GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (16)
  • 2015-2019  (16)
  • 2015  (16)
  • 1
    Online Resource
    Online Resource
    Small cell‐ versus large cell‐sized metal stent in endoscopic bilateral stent‐in‐stent placement for malignant hilar biliary obstruction
    Wiley ; 2015
    In:  Digestive Endoscopy Vol. 27, No. 6 ( 2015-09), p. 692-699
    Details
    In: Digestive Endoscopy, Wiley, Vol. 27, No. 6 ( 2015-09), p. 692-699
    Abstract: Although the large cell‐sized biliary stent facilitates contralateral stent deployment through the mesh of the first metallic stent for stent‐in‐stent ( SIS ) technique, there are concerns about its vulnerability to tumor ingrowth. The aim of the present study was to compare the clinical outcomes of endoscopic bilateral SIS placement according to the cell size of a self‐expandable metallic stent ( SEMS ). Methods A total of 58 patients were enrolled who underwent endoscopic bilateral SIS placement of SEMS for malignant hilar biliary obstruction as a result of cholangiocarcinoma or gallbladder cancer. Finally, 43 patients who underwent successful stent insertion were included in the analysis and divided into the small cell‐sized stent ( SCS ; n  = 21) and the large cell‐sized stent ( LCS ; n  = 22) groups. We retrospectively compared comprehensive clinical and laboratory data in both groups. Results There were no significant differences between the two groups in successful drainage ( SCS   vs   LCS , 100% vs 100%, respectively), early complications (38.1% vs 18.2%), late complications (14.3% vs 22.7%), stent occlusion (42.9% vs 45.5%), tumor ingrowth (33.3% vs 45.5%) or overgrowth (9.5% vs 0%). Duration of stent patency and overall survival were not significantly different between the two groups ( P  = 0.086 and P  = 0.320, respectively). Conclusions Endoscopic bilateral SIS placement for malignant hilar biliary obstruction shows no differences in stent patency, survival, complications and clinical course according to the cell size of SEMS .
    Type of Medium: Online Resource
    ISSN: 0915-5635 , 1443-1661
    URL: Issue
    URL: Article
    DOI: 10.1111/den.2015.27.issue-6
    DOI: 10.1111/den.12466
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2020071-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Clinical outcome and prognostic factors after salvage surgery for isolated regional squamous cell carcinoma recurrences : Salvage treatment for isolated regional recurrences
    Wiley ; 2015
    In:  Head & Neck Vol. 37, No. 11 ( 2015-11), p. 1612-1617
    Details
    In: Head & Neck, Wiley, Vol. 37, No. 11 ( 2015-11), p. 1612-1617
    Type of Medium: Online Resource
    ISSN: 1043-3074
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v37.11
    DOI: 10.1002/hed.23799
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2001440-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    A robust prediction method of surface deflection using stoning simulation and curvature analysis
    Wiley ; 2015
    In:  steel research international Vol. 86, No. 8 ( 2015-08), p. 886-893
    Details
    In: steel research international, Wiley, Vol. 86, No. 8 ( 2015-08), p. 886-893
    Abstract: Recently, numerical predictions for surface deflection by finite element analysis have been carried out actively by various methods, such as curvature analysis, stoning simulation, and highlighting. Measures of surface deflection based on curvature analysis had been proposed by several researchers and have shown good correspondence with experimental results. The maximum variation of curvature difference between the panel and the tool was also proposed as a measure for surface deflection. However, the curvature is strongly dependent on the calculation method and the quality of data points. On the other hand, a measure based on stoning simulation has not been extensively studied yet due to the insufficient information from stoning simulation. Regardless of the lack of a reliable measure, stoning simulation has been widely accepted in the field owing to its robustness to noise, and easiness of use and understanding. In this paper, we propose a new robust prediction method that uses stoning simulation and curvature analysis sequentially. The method combines the merits of the two methods in an integrated approach. First, for detection and finding the approximate shape of surface deflection, stoning simulation was utilized. Next, for the more accurate quantification of surface deflection, curvature analysis was applied. We used an adaptive span method to calculate the curvature stably and accurately regardless of the noise. As a verification example, a shallow rectangular drawing with inner rectangular embossing was considered. Experimental and simulation results were compared, and they demonstrated that the proposed approach can be utilized for the reliable detection of surface deflection and the accurate quantification of surface deflection.
