In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 141, No. 5_Supplement ( 2017-05-01), p. 3505-3505
Abstract:
Ultrasonic standing waves are often used in biomedical applications. It has become quite common to move beads, cells, droplets, and other particles for sorting or biomedical analysis in microfluidic cavities by bulk acoustic waves or by vibrations excited by piezoelectric transducers. The motion of particles is determined by streaming and radiation forces. For the calculation of the radiation forces acting on single particles Gorkov’s potential is considered to be the modeling tool of choice, once the acoustic field and the properties of constituents (fluid and particle density and compressibility, respectively) are known. For the acoustic streaming, predictions can be made numerically. For both aspects large uncertainties exist, due to the complexity of the system and fluid structure interaction at multiple levels. In this paper, first various characterization tools for the acoustic field in the cavity are described. They consist of the interplay between numerical modeling of the device, impedance analysis of the piezoelectric transducer used, interferometric analysis of surface displacements and an optical trap to measure the forces on the particles directly. Secondly, a number of recent applications are shown, including the sorting and immobilization of C. elegans. Furthermore, fascinating behavior of multiple interacting particles is reported.
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2017
detail.hit.zdb_id:
1461063-2
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