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  • Wiley  (57)
  • 2015-2019  (57)
  • 2018  (57)
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  • 2015-2019  (57)
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  • 2018  (57)
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  • 1
    Online Resource
    Online Resource
    Integrative functional genomics identifies regulatory genetic variant modulating RAB31 expression and altering susceptibility to breast cancer
    Wiley ; 2018
    In:  Molecular Carcinogenesis Vol. 57, No. 12 ( 2018-12), p. 1845-1854
    Details
    In: Molecular Carcinogenesis, Wiley, Vol. 57, No. 12 ( 2018-12), p. 1845-1854
    Abstract: Despite the successes of genome‐wide association study (GWAS) in identifying breast cancer (BC) risk‐associated variants, only a small fraction of the heritability can be explained. The greatest challenge in the post‐GWAS is to identify causal variants and underlying mechanisms responsible for BC susceptibility. In this study, we integrated functional genomic data from ENCODE ChIP‐seq, ANNOVAR, and the TRANSFAC matrix to identify potentially regulatory variants with modulating FOXA1‐binding affinity across the whole genome, and then conducted a two‐stage case‐control study including 2164 cases and 2382 controls to investigate the associations between candidate SNPs and BC susceptibility. We identified a BC susceptibility SNP, rs6506689 G 〉 T, with an odds ratio (OR) of 1.23 (95% confidence interval = 1.07‐1.40, P  = 0.003) under a dominant model in the combined study. Biological assays indicated that the germline G 〉 T variation at rs6506689 creates a FOXA1‐binding site and up‐regulates the expression of RAB31, thus playing an important role in the development of BC. Our results highlight the importance of regulatory genetic variants in the development of BC by influencing TF‐DNA interaction and provide critical insights to pinpoint causal genetic variants.
    Type of Medium: Online Resource
    ISSN: 0899-1987 , 1098-2744
    URL: Issue
    URL: Article
    DOI: 10.1002/mc.v57.12
    DOI: 10.1002/mc.22902
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2001984-1
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  • 2
    Online Resource
    Online Resource
    Genome editing in Streptococcus mutans through self‐targeting CRISPR arrays
    Wiley ; 2018
    In:  Molecular Oral Microbiology Vol. 33, No. 6 ( 2018-12), p. 440-449
    Details
    In: Molecular Oral Microbiology, Wiley, Vol. 33, No. 6 ( 2018-12), p. 440-449
    Abstract: Streptococcus mutans is the primary etiological agent of human dental caries. Its major virulence factors, glucosyltransferases (Gtfs), utilize sucrose to synthesize extracellular polysaccharides (EPS), leading to the formation of dental plaque biofilm. The current study was designed to develop a novel self‐targeting gene editing technology that targeted gtfs to inhibit biofilms formation. The CRISPR‐Cas system (ie, clustered regularly interspaced short palindromic repeat, with CRISPR‐associated proteins) provides sequence‐specific protection against foreign genetic materials in archaea and bacteria, and has been widely developed for genomic engineering. The first aim of this study was to test whether components of the CRISPR‐Cas9 system from S mutans UA159 is necessary to defend against foreign DNA. The data showed that a suitable PAM site, tracrRNA, Cas9, and RNase III are indispensable elements to perform normal function of S mutans CRISPR‐Cas9 system. Based on these results, we designed self‐targeting CRISPR arrays (containing spacer sequences identifying with gtfB ) and cloned them onto plasmids. Afterward, we transformed the plasmids and editing templates into UA159 (self‐targeting) to acquire desired mutants. Our data showed that this technology performed well and was able to successfully edit gtfB or gtfBgtfC genes. This resulted in high reduction in EPS synthesis and was able to breakdown biofilm formation, which is also a promising tool for dental clinics in order to prevent the formation of S mutans biofilms in the future.
