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  • 1
    Online Resource
    Online Resource
    Research on Robust Design and Optimization of Embedded Network Electronic Information System
    IOP Publishing ; 2020
    In:  Journal of Physics: Conference Series Vol. 1550, No. 3 ( 2020-05-01), p. 032119-
    Details
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 1550, No. 3 ( 2020-05-01), p. 032119-
    Abstract: At present, in the process of designing and optimizing the robustness of embedded network electronic information systems, it is found that many factors in the system have some correlation with robustness, and there are individual differences in the factors affecting robustness, which also have different effects on robustness at the same time. The optimization design of the calculation method for the robustness of the embedded network electronic information system is organically combined with chaos and particle swarm optimization, through experiments and simulations, it proves that the optimized design has high accuracy.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    URL: Article
    DOI: 10.1088/1742-6596/1550/3/032119
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2166409-2
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  • 2
    Online Resource
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    In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19
    Elsevier BV ; 2020
    In:  Cell Metabolism Vol. 32, No. 2 ( 2020-08), p. 176-187.e4
    Details
    In: Cell Metabolism, Elsevier BV, Vol. 32, No. 2 ( 2020-08), p. 176-187.e4
    Type of Medium: Online Resource
    ISSN: 1550-4131
    URL: Article
    DOI: 10.1016/j.cmet.2020.06.015
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2174469-5
    SSG: 12
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  • 3
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    Determination of 10 Haloacetamides in drinking water by gas chromatography with automated solid phase extraction
    Elsevier BV ; 2020
    In:  Journal of Chromatography B Vol. 1150 ( 2020-08), p. 122191-
    Details
    In: Journal of Chromatography B, Elsevier BV, Vol. 1150 ( 2020-08), p. 122191-
    Type of Medium: Online Resource
    ISSN: 1570-0232
    URL: Article
    DOI: 10.1016/j.jchromb.2020.122191
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1491259-4
    SSG: 11
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  • 4
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    Tunable polarization beam splitter and broadband optical power sensor using hybrid microsphere resonators
    Optica Publishing Group ; 2020
    In:  Optics Express Vol. 28, No. 22 ( 2020-10-26), p. 32847-
    Details
    In: Optics Express, Optica Publishing Group, Vol. 28, No. 22 ( 2020-10-26), p. 32847-
    Abstract: Based on silica microsphere resonators embedded with iron oxide nanoparticles, we proposed and fabricated an all-optical and continuously tunable polarization beam splitter (PBS), and a broadband optical power sensor (OPS) with high sensitivity. The PBS is realized since the effective refractive indexes of the transverse-electric and transverse-magnetic polarization modes in the microsphere resonator are different. Due to the excellent photothermal effect of iron oxide nanoparticles, we realized the all-optical and continuously tunable PBS based on the hybrid microsphere resonator. A maximum polarization splitting ratio of 20 dB and a tuning range of 5 nm are achieved. Based on this mechanism, the hybrid microsphere resonator can also be used as a broadband OPS. The sensitivity of the OPS is 0.487 nm/mW, 0.477 nm/mW, and 0.398 nm/mW when the probe wavelength is 690 nm, 980 nm, and 1550 nm, respectively. With such good performances, the tunable PBS and the broadband OPS have great potential in applications such as optical routers, switches and filters.
    Type of Medium: Online Resource
    ISSN: 1094-4087
    URL: Article
    DOI: 10.1364/OE.406083
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2020
    detail.hit.zdb_id: 1491859-6
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  • 5
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    The Role of Oxymatrine in Amelioration of Acute Lung Injury Subjected to Myocardial I/R by Inhibiting Endoplasmic Reticulum Stress in Diabetic Rats
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-11-26), p. 1-13
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-11-26), p. 1-13
