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Morphogenesis of filaments growing in flexible confinements (2014)

R. Vetter; F. K. Wittel; H. J. Herrmann

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2014-07-18

Description: Article Growing polymer chains are often confined within vesicles in biological systems. Here, the authors study how material properties such as friction, flexibility and thickness affect confined polymer filaments when they grow beyond their equilibrium size, identifying four unique morphologies. Nature Communications doi: 10.1038/ncomms5437 Authors: R. Vetter, F. K. Wittel, H. J. Herrmann

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Nature Publishing Group (NPG)

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Chen, R. C., Chang, P., Vetter, R. J., Lukka, H., Stokes, W. A., Sanda, M. G., Watkins-Bruner, D., Reeve, B. B., Sandler, H. M.

Oxford University Press

In: JNCI Journal of the National Cancer Institute

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Publication Date: 2014-07-10

Description: The National Cancer Institute (NCI) Symptom Management and Health-Related Quality of Life Steering Committee convened four working groups to recommend core sets of patient-reported outcomes to be routinely incorporated in clinical trials. The Prostate Cancer Working Group included physicians, researchers, and a patient advocate. The group’s process included 1) a systematic literature review to determine the prevalence and severity of symptoms, 2) a multistakeholder meeting sponsored by the NCI to review the evidence and build consensus, and 3) a postmeeting expert panel synthesis of findings to finalize recommendations. Five domains were recommended for localized prostate cancer: urinary incontinence, urinary obstruction and irritation, bowel-related symptoms, sexual dysfunction, and hormonal symptoms. Four domains were recommended for advanced prostate cancer: pain, fatigue, mental well-being, and physical well-being. Additional domains for consideration include decisional regret, satisfaction with care, and anxiety related to prostate cancer. These recommendations have been endorsed by the NCI for implementation.

Electronic ISSN: 1460-2105

Topics: Medicine

Published by Oxford University Press

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Mechanism of Tc toxin action revealed in molecular detail (2014)

D. Meusch ; C. Gatsogiannis ; R. G. Efremov ; [et al.]

Nature Publishing Group (NPG)

In: Nature. 508(7494): 61-5. doi: 10.1038/nature13015.

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Publication Date: 2014-02-28

Description: Tripartite Tc toxin complexes of bacterial pathogens perforate the host membrane and translocate toxic enzymes into the host cell, including in humans. The underlying mechanism is complex but poorly understood. Here we report the first, to our knowledge, high-resolution structures of a TcA subunit in its prepore and pore state and of a complete 1.7 megadalton Tc complex. The structures reveal that, in addition to a translocation channel, TcA forms four receptor-binding sites and a neuraminidase-like region, which are important for its host specificity. pH-induced opening of the shell releases an entropic spring that drives the injection of the TcA channel into the membrane. Binding of TcB/TcC to TcA opens a gate formed by a six-bladed beta-propeller and results in a continuous protein translocation channel, whose architecture and properties suggest a novel mode of protein unfolding and translocation. Our results allow us to understand key steps of infections involving Tc toxins at the molecular level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meusch, Dominic -- Gatsogiannis, Christos -- Efremov, Rouslan G -- Lang, Alexander E -- Hofnagel, Oliver -- Vetter, Ingrid R -- Aktories, Klaus -- Raunser, Stefan -- England -- Nature. 2014 Apr 3;508(7494):61-5. doi: 10.1038/nature13015. Epub 2014 Feb 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany [2]. ; Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universitat Freiburg, 79104 Freiburg, Germany. ; Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany. ; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany. ; 1] Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universitat Freiburg, 79104 Freiburg, Germany [2] BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universitat Freiburg, 79104 Freiburg, Germany. ; 1] Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany [2] Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Thielallee 63, 14195 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24572368" target="_blank"〉PubMed〈/a〉

