GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • American Physical Society (APS)  (6)
  • The American Physiological Society (APS)  (6)
  • 2015-2019  (12)
  • 2016  (12)
  • 1
    facet.materialart.
    Unknown
    SREBP inhibition ameliorates renal injury after unilateral ureteral obstruction (2016)
    The American Physiological Society (APS)
    Details
    Publication Date: 2016-09-03
    Description: Tubulointerstitial fibrosis is a major feature associated with declining kidney function in chronic kidney disease of diverse etiology. No effective means as yet exists to prevent the progression of fibrosis. We have shown that the transcription factor sterol-regulatory element-binding protein 1 (SREBP-1) is an important mediator of the profibrotic response to transforming growth factor-β (TGF-β) and angiotensin II, both key cytokines in the fibrotic process. Here, we examined the role of SREBP in renal interstitial fibrosis in the unilateral ureteral obstruction (UUO) model. The two isoforms of SREBP (-1 and -2) were activated by 3 days after UUO, with SREBP-1 showing a more sustained activation to 21 days. We then examined whether SREBP1/2 inhibition with the small-molecule inhibitor fatostatin could attenuate fibrosis after 14 days of UUO. SREBP activation was confirmed to be inhibited by fatostatin. Treatment decreased interstitial fibrosis, TGF-β signaling, and upregulation of α-smooth muscle actin (SMA), a marker of fibroblast activation. Fatostatin also attenuated inflammatory cell infiltrate and apoptosis. Associated with this, fatostatin preserved proximal tubular mass. The significant increase in atubular glomeruli observed after UUO, known to correlate with irreversible renal functional decline, was also decreased by treatment. In cultured primary fibroblasts, TGF-β1 induced the activation of SREBP-1 and -2. Fatostatin blocked TGF-β1-induced α-SMA and matrix protein upregulation. The inhibition of SREBP is thus a potential novel therapeutic target in the treatment of fibrosis in chronic kidney disease.
    Print ISSN: 1931-857X
    Electronic ISSN: 1522-1466
    Topics: Medicine
    Published by The American Physiological Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Intraspecific scaling laws are preserved in ventricular hypertrophy but not in heart failure (2016)
    The American Physiological Society (APS)
    Details
    Publication Date: 2016-11-03
    Description: It is scientifically and clinically important to understand the structure-function scaling of coronary arterial trees in compensatory (e.g., left and right ventricular hypertrophy, LVH and RVH) and decompensatory vascular remodeling (e.g., congestive heart failure, CHF). This study hypothesizes that intraspecific scaling power laws of vascular trees are preserved in hypertrophic hearts but not in CHF swine hearts. To test the hypothesis, we carried out the scaling analysis based on morphometry and hemodynamics of coronary arterial trees in moderate LVH, severe RVH, and CHF compared with age-matched respective control hearts. The scaling exponents of volume-diameter, length-volume, and flow-diameter power laws in control hearts were consistent with the theoretical predictions (i.e., 3, 7/9, and 7/3, respectively), which remained unchanged in LVH and RVH hearts. The scaling exponents were also preserved with an increase of body weight during normal growth of control animals. In contrast, CHF increased the exponents of volume-diameter and flow-diameter scaling laws to 4.25 ± 1.50 and 3.15 ± 1.49, respectively, in the epicardial arterial trees. This study validates the predictive utility of the scaling laws to diagnose vascular structure and function in CHF hearts to identify the borderline between compensatory and decompensatory remodeling.