    Type of Medium: Online Resource
    ISSN: 1611-3683 , 1869-344X
    URL: Issue
    URL: Article
    DOI: 10.1002/srin.v86.8
    DOI: 10.1002/srin.201400581
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2148555-0
    SSG: 19,1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Combined use of basal insulin analog and acarbose reduces postprandial glucose in patients with uncontrolled type 2 diabetes
    Wiley ; 2015
    In:  Journal of Diabetes Investigation Vol. 6, No. 2 ( 2015-03), p. 219-226
    Details
    In: Journal of Diabetes Investigation, Wiley, Vol. 6, No. 2 ( 2015-03), p. 219-226
    Abstract: Early initiation of basal insulin therapy is recommended for normalizing fasting blood glucose in type 2 diabetes mellitus. However, basal insulin treatment might not adequately control postprandial glucose levels. The present study evaluated whether the combination of the α‐glucosidase inhibitor, acarbose, and basal insulin improved blood glucose control under daily‐life treatment conditions in a large sample of K orean patients. Materials and Methods The present study was a multicenter, prospective, observational study under daily‐life treatment conditions. A total of 539 patients with type 2 diabetes who were treated with basal insulin and additional acarbose were enrolled and followed up for 20 weeks. Changes in hemoglobin A 1c, fasting and postprandial blood glucose were evaluated at baseline and at the end of the observation period. The physician and patient satisfaction of the combination treatment and safety were assessed. Results Hemoglobin A 1c decreased by 0.55 ± 1.05% from baseline ( P  〈  0.0001). Fasting and postprandial blood glucose levels were reduced by 0.89 ± 3.79 and 2.59 ± 4.77 mmol/L (both P  〈  0.0001). The most frequently reported adverse drug reactions were flatulence (0.37%) and abnormal gastrointestinal sounds (0.37%), and all were mild in intensity and transient. In the satisfaction evaluation, 79.0% of physicians and 77.3% of patients were ‘very satisfied’ or ‘satisfied’ with the combined basal insulin and acarbose therapy. Conclusions Combination therapy of basal insulin and acarbose in patients with type 2 diabetes improved glucose control, and had no drug‐specific safety concerns, suggesting that the treatment might benefit individuals who cannot control blood glucose with basal insulin alone.
    Type of Medium: Online Resource
    ISSN: 2040-1116 , 2040-1124
    URL: Issue
    URL: Article
    DOI: 10.1111/jdi.2015.6.issue-2
    DOI: 10.1111/jdi.12261
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2542077-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Stable isotopic labeling‐based quantitative targeted glycomics (i‐ QT a G )
    Wiley ; 2015
    In:  Biotechnology Progress Vol. 31, No. 3 ( 2015-05), p. 840-848
    Details
    In: Biotechnology Progress, Wiley, Vol. 31, No. 3 ( 2015-05), p. 840-848
    Abstract: Mass spectrometry (MS) analysis combined with stable isotopic labeling is a promising method for the relative quantification of aberrant glycosylation in diseases and disorders. We developed a stable i sotopic labeling‐based q uantitative targeted g lycomics (i‐QTaG) technique for the comparative and quantitative analysis of total N‐glycans using matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS). We established the analytical procedure with the chemical derivatizations (i.e., sialic acid neutralization and stable isotopic labeling) of N‐glycans using a model glycoprotein (bovine fetuin). Moreover, the i‐QTaG using MALDI‐TOF MS was evaluated with various molar ratios (1:1, 1:2, 1:5) of 13 C 6 / 12 C 6 ‐2‐aminobenzoic acid‐labeled glycans from normal human serum. Finally, this method was applied to direct comparison of the total N‐glycan profiles between normal human sera ( n  = 8) and prostate cancer patient sera ( n  = 17). The intensities of the N‐glycan peaks from i‐QTaG method showed a good linearity ( R 2   〉  0.99) with the amount of the bovine fetuin glycoproteins. The ratios of relative intensity between the isotopically 2‐AA labeled N‐glycans were close to the theoretical molar ratios (1:1, 1:2, 1:5). We also demonstrated that the up‐regulation of the Lewis antigen (∼82%) in sera from prostate cancer patients. In this proof‐of‐concept study, we demonstrated that the i‐QTaG method, which enables to achieve a reliable comparative quantitation of total N‐glycans via MALDI‐TOF MS analysis, has the potential to diagnose and monitor alterations in glycosylation associated with disease states or biotherapeutics. © 2015 American Institute of Chemical Engineers Biotechnol. Prog ., 31:840–848, 2015
