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Marine Conservation Paleobiology (2018)

Tyler, Carrie L. ; Schneider, Chris L.

Cham : Springer International Publishing

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Keywords: Earth sciences ; Earth Sciences ; Paleontology ; Ecosystems ; Aquatic ecology ; Conservation biology ; Ecology ; Environmental management ; Marine sciences ; Freshwater ; Earth sciences ; Paleontology ; Ecosystems ; Aquatic ecology ; Conservation biology ; Ecology ; Environmental management ; Marine sciences ; Freshwater ; Fossil ; Geobiologie ; Paläobiologie ; Fossile Meerestiere ; Paläontologie ; Meeresökosystem ; Palökologie ; Meeresökosystem ; Fossil ; Geobiologie ; Paläobiologie ; Fossile Meerestiere ; Paläontologie ; Meeresökosystem ; Palökologie ; Meeresökosystem

Description / Table of Contents: An Overview of Conservation Paleobiology -- Should Conservation Paleobiologists Save the World on their Own Time? -- Conceptions of Long-Term Data among Marine Conservation Biologists and What Conservation Paleobiologists Need to Know -- Effectively Connecting Conservation Paleobiological Research to Environmental Management: Examples from Greater Everglades’ Restoration of Southwest Florida -- Using the Fossil Record to Establish a Baseline and Recommendations for Oyster Mitigation in the Mid-Atlantic U.S. -- Coral Reefs in Crisis: The Reliability of Deep-Time Food Web Reconstructions as Analogs for the Present -- Exploring the Species-Area Relationship within a Paleontological Context, and the Implications for Modern Conservation Biology -- Refugia Past, Present, and Future: Lessons from Ancient Geologic Crises for Modern Marine Ecosystem Conservation -- Training Tomorrow’s Conservation Paleobiologists -- A Conceptual Map of Conservation Paleobiology: Visualizing a Discipline.

Type of Medium: Online Resource

Pages: Online-Ressource (XII, 261 p. 55 illus., 28 illus. in color, online resource)

ISBN: 9783319737959

Series Statement: Topics in Geobiology 47

URL: https://doi.org/10.1007/978-3-319-73795-9

URL: http://dx.doi.org/10.1007/978-3-319-73795-9

DOI: 10.1007/978-3-319-73795-9

Language: English

Note: Includes bibliographical references and index

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GEOMAR CATALOGUE

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Bioökonomie International 2013: CamOil - Biotechnologische Verbesserung von Camelina sativa zur Erhöhung des Ölgehalts der Samen, Teilprojekt A : Veröffentlichung der Ergebnisse von Forschungsvorhaben im BMBF-Programm : Projektlaufzeit: 01.01.2015 bis 31.12.2017 (2018)

Feußner, Ivo [VerfasserIn] 1964-

Göttingen : Georg-August-Universität Göttingen

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Keywords: Forschungsbericht ; Öldotter ; Samenöl

Type of Medium: Online Resource

Pages: 1 Online-Ressource (33 Seiten, 1,31 MB) , Diagramme

URL: https://doi.org/10.2314/GBV:1047390795

DOI: 10.2314/GBV:1047390795

Language: German

Note: Förderkennzeichen BMBF 031A589A. - Verbund-Nummer 01151933 , weitere Autoren dem Berichtsblatt entnommen , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden

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Writing Successful Science Proposals : Third Edition. (2018)

Friedland, Andrew J.

New Haven :Yale University Press,

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Keywords: Proposal writing in research. ; Electronic books.

Description / Table of Contents: No detailed description available for "Writing Successful Science Proposals".

Type of Medium: Online Resource

Pages: 1 online resource (282 pages)

Edition: 3rd ed.

ISBN: 9780300241181

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5484514

DDC: 001.44

Language: English

Note: Cover -- Half Title -- Title -- Copyright -- Contents -- Preface -- Acknowledgments -- A Note to the Reader -- Chapter 1. Getting Started -- Chapter 2. Authorship from Start to Finish -- Chapter 3. Basic Organization and Effective Communication -- Chapter 4. Developing Your Conceptual Framework and Significance Section -- Chapter 5. A Title May Be More Important Than You Think -- Chapter 6. The Project Summary Guides the Reader -- Chapter 7. Objectives, Hypotheses, and Specific Aims: An Exhaustive List Is Exhausting -- Chapter 8. Lay the Foundation in the Introduction -- Chapter 9. Experimental Design and Methods: What Will You Actually Do? -- Chapter 10. Plan for Expected and Unexpected Results -- Chapter 11. A Reality Check with the Timeline and Project Management Plan -- Chapter 12. References in Detail: How Many and How Recent? -- Chapter 13. Preparing a Budget -- Chapter 14. Submitting and Tracking Your Proposal -- Chapter 15. The Three R's: Rethink, Revise, and Resubmit -- Chapter 16. Funding Innovative Research through Private Foundations -- Chapter 17. Team Science for Tackling Complex Problems -- Chapter 18. Ethics and Research -- References and Resources -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- W.

