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Fully integrated quantum photonic circuit with an electrically driven light source (2016)

Svetlana Khasminskaya; Felix Pyatkov; Karolina Słowik; Simone Ferrari; Oliver Kahl; Vadim Kovalyuk; Patrik Rath; Andreas Vetter; Frank Hennrich; Manfred M. Kappes; G. Gol'tsman; A. Korneev; Carsten Rockstuhl; Ralph Krupke; Wolfram H. P. Pernice

Nature Publishing Group (NPG)

In: Nature Photonics

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Publikationsdatum: 2016-11-01

Beschreibung: Nature Photonics 10, 727 (2016). doi:10.1038/nphoton.2016.178 Authors: Svetlana Khasminskaya, Felix Pyatkov, Karolina Słowik, Simone Ferrari, Oliver Kahl, Vadim Kovalyuk, Patrik Rath, Andreas Vetter, Frank Hennrich, Manfred M. Kappes, G. Gol'tsman, A. Korneev, Carsten Rockstuhl, Ralph Krupke & Wolfram H. P. Pernice

Print ISSN: 1749-4885

Digitale ISSN: 1749-4893

Thema: Physik

Publiziert von Nature Publishing Group (NPG)

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16Stimator: statistical estimation of ribosomal gene copy numbers from draft genome assemblies (2016)

Matthew Perisin; Madlen Vetter; Jack A Gilbert; Joy Bergelson

Nature Publishing Group (NPG)

In: ISME Journal

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Publikationsdatum: 2016-03-16

Beschreibung: 16Stimator: statistical estimation of ribosomal gene copy numbers from draft genome assemblies The ISME Journal 10, 1020 (April 2016). doi:10.1038/ismej.2015.161 Authors: Matthew Perisin, Madlen Vetter, Jack A Gilbert & Joy Bergelson

Print ISSN: 1751-7362

Digitale ISSN: 1751-7370

Thema: Biologie

Publiziert von Nature Publishing Group (NPG) im Namen von The International Society for Microbial Ecology (ISME).

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Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow [Basic Sciences] (2016)

Zilberman-Rudenko, J., Itakura, A., Wiesenekker, C. P., Vetter, R., Maas, C., Gailani, D., Tucker, E. I., Gruber, A., Gerdes, C., McCarty, O. J. T.

American Heart Association (AHA)

In: Arteriosclerosis, Thrombosis, and Vascular Biology

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Publikationsdatum: 2016-02-25

Beschreibung: Objective— Coagulation factor XI (FXI) has been shown to contribute to thrombus formation on collagen or tissue factor–coated surfaces in vitro and in vivo by enhancing thrombin generation. Whether the role of the intrinsic pathway of coagulation is restricted to the local site of thrombus formation is unknown. This study was aimed to determine whether FXI could promote both proximal and distal platelet activation and aggregate formation in the bloodstream. Approach and Results— Pharmacological blockade of FXI activation or thrombin activity in blood did not affect local platelet adhesion, yet reduced local platelet aggregation, thrombin localization, and fibrin formation on immobilized collagen and tissue factor under shear flow, ex vivo. Downstream of the thrombus formed on immobilized collagen or collagen and 10 pmol/L tissue factor, platelet CD62P expression, microaggregate formation, and progressive platelet consumption were significantly reduced in the presence of FXI function-blocking antibodies or a thrombin inhibitor in a shear rate– and time-dependent manner. In a non-human primate model of thrombus formation, we found that inhibition of FXI reduced single platelet consumption in the bloodstream distal to a site of thrombus formation. Conclusions— This study demonstrates that the FXI–thrombin axis contributes to distal platelet activation and procoagulant microaggregate formation in the blood flow downstream of the site of thrombus formation. Our data highlight FXI as a novel therapeutic target for inhibiting distal platelet consumption without affecting proximal platelet adhesion.