    Type of Medium: Online Resource
    ISSN: 2041-1006 , 2041-1014
    URL: Issue
    URL: Article
    DOI: 10.1111/omi.2018.33.issue-6
    DOI: 10.1111/omi.12247
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2532744-6
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  • 3
    Online Resource
    Online Resource
    Validity of web‐based self‐assessment of pubertal development against pediatrician assessments
    Wiley ; 2018
    In:  Pediatric Investigation Vol. 2, No. 3 ( 2018-09), p. 141-148
    Details
    In: Pediatric Investigation, Wiley, Vol. 2, No. 3 ( 2018-09), p. 141-148
    Abstract: A web‐based instrument for self‐assessment of puberty could be convenient and feasible for large‐scale multicenter population‐based epidemiological studies for Tanner stages evaluation. Objective To validate web‐based self‐assessment of pubertal development against assessment by a pediatrician. Methods Outpatients aged 8–18 years were consecutively recruited in the endocrinology department of Beijing Children's Hospital from October 2016 to August 2017. A web‐based self‐assessment instrument for pubertal development was introduced to participants by an appointed pediatrician. Tanner stage of puberty was self‐assessed by participants in a private environment. Participants were then examined by a senior pediatrician underwent blinded assessment. Weighted kappa and Spearman correlation analyses were conducted to evaluate agreement. The accuracy of the web‐based instrument for self‐assessment of pubertal onset was evaluated according to sensitivity, specificity, positive predictive value and negative predictive value Results A total of 174 participants (including 82 girls and 92 boys) were assessed consecutively. Correlation coefficients were 0.872 for pubic hair and 0.933 for testicular volume ( P 〈 0.001) among boys; a similar result was obtained for the weighted kappa value (0.825). For girls, the correlation coefficient and weighted kappa for pubic hair was 0.785 and 0.878, respectively. However, breast self‐assessment had a medium level of agreement with pediatrician assessment (weighted kappa , 0.495; correlation coefficient, 0.643). Moreover, the accuracy of self‐assessment in children aged 10 years or above was better than that in children aged less than 10 years. Interpretation Assessment of pubertal development using a web‐based self‐assessment instrument could be less accurate among children aged less than 10 years, especially for girls’ breast assessment. Therefore, self‐assessment of pubertal development, especially for breast development, should be interpreted cautiously.
    Type of Medium: Online Resource
    ISSN: 2574-2272 , 2574-2272
    URL: Issue
    URL: Article
    DOI: 10.1002/ped4.2018.2.issue-3
    DOI: 10.1002/ped4.12050
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2934365-3
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  • 4
    Online Resource
    Online Resource
    Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1‐mediated deacetylation of FXR and PGC‐1α
    Wiley ; 2018
    In:  Journal of Hepato-Biliary-Pancreatic Sciences Vol. 25, No. 3 ( 2018-03), p. 195-205
    Details
    In: Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 25, No. 3 ( 2018-03), p. 195-205
    Abstract: The purpose of the present study was to investigate the effect and potential mechanism of chlorogenic acid (CA) on liver injury induced by cholestasis in a rat model of bile duct ligation (BDL). Methods Rats received vehicle or CA (20, 50, or 100 mg/kg per day) orally for 3 days. On the 4th day, the rats underwent sham or BDL surgery, and were orally administrated vehicle or CA for 3 or 7 days. mRNA and protein expression levels were evaluated by qRT‐PCR and western blot. Results After BDL, plasma levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), and total bile acids (TBA) were increased and typical pathological changes were observed in liver morphology. Hepatic uptake transporters (Ntcp, Oatp 1a4, and Oatp 1b2) were downregulated, while efflux transporters (Bsep and Mrp 2/3/4) were upregulated. BDL inhibited the expressions of Cyp7a1, Cyp8b1, and Cyp27a1 and induced Ugt1a1. CA treatment decreased ALT, AST, TBIL, and TBA ( P  〈   0.05) and alleviated the liver pathological changes. The degree of expression changes in the transporters and enzymes was extended by CA ( P  〈   0.05). SIRT1 protein was induced after CA treatment in BDL rats. Conclusions Chlorogenic acid attenuated hepatotoxicity and cholestasis by decreasing the uptake and synthesis of bilirubin and bile acids and accelerating the metabolism and efflux of bilirubin and bile acids.
