In:
British Journal of Nutrition, Cambridge University Press (CUP), Vol. 115, No. 1 ( 2016-01-14), p. 121-128
Abstract:
Many studies have suggested that folate-related one-carbon metabolism-related nutrients may play a role in certain cancer risks, but few studies have assessed their associations with the risk for nasopharyngeal carcinoma (NPC). In this study, we investigated the association between four folate-related one-carbon metabolism-related nutrients (folate, vitamin B 6 , vitamin B 12 and methionine) and NPC risk in Chinese adults. A total of 600 patients newly diagnosed (within 3 months) with NPC were individually matched with 600 hospital-based controls by age, sex and household type (urban v . rural). Folate, vitamin B 6 , vitamin B 12 and methionine intakes were measured using a validated seventy-eight-item FFQ. A higher dietary folate or vitamin B 6 intake was associated with a lower NPC risk after adjusting for potential confounders. The adjusted OR of NPC for quartiles 2–4 ( v . 1) were 0·66 (95 % CI 0·48, 0·91), 0·52 (95 % CI 0·37, 0·74) and 0·34 (95 % CI 0·23, 0·50) ( P trend 〈 0·001) for folate and 0·72 (95 % CI 0·52, 1·00), 0·55 (95 % CI 0·39, 0·78) and 0·44 (95 % CI 0·30, 0·63) ( P trend 〈 0·001) for vitamin B 6 . No significant association with NPC risk was observed for dietary vitamin B 12 or methionine intake. The risk for NPC with dietary folate intake was more evident in the participants who were not exposed to toxic substances than in those who were exposed ( P interaction =0·014). This study suggests that dietary folate and vitamin B 6 may be protective for NPC in a high-risk population.
Type of Medium:
Online Resource
ISSN:
0007-1145
,
1475-2662
DOI:
10.1017/S0007114515004146
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2016
detail.hit.zdb_id:
2016047-1
SSG:
12
SSG:
21
Permalink