In:
Biomarkers in Medicine, Future Medicine Ltd, Vol. 11, No. 7 ( 2017-07), p. 569-578
Kurzfassung:
Aim: The study evaluated the relationship of extracellular matrix and renin angiotensin system with myocardial dysfunction in Type 2 diabetes mellitus. Methods: All patients underwent resting and exercise echocardiography, including conventional parameters, E/E′ ratio, global longitudinal strain and diastolic function reserve index. Plasma matrix metalloproteinase-1, TIMP-1, amino-terminal propeptide of type I and type III procollagen and renin angiotensin system activity were measured. Results: As patients with diastolic dysfunction had a higher plasma level of TIMP-1 and propeptide of type III procollagen than those with no diastolic dysfunction. After multivariate adjustment, TIMP-1 associated with E/E′ (both at rest and stress) and diastolic function reserve index. Conclusion: TIMP-1 is independently associated with myocardial diastolic dysfunction in patients with Type 2 diabetes mellitus.
Materialart:
Online-Ressource
ISSN:
1752-0363
,
1752-0371
DOI:
10.2217/bmm-2017-0044
Sprache:
Englisch
Verlag:
Future Medicine Ltd
Publikationsdatum:
2017
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