    Type of Medium: Online Resource
    ISSN: 1868-6974 , 1868-6982
    URL: Issue
    URL: Article
    DOI: 10.1002/jhbp.2018.25.issue-3
    DOI: 10.1002/jhbp.537
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2536390-6
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  • 5
    Online Resource
    Online Resource
    Influence of voltage on the H‐bridge of a large capacitor bank
    Wiley ; 2018
    In:  IEEJ Transactions on Electrical and Electronic Engineering Vol. 13, No. 7 ( 2018-07), p. 971-978
    Details
    In: IEEJ Transactions on Electrical and Electronic Engineering, Wiley, Vol. 13, No. 7 ( 2018-07), p. 971-978
    Abstract: Unbalance protection is often used in high‐voltage power capacitor banks as their main relay protection. Based on the analysis of the force of the capacitor, we show that the capacitance of the oil‐filled capacitor will change with the change of the field strength, and we deduce the theoretical equation of the capacitance change with the voltage. On the basis of this, we study the relationship between the capacitance and the voltage. Taking a real capacitor device as an example, the effect of voltage on unbalance leveling is studied by Monte Carlo simulations. The results show that the capacitance of the oil‐impregnated high‐voltage capacitor is affected by the voltage and may lead to the failure of the unbalance protection leveling. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
    Type of Medium: Online Resource
    ISSN: 1931-4973 , 1931-4981
    URL: Issue
    URL: Article
    DOI: 10.1002/tee.2018.13.issue-7
    DOI: 10.1002/tee.22653
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2241861-1
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  • 6
    Online Resource
    Online Resource
    Kinetic Modeling of Palmitamidopropyl Betaine Synthesis
    Wiley ; 2018
    In:  Journal of Surfactants and Detergents Vol. 21, No. 5 ( 2018-09), p. 647-655
    Details
    In: Journal of Surfactants and Detergents, Wiley, Vol. 21, No. 5 ( 2018-09), p. 647-655
    Abstract: In this work, the reaction kinetics of betaine synthesis were investigated. Specifically, an integral method was used to analyze the experimental data of the amidation reaction over the temperature range of 413.15–453.15 K and the data of the quaternization reaction over the temperature range of 348.15–368.15 K. The 2 reaction steps were shown to match the second‐order bimolecular kinetics model, and their equations could be deduced from the experimental data at different temperatures. The activation energy, E a , and the pre‐exponential factor, A , were obtained from the equilibrium constant at different temperatures using the Arrhenius equation. For the 2 reactions, the activation energies were 31.68 and 47.03 kJ mol −1 , respectively, and the preexponential factors were 26.99 and 4.07 × 10 4 . Over the tested temperature range, the kinetic model equations were verified by comparing the additional experimental data with the theoretical values. This study provides a theoretical basis for the continuous production of palmitamidopropyl betaine.
    Type of Medium: Online Resource
    ISSN: 1097-3958 , 1558-9293
    URL: Issue
    URL: Article
    DOI: 10.1002/jsde.2018.21.issue-5
    DOI: 10.1002/jsde.12156
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2109638-7
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  • 7
    Online Resource
    Online Resource
    3‐Hydroxyflavone enhances the toxicity of ZnO nanoparticles in vitro
    Wiley ; 2018
    In:  Journal of Applied Toxicology Vol. 38, No. 9 ( 2018-09), p. 1206-1214
    Details
    In: Journal of Applied Toxicology, Wiley, Vol. 38, No. 9 ( 2018-09), p. 1206-1214
    Abstract: Recent study suggested that phytochemicals might reduce the toxicity of nanoparticles (NPs). The present study investigated the combined toxicity of ZnO NPs and 3‐hydroxyflavone (H3). H3 influenced the colloidal stability of ZnO NPs, and surprisingly enhanced the cytotoxicity of NPs to both cancerous and normal cells. Co‐exposure to ZnO NPs and H3 increased NP–cell interactions, induced a relatively higher level of reactive oxygen species and altered the endoplasmic reticulum stress–apoptosis pathway, which could be responsible for the combined toxicity.