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Marine Conservation Paleobiology. (2018)

Tyler, Carrie L.

Cham :Springer International Publishing AG,

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Keywords: Conservation biology. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (268 pages)

Edition: 1st ed.

ISBN: 9783319737959

Series Statement: Topics in Geobiology Series ; v.47

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5372083

DDC: 560

Language: English

Note: Intro -- Preface -- Acknowledgements -- Contents -- Contributors -- An Overview of Conservation Paleobiology -- 1 Defining and Establishing Conservation Paleobiologyas a Discipline -- 2 Data in Conservation Paleobiology -- 3 Looking Forward -- References -- Should Conservation Paleobiologists Save the World on Their Own Time? -- 1 Always Academicize? -- 2 To Advocate, or Not to Advocate -- 3 Speaking Honestly to Power -- 4 From Pure Scientist to Honest Broker -- 5 Keeping It Real -- 6 Overcoming the Fear Factor -- 7 Later Is Too Late -- References -- Conceptions of Long-Term Data Among Marine Conservation Biologists and What Conservation Paleobiologists Need to Know -- 1 What is "Long Term"? -- 2 Survey Implementation -- 3 Survey Responses and What They Mean for Conservation Paleobiologists -- Conservation Goals -- Long-Term Data -- Environmental Stressors -- Baselines -- Challenges -- 4 Takeaways for Conservation Paleobiologists -- 5 Moving Forward -- Appendix 1: Survey Questions -- Appendix 2: Survey Population Selection -- Appendix 3: Categorization of Responses -- References -- Effectively Connecting Conservation Paleobiological Research to Environmental Management: Examples from Greater Everglades' Restoration of Southwest Florida -- 1 Introduction -- 2 Defining the Problem -- 3 Ensuring Success as a Conservation Paleobiologist -- Developing Partnerships and Collaborative Teams -- Becoming or Engaging a Liaison -- Participate in "Management Collaboratives" -- Compose Technical Reports in Addition to Peer-Reviewed Journal Articles -- Present Your Findings to Stake Holder Groups -- Attend and Present at Environmental Science and Restoration Conferences -- Train our Students -- Reward Faculty for Conducting Community-Engaged Scholarship -- Promote and Reward Community Service for Work with Environmental Agencies and NGOs. , 4 Case Studies from Greater Everglades' Restoration -- Case Study 1: Water Management of the Caloosahatchee River -- Case Study 2: Picayune Strand Restoration Project -- 5 Conclusions -- References -- Using the Fossil Record to Establish a Baseline and Recommendations for Oyster Mitigation in the Mid-Atlantic U.S. -- 1 Introduction -- 2 Methods -- Pleistocene Localities -- Field and Museum Sampling -- Oyster Size and Abundance Data -- Reconstructing Paleotemperature and Salinity -- Modern and Colonial Data -- 3 Results -- Paleoenvironmental Reconstruction of Holland Point -- Paleotemperature -- Paleosalinity -- Shell Height -- Growth Rate -- 4 Discussion -- Comparing Pleistocene to Modern Oysters -- Environmental Controls on Oyster Size -- Human Factors Influencing Oyster Size -- Implications for Restoration -- A Role for Conservation Paleobiology -- 5 Conclusion -- References -- Coral Reefs in Crisis: The Reliability of Deep-Time Food Web Reconstructions as Analogs for the Present -- 1 Introduction -- Preserving the Past -- Endangered Coral Reefs -- 2 Fossilizing a Coral Reef -- Dietary Breadth -- Trophic Chains and Levels -- Modularity -- 3 Guild Structure and Diversity -- Identifying Guilds in a Food Web -- 4 Reconstructing the Community -- Diversity and Evenness -- Simulated Food Webs -- 5 Summary -- Appendix 1 -- Hypergeometric Variance -- Appendix 2 -- References -- Exploring the Species -Area Relationship Within a Paleontological Context, and the Implications for Modern Conservation Biology -- 1 Introduction -- 2 Geological Setting -- 3 Methods -- 4 Results -- 5 Discussion -- 6 Conclusion -- References -- Marine Refugia Past, Present, and Future: Lessons from Ancient Geologic Crises for Modern Marine Ecosystem Conservation -- 1 Introduction -- 2 Defining Refugium. , A Species Must Have a Range Contraction, Range Shift, or Migration in Order to Escape the Onset of Global Environmental Degradation That Would Otherwise Cause Extinction of That Species -- Range Shifts -- Habitat Shifts -- Isolated Geographic Refugia -- Life History Refugia -- Cryptic Refugia -- Harvest Refugia -- The Environmental Conditions of a Refugium Are Sufficiently Habitable Such That the Species' Population Remains Viable During Its Time in the Refugium -- A Species' Population Is Smaller in the Refugium Than Its Pre-environmental Perturbation Size -- The Species Remains in the Refugium for Many Generations -- After the Environmental Crisis Ends, the Species Recovers by Inhabiting Newly Re-opened Habitats, Either Through Population Expansion or Through Adaptive Radiation -- Otherwise, the Refugium Became a Trap -- 3 Identifying Ancient Refugia -- Fossil Data -- Phylogeographic Studies -- Species Distribution Models -- 4 Lessons from the Past for Identifying Future Refugia -- As the Marine Environment Continues to Change, Refugia May Need to Shift -- Refugial Size and Connectivity Can Enhance Survivorship, But Can Also Have Evolutionary Consequences -- Conditions Inside Refugia May Not Necessarily Remain Pristine, But Will Need to Be of Sufficiently Lower Magnitude of Total Stress to Maintain Viable Populations -- Beware the Refugial Trap -- 5 Future Directions for Investigating Ancient Refugia -- 6 Conclusions -- Appendix -- References -- Training Tomorrow's Conservation Paleobiologists -- 1 Business As Usual Is Not Enough -- 2 A Call to Action -- 3 Bridging the Gap -- Recommendation 1 -- Recommendation 2 -- Recommendation 3 -- Recommendation 4 -- Recommendation 5 -- Recommendation 6 -- 4 Okay, But… -- 5 In the Meantime… -- 6 A Bright Future -- References -- A Conceptual Map of Conservation Paleobiology: Visualizinga Discipline. , 1 Determining the Current State and Structure of Conservation Paleobiology -- 2 Mapping a Discipline -- Bibliographic Co-Authorship Visualizations -- Text Co-Occurrence Visualizations -- Bibliographic Co-Citation Visualizations -- Bibliographic Coupling Visualizations -- 3 Bibliometric Networks -- Bibliographic Co-Authorship Networks -- Text Co-Occurrence Networks -- Bibliographic Co-Citation Networks -- Bibliometric Coupling Networks -- 4 The Intellectual Landscape -- 5 Emerging Frontiers -- 6 Conclusions -- References -- Index.