    Abstract: Background. Oxymatrine (OMT) is the primary pharmacological component of Sophora flavescens Aiton., which has been shown to possess potent antifibrotic, antioxidant, and anti-inflammatory activities. The aim of the present study was to clarify the protective mechanism of OMT on acute lung injury (ALI) subjected to myocardial ischemia/reperfusion (I/R). Methods. A myocardial I/R-induced ALI model was achieved in diabetic rats by occluding the left anterior descending coronary artery for 1 h, followed by reperfusion for 1 h. The levels of inflammatory factors (tumor necrosis factor-α, interleukin- (IL-) 6, and IL-17) in bronchoalveolar lavage fluid were assessed using commercially available kits. The index of myocardial injury, including the detection of cardiac troponin I (cTnI), cardiac troponin T (cTnT), lactate dehydrogenase (LDH), and creatine kinase-MB (CK-MB), was also determined using commercially available kits. Hematoxylin and eosin staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling were used to identify histological changes. The expression levels of endoplasmic reticulum chaperone BiP (GRP78), DNA damage-inducible transcript 3 protein (CHOP), eukaryotic translation initiation factor 2-alpha kinase 3 (PERK), inositol dependent enzyme 1α (IRE1α), ATF6, caspase-3, -9, and-12, Bcl-2, and Bax were determined by Western blotting. The mRNA expression levels of GRP78 and CHOP were detected by reverse transcription-quantitative PCR. Results. Myocardial I/R increased the levels of cTnI, cTnT, LDH, and CK-MB in diabetic rats. Damaged and irregularly arranged myocardial cells were also observed, as well as more serious ALI with higher lung injury scores and WET/DRY ratios and lower PaO2. Moreover, the expression of key proteins of endoplasmic reticulum stress (ERS) was increased by I/R injury, including phosphorylated- (p-) PERK, p-IRE1ɑ, and ATF6, as well as decreased levels of apoptosis. These effects were all significantly reversed by OMT treatment. Conclusions. OMT protects against ALI subjected to myocardial I/R by inhibiting ERS in diabetic rats.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2020/8836904
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 6
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    Phosphorus-containing silane modified steel slag waste to reduce fire hazards of rigid polyurethane foams
    Elsevier BV ; 2020
    In:  Advanced Powder Technology Vol. 31, No. 4 ( 2020-04), p. 1420-1430
    Details
    In: Advanced Powder Technology, Elsevier BV, Vol. 31, No. 4 ( 2020-04), p. 1420-1430
    Type of Medium: Online Resource
    ISSN: 0921-8831
    URL: Article
    DOI: 10.1016/j.apt.2020.01.019
    RVK:
    ZM 0001
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2032425-X
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  • 7
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    Correction: miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer
    Springer Science and Business Media LLC ; 2020
    In:  Cancer Gene Therapy Vol. 27, No. 12 ( 2020-12), p. 976-978
    Details
    In: Cancer Gene Therapy, Springer Science and Business Media LLC, Vol. 27, No. 12 ( 2020-12), p. 976-978
    Type of Medium: Online Resource
    ISSN: 0929-1903 , 1476-5500
    URL: Article
    DOI: 10.1038/s41417-020-00241-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1212513-1
    detail.hit.zdb_id: 2004200-0
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  • 8
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    Antibody Detection and Dynamic Characteristics in Patients With Coronavirus Disease 2019
    Oxford University Press (OUP) ; 2020
    In:  Clinical Infectious Diseases Vol. 71, No. 8 ( 2020-11-05), p. 1930-1934
    Details
    In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 71, No. 8 ( 2020-11-05), p. 1930-1934
    Abstract: The coronavirus disease 2019 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been rapidly spreading nationwide and abroad. A serologic test to identify antibody dynamics and response to SARS-CoV-2 was developed. Methods The antibodies against SARS-CoV-2 were detected by an enzyme-linked immunosorbent assay based on the recombinant nucleocapsid protein of SARS-CoV-2 in patients with confirmed or suspected COVID-19 at 3–40 days after symptom onset. The gold standard for COVID-19 diagnosis was nucleic acid testing for SARS-CoV-2 by real-time reverse-transcription polymerase chain reaction (rRT-PCR). The serodiagnostic power of the specific immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against SARS-CoV-2 was investigated in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and consistency rate. Results The seroconversion of specific IgM and IgG antibodies were observed as early as the fourth day after symptom onset. In the patients with confirmed COVID-19, sensitivity, specificity, PPV, NPV, and consistency rate of IgM were 77.3% (51/66), 100%, 100%, 80.0%, and 88.1%, respectively, and those of IgG were 83.3% (55/66), 95.0%, 94.8%, 83.8%, and 88.9%. In patients with suspected COVID-19, sensitivity, specificity, PPV, NPV, and consistency rate of IgM were 87.5% (21/24), 100%, 100%, 95.2%, and 96.4%, respectively, and those of IgG were 70.8% (17/24), 96.6%, 85.0%, 89.1%, and 88.1%. Both antibodies performed well in serodiagnosis for COVID-19 and rely on great specificity. Conclusions The antibodies against SARS-CoV-2 can be detected in the middle and later stages of the illness. Antibody detection may play an important role in the diagnosis of COVID-19 as a complementary approach to viral nucleic acid assays.
    Type of Medium: Online Resource
    ISSN: 1058-4838 , 1537-6591
    URL: Article
    DOI: 10.1093/cid/ciaa461
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2002229-3
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  • 9
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    The clinical significance of gabapentin in combination with opioids in controlling outbreak of pain in cancer patients.
