In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 5 ( 2023-5-23), p. e0286222-
Abstract:
Supplementation with Fortetropin® (FOR), a naturally occurring component from fertilized egg yolks, reduces circulating myostatin concentration. We hypothesized that FOR would mitigate muscle atrophy during immobilization. We examined the effect of FOR supplementation on muscle size and strength during 2-wk of single-leg immobilization and recovery. Twenty-four healthy young men (22 ± 2 yrs; BMI = 24.3 ± 2.9 kg/m 2 ) were randomly allocated to either a Fortetropin® supplement (FOR-SUPP, n = 12) group consuming 19.8 g/d of FOR or placebo (PLA-SUPP, n = 12) group consuming energy- and macronutrient-matched cheese powder for 6-wk. The 6-wk period consisted of 2-wk run-in, 2-wk single-leg immobilization, and 2-wk recovery phase returning to habitual physical activities. Ultrasonography, dual-energy X-ray absorptiometry, muscle biopsies and isometric peak torque assessments were performed prior to and following each phase (days 1, 14, 28, and 42) to measure vastus lateralis and muscle fiber cross-section area (CSA), leg lean mass (LM), and muscular strength. Blood samples were taken on days 1 and 42 for measurement of plasma myostatin concentration, which increased in PLA-SUPP (4221 ± 541 pg/mL to 6721 ± 864 pg/mL, P = 0.013) but not in FOR-SUPP (5487 ± 489 pg/mL to 5383 ± 781 pg/mL, P = 0.900). After the immobilization phase, vastus lateralis CSA, LM, and isometric peak torque were decreased by 7.9 ± 1.7% ( P 〈 0.001), -1.6 ± 0.6% ( P = 0.037), and -18.7 ± 2.7% ( P 〈 0.001) respectively, with no difference between groups. The decreased peak torque was recovered after 2-wk of normal activity (vs. day 1, P = 0.129); however, CSA and LM were not recovered (vs. day 1, P 〈 0.001 and P = 0.003, respectively), with no differences between groups. Supplementation with FOR prevented the rise in circulating myostatin but not disuse-induced muscle atrophy in young men after 2-wk of single-leg immobilization.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0286222
DOI:
10.1371/journal.pone.0286222.g001
DOI:
10.1371/journal.pone.0286222.g002
DOI:
10.1371/journal.pone.0286222.g003
DOI:
10.1371/journal.pone.0286222.g004
DOI:
10.1371/journal.pone.0286222.g005
DOI:
10.1371/journal.pone.0286222.g006
DOI:
10.1371/journal.pone.0286222.g007
DOI:
10.1371/journal.pone.0286222.t001
DOI:
10.1371/journal.pone.0286222.t002
DOI:
10.1371/journal.pone.0286222.t003
DOI:
10.1371/journal.pone.0286222.s001
DOI:
10.1371/journal.pone.0286222.s002
DOI:
10.1371/journal.pone.0286222.s003
DOI:
10.1371/journal.pone.0286222.s004
DOI:
10.1371/journal.pone.0286222.s005
DOI:
10.1371/journal.pone.0286222.s006
DOI:
10.1371/journal.pone.0286222.s007
DOI:
10.1371/journal.pone.0286222.s008
DOI:
10.1371/journal.pone.0286222.r001
DOI:
10.1371/journal.pone.0286222.r002
DOI:
10.1371/journal.pone.0286222.r003
DOI:
10.1371/journal.pone.0286222.r004
DOI:
10.1371/journal.pone.0286222.r005
DOI:
10.1371/journal.pone.0286222.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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