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  • 1
    Online Resource
    Online Resource
    Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the REACTION study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 6 ( 2021-06), p. 458-468
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 6 ( 2021-06), p. 458-468
    Abstract: 既往研究提示月经初潮年龄与糖尿病风险有关。然而尚不清楚理想的心血管健康指标对月经初潮年龄与成年后糖尿病风险之间关系的影响。 方法 我们纳入全国多中心REACTION研究(中国2型糖尿病患者恶性肿瘤发生风险的流行病学研究)中121431名女性。糖尿病的诊断基于口服葡萄糖耐量试验和糖化血红蛋白测值。使用Logistic回归和乘法项交互作用分析理想的心血管健康指标在月经初潮年龄与糖尿病相关性之间的潜在交互作用。 结果 多变量校正后; 与月经初潮年龄14‐17岁者相比; 月经初潮年龄 〈 14岁和 〉  17岁组的糖尿病风险比值比(95%可信区间)分别为1.22(1.17‐1.28)和0.89(0.85‐0.93)。分层分析中; 在总胆固醇; 血压水平和月经初潮年龄与糖尿病风险之间存在显著的交互作用(交互作用P 值分别为 0.0091和0.0019)。在有≤3个理想的心血管健康指标的女性中观察到月经初潮年龄 〈 14岁与成年后糖尿病发生风险增加显著相关; 但在有4个或更多理想的心血管健康指标的女性中则没有观察到显著的风险增加(理想的心血管健康指标的数量与月经初潮年龄之间的交互作用P值 = 0.0001)。 结论 女性成年后患糖尿病的风险与月经初潮年龄呈负相关; 而这种关系或可因理想的心血管健康指标而改变。需进一步研究以阐明其中的相互关系以及研究结果的普遍性。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.6
    DOI: 10.1111/1753-0407.13128
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2485432-3
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  • 2
    Online Resource
    Online Resource
    Unclonable Micro‐Texture with Clonable Micro‐Shape towards Rapid, Convenient, and Low‐Cost Fluorescent Anti‐Counterfeiting Labels
    Wiley ; 2021
    In:  Small Vol. 17, No. 30 ( 2021-07)
    Details
    In: Small, Wiley, Vol. 17, No. 30 ( 2021-07)
    Abstract: An ideal anti‐counterfeiting label not only needs to be unclonable and accurate but also must consider cost and efficiency. But the traditional physical unclonable function (PUF) recognition technology must match all the images in a database one by one. The matching time increases with the number of samples. Here, a new kind of PUF anti‐counterfeiting label is introduced with high modifiability, low reagent cost (2.1 × 10 −4 USD), simple and fast authentication (overall time 12.17 s), high encoding capacity (2.1 × 10 623 ), and its identification software. All inorganic perovskite nanocrystalline films with clonable micro‐profile and unclonable micro‐texture are prepared by laser engraving for lyophilic patterning, liquid strip sliding for high throughput droplet generation, and evaporative self‐assembling for thin film deposition. A variety of crystal film profile shapes can be used as “specificator” for image recognition, and the verification time of recognition technology based on this divide‐and‐conquer strategy can be decreased by more than 20 times.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v17.30
    DOI: 10.1002/smll.202100244
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2168935-0
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  • 3
    Online Resource
    Online Resource
    Public–private partnership model for intensive maize production in China: A synergistic strategy for food security and ecosystem economic budget
    Wiley ; 2021
    In:  Food and Energy Security Vol. 10, No. 4 ( 2021-11)
    Details
    In: Food and Energy Security, Wiley, Vol. 10, No. 4 ( 2021-11)
    Abstract: Small farms are the mainstay of maize production in China. Its productivity is relatively low despite large farm inputs and the associated environmental footprints. Here, we studied public–private partnership (PPP) model for sustainable intensification of maize production to achieve co‐benefits of food security and environmental sustainability. The PPP model enabled the development of an effective partnership by bringing complementary skills, knowledge, proprietary products and technologies, and resources of public research community and private enterprises to create a new, operational maize farming system in China. We conducted on‐farm research with farmer participation in four major maize‐growing regions spanning temperate to sub‐tropical zones in China for 2 years. The PPP model achieved 78.7% of maize yield potential compared with 61.8% realized in smallholder farm (SHF) (11.0 Mg ha −1 vs. 8.6 Mg ha −1 ). Overall, environmental externalities of PPP were up to 32.7% lower than that of SHF, depending on the region studied. PPP significantly reduced reactive nitrogen losses by 31.3%–35.5% compared with SHF in both years. There was no significant difference between PPP and SHF for greenhouse gas emission in 2018, but it was significantly lower in PPP (19%) compared to SHF in 2019. Similarly, PPP significantly reduced soil acidification potential (by 10.1%–42.2%) and eutrophication of waterbodies (21.5%) in comparison to SHF. Overall, the net ecosystem economic budget increased 277 USD ha −1 with PPP. The PPP model provides new insights into improving food security and ecosystem and economic budget. As a logical progression to our research, future work should focus on (a) the reasons for the persistence of inter‐regional yield gap in PPP model and (b) to gain a better understanding of socioeconomic drivers critical for successful PPP in different maize‐growing regions.
