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  • Wiley  (4)
  • 2020-2024  (4)
  • 2022  (4)
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  • Wiley  (4)
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  • 2020-2024  (4)
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  • 2022  (4)
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  • 1
    Online Resource
    Online Resource
    Herbivore grazing mitigates the negative effects of nitrogen deposition on soil organic carbon in low‐diversity grassland
    Wiley ; 2022
    In:  Journal of Applied Ecology Vol. 59, No. 2 ( 2022-02), p. 483-491
    Details
    In: Journal of Applied Ecology, Wiley, Vol. 59, No. 2 ( 2022-02), p. 483-491
    Abstract: Changes in soil carbon (C) sequestration in grassland ecosystems have important impacts on the global C cycle. As such, it is important that researchers better understand the underlying mechanisms affecting soil C. Increasing evidence has shown that atmospheric nitrogen (N) deposition can cause dramatic changes in grassland soil C. It remains unclear whether herbivore grazing, a primary means to manage and utilize grassland resources, can regulate the effects of N deposition on soil C, and whether these effects are dependent on plant community diversity. Here, we examined the joint effects of herbivore grazing and N‐addition on soil organic C (SOC) stocks in two types of communities with low and high plant diversity respectively. Our results showed that the effects of N‐addition and its combination with herbivore grazing on grassland SOC were inconsistent in the two types of communities. In the low‐diversity community, N‐addition greatly decreased SOC stocks, while grazing significantly increased it. Additionally, the grazing‐induced increase in soil C stocks in the presence of N‐addition was so great that it completely counteracted the significant decline in SOC induced by N‐addition. However, in the high‐diversity community, we observed no effects of N‐addition on SOC and grazing increased SOC only in the absence of N‐addition and had no significant effect in the presence of N‐addition. Synthesis and applications . Our study suggests that increased N deposition can trigger a remarkable reduction in soil C sequestration in grasslands with low plant diversity, but that herbivore grazing can offset this decline, which may help to mitigate greenhouse gas emissions caused by atmospheric N deposition. As a result, we suggest that moderate herbivore grazing should be considered as an effective grassland management measure for maintaining and improving grassland soil C sequestration as the increasing global changes such as elevated atmospheric carbon dioxide, N deposition and biodiversity losses threat.
    Type of Medium: Online Resource
    ISSN: 0021-8901 , 1365-2664
    URL: Issue
    URL: Article
    DOI: 10.1111/jpe.v59.2
    DOI: 10.1111/1365-2664.14066
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020408-5
    detail.hit.zdb_id: 410405-5
    SSG: 12
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    Online Resource
  • 2
    Online Resource
    Online Resource
    A novel prognostic model for papillary thyroid cancer based on epithelial–mesenchymal transition‐related genes
    Wiley ; 2022
    In:  Cancer Medicine Vol. 11, No. 23 ( 2022-12), p. 4703-4720
    Details
    In: Cancer Medicine, Wiley, Vol. 11, No. 23 ( 2022-12), p. 4703-4720
    Abstract: The frequent incidence of postsurgical recurrence issues in papillary thyroid cancer (PTC) patients is a primary concern considering the low cancer‐related mortality. Previous studies have demonstrated that epithelial–mesenchymal transition (EMT) activation is closely related to PTC progression and invasion. In this study, we aimed to develop a novel EMT signature and ancillary nomogram to improve personalized prediction of progression‐free interval (PFI). Methods First, we carried out a differential analysis of PTC samples and pairwise normal thyroid samples to explore the differentially expressed genes (DEGs). The intersection of the DEGs with EMT‐related genes (ERGs) were identified as differentially expressed EMT‐related genes (DE‐ERGs). We determined PFI‐related DE‐ERGs by Cox regression analysis and then established a novel gene classifier by LASSO regression analysis. We validated the signature in external datasets and in multiple cell lines. Further, we used uni‐ and multivariate analyses to identify independent prognostic characters. Results We identified 244 prognosis‐related DE‐ERGs. The 244 DE‐ERGs were associated with several pivotal oncogenic processes. We also constructed a novel 10‐gene signature and relevant prognostic model for recurrence prediction of PTC. The 10‐gene signature had a C‐index of 0.723 and the relevant nomogram had a C‐index of 0.776. The efficacy of the signature and nomogram was satisfying and closely correlated with relevant clinical parameters. Furthermore, the signature also had a unique potential in differentiating anaplastic thyroid cancer (ATC) samples. Conclusions The novel EMT signature and nomogram are useful and convenient for personalized management for thyroid cancer.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v11.23