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Microfluidic Cell Culture Systems. (2018)

Borenstein, Jeffrey T.

San Diego :Elsevier,

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Keywords: Cell culture-Laboratory manuals. ; Electronic books.

Type of Medium: Online Resource

Pages: 1 online resource (398 pages)

Edition: 2nd ed.

ISBN: 9780128136720

Series Statement: Micro and Nano Technologies Series

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5507849

DDC: 660.6

Language: English

Note: Front Cover -- Microfluidic Cell Culture Systems -- Copyright -- Contents -- Contributors -- Chapter 1: Design principles for dynamic microphysiological systems -- 1. Introduction -- 1.1. What Are Microfluidic Multiorgan Cell Culture Systems? -- 1.2. General Principles for Multiorgan System Development -- 1.3. Value of Microfluidic Multiorgan Systems -- 1.3.1. Improvements in effectiveness and expense of drug development process -- 1.3.2. PK/PD modeling and understanding basic human biology -- 1.3.3. Personalized medicine and clinical diagnostics -- 2. Principles of Multiorgan System Development -- 2.1. Reconfigurability for Diverse, Dynamic Model Integration -- 2.1.1. Physical reconfigurability -- 2.1.2. On-the-fly reprogrammable organ configuration -- 2.2. Platform Scalability to Accommodate Organ System Complexity -- 2.3. Physiologic Tissue Perfusion -- 2.4. Physiologic Scaling of Tissues and Media -- 2.4.1. Appropriate scaling to maintain physiologic relevance -- Allometric scaling -- Physiologic scaling -- 2.5. Common Media -- 2.6. Facile, In-Line, Noninvasive Tissue Monitoring -- 2.7. Materials and Methods of Construction -- 3. Multiorgan Systems -- 3.1. Electromagnetic Multiorgan Platform Technology -- 3.2. Demonstration of Platform Fidelity -- Liver-Airway Multiorgan System [15] -- 3.3. EVATAR -- Multiorgan System Recapitulation of the Female Reproductive Tract -- 4. Limitations of Microfluidic Multiorgan Systems -- 4.1. Engineering and Technological Limitations -- 4.2. Biological Limitations -- 4.2.1. Cell source -- 4.2.2. User handling of complex systems -- 4.2.3. Experimental consistency through automation -- 5. Future of Microfluidic Multiorgan Systems -- References -- Chapter 2: Microfluidic systems for controlling stem cell microenvironments*** -- 1. Introduction -- 2. Microfluidic Elements for Cell Culture. , 2.1. Cell Sorting and Filtering -- 2.2. Cell Isolation and Storage -- 2.3. Cell Lysis -- 2.4. Surface Patterning -- 2.5. Microfluidic Mixing, Concentration Gradients and Combinatorial Solutions -- 2.6. On-Chip Cell Culture -- 2.7. Cell Analysis On-Chip -- 3. Controlling Cellular Microenvironments -- 3.1. Soluble Factors and Chemical Stimuli -- 3.2. Mechanical Stimuli -- 3.2.1. Substrate properties -- 3.2.2. Shear stress and other mechanical effects -- 3.3. Electrical Stimuli -- 3.4. Cell-Cell Contact and Co-Culture -- 3.5. Development and Mimicking of Extracellular Matrices -- 4. Challenges and Outlook -- Acknowledgments -- References -- Chapter 3: Microfluidic platforms with nanoscale features -- 1. Introduction -- 2. Engineering of Nanoscale Features -- 2.1. Fabrication of Irregular Nanoscale Features -- 2.2. Fabrication of Regular Nanoscale Features -- 2.2.1. Focused particle