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  • SAGE Publications  (5)
  • 2015-2019  (5)
  • 2015  (5)
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  • SAGE Publications  (5)
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  • 2015-2019  (5)
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  • 2015  (5)
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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2015
    In:  Acta Radiologica Vol. 56, No. 4 ( 2015-04), p. 482-486
    In: Acta Radiologica, SAGE Publications, Vol. 56, No. 4 ( 2015-04), p. 482-486
    Abstract: There is growing evidence that essential tremor (ET) is a multiple-system disorder. Previous PET studies in ET typically have measured brain oxygen consumption and cerebral blood flow. Purpose To compare ET patients with control subjects to investigate any regional change in cerebral glucose metabolism through statistical parametric mapping (SPM) analysis of F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). Material and Methods We studied 17 patients with ET (17 men; mean age, 67.3 ± 4.8 years) and age-sex matched normal subjects. All subjects underwent FDG-PET imaging, and evaluated severity of tremor symptoms was measured as score on the Fahn-Tolosa-Marin rating scale (FTM). We also evaluated detailed the medical history and neurological examinations in all patients. Results The mean age of tremor onset was 57.6 ± 12.9 years and the mean FTM score was 15.1 ± 4.9. Brain FDG-PET analysis demonstrated hypometabolism in the medial frontal lobe, medial temporal lobe, and the precuneus of parietal lobe. However, there was no significant difference of glucose metabolism in the cerebellum. Conclusion We propose that motor symptom of ET are caused by electrophysiological disturbances within cortical–cerebellar networks, rather than degenerative process of cerebellum, because the metabolism of the cerebellum was normal at rest. Furthermore, the abnormal glucose metabolism in the cerebral regions that do not mainly participate in motor function suggest that these regions may play a role as early markers of non-motor manifestations.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2024579-8
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  • 2
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 21, No. 1 ( 2015-01), p. 48-57
    Abstract: The effect of anticoagulation by heparin on patients with non-ST elevation acute coronary syndrome (NSTE-ACS), receiving early dual antiplatelet therapy, has not been fully evaluated. We classified 355 patients with NSTE-ACS according to the adequacy of anticoagulation (percentage of low activated partial thromboplastin time [APTT] level). The 6-hour APTT level was optimal in only 23.1% of the patients treated with unfractionated heparin. The rate of poor preprocedural coronary blood flow (thrombolysis in myocardial infarction grade 〈 3, 39.1%, 30.5%, 30.3%, and 33.9% in the 100% low-, 99%∼50% low-, 49%∼1% low-, and 0% low-APTT group, respectively, P = .632) and bleeding events did not differ between the groups. Instead, in multivariate analysis, the diagnosis of myocardial infarction was the only independent predictor of poor coronary flow. For bleeding events, the usage of glycoprotein IIb/IIIa inhibitor appeared to be a sole risk factor. In conclusion, inadequate preprocedural anticoagulation was not associated with adverse outcomes in patients with NSTE-ACS treated with dual antiplatelet agents.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2230591-9
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  • 3
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 43, No. 12 ( 2015-12), p. 3013-3021
    Abstract: After an anterior cruciate ligament (ACL) injury, the uninjured contralateral lower limb may become weakened because of neuromuscular changes, proprioceptive deficits, and disuse of the limb; this weakness predisposes the limb to ACL injury. However, no results have been reported regarding weakness in the contralateral limb after ACL injury. Hypothesis: Muscle strength and functional status of the contralateral lower limb are reduced after unilateral ACL injury. Study Design: Cohort study; Level of evidence, 3. Methods: The ACL group consisted of 75 patients who underwent primary unilateral ACL reconstruction and were followed at 3, 6, 12, and 24 months postoperatively. A group of 75 healthy individuals (controls) were matched one-to-one with the ACL group for age, sex, body mass index, and initial Tegner activity level. The side that was evaluated in each control subject corresponded to the injured limb in the matched ACL subject. Isokinetic muscle strength, including extension peak torque per body weight (EPT) and flexion peak torque per body weight (FPT), was evaluated at angular velocities of 60 and 180 deg/s. Patients were also evaluated by single-legged hop test. Results: Compared with the EPT at 60 deg/s in the control group (290.9 ± 40.1 N·m/kg), the value in the ACL group 24-month follow-up (276.6 ± 42.8 N·m/kg) as well as other follow-up times was significantly lower ( P 〈 .05), whereas the EPT at 180 deg/s and the FPT at 60 and 180 deg/s in the ACL group were significantly lower than the control group at 3-month follow-up but were restored to normal levels at final follow-up. Results from the single-legged hop test demonstrated that the ACL group performed at a significantly lower level than the control group at 24-month follow-up (158.4 ± 25.3 vs 176.3 ± 24.7 cm; P 〈 .05) as well as other follow-up times. However, both measurements improved significantly as the follow-up time progressed. Conclusion: After ACL injury, isokinetic extensor muscle strength and functional status of the contralateral limb were reduced, even at 24 months after ACL reconstruction. However, both measurements improved significantly as the follow-up time progressed. In contrast, flexion muscle strength was restored to normal levels. Therefore, care should be taken to restore muscle strength and functional status in not only the ACL-reconstructed knee but also the uninjured limb.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 4
    In: Acta Radiologica, SAGE Publications, Vol. 56, No. 6 ( 2015-06), p. 727-732
    Abstract: No systematic and quantitative system for evaluation of cervical neural foraminal stenosis (CNFS) has been reported. Purpose To evaluate whether the new magnetic resonance (MR) grading system for CNFS correlates with clinical manifestations and to propose a modified grading system more useful for clinical practice. Material and Methods We examined 356 patients who underwent MR imaging (MRI) of the cervical spine. The presence and grade of cervical foraminal stenosis at the maximal narrowing point were assessed using the new grading system suggested by Kim et al. (Kim system) and a modification of this grading system (modified Kim system) based on T2 axial images. Grade 0: narrowest neural foramen  〉  extraforaminal root; Grade 1: ≤ extraforaminal root; Grade 2: 〈 50% of extraforaminal root. Modified Kim system: Grade 0: 〉 80%, Grade 1: 〈 80% but 〉 50%, Grade 2 as for the Kim system. Results were correlated with clinical manifestations and neurologic physical examination findings (positive neurologic manifestation [PNM]). Results Analysis of correlation coefficients (Rs) showed moderate correlation between grades and clinical manifestations using the Kim system (0.484–0.562) and moderate to high correlation between grades and PNMs using the modified Kim system (0.517–0.782). Conclusion The Kim system showed moderate correlation clinical findings, while the modified Kim system still showed moderate but slightly stronger correlation. In both systems, grade 0 could denote negative neurologic manifestations. Although a considerable number of grade 1 and 2 cases in both systems had PNM, fulfilling the criteria for grades 1 and 2 CNFS, it does not perfectly predict PNM.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2024579-8
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  • 5
    In: Molecular Imaging, SAGE Publications, Vol. 14, No. 1 ( 2015-01), p. 7290.2014.00050-
    Type of Medium: Online Resource
    ISSN: 1536-0121 , 1536-0121
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2069848-3
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