    Type of Medium: Online Resource
    ISSN: 8756-7938 , 1520-6033
    URL: Issue
    URL: Article
    DOI: 10.1002/btpr.v31.3
    DOI: 10.1002/btpr.2078
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2003526-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Comparison of VMAT‐SABR treatment plans with flattening filter (FF) and flattening filter‐free (FFF) beam for localized prostate cancer
    Wiley ; 2015
    In:  Journal of Applied Clinical Medical Physics Vol. 16, No. 6 ( 2015-11), p. 302-313
    Details
    In: Journal of Applied Clinical Medical Physics, Wiley, Vol. 16, No. 6 ( 2015-11), p. 302-313
    Abstract: The purpose of this study is to investigate the feasibility of using a flattening filter‐free (FFF) beam with an endorectal balloon for stereotactic ablative body radiotherapy (SABR) of clinically localized prostate cancer. We assessed plans of SABR with volumetric‐modulated arc therapy (VMAT) that used a flattening filter (FF) beam and an FFF beam and compared the verification results of dosimetric quality assurance for all pretreatment plans. A total of 20 patients with prostate cancer were enrolled in the study. SABR plans using VMAT with two full arcs were optimized in the Eclipse treatment planning system. All plans prescribed 42.7 Gy in 7 fractions of 6.1 Gy each. Four SABR plans were computed for each patient: two with FF beams and two with FFF beams of 6 and 10 MV. For all plans, the cumulative dose‐volume histograms (DVHs) for the target volumes and organs at risk (OARs) were recorded and compared. Pretreatment quality assurance (QA) was performed using the I'm RT MatriXX system and radiochromic EBT3 film to verify treatment delivery, and gamma analysis was used to quantify the agreement between calculations and measurements. In addition, total monitor units (MUs) and delivery time were investigated as technical parameters of delivery. All four plans achieved adequate dose conformity to the target volumes and had comparable dosimetric data. The DVHs of all four plans for each patient were very similar. All plans were highly conformal with and , and the doses were homogeneous (HI = 0.08–0.15). Sparing for the bladder and rectum was slightly better with the 10 MV FF and FFF plans than with the 6 MV FF and FFF plans, but the difference was negligible. However, there was no significant difference in sparing for the other OARs. The mean agreement with the criterion was higher than 97% for verifying all plans. For the criterion, the corresponding agreement values were more than 90%, which showed that the plans were acceptable. The mean MUs and delivery time used were and min for 6 MV FF, and min for 6 MV FFF, and min for 10 MV FF, and and min for 10 MV FFF, respectively. In the current study, the dose distributions of the prostate SABR plans using 6 and 10 MV FFF beams were similar to those using 6 and 10 MV FF beams. However, this study confirmed that SABR treatment using an FFF beam had an advantage with respect to delivery time. In addition, all pretreatment plans were verified as acceptable and their results were comparable. Therefore, the results of this study suggest that the use of an FFF beam for prostate SABR is a feasible and efficient technique, if carefully applied. PACS numbers: 87.55.D, 87.55.dk
    Type of Medium: Online Resource
    ISSN: 1526-9914 , 1526-9914
    URL: Article
    DOI: 10.1120/jacmp.v16i6.5728
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2010347-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    A randomized, double‐blind, placebo‐controlled, phase II clinical trial to investigate the efficacy and safety of oral DA‐1229 in patients with type 2 diabetes mellitus who have inadequate glycaemic control with diet and exercise
    Wiley ; 2015
    In:  Diabetes/Metabolism Research and Reviews Vol. 31, No. 3 ( 2015-03), p. 295-306
    Details
    In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 31, No. 3 ( 2015-03), p. 295-306
    Abstract: DA‐1229 is a novel, potent and selective DPP‐IV inhibitor that is orally bioavailable. In a pharmacodynamic study, more than 80% of DPP‐IV was inhibited by a single dose of 5 mg or higher of DA‐1229, and this level of inhibition was maintained for at least 24 h after a single dose of 10 mg or higher of DA‐1229. This phase II clinical trial was designed to evaluate the efficacy and safety of oral DA‐1229 and to determine the optimal dose to use for a phase III clinical study in Korean subjects with type 2 diabetes.