Schlagwort(e): Platelets, Thrombosis

Print ISSN: 1079-5642

Digitale ISSN: 1524-4636

Thema: Medizin

Publiziert von American Heart Association (AHA)

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Diffractive imaging of a rotational wavepacket in nitrogen molecules with femtosecond megaelectronvolt electron pulses (2016)

Jie Yang; Markus Guehr; Theodore Vecchione; Matthew S. Robinson; Renkai Li; Nick Hartmann; Xiaozhe Shen; Ryan Coffee; Jeff Corbett; Alan Fry; Kelly Gaffney; Tais Gorkhover; Carsten Hast; Keith Jobe; Igor Makasyuk; Alexander Reid; Joseph Robinson; Sharon Vetter; Fenglin Wang; Stephen Weathersby; Charles Yoneda; Martin Centurion; Xijie Wang

Nature Publishing Group (NPG)

In: Nature Communications

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Publikationsdatum: 2016-04-07

Beschreibung: Article Imaging changes in molecular geometries with sufficient temporal and spatial resolution to image nuclei is a critical challenge in the chemical sciences. Here the authors report gasphase Megaelectronvolt electron diffraction with 100 fs temporal resolution and subAngstrom spatial resolution. Nature Communications doi: 10.1038/ncomms11232 Authors: Jie Yang, Markus Guehr, Theodore Vecchione, Matthew S. Robinson, Renkai Li, Nick Hartmann, Xiaozhe Shen, Ryan Coffee, Jeff Corbett, Alan Fry, Kelly Gaffney, Tais Gorkhover, Carsten Hast, Keith Jobe, Igor Makasyuk, Alexander Reid, Joseph Robinson, Sharon Vetter, Fenglin Wang, Stephen Weathersby, Charles Yoneda, Martin Centurion, Xijie Wang

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Nature Publishing Group (NPG)

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The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family (2016)

Busch, B., Bley, N., Müller, S., Glass, M., Misiak, D., Lederer, M., Vetter, M., Strauss, H.-G., Thomssen, C., Hüttelmaier, S.

Oxford University Press

In: Nucleic Acids Research

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Publikationsdatum: 2016-05-06

Beschreibung: The tumor-suppressive let-7 microRNA family targets various oncogene-encoding mRNAs. We identify the let-7 targets HMGA2, LIN28B and IGF2BP1 to form a let-7 antagonizing self-promoting oncogenic triangle. Surprisingly, 3'-end processing of IGF2BP1 mRNAs is unaltered in aggressive cancers and tumor-derived cells although IGF2BP1 synthesis was proposed to escape let-7 attack by APA-dependent (alternative polyadenylation) 3' UTR shortening. However, the expression of the triangle factors is inversely correlated with let-7 levels and promoted by LIN28B impairing let-7 biogenesis. Moreover, IGF2BP1 enhances the expression of all triangle factors by recruiting the respective mRNAs in mRNPs lacking AGO proteins and let-7 miRNAs. This indicates that the downregulation of let-7, largely facilitated by LIN28B upregulation, and the protection of let-7 target mRNAs by IGF2BP1-directed shielding in mRNPs synergize in enhancing the expression of triangle factors. The oncogenic potential of this triangle was confirmed in ovarian cancer (OC)-derived ES-2 cells transduced with let-7 targeting decoys. In these, the depletion of HMGA2 only diminishes tumor cell growth under permissive conditions. The depletion of LIN28B and more prominently IGF2BP1 severely impairs tumor cell viability, self-renewal and 2D as well as 3D migration. In conclusion, this suggests the targeting of the HMGA2-LIN28B-IGF2BP1 triangle as a promising strategy in cancer treatment.

Print ISSN: 0305-1048

Digitale ISSN: 1362-4962

Thema: Biologie

Publiziert von Oxford University Press

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The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models (2016)

S Dutta; A Krause; S Vosberg; T Herold; B Ksienzyk; L Quintanilla-Martinez; B Tizazu; M Chopra; A Graf; S Krebs; H Blum; P A Greif; A Vetter; K Metzeler; M Rothenberg-Thurley; M R Schneider; M Dahlhoff; K Spiekermann; U Zimber-Strobl; E Wolf; S K Bohlander

Nature Publishing Group (NPG)

In: Leukemia

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Publikationsdatum: 2016-05-05

Beschreibung: The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models Leukemia 30, 1166 (May 2016). doi:10.1038/leu.2015.349 Authors: S Dutta, A Krause, S Vosberg, T Herold, B Ksienzyk, L Quintanilla-Martinez, B Tizazu, M Chopra, A Graf, S Krebs, H Blum, P A Greif, A Vetter, K Metzeler, M Rothenberg-Thurley, M R Schneider, M Dahlhoff, K Spiekermann, U Zimber-Strobl, E Wolf & S K Bohlander

Print ISSN: 0887-6924

Digitale ISSN: 1476-5551

Thema: Medizin

Publiziert von Nature Publishing Group (NPG)

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