    Keywords: Call for Papers: Quantitative Analyses of Coronary Vascular and Cardiac Mechanics in Health and Dise, Call for Papers: Plasma Membrane Integrity in Cardiovascular Physiology and Pathology
    Print ISSN: 0363-6135
    Electronic ISSN: 1522-1539
    Topics: Medicine
    Published by The American Physiological Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Lifetime measurements in ^{180} Pt (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-04-13
    Description: Author(s): Q. M. Chen, X. G. Wu, Y. S. Chen, C. B. Li, Z. C. Gao, G. S. Li, F. Q. Chen, C. Y. He, Y. Zheng, S. P. Hu, J. Zhong, Y. H. Wu, H. W. Li, and P. W. Luo Lifetimes of the yrast states in Pt 180 have been measured from 4 + to 8 + using the recoil distance Doppler-shift technique in the coincidence mode. These states were populated by the reaction Gd 156 ( Si 28 , 4 n ) Pt 180 at a beam energy of 144 MeV. The differential decay curve method was applied to determine… [Phys. Rev. C 93, 044310] Published Tue Apr 12, 2016
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Superconductivity and multiple pressure-induced phases in BaPt_{2} As_{2} (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-11-17
    Description: Author(s): C. Y. Guo, W. B. Jiang, M. Smidman, F. Han, C. D. Malliakas, B. Shen, Y. F. Wang, Y. Chen, X. Lu, M. G. Kanatzidis, and H. Q. Yuan The recently discovered BaPt 2 As 2 shows a structural distortion at around 275 K, followed by the emergence of superconductivity at lower temperatures. Here we identify the presence of charge-density-wave order at room temperature and ambient pressure using single-crystal x-ray diffraction, with both … [Phys. Rev. B 94, 184506] Published Wed Nov 16, 2016
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Beam commissioning for a superconducting proton linac (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-12-29
    Description: Author(s): Zhi-Jun Wang, Yuan He, Huan Jia, Wei-ping Dou, Wei-long Chen, X. L. Zhang, Shu-hui Liu, Chi Feng, Yue Tao, Wang-sheng Wang, Jian-qiang Wu, Sheng-hu Zhang, and Hong-Wei Zhao To develop the next generation of safe and cleaner nuclear energy, the accelerator-driven subcritical (ADS) system emerges as one of the most attractive technologies. It will be able to transmute the long-lived transuranic radionuclides produced in the reactors of today’s nuclear power plants into s… [Phys. Rev. Accel. Beams 19, 120101] Published Tue Dec 27, 2016
    Keywords: Low- and Intermediate-Energy Accelerators
    Electronic ISSN: 1098-4402
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Role of miR-124 and miR-141 in the regulation of vascular reactivity and the relationship to RhoA and Rac1 after hemorrhage and hypoxia (2016)
    The American Physiological Society (APS)
    Details
    Publication Date: 2016-01-17
    Description: Recent studies show that hypoxia can alter expression levels of microRNAs (miRNAs). Whether hypoxia or hemorrhage-induced vascular hyporeactivity is related to miRNAs and the underlying mechanisms of this process is not clear. Using hypoxia-treated superior mesenteric arteries (SMAs) and vascular smooth muscle cells (VSMCs) of rats that underwent hemorrhage, we observed the regulatory effects of miR-124/miR-141 on vascular reactivity, the relationship of these miRNAs to RhoA and Rac1, and the mutual regulation of miR-124 and miR-141. The contractile responses of SMAs and VSMCs showed an increase in early stages and a decrease in late stages of hypoxia and hemorrhage. Forty-five miRNAs appeared to have been significantly changed in SMAs after hypoxia, and miR-124 and miR-141 underwent the most change. Overexpressed miR-124 or miR-141 and their antisenses appeared to alter both vascular reactivity and expression of the proteins RhoA and Rac1 after hypoxia. miR-124 inhibited Rac1 by acting at the Rac1 mRNA 3'-untranslated region (UTR), but it led to an increase in RhoA by inhibiting miR-141. miR-141 inhibited RhoA by acting at the RhoA mRNA 3'-UTR, but it led to an increase in Rac1 by inhibiting miR-124. Further study found that miR-124 inhibited miR-141 via transcription factor early growth response gene-1 (Egr-1), whereas miR-141 inhibited miR-124 via transcription of nuclear factor erythroid 2-related factor 2 (Nrf-2). These results suggest that miR-124 and miR-141 participate in the regulation of vascular reactivity after hypoxia and hemorrhage by regulating expression of the RhoA and Rac1 proteins, and in doing so, miR-124 and miR-141 are mutually regulated. These findings provide potential targets for restoring vascular function as part of the treatment protocol for hemorrhagic shock and some other critical illness.