    Type of Medium: Online Resource
    ISSN: 2048-3694 , 2048-3694
    URL: Issue
    URL: Article
    DOI: 10.1002/fes3.v10.4
    DOI: 10.1002/fes3.317
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2663354-1
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  • 4
    Online Resource
    Online Resource
    The important roles of protein SUMOylation in the occurrence and development of leukemia and clinical implications
    Wiley ; 2021
    In:  Journal of Cellular Physiology Vol. 236, No. 5 ( 2021-05), p. 3466-3480
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 236, No. 5 ( 2021-05), p. 3466-3480
    Abstract: Leukemia is a severe malignancy of the hematopoietic system, which is characterized by uncontrolled proliferation and dedifferentiation of immature hematopoietic precursor cells in the lymphatic system and bone marrow. Leukemia is caused by alterations of the genetic and epigenetic regulation of processes underlying hematologic malignancies, including SUMO modification (SUMOylation). Small ubiquitin‐like modifier (SUMO) proteins covalently or noncovalently conjugate and modify a large number of target proteins via lysine residues. SUMOylation is a small ubiquitin‐like modification that is catalyzed by the SUMO‐specific activating enzyme E1, the binding enzyme E2, and the ligating enzyme E3. SUMO is covalently linked to substrate proteins to regulate the cellular localization of target proteins and the interaction of target proteins with other biological macromolecules. SUMOylation has emerged as a critical regulatory mechanism for subcellular localization, protein stability, protein–protein interactions, and biological function and thus regulates normal life activities. If the SUMOylation process of proteins is affected, it will cause a cellular reaction and ultimately lead to various diseases, including leukemia. There is growing evidence showing that a large number of proteins are SUMOylated and that SUMOylated proteins play an important role in the occurrence and development of various types of leukemia. Targeting the SUMOylation of proteins alone or in combination with current treatments might provide powerful targeted therapeutic strategies for the clinical treatment of leukemia.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v236.5
    DOI: 10.1002/jcp.30143
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing
    Wiley ; 2021
    In:  Advanced Functional Materials Vol. 31, No. 34 ( 2021-08)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 31, No. 34 ( 2021-08)
    Abstract: Real‐time monitoring of wound healing remains a major challenge in clinical tissue regeneration, calling the need for the development of biomaterial‐guided on‐site monitoring wound healing technology. In this study, multifunctional double colorimetry‐integrated polyacrylamide‐quaternary ammonium chitosan‐carbon quantum dots (CQDs)‐phenol red hydrogels are presented, aiming to simultaneously detect the wound pH level, reduce bacterial infection, and promote wound healing. The hybridization of CQDs and pH indicator (phenol red) with the hydrogels enables their high responsiveness, reversibility, and accurate indication of pH variability to reflect the dynamic wound status in the context of both ultraviolet and visible light. Furthermore, these visual images can be collected by smartphones and converted into on‐site wound pH signals, allowing for a real‐time evaluation of the wound dynamic conditions in a remote approach. Notably, the hydrogels exhibit excellent hemostatic and adhesive properties, maintain sufficient wound moisture, and promote wound healing via their high antibacterial activity (against Staphylococcus Aureus , and Escherichia Coli ) and skin repair function. Overall, the resulting hydrogels have high potential as a novel smart and flexible wound dressing platform for theranostic skin regeneration.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v31.34
    DOI: 10.1002/adfm.202102599
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 6
    Online Resource
    Online Resource
    Gestational hyperglycemia and the risk of cardiovascular diseases among elderly Chinese women: Findings from the REACTION study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 12 ( 2021-12), p. 949-959
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 12 ( 2021-12), p. 949-959