Keywords: ADP Ribose Transferases/metabolism ; Bacterial Toxins/*chemistry/*metabolism ; Binding Sites ; Cell Membrane/metabolism ; Crystallography, X-Ray ; Host Specificity ; Hydrogen-Ion Concentration ; Models, Molecular ; Neuraminidase/chemistry ; Photorhabdus/*chemistry ; Porosity ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; Protein Transport ; Protein Unfolding ; Structure-Activity Relationship

Print ISSN: 0028-0836

Electronic ISSN: 1476-4687

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Published by Nature Publishing Group (NPG)

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Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain (2014)

Aline Dantas de Araujo; Mehdi Mobli; Joel Castro; Andrea M. Harrington; Irina Vetter; Zoltan Dekan; Markus Muttenthaler; Jing; Jing Wan; Richard J. Lewis; Glenn F. King; Stuart M. Brierley; Paul F. Alewood

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2014-02-01

Description: Article Peptide drugs are attractive as therapeutics for gut-based applications, although they may be susceptible to reduction and degradation. Here, the authors develop seleno-oxytocin analogues, with enhanced stability at no cost to potency, and demonstrate their efficacy at colonic nociceptor inhibition in a mouse model. Nature Communications doi: 10.1038/ncomms4165 Authors: Aline Dantas de Araujo, Mehdi Mobli, Joel Castro, Andrea M. Harrington, Irina Vetter, Zoltan Dekan, Markus Muttenthaler, JingJing Wan, Richard J. Lewis, Glenn F. King, Stuart M. Brierley, Paul F. Alewood

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Nature Publishing Group (NPG)

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Electrocardiographic Screening of All Infants, Children, and Teenagers Should Be Performed [Controversies in Cardiovascular Medicine] (2014)

Vetter, V. L.

American Heart Association (AHA)

In: Circulation

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Publication Date: 2014-08-20

Keywords: Electrocardiology, Other diagnostic testing

Electronic ISSN: 1524-4539

Topics: Medicine

Published by American Heart Association (AHA)

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Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin (2014)

Deuis, J. R., Lim, Y. L., Rodrigues de Sousa, S., Lewis, R. J., Alewood, P. F., Cabot, P. J., Vetter, I.

Oxford University Press

In: Neuro-Oncology

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Publication Date: 2014-09-17

Description: Background Peripheral neuropathy is the major dose-limiting side effect of cisplatin and oxaliplatin, and there are currently no effective treatments available. The aim of this study was to assess the pharmacological mechanisms underlying chemotherapy-induced neuropathy in novel animal models based on intraplantar administration of cisplatin and oxaliplatin and to systematically evaluate the analgesic efficacy of a range of therapeutics. Methods Neuropathy was induced by a single intraplantar injection of cisplatin or oxaliplatin in C57BL/6J mice and assessed by quantification of mechanical and thermal allodynia. The pharmacological basis of cisplatin-induced neuropathy was characterized using a range of selective pharmacological inhibitors. The analgesic effects of phenytoin, amitriptyline, oxcarbazepine, mexiletine, topiramate, retigabine, gabapentin, fentanyl, and Ca 2+/ Mg 2+ were assessed 24 hours after induction of neuropathy. Results Intraplantar administration of cisplatin led to the development of mechanical allodynia, mediated through Na v 1.6-expressing sensory neurons. Unlike intraplantar injection of oxaliplatin, cold allodynia was not observed with cisplatin, consistent with clinical observations. Surprisingly, only fentanyl was effective at alleviating cisplatin-induced mechanical allodynia despite a lack of efficacy in oxaliplatin-induced cold allodynia. Conversely, lamotrigine, phenytoin, retigabine, and gabapentin were effective at reversing oxaliplatin-induced cold allodynia but had no effect on cisplatin-induced mechanical allodynia. Oxcarbazepine, amitriptyline, mexiletine, and topiramate lacked efficacy in both models of acute chemotherapy-induced neuropathy. Conclusion This study established a novel animal model of cisplatin-induced mechanical allodynia consistent with the A-fiber neuropathy seen clinically. Systematic assessment of a range of therapeutics identified several candidates that warrant further clinical investigation.

