer to Identify Estrogen Receptor Target Genes -- Abstract -- Introduction -- Estrogen Receptors -- Mechanisms of ER Action -- Global Gene Expression Profiling of ER Action -- Future Considerations -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Chapter 13: Trans-plasma Membrane Electron Transport in Human Blood Platelets: An Update -- Abstract -- Plasma Membrane Redox System -- Medicinal Effects on Platelet PMR System -- Acknowledgements -- Conflict of Interest -- Abbreviations -- References -- Chapter 14: Role of Intermediate States in Protein Folding and Misfolding -- Abstract -- Introduction -- Acknowledgements -- Conflict of Interest -- Disclosure -- References -- Index.

Note: Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- List of figures -- List of tables -- List of Contributors -- Preface -- Acknowledgments -- Chapter 1 A brief history and overview of landscape ecology -- Part I Theory and concepts in landscape ecology -- Chapter 2 Landscape mosaics and the patch-corridor-matrix model -- Chapter 3 Scale and hierarchy in landscape ecology -- Chapter 4 Landscape connectivity -- Part II Landscape processes -- Chapter 5 Spatially structured ecosystems, connectivity, and movement -- Chapter 6 Habitat fragmentation -- Chapter 7 Nutrient flows in the landscape -- Chapter 8 The disturbance regime concept -- Chapter 9 Impacts of climate changes and amplified natural disturbance on global ecosystems -- Chapter 10 Change from within: Bottom-up disturbances of ecosystems -- Part III Methods and tools for landscape ecology -- Chapter 11 Fieldwork in landscape ecology -- Chapter 12 Remote sensing and landscape mapping -- Chapter 13 Sensors in the landscape -- Chapter 14 The role of paleoecology in understanding landscape-level ecosystem dynamics -- Chapter 15 Landscape pattern analysis -- Chapter 16 Quantitative modelling and computer simulation -- Chapter 17 Landscape character assessment and participatory approaches -- Chapter 18 Experimentation in landscape ecology -- Part IV Landscape ecology frontiers -- Chapter 19 Landscape ecology contributions to biodiversity conservation -- Chapter 20 Ecosystem services in the landscape -- Chapter 21 Riverscapes -- Chapter 22 Landscape restoration -- Chapter 23 Landscapes and climate change - case studies from Europe -- Index.