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  • Articles  (28)
  • 2020-2022
  • 2000-2004  (6)
  • 1985-1989  (22)
  • Chemistry and Pharmacology  (27)
  • Mathematics  (1)
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  • Articles  (28)
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  • 1
    Electronic Resource
    Electronic Resource
    Atenolol versus pindolol: Side-effects in hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 89-91 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; pindolol ; sleep disturbance ; β-blockers ; dreaming ; fatigue ; hypertension ; lipophilicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary This randomized crossover out-patient study was designed to compare the antihypertensive effects of atenolol and pindolol. After a wash-out period of two weeks in pretreated cases, 107 patients with essential hypertension were given either atenolol 100 mg once-daily or pindolol 20 mg slow release (SR) once-daily. Both atenolol and pindolol lowered blood pressure over the 24 week period. The diastolic blood pressure reduction was significantly greater (p〈0.01) with atenolol than with pindolol. Before β-blocker therapy, many patients had already experienced side-effects such as fatigue, sleep disturbances and dreams. This probably relates to the high sensitivity of the analogue scale used to assess side-effects, and to the high incidence of such symptoms in untreated patients. As the study progressed there was a reduction in the frequency of fatigue (p〈0.03) and dreams (p〈0.05) in both groups, whereas sleep disturbances significantly increased under pindolol (p〈0.05) but decreased under atenolol (p〈0.05). The only important side-effect difference between the two β-blockers was the higher incidence of sleep disturbances with pindolol which may be due to the higher lipophilicity of this β-blocker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543717
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis, characterization, and reactivity of .alpha.-ketoacyl complexes of platinum(II) and palladium(II). Crystal structures of trans-Pt(PPh3)2(Cl)(COCOPh) and cis-Pt(PPh3)2(COPh)(CO2Me) (1987)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 109 (1987), S. 148-156 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00235a023
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  • 3
    Electronic Resource
    Electronic Resource
    The Sc+NO→ScO+N reaction: Rotational state distribution in ScOX 2Σ+(v″=0) (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 11106-11117 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The Sc+NO→ScO+N reaction has been investigated in a beam-gas arrangement, with characterization of ScO products by cw laser-induced fluorescence: absorption versus laser frequency over the A 2Π(v′=1)–X 2Σ+(v″=0) band and fluorescence over the A 2Π(v′=1)–X 2Σ+(v″=1) one. It leads to the direct determination of the nascent rotational state distribution in the X 2Σ+(v″=0) level of ScO. This distribution is close to a Prior statistical one, with a well-characterized weak "surprisal," indicating that a momentum constraint takes place during the reaction process. In the frame of this statistical distribution, a new accurate value for the dissociation energy of ScO is proposed: D00(ScO)=(6.92±0.01) eV. Spectroscopic data are reported for the A 2Π(v′=1)–X 2Σ+(v=0) band, up to N=98. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1421072
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  • 4
    Electronic Resource
    Electronic Resource
    A full description of the potential curve of the B 1Πu state of 7Li2 (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 114 (2001), S. 8445-8458 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: An accurate potential curve for the bound and quasibound region of the B 1Πu state of 7Li2 is produced by analyzing high resolution sub-Doppler B 1Πu←X 1Σg+ excitation spectra in conjunction with lower resolution data of Hessel and Vidal [J. Chem. Phys. 70, 4439 (1979)] and of Russier et al. [J. Mol. Spectrosc. 168, 39 (1994)]. The bound and quasibound part of the curve is generated by the direct fit of molecular energies to a numerical potential; the outermost (repulsive) part of the curve is calculated by an asymptotic method using Coulombic and exchange parameters determined from the 1 1Πg and A 1Σu+ states of the lithium dimer. The full potential energy curve of the B 1Πu state reproduces all measured energies of f parity, and the widths of the predissociated lines, to within the experimental accuracy. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1364687
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  • 5
    Electronic Resource
    Electronic Resource
    The GTPase-activating protein Rap1GAP uses a catalytic asparagine (2004)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 429 (2004), S. 197-201 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It regulates integrin-mediated cell adhesion and might activate extracellular signal-regulated kinase. Like other Ras-like GNBPs, Rap1 is regulated by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature02505
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  • 6
    Electronic Resource
    Electronic Resource
    RanGAP mediates GTP hydrolysis without an arginine finger (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 415 (2002), S. 662-666 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] GTPase-activating proteins (GAPs) increase the rate of GTP hydrolysis on guanine nucleotide-binding proteins by many orders of magnitude. Studies with Ras and Rho have elucidated the mechanism of GAP action by showing that their catalytic machinery is both stabilized by GAP binding and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/415662a
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  • 7
