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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Histopathology 46 (2005), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2017-04-11
    Description: The contributions of autonomous underwater gliders as an observing platform in the in-situ global ocean observing system (GOOS) are investigated. The assessment is done in two ways: First, the existing in-situ observing platforms contributing to GOOS (floats, surface drifters, moorings, research/commercial ships) are characterized in terms of their current capabilities in sampling key physical and bio-geochemical oceanic processes. Next the gliders’ capabilities are evaluated in the context of key applications. This includes an evaluation of 140 references presented in the peer-reviewed literature. It is found that GOOS has adequate coverage of sampling in the open ocean for several physical processes. There is a lack of data in the present GOOS in the transition regions between the open ocean and shelf seas. However, most of the documented scientific glider applications operate in this region, suggesting that a sustained glider component in the GOOS could fill that gap. Glider data are included for routine product generation (e.g. alerts, maps). Other noteworthy process-oriented applications where gliders are important survey tools include local sampling of the (sub)mesoscale, sampling in shallow coastal areas, measurements in hazardous environments, and operational monitoring. In most cases, the glider studies address investigations and monitoring of processes across multiple disciplines, making use of the ease to implement a wide range of sensors to gliders. The maturity of glider operations, the wide range of applications that map onto growing GOOS regional needs, and the maturity of glider data flow all justify the formal implementation of gliders into the GOOS. Remaining challenges include the execution of coordinated multinational missions in a sustained mode as well as considering capacity-building aspects in glider operations as well as glider data use.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
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  • 3
    Publication Date: 2015-04-01
    Description: Since 2006, the European Near Earth Asteroids Research (EURONEAR) project has been contributing to the research of near-Earth asteroids (NEAs) within a European network. One of the main aims is the amelioration of the orbits of NEAs, and starting in 2014 February we focus on the recovery of one-opposition NEAs using the Isaac Newton Telescope (INT) in La Palma in override mode. Part of this NEA recovery project, since 2014 June EURONEAR serendipitously started to discover and secure the first NEAs from La Palma and using the INT, thanks to the teamwork including amateurs and students who promptly reduce the data, report discoveries and secure new objects recovered with the INT and few other telescopes from the EURONEAR network. Five NEAs were discovered with the INT, including 2014 LU14, 2014 NL52 (one very fast rotator), 2014 OL339 (the fourth known Earth quasi-satellite), 2014 SG143 (a quite large NEA), and 2014 VP. Another very fast moving NEA was discovered but was unfortunately lost due to lack of follow-up time. Additionally, another 14 NEA candidates were identified based on two models, all being rapidly followed-up using the INT and another 11 telescopes within the EURONEAR network. They include one object discovered by Pan-STARRS, two Mars crossers, two Hungarias, one Jupiter trojan, and other few inner main belt asteroids (MBAs). Using the INT and Sierra Nevada 1.5 m for photometry, then the Gran Telescopio de Canarias for spectroscopy, we derived the very rapid rotation of 2014 NL52, then its albedo, magnitude, size, and its spectral class. Based on the total sky coverage in dark conditions, we evaluate the actual survey discovery rate using 2-m class telescopes. One NEA is possible to be discovered randomly within minimum 2.8 deg 2 and maximum 5.5 deg 2 . These findings update our past statistics, being based on double sky coverage and taking into account the recent increase in discovery.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 4
    Publication Date: 2016-01-15
    Description: Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis Cell Death and Disease 7, e2059 (January 2016). doi:10.1038/cddis.2015.361 Authors: A Ruiz, S Rockfield, N Taran, E Haller, R W Engelman, I Flores, P Panina-Bordignon & M Nanjundan
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
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  • 5
    Publication Date: 2016-07-30
    Description: Amino acid permeases (AAPs) in the plasma membrane (PM) of Saccharomyces cerevisiae are responsible for the uptake of amino acids and involved in regulation of their cellular levels. Here, we report on a strong and complex module for PM association found in the C-terminal tail of AAPs. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the PM, and have features that discriminate them from the termini of organellar amino acid transporters. We show that this sequence (named PMasseq) contains an amphipathic α-helix and the FWC signature, which is palmitoylated by palmitoyltransferase Pfa4. Variations of PMasseq, found in different AAPs, lead to different mobilities and localization patterns, whereas the disruption of the sequence has an adverse effect on cell viability. We propose that PMasseq modulates the function and localization of AAPs along the PM. PMasseq is one of the most complex protein signals for plasma membrane association across species and can be used as a delivery vehicle for the PM.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
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  • 6
    Publication Date: 2018-04-25
    Description: MEK inhibition in combination with a glycogen synthase kinase-3β (GSK3β) inhibitor, referred as the 2i condition, favors pluripotency in embryonic stem cells (ESCs). However, the mechanisms by which the 2i condition limits ESC differentiation and whether RAS proteins are involved in this phenomenon remain poorly understood. Here we show that RAS nullyzygosity reduces the growth of mouse ESCs (mESCs) and prohibits their differentiation. Upon RAS deficiency or MEK inhibition, ERF (E twenty-six 2 [Ets2]-repressive factor), a transcriptional repressor from the ETS domain family, translocates to the nucleus, where it binds to the enhancers of pluripotency factors and key RAS targets. Remarkably, deletion of Erf rescues the proliferative defects of RAS-devoid mESCs and restores their capacity to differentiate. Furthermore, we show that Erf loss enables the development of RAS nullyzygous teratomas. In summary, this work reveals an essential role for RAS proteins in pluripotency and identifies ERF as a key mediator of the response to RAS/MEK/ERK inhibition in mESCs.