    Abstract: 妊娠高血糖会增加以后患糖尿病的风险。然而，与妊娠高血糖相关的未来心血管疾病(Cardiovascular diseases, CVD)的风险仍然不确定。本研究旨在探讨妊娠高血糖对中国老年女性后续心血管疾病风险的影响及其可能的影响因素。 方法 我们在中国2型糖尿病患者恶性肿瘤发生风险的流行病学(REACTION)研究的老年妇女中开展了一项病例对照研究。研究纳入82名妊娠高血糖女性及410名按年龄和研究中心匹配的对照女性。心血管疾病信息(包括冠心病、中风和心肌梗死)通过调查员辅助的标准化问卷收集。 结果 有妊娠高血糖的女性更容易发生糖尿病 [比值比(Odd ratio, OR)，2.51； 95%可信区间(Confidence interval, CI)，1.50‐4.18] 和CVD(OR，1.98； 95%CI，1.05‐3.74)。即使没有进展为 2 型糖尿病，妊娠高血糖也与 CVD 风险增加相关(OR，2.88；95%CI，1.18‐7.00)。然而，亚组分析表明，与没有妊娠期高血糖或高血压的女性相比，同时有妊娠期高血糖和高血压的女性患心血管疾病的风险更高(OR，3.98；95%CI，1.65‐9.58)，而CVD风险在单纯有妊娠高血糖的女性中没有显著变化(OR，2.15；95%CI，0.71‐6.57)。分层分析表明，在超重/肥胖、缺乏体力活动或饮食不健康的人群中，妊娠高血糖会显著增加CVD风险。 结论 在中国老年女性中，妊娠期高血糖与晚年 CVD 风险增加有关。这种关联与是否发展为糖尿病无关，而可能会受到生活方式和高血压的影响。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.12
    DOI: 10.1111/1753-0407.13222
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2485432-3
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  • 7
    Online Resource
    Online Resource
    First‐Principles Study on Methane Adsorption Performance of Ti‐Modified Porous Graphene
    Wiley ; 2021
    In:  physica status solidi (b) Vol. 258, No. 11 ( 2021-11)
    Details
    In: physica status solidi (b), Wiley, Vol. 258, No. 11 ( 2021-11)
    Abstract: Porous graphene (PG) is an important candidate material for energy gas adsorption and storage due to its large specific surface area and low mass. Herein, based on first‐principles density functional theory, the adsorption performances of PG and titanium‐modified porous graphene (Ti‐PG) systems on methane (CH 4 ) molecules are investigated. It is discovered that the optimal adsorption position of a single CH 4 molecule on PG is the center C‐ring pore, and the adsorption energy is −0.228 eV. In the Ti‐PG system, the best position for Ti atom modification is the PG center pore, with a binding energy of −3.603 eV. When two Ti atoms modify the PG system, 24 CH 4 molecules can be adsorbed on both sides, the adsorption amount of CH 4 can reach 54.7 wt%, and the average adsorption energy is −0.207 eV. After the adsorption of CH 4 molecules, the electrostatic interaction between the overall electronegative CH 4 molecules and the electropositive Ti atom, the electrostatic interaction between the electropositive surface CH 4 molecules and the PG substrate, and the van der Waals force due to the polarity of CH 4 molecules create synergistic effects, which improve the CH 4 adsorption performance of the Ti‐PG system.
    Type of Medium: Online Resource
    ISSN: 0370-1972 , 1521-3951
    URL: Issue
    URL: Article
    DOI: 10.1002/pssb.v258.11
    DOI: 10.1002/pssb.202100168
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 208851-4
    detail.hit.zdb_id: 1481096-7
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  • 8
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    Online Resource
    First‐principles study on the methane adsorption properties by Ti‐modified graphyne
    Wiley ; 2021
    In:  International Journal of Quantum Chemistry Vol. 121, No. 24 ( 2021-12-15)
    Details
    In: International Journal of Quantum Chemistry, Wiley, Vol. 121, No. 24 ( 2021-12-15)
    Abstract: Graphyne (GY) is an allotrope composed of sp and sp 2 hybridized carbon atoms. In this paper, the adsorption performance of Ti‐modified GY (Ti‐GY) system on the adsorption of CH 4 molecules is studied based on first principles. The study found that the most stable adsorption site for Ti atoms is the six‐membered carbon ring pore site. There is a strong ionic interaction between the two, and the Ti‐GY system structure remains stable during the adsorption of CH 4 molecules. A single Ti‐modified GY can adsorb 7 CH 4 molecules on one side, and the adsorption structure is stratified, with average adsorption energy of −0.298 eV, and an adsorption capacity of 0.369 g g −1 ; two Ti‐modified GY adsorbs 14 CH 4 molecules on double‐sided, the average adsorption energy is about −0.300 eV, and the adsorption capacity reaches 0.484 g g −1 . The first layer of CH 4 molecules is adsorbed, which is mainly affected by the Ti atoms. There is a strong Coulomb interaction between it and Ti. With the increase of CH 4 molecules, the adsorption energy decreases; While the second layer of CH 4 molecules is due to the distance Ti atoms are far away, At this time, the interaction between the CH 4 molecules and the substrate is mainly the electrostatic interaction between the positively charged CH 4 molecules and the negatively charged GY and the van der Waals interaction between the CH 4 molecules. The adsorption performance of CH 4 molecules is closely related to the pore size of the two‐dimensional adsorbent. When the pore size is small, the interaction between molecules is enhanced and the average adsorption energy is larger. On the contrary, the larger the pore size, the higher the adsorption capacity.