beam lithography -- 2.2.2. Replication techniques -- 2.2.3. Stitching technique -- 3. Assembly of PDMS-Based Microfluidic Platforms -- 3.1. Reversible Assembly -- 3.2. Irreversible Bonding -- 3.3. Microtransfer Assembly -- 4. Microfluidic Platforms With Embedded Nanoscale Features for Cell Studies -- 4.1. Tumor Cell Isolation -- 4.2. Stem Cell Regulation -- 5. Summary -- Acknowledgment -- References -- Chapter 4: Microfabricated kidney tissue models -- 1. Introduction -- 2. Significance of Microfabricated Kidney Tissue Models -- 3. Kidney Structure and Function Relationship -- 4. Traditional Kidney Tissue Models -- 5. Crucial Signaling Elements for Kidney Tissue Models -- 5.1. Signaling Elements Delivered via Cell Substrate -- 5.1.1. Surface chemistry -- 5.1.2. Substrate stiffness -- 5.1.3. Substrate topography -- 5.2. Signaling Elements Delivered via Fluid Flow -- 5.2.1. Chemical -- 5.2.2. Flow-induced shear stress (FSS). , 6. Review of Current Microfabricated Kidney Tissue Models -- 6.1. Microfabricated Kidney Models With Controlled Flow-Induced Shear Stress -- 6.2. Microfabricated Kidney Models With Porous Membranes and Scaffolds -- 6.3. Microfabricated Kidney Models With User-Defined Substrate Topography -- 6.4. Microfabricated Kidney Models With Physiological Function -- 7. Summary and Future Direction -- References -- Chapter 5: Application of complex in vitro models (CIVMs) in drug discovery for safety testing and disease modeling -- 1. Introduction: General Concept (Overarching Theme) of Complex in vitro Models (CIVMs) -- 1.1. The CIVM Dawn in the Pharmaceutical Landscape -- 1.2. Expected Role of Complex in vitro Models in R& -- D -- 1.3. The Global Market of Complex in vitro Methods -- 1.4. Getting Closer to Human Patient Modeling: Current Gaps and Future Challenges -- 1.5. Qualification of CIVM -- 2. Complex in vitro Liver Models -- 2.1. Backgrounds -- 2.2. Liver Models -- 2.2.1. Sandwich cultures -- 2.2.2. 3D hepatocyte spheroids & -- multicellular spheroids -- 2.2.3. Hollow fiber bioreactor and organ(s)-on-a-chip -- 2.2.4. 3D bioprinted liver -- 2.3. Remaining Challenges and Limitations of Liver in vitro Models and Future Perspectives -- 3. Complex in vitro Skin Models -- 4. Complex in vitro Oncology Models -- 4.1. Background on Tissue Microenvironment (TME) for Solid Tumors -- 4.2. Tumor Models -- 4.2.1. Cells -- 4.2.2. Microscale tumor models -- 4.2.3. Ex vivo -- 4.2.4. Tumor spheroids -- 4.2.5. Avascular matrix/scaffold -- 4.2.6. Microvascular model -- 4.3. Challenges and Limitations -- 5. Multi Organ on a Chip Models -- 5.1. Description of the Types of Multi Organ on a Chip -- 5.2. Examples of MOOCs Linked to Drug Discovery -- 5.2.1. Safety and toxicity -- 5.2.2. PK-PD and efficacy -- 6. Conclusion -- References. , Chapter 6: Hepatic microphysiological systems: Current and future applications in drug discovery and development -- 1. Introduction -- 2. Current Emerging Technologies -- 2.1. Overview -- 2.2. Complex Two-Dimensional (2D) Plated Coculture Systems -- 2.3. Three-Dimensional (3D) Static Hepatic Cultures -- 2.4. Flow Based 3D Mono or Coculture Systems -- 3. Current Applications and Scope -- 3.1. Overview -- 3.2. Using Microphysiological Systems for Drug-Disposition Studies -- 3.3. Drug Toxicity