In:
Lung, Springer Science and Business Media LLC, Vol. 200, No. 5 ( 2022-10), p. 609-617
Abstract:
Low serum creatinine/cystatin C ratio (CCR) is associated with unfavorable characteristics in patients with chronic obstructive pulmonary disease (COPD); however, the relationship between CCR and in-hospital mortality of patients with acute exacerbation of COPD (AECOPD) is unexplored. Our objective was to assess the value of CCR for predicting in-hospital mortality of patients hospitalized with AECOPD. Methods Patients with AECOPD ( n = 597) were retrospectively enrolled. Patient’s clinical characteristics and laboratory tests, including serum cystatin C and creatinine, were reviewed. The prediction value of CCR was evaluated using area under the receiver operating characteristic curve (AUC) values. Factors potentially impacting in-hospital mortality were investigated using univariate and multivariate logistic regression analyses. Results Mortality rate during hospitalization was 10.05%. CCR was lower in non-surviving vs. survived patients (41.67 vs. 61.52, P 〈 0.001). AUC value for CCR for in-hospital mortality prediction was 0.79 [95% confidence interval (CI) 0.73–0.85]. On multivariate logistic regression analysis, in-hospital mortality was strongly associated with CCR 〈 52.27 [odds ratio (OR) 6.23, 95% CI (3.00–12.92), P 〈 0.001], age ≥ 81 years [OR 2.97, 95% CI (1.20–7.37), P = 0.019], oxygenation index 〈 300 [OR 3.28, 95% CI (1.27–8.44), P = 0.014], CRP 〉 8 mg/L [OR 1.84, 95% CI (1.15–2.95), P = 0.012], and D-dimer 〉 500 ng/L [OR 5.19, 95% CI (1.51–17.79), P = 0.009]. Conclusions CCR was significantly lower, and is a potential prognostic indicator, in patients with AECOPD who died during hospitalization.
Type of Medium:
Online Resource
ISSN:
0341-2040
,
1432-1750
DOI:
10.1007/s00408-022-00568-5
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
1459394-4
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