    Type of Medium: Online Resource
    ISSN: 1520-7552 , 1520-7560
    URL: Issue
    URL: Article
    DOI: 10.1002/dmrr.v31.3
    DOI: 10.1002/dmrr.2613
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2001565-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Dysport and Botox at a ratio of 2.5:1 units in cervical dystonia: A double‐blind, randomized study
    Wiley ; 2015
    In:  Movement Disorders Vol. 30, No. 2 ( 2015-02), p. 206-213
    Details
    In: Movement Disorders, Wiley, Vol. 30, No. 2 ( 2015-02), p. 206-213
    Abstract: We aimed to compare Dysport (abobotulinumtoxinA, Ipsen Biopharm, Slough, UK) and Botox (onabotulinumtoxinA, Allergan, Irvine, CA, USA) at a 2.5:1 ratio in the treatment of cervical dystonia (CD). A Dysport/Botox ratio of lower than 3:1 was suggested as a more appropriate conversion ratio, considering its higher efficacy and more frequent incidence of adverse effects not only in the treatment of CD but also in other focal movement disorders. A randomized, double‐blind, multicenter, non‐inferiority, two‐period crossover study was done in CD, with a duration of at least 18 months. Patients were randomly assigned to treatment for the first period with Dysport or Botox, and they were followed up for 16 weeks after the injection. After a 4‐week washout period, they were switched to the other formulation and then followed up for 16 weeks. The primary outcome was the changes in the Tsui scale between the baseline value and that at 1 month after each injection. A total of 103 patients were enrolled, and 94 completed the study. Mean changes in the Tsui scale between baseline and 4 weeks after each injection tended to favor Botox; however, this was not statistically significant (4.0 ± 3.9 points for the Dysport treatment vs. 4.8 ± 4.1 points for Botox; 95% confidence interval, −0.1‐1.7; P  = 0.091). The mean change of the Toronto western spasmodic torticollis rating scale score, the proportion of improvement in clinical global impression and patient global impression, and the incidences of adverse events were not significantly different between the two treatments. With regard to safety and efficacy, Dysport was not inferior to Botox in patients with CD at a conversion factor of 2.5:1. [ clinicaltrial.gov : NCT00950664] © The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v30.2
    DOI: 10.1002/mds.26085
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2041249-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Tissue Adhesive Catechol‐Modified Hyaluronic Acid Hydrogel for Effective, Minimally Invasive Cell Therapy
    Wiley ; 2015
    In:  Advanced Functional Materials Vol. 25, No. 25 ( 2015-07), p. 3814-3824
    Details
    In: Advanced Functional Materials, Wiley, Vol. 25, No. 25 ( 2015-07), p. 3814-3824
    Abstract: Current hyaluronic acid (HA) hydrogel systems often cause cytotoxicity to encapsulated cells and lack the adhesive property required for effective localization of transplanted cells in vivo. In addition, the injection of hydrogel into certain organs (e.g., liver, heart) induces tissue damage and hemorrhage. In this study, we describe a bioinspired, tissue‐adhesive hydrogel that overcomes the limitations of current HA hydrogels through its improved biocompatibility and potential for minimally invasive cell transplantation. HA functionalized with an adhesive catecholamine motif of mussel foot protein forms HA‐catechol (HA‐CA) hydrogel via oxidative crosslinking. HA‐CA hydrogel increases viability, reduces apoptosis, and enhances the function of two types of cells (human adipose‐derived stem cells and hepatocytes) compared with a typical HA hydrogel crosslinked by photopolymerization. Due to the strong tissue adhesiveness of the HA‐CA hydrogel, cells are easily and efficiently transplanted onto various tissues (e.g., liver and heart) without the need for injection. Stem cell therapy using the HA‐CA hydrogel increases angiogenesis in vivo, leading to improved treatment of ischemic diseases. HA‐CA hydrogel also improved hepatic functions of transplanted hepatocytes in vivo. Thus, this bioinspired, tissue‐adhesive HA hydrogel can enhance the efficacy of minimally invasive cell therapy.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v25.25
    DOI: 10.1002/adfm.201500006
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    A Fluorophore‐labeled Peptide of Human Ribosomal Protein S3 for the Detection of the 8‐Oxoguanine within the Cells
    Wiley ; 2015
    In:  Bulletin of the Korean Chemical Society Vol. 36, No. 10 ( 2015-10), p. 2451-2457
    Details
    In: Bulletin of the Korean Chemical Society, Wiley, Vol. 36, No. 10 ( 2015-10), p. 2451-2457
    Abstract: Detection and quantification of 8‐oxo‐7,8‐dihydroguanine (8‐ oxoG ) within cells are important for the study of the molecular mechanisms in cancer. Human ribosomal protein S3 ( hRpS3 ), which involved in DNA repair, has high binding affinity to 8‐ oxoG . We developed an imaging probe to detect 8‐ oxoG using a specific peptide of hRpS3 . Sequence analysis was conducted to elucidate the 8‐ oxoG ‐specific binding region of hRpS3 , and three truncated mutants, D1 (amino acids 1–85), D2 (amino acids 86–159), and D3 (amino acids 160–242), were constructed. Both wild‐type‐ hRpS3 and D2 were able to bind 8‐ oxoG , which is consistent with the results of a previous report on the role of K134 in Drosophila melanogaster RpS3 . We synthesized a specific peptide and covalently linked with a fluorophore ( FPR ‐552, similar to Cy3) to generate an 8‐ oxoG imaging probe. Our 8‐ oxoG S3 ‐probe successfully detected the presence of 8‐ oxoG in damaged cells. Furthermore, this probe has threefold higher sensitivity than 8‐ oxoG DNA lesion antibody.
    Type of Medium: Online Resource
    ISSN: 1229-5949 , 1229-5949
    URL: Issue
    URL: Article
    DOI: 10.1002/bkcs.2015.36.issue-10
    DOI: 10.1002/bkcs.10472
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2056474-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...