Testing With Hepatic Microphysiological Systems -- 3.4. Modeling Liver Disease in Microphysiological Systems -- 3.4.1. Metabolic liver diseases -- 3.4.2. Infectious/parasitic diseases -- 3.4.3. Metastatic liver disease -- 3.4.4. Genetic diseases of the liver -- 4. Considering Qualification and Contexts of Use for Liver MPS -- 5. Conclusion and Future Directions -- References -- Chapter 7: Microphysiological models of human organs: A case study on microengineered lung-on-a-chip systems -- 1. Introduction -- 2. Design Principle 1: Mimicking Structural and Multicellular Complexity -- 3. Design Principle 2: Recapitulating Mechanical and Biochemical Microenvironment -- 4. Case Study: lung-on-a-chip Technology -- 4.1. Early Demonstrations of Human Lung-on-a-Chip -- 4.2. Recent Advances in Lung-on-a-Chip Technology -- 4.2.1. Small airway-on-a-chip -- 4.2.2. Organotypic lung-on-a-chip model for the study of host-pathogen interactions -- 4.2.3. Alveolus-on-a-chip model of intravascular thrombosis -- 4.2.4. Lung tumor-on-a-chip -- 5. Future Prospects and Important Challenges -- References -- Chapter 8: Cardiac tissue models -- 1. Introduction -- 2. Myocardial Tissue: The Minimal Functional Unit of the Human Heart -- 2.1. Cells in the Myocardium -- 2.2. Extracellular Matrix in the Myocardium -- 2.3. Physiology of the Myocardium -- 3. Sources of Cardiac Myocytes. , 3.1. Primary Cardiac Myocytes -- 3.2. Human Stem Cell-Derived Cardiac Myocytes -- 3.2.1. Human embryonic stem cells (hESCs) -- 3.2.2. Human induced pluripotent stem cells (hiPSCs) -- 4. Engineering and Interrogating two-dimensional Cardiac Tissues -- 4.1. Fabrication Technologies for Two-Dimensional Cardiac Tissues -- 4.1.1. Microcontact printing -- 4.1.2. Surface molding -- 4.2. Sensing Technologies for Two-Dimensional Cardiac Tissues -- 4.2.1. Traction force microscopy -- 4.2.2. Muscular thin films (MTFs) -- 4.2.3. Microelectrode arrays (MEAs) -- 5. Engineering and Interrogating three-dimensional Cardiac Tissues -- 5.1. Fabrication Technologies for Three-Dimensional Cardiac Tissues -- 5.1.1. Molding cell-matrix solutions -- 5.1.2. Bioprinting -- 5.2. Sensing Technologies for Three-Dimensional Cardiac Tissues -- 5.2.1. Optical mapping -- 5.2.2. Micropost arrays -- 6. Screening Drug Safety and Efficacy in Cardiac Microphysiological Systems -- 6.1. Screening Cardiotoxicity -- 6.2. Modeling Acquired Cardiac Diseases -- 6.2.1. Myocardial ischemia -- 6.2.2. Pathological hypertrophy -- 6.3. Modeling Inherited Cardiac Diseases -- 6.3.1. Barth syndrome -- 6.3.2. Titinopathies -- 7. Outlook -- 7.1. Maturation of hiPSC-Derived Cardiac Myocytes -- 7.2. Integration of Non-Myocyte Cell Populations -- 7.3. Coupling With Other Organs -- 8. Conclusion -- References -- Chapter 9: Neural tissue micro-physiological systems in the era of patient-derived pluripotent stem cells -- 1. Introduction -- 2. Components of in vitro Neural Tissue Models -- 2.1. Cellular Components -- 2.1.1. Neural cell types differentiated from human iPSC -- 2.2. Materials and Format of Cell Culture -- 2.3. Blood Brain Barrier/Neurovascular Unit -- 3. Neurodegenerative Disease Models -- 3.1. Alzheimer's Disease -- 3.2. Parkinson's Disease -- 3.3. Huntington's Disease. , 3.4. Amyotrophic Lateral Sclerosis.