    Type of Medium: Online Resource
    ISSN: 0260-437X , 1099-1263
    URL: Issue
    URL: Article
    DOI: 10.1002/jat.v38.9
    DOI: 10.1002/jat.3633
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1475015-6
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  • 8
    Online Resource
    Online Resource
    Tuning the Activity of Carbon for Electrocatalytic Hydrogen Evolution via an Iridium‐Cobalt Alloy Core Encapsulated in Nitrogen‐Doped Carbon Cages
    Wiley ; 2018
    In:  Advanced Materials Vol. 30, No. 9 ( 2018-03)
    Details
    In: Advanced Materials, Wiley, Vol. 30, No. 9 ( 2018-03)
    Abstract: Graphene, a 2D material consisting of a single layer of sp 2 ‐hybridized carbon, exhibits inert activity as an electrocatalyst, while the incorporation of heteroatoms (such as N) into the framework can tune its electronic properties. Because of the different electronegativity between N and C atoms, electrons will transfer from C to N in N‐doped graphene nanosheets, changing inert C atoms adjacent to the N‐dopants into active sites. Notwithstanding the achieved progress, its intrinsic activity in acidic media is still far from Pt/C. Here, a facile annealing strategy is adopted for Ir‐doped metal‐organic frameworks to synthesize IrCo nanoalloys encapsulated in N‐doped graphene layers. The highly active electrocatalyst, with remarkably reduced Ir loading (1.56 wt%), achieves an ultralow Tafel slope of 23 mV dec −1 and an overpotential of only 24 mV at a current density of 10 mA cm −2 in 0.5 m sulfuric acid solution. Such superior performance is even superior to the noble‐metal catalyst Pt. Surface structural and computational studies reveal that the superior behavior originates from the decreased Δ G H* for HER induced by the electrons transferred from the alloy core to the graphene layers, which is beneficial for enhancing CH binding.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v30.9
    DOI: 10.1002/adma.201705324
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1474949-X
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  • 9
    Online Resource
    Online Resource
    Supramolecular Nanostructures of Structurally Defined Graphene Nanoribbons in the Aqueous Phase
    Wiley ; 2018
    In:  Angewandte Chemie International Edition Vol. 57, No. 13 ( 2018-03-19), p. 3366-3371
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 57, No. 13 ( 2018-03-19), p. 3366-3371
    Abstract: Structurally well‐defined graphene nanoribbons (GNRs) have attracted great interest because of their unique optical, electronic, and magnetic properties. However, strong π–π interactions within GNRs result in poor liquid‐phase dispersibility, which impedes further investigation of these materials in numerous research areas, including supramolecular self‐assembly. Structurally defined GNRs were synthesized by a bottom‐up strategy, involving grafting of hydrophilic poly(ethylene oxide) (PEO) chains of different lengths (GNR‐PEO). PEO grafting of 42–51 % percent produces GNR‐PEO materials with excellent dispersibility in water with high GNR concentrations of up to 0.5 mg mL −1 . The “rod–coil” brush‐like architecture of GNR‐PEO resulted in 1D hierarchical self‐assembly behavior in the aqueous phase, leading to the formation of ultralong nanobelts, or spring‐like helices, with tunable mean diameters and pitches. In aqueous dispersions the superstructures absorbed in the near‐infrared range, which enabled highly efficient conversion of photon energy into thermal energy.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v57.13
    DOI: 10.1002/anie.201712637
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 10
    Online Resource
    Online Resource
    Porphyrinic Metal–Organic Frameworks Coated Gold Nanorods as a Versatile Nanoplatform for Combined Photodynamic/Photothermal/Chemotherapy of Tumor
    Wiley ; 2018
    In:  Advanced Functional Materials Vol. 28, No. 8 ( 2018-02)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 28, No. 8 ( 2018-02)
    Abstract: In this paper, a simple, but effective method is reported to construct the core−shell gold nanorod@metal–organic frameworks (AuNR@MOFs) as a multifunctional theranostic platform by using functionalized AuNRs as seed crystal for the growth of porphyrinic MOFs on the surface of AuNR. Such a delicate tunable core−shell composite not only possesses the improved drug loading efficiency, near‐infrared light‐trigger drug release, and fluorescence imaging, but also can produce reactive oxygen species as well as photothermal activity to achieve combined cancer therapy. It is further demonstrated that the camptothecin loaded AuNR@MOFs show distinctively synergistic efficiency for damaging the cancer cell in vitro and inhibiting the tumor growth and metastasis in vivo. The development of this high‐performance incorporated nanostructure will provide more perspectives in the design of versatile nanomaterials for biomedical applications.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v28.8
    DOI: 10.1002/adfm.201705451
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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