    American Society of Clinical Oncology (ASCO) ; 2020
    In:  Journal of Clinical Oncology Vol. 38, No. 15_suppl ( 2020-05-20), p. e24142-e24142
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 38, No. 15_suppl ( 2020-05-20), p. e24142-e24142
    Abstract: e24142 Background: This study compared the pain relief effects of opioids combined with gabapentin and opioids alone after an outbreak of pain in patients with opioid-tolerant cancer pain to explore better cancer pain management. Methods: A total of 60 patients with moderate and severe cancer pain from September 2016 to April 2017 in the Department of Oncology of the Fourth Hospital of Hebei Medical University. They were randomly divided into two groups when they experienced an outbreak of pain, only oxycodone hydrochloride sustained-release tablets group (A group) 30 cases and gabapentin capsule combined with oxycodone hydrochloride sustained-release tablets group (B group) 30 cases, The degree of pain relief before and after treatment, the consumption of oxycodone hydrochloride sustained-release tablets, quality of life scores and adverse reactions, and nighttime sleep time were compared between the two groups. Results: 1. The NRS score in group B after treatment was significantly lower than that in group A after treatment (1.83±0.46 vs. 2.30±0.75). There was a statistically significant difference (P 〈 0.05). 2. The consumption of oxycodone hydrochloride sustained-release tablet in group B was lower than that in group A (19.000±6.074 vs. 25.667±10.063). There was statistical significance (P = 0.003). 3. The quality score was higher than before, and the quality of life score in group B was higher than that in group A (P 〈 0.05). 4. The main adverse reactions in both groups were constipation, nausea, vomiting and dizziness. The incidence was 86.67% vs. 50.00%、33.33% vs. 23.33%, 20.00% vs. 16.67%, respectively, there was no significant difference (P 〉 0.05). The nighttime sleep time of both groups was higher than that before treatment (6.017±0.636 vs. 5.167±0.735, 6.433±0.583 vs. 5.167±0.661). 5. The nighttime sleep time of Group B was longer than that of Group A after treatment (6.433±0.583 vs. 6.017±0.636). The difference was statistically significant (P 〈 0.05). Conclusions: Opioids combined with gabapentin are superior to opioids alone in the treatment of cancer pain with analgesic efficacy, improved quality of life, reduced opioid consumption, adverse drug reactions, and effective night time sleep.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2020.38.15_suppl.e24142
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2020
    detail.hit.zdb_id: 2005181-5
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  • 10
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    Studies on the efficacy of pyrotinib in the treatment of HER-2 positive advanced solid tumors.
    American Society of Clinical Oncology (ASCO) ; 2020
    In:  Journal of Clinical Oncology Vol. 38, No. 15_suppl ( 2020-05-20), p. e15639-e15639
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 38, No. 15_suppl ( 2020-05-20), p. e15639-e15639
    Abstract: e15639 Background: To explore the efficacy and safety of pyrotinib in the treatment of HER-2 positive advanced solid tumors patients. Methods: Patients with HER-2 positive advanced solid tumors in oncology department of our hospital from October 2018 to Janurary 2020 were collected. All the patients were given oral pyrotinib 400mg once a day in a 28-day cycle. The clinicopathological characteristics, treatment history, and curative effect were collected, and the adverse reactions related to the treatment were recorded. Results: 13 patients with HER-2 positive advanced solid tumors were enrolled, including 11 patients with metastatic breast cancer, 3 patients with metastatic colon cancer, 3 patients with gastric cancer. Among them, 10 patients were evaluated for efficacy and(or) side effect, of which 3 patients were excluded because they were not taken pyrotinib according to the medical order or they had no complete follow up data. The total mPFS was 5.63 months (95%CI: 2.533-5.467), partial remission (PR) were 3 cases(30%), stead diease(SD) were 6 cases(60%), progress diease was 1 case(10%). The overall response rate (ORR) and the disease control rate (DCR) were 23.1%, 69.2%, respectively. 2 patients received first-line treatment and 11 patients received second-or-further-line treatment. 11 cases of trastuzumab were changed to anti-HER-2 after treatment failure, of which 2 cases were treated with pirotinib after trastuzumab and lapatinib failed treatment. 12 cases with HER-2 overexpression and 1 case with HER-2 amplification. The incidence of pyrotinib side effects was 100%, which occurred in the first cycle of treatment and was common in grade 1 and 2. The common symptoms were diarrhea (100%), hand and foot skin reaction (38%), rash (8%), etc. Grade 3 to 4 adverse events occurred in 1 patient (8%) received pyrotinib plus capecitabine. 1 patient reduced pyrotinib dosage because of diarrhea. Nevertheless, diarrhea did not lead to discontinuation. Conclusions: The treatment of HER-2 positive advanced solid tumors with pyrotinib have good exact affect, and the toxicity could be controlled.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2020.38.15_suppl.e15639
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2020
    detail.hit.zdb_id: 2005181-5
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