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Partial Differential Equations in Fluid Mechanics. (2018)

Fefferman, Charles L.

Cambridge :Cambridge University Press,

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Keywords: Differential equations, Partial. ; Electronic books.

Description / Table of Contents: This volume, derived from the 'PDEs in Fluid Mechanics' workshop held at the University of Warwick in 2016, serves to consolidate and advance work in mathematical fluid dynamics. Consisting of surveys and original research, it will be a valuable resource for both established researchers and graduate students seeking an overview of current developments.

Type of Medium: Online Resource

Pages: 1 online resource (340 pages)

Edition: 1st ed.

ISBN: 9781316997031

Series Statement: London Mathematical Society Lecture Note Series ; v.Series Number 452

URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5500403

DDC: 532

Language: English

Note: Cover -- Series information -- Title page -- Copyright information -- Table of contents -- List of contributors -- Preface -- 1 Remarks on recent advances concerning boundary effects and the vanishing viscosity limit of the Navier-Stokes equations -- Abstract -- 1.1 Introduction and uniform estimates -- 1.2 Kato criterion for convergence to the regular solution -- 1.3 Mathematical and physical interpretation of Theorem 1.3 -- 1.3.1 Recirculation -- 1.3.2 The Prandtl equations and the Stewartson triple-deck ansatz -- 1.3.3 Von Karman turbulent Layer -- 1.3.4 Energy limit and d'Alembert paradox -- 1.4 Kato's criterion, anomalous energy dissipation, and turbulence -- References -- 2 Time-periodic flow of a viscous liquid past a body -- Abstract -- 2.1 Introduction -- 2.2 Notation -- 2.3 Preliminaries -- 2.4 An Embedding Theorem -- 2.5 Linearized Problem -- 2.6 Fully Nonlinear Problem -- Acknowledgements -- References -- 3 The Rayleigh-Taylor instability in buoyancy-driven variable density turbulence -- Abstract -- 3.1 Background to the Rayleigh-Taylor instability -- 3.2 The 3D Cahn-Hilliard-Navier-Stokes equations -- 3.3 The variable density model for two incompressible miscible fluids -- 3.3.1 The mathematical model -- 3.3.2 The roles played by θ = ln ρ and ∇θ -- 3.3.3 Summary of the D[sub(m)]-method used for the Navier-Stokes equations -- 3.4 Some L[sup(2m)]-estimates on ∇θ and ω -- 3.4.1 Definitions -- 3.4.2 The evolution of D[sub(1,θ)] -- References -- 4 On localization and quantitative uniqueness for elliptic partial differential equations -- Abstract -- 4.1 Introduction -- 4.2 A lower bound for the decay of Δu = W∇u + V u -- 4.3 A construction of a localized solution -- 4.4 A construction of a solution vanishing of high order -- 4.5 The equation Δu = Vu -- Acknowledgments -- References -- 5 Quasi-invariance for the Navier-Stokes equations. , 5.1 Introduction -- 5.2 Navier-Stokes equations -- 5.3 Burgers equation -- 5.4 Use of critical dependent variables -- 5.5 Cole-Hopf transform and Feynman-Kac formula -- 5.6 Dynamic scaling transform -- 5.6.1 Change of probability measures -- 5.6.2 Leray equations -- 5.6.3 Navier-Stokes equations -- 5.7 Summary -- Appendix A Wiener process -- References -- 6 Leray's fundamental work on the Navier-Stokes equations: a modern review of "Sur le mouvement d'un liquide visqueux emplissant l'espace" -- Abstract -- 6.1 Introduction -- 6.1.1 Preliminaries -- 6.1.2 The Oseen kernel T -- 6.2 The Stokes equations -- 6.2.1 A general forcing F -- 6.2.2 A forcing of the form F = −(Y · ∇)Y -- Notes -- 6.3 Strong solutions of the Navier-Stokes equations -- 6.3.1 Properties of strong solutions -- 6.3.2 