    DOI: 10.1002/cam4.4836
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2659751-2
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  • 3
    Online Resource
    Online Resource
    Fraxetin exerts anticancer effect in glioma by suppressing MiR ‐21‐3p
    Wiley ; 2022
    In:  Drug Development Research Vol. 83, No. 2 ( 2022-04), p. 501-511
    Details
    In: Drug Development Research, Wiley, Vol. 83, No. 2 ( 2022-04), p. 501-511
    Abstract: Fraxetin (FXT) exerts anticancer function in multiple cancers, but its function on glioma was ill‐defined. This article expounded the mechanism by which FXT exerts an anticancer effect in glioma. The effect of gradient concentration of FXT on the viability of glioma cell lines was determined by cell counting kit 8. Effects of FXT on proliferation, apoptosis, and cell cycle in glioma cell lines were determined by colony formation assay, flow cytometry, and Hoechst 33342 staining. Expressions of apoptosis‐related gene, cycle‐related gene, and glioma‐related miRNAs after FXT (25 and 50 μmol/L) treatment were determined by quantitative reverse transcription polymerase chain reaction and western blot as needed. After miR‐21‐3p overexpression, cell viability and apoptosis of glioma cell lines treated with FXT (50 μmol/L) were tested again. Although 1 μmol/L FXT had no significant effect on cell viability, 5, 10, 25, and 50 μmol/L FXT suppressed cell viability in a concentration‐dependent manner. FXT inhibited proliferation, promoted apoptosis, and induced cell cycle arrest in G0/G1 phase in glioma cell lines. These effects may be achieved by elevated expressions of Bax and cleaved caspase‐3 and diminished expressions of Bcl‐2, Bcl‐XL, cyclin E1, cyclin D1, and cyclin‐dependent kinase‐6. FXT attenuated the contents of miR‐21‐3p and miR‐455‐3p, and escalated the contents of miR‐124‐3p and miR‐7‐5p. The regulation of FXT on cell viability, proliferation and apoptosis was reversed by miR‐21‐3p overexpression. FXT suppressed the development of glioma cells by downregulating miR‐21‐3p.
    Type of Medium: Online Resource
    ISSN: 0272-4391 , 1098-2299
    URL: Issue
    URL: Article
    DOI: 10.1002/ddr.v83.2
    DOI: 10.1002/ddr.21881
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1500191-X
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia
    Wiley ; 2022
    In:  Genes, Chromosomes and Cancer Vol. 61, No. 8 ( 2022-08), p. 503-508
    Details
    In: Genes, Chromosomes and Cancer, Wiley, Vol. 61, No. 8 ( 2022-08), p. 503-508
    Abstract: FUS::ERG rearrangement is a recurrent abnormality seen in a subgroup of acute myeloid leukemia (AML) with a poor prognosis. We described here a novel HNRNPH1::ERG rearrangement in a de novo AML. The patient was unresponsive to routine chemotherapy and succumbed to the disease just 3 months after diagnosis. Two additional cases of AML with HNRNPH1::ERG rearrangement were discovered by searching a publicly available sequencing database. The three patients share several clinical phenotypes with the FUS::ERG rearranged AML, including high blast count at diagnosis, pediatric or young adult‐onset, and poor overall survival. In addition, hnRNPH1 and FUS are both hnRNP family members, a group of RNA‐binding proteins functioning in RNA metabolism and transport. Therefore, we suggest that patients with HNRNPH1::ERG or FUS::ERG rearrangement belong to the same distinct clinicopathologic subtype of AML, that is, AML with ERG rearrangement. Based on a previous study showing that FUS::ERG binds to the retinoic acid‐responsive elements and that all‐ trans retinoic acid‐induced cell differentiation of AML cells, we support the clinical evaluation of an APL‐like therapeutic regimen for AML with ERG rearrangement.
    Type of Medium: Online Resource
    ISSN: 1045-2257 , 1098-2264
    URL: Issue
    URL: Article
    DOI: 10.1002/gcc.v61.8
    DOI: 10.1002/gcc.23051
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1018988-9
    detail.hit.zdb_id: 1492641-6
    SSG: 12
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