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  • 2020-2022  (1)
  • 1980-1984  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 21 (1982), S. 35-46 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 7 (1984), S. 12-14 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A variety of phagocytic cell and lymphocyte assays were employed to evaluate the immune status of four patients with methylmalonicaciduria. One patient had a depressed absolute granulocyte count and two patients had depressed neutrophil and monocyte chemotactic responses. All subjects had normal neutrophil phagocytic and bactericidal activities. One patient had a decreased T-cell number; blastogenic responses to phytohaemagglutinin and pokeweed mitogen were normal in all subjects. B lymphocyte measurements were variably abnormal; two children had decreased B-cell numbers; two had marginally decreased IgG levels; a third had an undetectable rubella titre; and two had elevated serum IgE concentrations.In vitro exposure of normal cells to methylmalonic acid concentrations up to 50mg/100 ml did not affect chemotactic or lymphoproliferative responses. In conclusion, although B-cell function may be affected, no consistent abnormality of lymphocyte or phagocytic cell functions could be attributed to the metabolic disorder.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2021-10-06
    Description: An approach to analyze high-end sea level rise is presented to provide a conceptual framework for high-end estimates as a function of time scale, thereby linking robust sea level science with stakeholder needs. Instead of developing and agreeing on a set of high-end sea level rise numbers or using an expert consultation, our effort is focused on the essential task of providing a generic conceptual framework for such discussions and demonstrating its feasibility to address this problem. In contrast, information about high-end sea level rise projections was derived previously either from a likely range emerging from the highest view of emissions in the Intergovernmental Panel on Climate Change assessment (currently the Representative Concentration Pathway 8.5 scenario) or from independent ad hoc studies and expert solicitations. Ideally, users need high-end sea level information representing the upper tail of a single joint sea level frequency distribution, which considers all plausible yet unknown emission scenarios as well as involved physical mechanisms and natural variability of sea level, but this is not possible. In the absence of such information we propose a framework that would infer the required information from explicit conditional statements (lines of evidence) in combination with upper (plausible) physical bounds. This approach acknowledges the growing uncertainty in respective estimates with increasing time scale. It also allows consideration of the various levels of risk aversion of the diverse stakeholders who make coastal policy and adaptation decisions, while maintaining scientific rigor.
    Keywords: 551.46 ; 627.4 ; sea level rise ; high‐end estimates
    Language: English
    Type: map
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