Local existence and uniqueness of strong solutions -- 6.3.3 Characterisation of singularities -- 6.3.4 Semi-strong solutions -- Notes -- 6.4 Weak solutions of the Navier-Stokes equations -- 6.4.1 Well-posedness for the regularised equations -- 6.4.2 Global existence of a weak solution -- 6.4.3 Structure of the weak solution -- Notes -- Acknowledgements -- 6.5 Appendix -- 6.5.1 The heat equation and the heat kernel -- 6.5.2 The extension of Young's inequality for convolutions -- 6.5.3 Decay estimates of P(x, t) -- 6.5.4 Properties of the Stokes equations -- 6.5.5 Integral inequalities -- 6.5.6 The Volterra equation -- 6.5.7 A proof of (6.85) without the use of the Lemma 6.4 -- 6.5.8 Smooth approximation of the forcing -- References -- 7 Stable mild Navier-Stokes solutions by iteration of linear singular Volterra integral equations -- Abstract -- 7.1 The initial-boundary value problem of the Navier-Stokes equations -- 7.2 Results on stability of Navier-Stokes solutions -- 7.3 Bounds on P(u · ∇v) and on e[sup(−tA)]. , 7.4 The approximation schemes of Fujita-Kato and Giga-Miyakawa: sketch of the proof in Fujita & -- Kato (1964) for the uniform bound of the approximations -- 7.5 Stable mild Navier-Stokes solutions Theorems 7.4-7.6 -- 7.6 Basic results on linear singular Volterra integral equations -- 7.7 Proof of the theorems -- References -- 8 Energy conservation in the 3D Eulerequations on T[sup(2)] × R[sub(+)] -- Abstract -- 8.1 Introduction -- 8.2 Energy conservation without boundaries -- 8.2.1 Weak solutions of the Euler equations -- 8.2.2 Using u[sub(ε)] as a test function -- 8.2.3 'Mollifying the equation' -- 8.2.4 Energy Conservation -- 8.3 Two spatial conditions for energy conservation in the absence of boundaries -- 8.4 Energy Balance on T[sup(2)] × R[sub(+)] -- 8.4.1 Weak solutions of the Euler equations on D[sub(+)] := T[sup(2)] × R[sub(+)] -- 8.4.2 Half-plane reflection map -- 8.5 Energy Conservation on D[sub(+)] -- 8.6 Conclusion -- 8.7 Afterward: the result of Bardos & -- Titi on a general bounded domain -- Acknowledgements -- References -- 9 Regularity of Navier-Stokes flows with bounds for the velocity gradient along streamlines and an effective pressure -- Abstract -- 9.1 Introduction -- 9.2 Preliminaries -- 9.3 Results -- 9.4 Conclusion -- References -- 10 A direct approach to Gevrey regularity on the half-space -- Abstract -- 10.1 Introduction -- 10.2 Preliminaries -- 10.3 Derivative reduction -- 10.3.1 Normal derivative reduction -- 10.3.2 Tangential derivative reduction -- 10.3.3 The time-derivative reduction -- 10.4 Proof of Theorem 10.1 -- 10.4.1 The S[sub(1)] term -- 10.4.2 The S[sub(2)] term -- 10.4.3 The S[sub(3)] term -- 10.4.4 The S[sub(4)] term -- 10.4.5 The S[sub(5)] term -- 10.4.6 The S[sub(6)] term -- 10.4.7 Conclusion of the proof -- 10.5 Derivative reduction for the Stokes problem and the proof of Theorem 10.2. , 10.5.1 Normal derivative reduction for the Stokes operator -- 10.5.2 Tangential derivative reduction for the Stokes operator -- 10.5.3 Time derivative reduction for the Stokes operator -- Acknowledgments -- References -- 11 Weak-Strong Uniqueness in Fluid Dynamics -- Abstract -- 11.1 Introduction -- 11.2 The Relative Energy Method -- 11.3 Dissipative Measure-Valued Solutions -- 11.4 Dealing with Viscosity -- 11.4.1 Incompressible Navier-Stokes Equations -- 11.4.2 Compressible Navier-Stokes Equations -- 11.5 Physical Boundaries in the Inviscid Situation -- 11.6 An Alternative Approach -- References.

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Pancreatic cancer (2018)

Neoptolemos, John P. ; Urrutia, Raul ; Abbruzzese, James L. ; [et al.]