    Electronic Resource
    Electronic Resource
    Length formulas for the local cohomology of exterior powers (1986)
    Springer
    Mathematische Zeitschrift 191 (1986), S. 145-158 
    Details
    ISSN: 1432-1823
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01163615
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  • 8
    Electronic Resource
    Electronic Resource
    Interactions between cyclic AMP-dependent protein phosphorylation and lipid transmethylation reactions in isolated porcine cardiac sarcolemma (1989)
    Springer
    Molecular and cellular biochemistry 91 (1989), S. 51-61 
    Details
    ISSN: 1573-4919
    Keywords: heart ; sarcolemma ; phosphatidylethanolamine N-methylation ; cyclic AMP ; protein phosphorylation ; S-adenosyl-L-methionine ; neutral lipid methylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Premethylation of purified porcine cardiac sarcolemma (SL) in the presence of 0.15, 10 and 150 µM S-adenosyl-L-methionine (AdoMet) did not change the phosphorylation of SL proteins catalyzed either by intrinsic cyclic AMP-dependent protein kinase (cAK) or by added catalytic (C) subunit of this enzyme. On the other hand, membrane exhibited increased lipid methyltransferase activity after preincubation with MgATP and C subunit. Prephosphorylation of membranes stimulated the total [3H]-methyl incorporation into SL lipids assayed at 0.15 µM [3H]AdoMet due to an enhancement of Vmax and without changes in the Km value for AdoMet. Analysis of the methylated lipid products revealed an increased methyl group incorporation into a nonpolar lipid fraction whereas phosphatidylethanolamine-N-methylation was not affected by phosphorylation. The results suggest that the cyclic AMP-mediated signal transduction at the level of cardiac SL is not affected by methylation-induced modifications of the membrane lipid microdomains. On the other hand, an intrinsic SL lipid methyltransferase activity is apparently not related to the N-methylation of phospholipids, is modulated by cyclic AMP-dependent protein phosphorylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228079
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of sustained mechanical stress on Egr-1 mRNA expression in cultured human endothelial cells (2000)
    Springer
    Molecular and cellular biochemistry 210 (2000), S. 101-108 
    Details
    ISSN: 1573-4919
    Keywords: human endothelial cells ; mechanical stress ; immediate early genes ; protein kinase C ; calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Restenosis after initially successful balloon angioplasty of coronary artery stenosis remains a major problem in clinical cardiology. Previous studies have identified pathogenetic factors which trigger cell proliferation and vascular remodeling ultimately leading to restenosis. Since there is evidence that endothelial cells adjacent to the angioplasty wound area synthesize factors which may initiate this process, we investigated the effects of mechanical stimulation on endothelial gene expression in vitro and focussed on the influence of sustained mechanical stress on expression of immediate early genes which have previously been shown to be induced in the vascular wall in vivo. Primary cultured human umbilical vein endothelial cells (HUVEC) and the human endothelial cell line EA.hy 926 were plated on collagen-coated silicone membranes and subjected to constant longitudinal stress of approximately 20% for 10 min to 6 h. Total RNA was isolated and the expression of the immediate early genes c-Fos and Egr-1 was studied by Northern blot analysis. We found a rapid upregulation c-Fos and Egr-1 mRNA which started at 10 min and reached its maxima at 30 min. HUVEC lost most of their stretch response after the third passage whereas immediate early gene expression was constantly in EA.hy 926 cells. Using specific inhibitors we investigated the contribution of several signal transduction pathways to stretch-activated Egr-1 mRNA expression. We found significant suppression of stretch-induced Egr-1 mRNA expression by protein kinase C (PKC) inhibition (p 〈 0.05) and by calcium depletion (EA.hy926, p 〈 0. 05; HUVEC, p = 0.063). No effect on stretch-activated Egr-1 mRNA expression was detected by inhibition of protein kinase A, blockade of stretch-activated cation channels or inhibition of microtubule synthesis. We conclude that sustained mechanical strain induces Egr-1 mRNA expression by PKC- and calcium-dependent mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007126218740
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  • 10
    Electronic Resource
    Electronic Resource
    Single bead parallel synthesis and screening (2000)
    Springer
    Molecular diversity 5 (2000), S. 111-116 
    Details
    ISSN: 1573-501X
    Keywords: combinatorial chemistry ; delivery microreactors ; drop-on-demand liquid ; miniaturization ; photolysis ; silicon wafer ; single bead synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Microstructured silicon wafers were employed as miniaturizedsolid-phase reaction vessels as well as miniaturized microtiter plates. Employing piezoelectric drop-on-demand liquidjets, a combinatorial library of 256 Peptides was synthesizedon single beads. The synthesis protocol was associated to thelocation in the silicon nano-well arrangement. Products werephotolytically cleaved in the same well that was used forsynthesis and subsequently interrogated for thrombin inhibitionin a homogeneous competition assay. The assay procedure wasbased on drop-on-demand liquid delivery and laser inducedfluorescence imaging. The novel format proved useful for theintegration of both synthesis and screening into one platform,a prerequisite for an iterative, evolutionary approach towardsdrug discovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016287827310
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