    Type of Medium: Online Resource
    ISSN: 0020-7608 , 1097-461X
    URL: Issue
    URL: Article
    DOI: 10.1002/qua.v121.24
    DOI: 10.1002/qua.26811
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1475014-4
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  • 9
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    Online Resource
    The association between age at diagnosis of type 2 diabetes and albuminuria in Chinese adults: A nationwide population study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 12 ( 2021-12), p. 987-997
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 12 ( 2021-12), p. 987-997
    Abstract: 2型糖尿病的诊断年龄在全球及中国呈年轻化的趋势。目前较少研究糖尿病诊断年龄与白蛋白尿患病风险的相关性。本研究拟探讨糖尿病诊断年龄是否为白蛋白尿风险相关的独立危险因素。 方法 我们使用了来自中国大陆207961名研究对象的全国多中心研究数据。从年龄、性别和研究中心匹配的非糖尿病人群中随机选择正常对照, 另外对已诊断糖尿病患者的病程进行匹配, 最终共有31366 名新诊断2型糖尿病患者和 31366名正常对照, 及7490名已诊断2型糖尿病和7490名正常对照纳入分析。使用多元Logistic回归分析在不同糖尿病诊断年龄层中2型糖尿病患者与正常对照患白蛋白尿的风险。 结果 虽然年龄越大, 白蛋白尿患病风险越高, 但是2型糖尿病患者与正常对照组白蛋白尿的比值比随着诊断年龄的增加而降低。与正常对照组相比, 年龄 〈 50、50‐59、60‐69 或≥70 岁诊断为糖尿病的患者经过多变量校正后白蛋白尿风险仍然增加, 新诊断糖尿病分别增加了 81%、60%、45% 和 33%, 已诊断糖尿病分别增加了 135%、121%、90% 和 58%。 结论 在中国成人中, 2型糖尿病诊断年龄越低, 其白蛋白尿风险升高越明显。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.12
    DOI: 10.1111/1753-0407.13213
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2485432-3
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  • 10
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    Visit‑to‑visit blood pressure variability is associated with arterial stiffness in Chinese adults: A prospective analysis
    Wiley ; 2021
    In:  The Journal of Clinical Hypertension Vol. 23, No. 4 ( 2021-04), p. 802-812
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 23, No. 4 ( 2021-04), p. 802-812
    Abstract: Blood pressure (BP) variability may have its effect on the development of vascular disease. The authors aimed to examine the association between the visit‐to‐visit variability (VVV) of BP and arterial stiffness in Chinese adults. The authors included 1407 participants from a prospective cohort study of community residents who were ≥40 years, without a history of myocardial infarction or stroke, and with data at the baseline, the second and the third visits in 2008, 2009, and 2013. The VVV of BP was defined as the standard deviation (SD), the coefficient of variation (CV), the average successive variability (ASV), and the variability independent of the mean (VIM) in BP levels at the 3 visits. Arterial stiffness was measured by brachial‐ankle pulse wave velocity (ba‐PWV) at the 2nd and the 3rd visits. Levels of ba‐PWV change and the occurrence of an elevated ba‐PWV increased significantly in the highest tertile of VVV measures of systolic BP (SBP) and pulse pressure (PP) compared with the lowest tertile, respectively. The multivariable regression analysis revealed that VVV measures of SBP and PP were significantly associated with levels of ba‐PWV change and the risks of developing an elevated ba‐PWV. The odds ratios (ORs) and 95% confidence intervals (CIs) for the risk were 2.12 (1.57–3.12) and 1.92 (1.38–2.68) in participants with the highest versus the lowest tertile of SBP‐SD and PP‐SD, respectively. No significant association was found for diastolic BP variability measures. The increased long‐term variabilities of SBP and PP were associated with an increased risk of arterial stiffness.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.v23.4
    DOI: 10.1111/jch.14166
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2058690-5
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