New York, NY : Springer

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Keywords: Medicine ; Cancer research ; Biomedicine ; Oncology ; Oncology ; Endocrinology ; Cancer. ; Pancreatic Neoplasms ; Bauchspeicheldrüsenkrebs

Description / Table of Contents: In organizing the second edition of this renowned Handbook, Dr. Neoptolemos and his co-editors have produced and updated a revised edition to the distinguished Major Reference Work devoted to pancreatic cancer. Like its preceding edition, the second edition continues to have a widespread appeal among clinicians, pathologists and basic scientists, who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer, (there is currently an unprecedented investment by academia and industry in this field), each research’s knowledge of other specialty areas outside his or her own is often quite limited. The aim of the new edition is to place the tangible advances, including new developments in surgical approaches with regards to resection techniques, the state of laparoscopic approaches, the growing impact of surgical approaches in the management of recurrent pancreatic cancer, controversies in the management of IMPN as the precursor lesion for PDAC and others - readily at hand. The second edition focuses on advances that will not become dated, and the editors have chosen authors, who are the very best in each area

Type of Medium: Online Resource

Pages: Online-Ressource (244 illus., 177 illus. in color. eReference, online resource)

Edition: 2nd ed. 2018

ISBN: 9781493971930

Series Statement: SpringerLink

URL: https://doi.org/10.1007/978-1-4939-7193-0

DOI: 10.1007/978-1-4939-7193-0

Language: English

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Behavioral neurobiology of psychedelic drugs (2018)

Halberstadt, Adam L. ; Vollenweider, Franz Xaver ; Nichols, David E. 1944-

Berlin, Germany : Springer

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Keywords: Medicine ; Biomedicine ; Neurosciences ; Medicinal chemistry ; Psychopharmacology ; Hallucinogens ; Brain drug effects ; Delusions chemically induced ; Neurobehavioral Manifestations drug effects ; Halluzinogen ; Pharmazeutische Chemie ; Neurobiologie

Description / Table of Contents: This volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action. Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds

Type of Medium: Online Resource

Pages: 1 Online-Ressource

ISBN: 9783662558805

Series Statement: Current topics in behavioral neurosciences volume 36

URL: https://doi.org/10.1007/978-3-662-55880-5

DOI: 10.1007/978-3-662-55880-5

Language: English

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Integrative Structural Biology with Hybrid Methods (2018)

Nakamura, Haruki ; Kleywegt, Gerard ; Burley, Stephen K. ; [et al.]

Singapore : Springer Singapore

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Keywords: Biochemistry ; Cytology ; Protein Structure ; Biochemistry ; Cytology ; Proteins . ; Cell biology. ; Molecular Structure ; Chemistry Techniques, Analytical ; Models, Molecular ; Molecular Biology methods

Description / Table of Contents: This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested in this book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics

Type of Medium: Online Resource

Pages: Online-Ressource (VI, 272 p. 61 illus., 44 illus. in color, online resource)

Edition: Springer eBook Collection. Biomedical and Life Sciences

ISBN: 9789811322006

Series Statement: Advances in Experimental Medicine and Biology 1105

URL: https://doi.org/10.1007/978-981-13-2200-6

URL: http://dx.doi.org/10.1007/978-981-13-2200-6

DOI: 10.1007/978-981-13-2200-6

Language: English

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The Mammalian Auditory Pathways : Synaptic Organization and Microcircuits (2018)

Oliver, Douglas L. 1913- ; Cant, Nell B. ; Fay, Richard R. ; [et al.]

Cham : ASA Press, Springer

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Keywords: Medicine ; Biomedicine ; Neurosciences ; Otorhinolaryngology ; Neurobiology ; Medicine ; Neurosciences ; Otorhinolaryngology ; Neurobiology ; Auditory Pathways physiology ; Synaptic Transmission physiology ; Auditorisches System ; Säugetiere

Description / Table of Contents: Preface -- Introduction to Mammalian Auditory Pathways -- Overview of Auditory Projection Pathways and Intrinsic Microcircuits -- Microcircuits of the Ventral Cochlear Nucleus -- Microcircuits of the Dorsal Cochlear Nucleus -- Integration of Synaptic and Intrinsic Conductances Shapes Microcircuits in the Superior Olivary Complex -- Neurons, Connections, and Microcircuits of the Inferior Colliculus -- Sensing Sound Through Thalamocortical Afferent Architecture and Cortical Microcircuits -- Auditory Cortex Circuits -- Circuits for Modulation of Auditory Function -- Index.

Type of Medium: Online Resource

Pages: Online-Ressource (XVIII, 267 p, online resource)

ISBN: 9783319717982

Series Statement: Springer Handbook of Auditory Research 65

URL: https://doi.org/10.1007/978-3-319-71798-2

URL: http://dx.doi.org/10.1007/978-3-319-71798-2

DOI: 10.1007/978-3-319-71798-2

RVK:

WW 1691

Language: English

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