    Print ISSN: 0890-9369
    Topics: Biology
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  • 7
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    American Society of Hematology (ASH)
    In: Blood
    Publication Date: 2018-03-16
    Keywords: Free Research Articles, BloodWork, Myeloid Neoplasia
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 8
    Publication Date: 2016-12-02
    Description: The generation of accelerograms using stochastic methods has been a very useful methodology for solving the problem of the lack of appropriate strong-motion records for seismic design. Here, we propose the generation of synthetic strong motion for subduction earthquakes that present well-developed P waves and energetic arrivals of S waves associated with the main asperities of the source of these events. The first few seconds of these accelerograms are dominated by P waves; however, the strong motion is a mixture of S and P waves arriving at the same time. The traditional method considers only S waves. We propose to improve the stochastic generation of accelerograms taking into account a stratified velocity model, incident and azimuthal angles, free surface factors, and energy partition to incorporate the P and SV waves in the simulation. Finally, the simulated accelerograms are compared with the observed data recorded on rock by the Integrated Plate boundary Observatory Chile (IPOC) network during the 2007 Tocopilla and 2014 Iquique earthquakes. The use of P , SV , and SH waves in the stochastic simulation allowed us to generate three-component synthetic records. The early seconds are clearly associated with P waves, and the three components reproduce the shape and the amplitude in time and spectral domains for the observed and simulated records. Online Material: Figures showing fit between observed and simulated waveforms, maximum amplitude of acceleration response spectra, peak ground velocities, and peak ground accelerations.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 9
    Publication Date: 2017-02-23
    Description: The accumulated stress in subduction zones is discharged with earthquake and aseismic activity; the latter is hosted in rheological complex regions, characterized by high pore fluid pressure, and is often accompanied by repeated earthquakes and earthquake swarms. The spatiotemporal analysis of seismic activity can reveal the presence of aseismic transients associated with large earthquakes. Here we study 20 years of seismicity prior to and after the M w 8.3 earthquake that occurred in A.D. 2015 in central Chile. We identified several earthquake swarms before the main shock and repeating aftershocks at the border of the main slip area. Spatial clustering of the seismic activity shares similar orientation with the main fracture zones observed on the outer rise of the subducting Nazca plate. Our findings suggest that the fracture zones enclosing the rupture are playing a major role in accommodating the pre and post–main shock stress evolution. We further recognize how fracture regions have acted as barriers to the propagation of large earthquakes in the region.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 10
    Publication Date: 2017-04-19
    Description: 〈span class="paragraphSection"〉〈div class="boxTitle"〉Abstract〈/div〉We study the seismic source of the 2015 (〈span style="font-style:italic;"〉M〈/span〉〈sub〉w〈/sub〉 6.7) Jujuy, Argentina intermediate depth earthquake. We first constrain the fault plane by using a teleseismic inversion and by determining the aftershock distribution. Then, we perform kinematic and dynamic inversions to retrieve the parameters that control the rupture process, using data at regional distances, and modelling the source as an elliptical patch. Best models suggest a subshear rupture propagation with a duration of ∼5 s. Results from the dynamic modelling suggest a stress drop of 11.87 MPa and a fracture energy rate of 2.95 MJ m〈sup〉−2〈/sup〉, which are slightly less but of the same order as those of other events of similar size. Finally, we perform a Monte-Carlo inversion to explore the behaviour of the frictional parameters in the solution space, and then we compare our results with other intraslab events. We find that the 〈span style="font-style:italic;"〉κ〈/span〉 parameter (ratio between strain energy and fracture energy) and the relation between seismic moment and stress drop are similar for all the considered events.〈/span〉
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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