Print ISSN: 1522-8517

Electronic ISSN: 1523-5866

Topics: Medicine

Published by Oxford University Press on behalf of The Society for Neuro-Oncology (SNO).

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Rovers minimize human disturbance in research on wild animals (2014)

Yvon Le Maho; Jason D Whittington; Nicolas Hanuise; Louise Pereira; Matthieu Boureau; Mathieu Brucker; Nicolas Chatelain; Julien Courtecuisse; Francis Crenner; Benjamin Friess; Edith Grosbellet; Laëtitia Kernaléguen; Frédérique Olivier; Claire Saraux; Nathanaël Vetter; Vincent A Viblanc; Bernard Thierry; Pascale Tremblay; René Groscolas; Céline Le Bohec

Nature Publishing Group (NPG)

In: Nature Methods

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Publication Date: 2014-11-26

Description: Nature Methods 11, 1242 (2014). doi:10.1038/nmeth.3173 Authors: Yvon Le Maho, Jason D Whittington, Nicolas Hanuise, Louise Pereira, Matthieu Boureau, Mathieu Brucker, Nicolas Chatelain, Julien Courtecuisse, Francis Crenner, Benjamin Friess, Edith Grosbellet, Laëtitia Kernaléguen, Frédérique Olivier, Claire Saraux, Nathanaël Vetter, Vincent A Viblanc, Bernard Thierry, Pascale Tremblay, René Groscolas & Céline Le Bohec Investigating wild animals while minimizing human disturbance remains an important methodological challenge. When approached by a remote-operated vehicle (rover) which can be equipped to make radio-frequency identifications, wild penguins had significantly lower and shorter stress responses (determined by heart rate and behavior) than when approached by humans. Upon immobilization, the rover—unlike humans—did not disorganize colony structure, and stress rapidly ceased. Thus, rovers can reduce human disturbance of wild animals and the resulting scientific bias.

Print ISSN: 1548-7091

Electronic ISSN: 1548-7105

Topics: Biology , Medicine

Published by Nature Publishing Group (NPG)

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Genome-wide association study of Arabidopsis thaliana leaf microbial community (2014)

Matthew W. Horton; Natacha Bodenhausen; Kathleen Beilsmith; Dazhe Meng; Brian D. Muegge; Sathish Subramanian; M. Madlen Vetter; Bjarni J. Vilhjálmsson; Magnus Nordborg; Jeffrey I. Gordon; Joy Bergelson

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2014-11-12

Description: Article The effect of a host's genetic variation on the structure of its microbial community is poorly understood. Here, Horton et al. reveal associations between genetic variants in the plant model species Arabidopsis thaliana and the composition of the leaves' microbial communities. Nature Communications doi: 10.1038/ncomms6320 Authors: Matthew W. Horton, Natacha Bodenhausen, Kathleen Beilsmith, Dazhe Meng, Brian D. Muegge, Sathish Subramanian, M. Madlen Vetter, Bjarni J. Vilhjálmsson, Magnus Nordborg, Jeffrey I. Gordon, Joy Bergelson

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Nature Publishing Group (NPG)

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Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails (2014)

Sébastien Dutertre; Ai-Hua Jin; Irina Vetter; Brett Hamilton; Kartik Sunagar; Vincent Lavergne; Valentin Dutertre; Bryan G. Fry; Agostinho Antunes; Deon J. Venter; Paul F. Alewood; Richard J. Lewis

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2014-03-26

Description: Article Marine cone snails use venom for defence and predation. Here, Dutertre et al. show that cone snails produce structurally and functionally distinct venoms for each purpose and that defence toxins are potent on fish and mammalian targets, suggesting that they have evolved specifically for protection. Nature Communications doi: 10.1038/ncomms4521 Authors: Sébastien Dutertre, Ai-Hua Jin, Irina Vetter, Brett Hamilton, Kartik Sunagar, Vincent Lavergne, Valentin Dutertre, Bryan G. Fry, Agostinho Antunes, Deon J. Venter, Paul F. Alewood, Richard J. Lewis

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Nature Publishing Group (NPG)

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