    Print ISSN: 0363-6135
    Electronic ISSN: 1522-1539
    Topics: Medicine
    Published by The American Physiological Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Heisenberg antiferromagnet on the Husimi lattice (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-03-01
    Description: Author(s): H. J. Liao, Z. Y. Xie, J. Chen, X. J. Han, H. D. Xie, B. Normand, and T. Xiang We perform a systematic study of the antiferromagnetic Heisenberg model on the Husimi lattice using numerical tensor-network methods based on projected entangled simplex states. The nature of the ground state varies strongly with the spin quantum number S . For S = 1 2 , it is an algebraic (gapless) quan… [Phys. Rev. B 93, 075154] Published Mon Feb 29, 2016
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Nodeless superconductivity in noncentrosymmetric PbTaSe_{2} single crystals (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-02-09
    Description: Author(s): G. M. Pang, M. Smidman, L. X. Zhao, Y. F. Wang, Z. F. Weng, L. Q. Che, Y. Chen, X. Lu, G. F. Chen, and H. Q. Yuan Noncentrosymmetric superconductors such as PbTaSe 2 have been the focus of intensive study due to their unconventional properties and they have also recently been proposed as candidates for topological superconductivity and Majorana fermions. To test this, it is important to characterize the superconducting order parameter. The authors here report precise temperature-dependent measurements of the London penetration depth of PbTaSe 2 . The results indicate fully gapped s -wave BCS-type superconductivity, which is rather puzzling. This compound is known to have a topologically nontrivial band structure and a strong antisymmetric spin-orbit coupling, which, in 2D superconductors, is expected to produce an order parameter with mixed spin singlet and spin triplet components. [Phys. Rev. B 93, 060506(R)] Published Fri Feb 05, 2016
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Slow recovery of the impaired fatigue resistance in postunloading mouse soleus muscle corresponding to decreased mitochondrial function and a compensatory increase in type I slow fibers (2016)
    The American Physiological Society (APS)
    Details
    Publication Date: 2016-01-02
    Description: Unloading or disuse rapidly results in skeletal muscle atrophy, switching to fast-type fibers, and decreased resistance to fatigue. The recovery process is of major importance in rehabilitation for various clinical conditions. Here we studied mouse soleus muscle during 60 days of reloading after 4 wk of hindlimb suspension. Unloading produced significant atrophy of soleus muscle with decreased contractile force and fatigue resistance, accompanied by switches of myosin isoforms from IIa to IIx and IIb and fast troponin T to more low-molecular-weight splice forms. The total mass, fiber size, and contractile force of soleus muscle recovered to control levels after 15 days of reloading. However, the fatigue resistance showed a trend of worsening during this period with significant infiltration of inflammatory cells at days 3 and 7 , indicating reloading injuries that were accompanied by active regeneration with upregulations of filamin-C, αB-crystallin, and desmin. The fatigue resistance partially recovered after 30–60 days of reloading. The expression of peroxisome proliferator-activated receptor coactivator 1α and mitofusin-2 showed changes parallel to that of fatigue resistance after unloading and during reloading, suggesting a causal role of decreased mitochondrial function. Slow fiber contents in the soleus muscle were increased after 30–60 days of reloading to become significantly higher than the normal level, indicating a secondary adaption to compensate for the slow recovery of fatigue resistance.
    Print ISSN: 0363-6143
    Electronic ISSN: 1522-1563
    Topics: Medicine
    Published by The American Physiological Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Orbital-frustration-induced ordering in semiconductor alloys (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-06-01
    Description: Author(s): Kai Liu, Wanjian Yin, Shiyou Chen, X. G. Gong, S.-H. Wei, and H. J. Xiang It is well known that ternary zinc-blende semiconductors are always more stable in the chalcopyrite (CH) structure than the Cu-Au (CA) structure because the CH structure has a large Coulomb interaction and a reduced strain energy. Surprisingly, an experimental study showed that the ZnFeS e 2 alloy tak… [Phys. Rev. B 93, 205207] Published Tue May 31, 2016
    Keywords: Semiconductors I: bulk
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...