In:
Clinical Endocrinology, Wiley, Vol. 79, No. 3 ( 2013-09), p. 356-363
Abstract:
The liver‐secreted protein fetuin‐ A is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis. We examined the effect of caloric restriction ( CR ) on fetuin‐ A levels and concomitant changes in hepatic steatosis and cardiovascular risk factors in rats and humans. Design and Subjects We performed a randomized, controlled clinical trial to examine circulating fetuin‐ A levels and cardiovascular risk parameters including visceral fat area ( VFA ), atherogenic lipid profile, inflammatory markers, adipokines levels and brachial artery endothelial function in 76 overweight women with type 2 diabetes before and after 12 weeks of CR . In addition, the effects of CR on hepatic steatosis and fetuin‐ A m RNA expression were evaluated in O tuska L ong E vans T okushima F atty ( OLETF ) rats, an animal model of obesity and type 2 diabetes. Results Circulating fetuin‐ A levels were significantly decreased after 12 weeks of CR and were accompanied by improvements in VFA , blood pressure, glucose, lipid profiles and liver function. The CR group also showed a significant decrease in apolipoprotein B , leptin and insulin resistance compared to those in the control group, although endothelial function was not different. Multiple regression analysis showed that the changes in fetuin‐ A levels were independently associated with CR and changes in hs CRP and adiponectin ( R 2 = 0·156). Moreover, CR significantly reduced hepatic steatosis and fetuin‐ A expression, as well as weight, glucose, total cholesterol and triglyceride levels, in OLETF rats. Conclusion Caloric restriction significantly reduced the hepatic expression of fetuin‐ A and its circulating levels and improved several cardiovascular risk factors in obese rats and humans with type 2 diabetes.
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2013.79.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
121745-8
detail.hit.zdb_id:
2004597-9
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