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  • PANGAEA  (24)
  • Nature Publishing Group (NPG)  (3)
  • Oxford University Press  (3)
  • Wiley-Blackwell  (3)
  • Institute of Physics Publishing (IOP)
  • Springer
  • 2015-2019
  • 2010-2014  (33)
  • 1975-1979
  • 1970-1974
  • 1955-1959
  • 1915-1919
  • 2012  (33)
Publikationsart
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Erscheinungszeitraum
  • 2015-2019
  • 2010-2014  (33)
  • 1975-1979
  • 1970-1974
  • 1955-1959
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Jahr
  • 1
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    Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling (2012)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2012-10-04
    Beschreibung: Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling The EMBO Journal 31, 3795 (2012). doi:10.1038/emboj.2012.207 Authors: Irina Vetter, Filip Touska, Andreas Hess, Rachel Hinsbey, Simon Sattler, Angelika Lampert, Marina Sergejeva, Anastasia Sharov, Lindon S Collins, Mirjam Eberhardt, Matthias Engel, Peter J Cabot, John N Wood, Viktorie Vlachová, Peter W Reeh, Richard J Lewis & Katharina Zimmermann Ciguatoxins are sodium channel activator toxins that cause ciguatera, the most common form of ichthyosarcotoxism, which presents with peripheral sensory disturbances, including the pathognomonic symptom of cold allodynia which is characterized by intense stabbing and burning pain in response to mild cooling. We show that
    Schlagwort(e): ciguatoxincold allodyniaNavnociceptorTRPA1
    Print ISSN: 0261-4189
    Digitale ISSN: 1460-2075
    Thema: Biologie , Medizin
    Publiziert von Nature Publishing Group (NPG) im Namen von The European Molecular Biology Organization (EMBO).
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  • 2
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    Simulating water temperatures and stratification of a pre-alpine lake with a hydrodynamic model: calibration and sensitivity analysis of climatic input parameters (2012)
    Wiley-Blackwell
    Details
    Publikationsdatum: 2012-12-18
    Beschreibung: We report on the calibration of the one-dimensional hydrodynamic lake model DYRESM to simulate the water temperature conditions of the pre-alpine Lake Ammersee (South-east Germany) which is representative of deep and large lakes in this region. Special focus is given to the calibration in order to reproduce the correct thermal distribution and stratification including the time of onset and duration of summer stratification. To ensure the application of the model to investigate the impact of climate change on lakes, an analysis of the model sensitivity under stepwise modification of meteorological input parameters (air temperature, wind speed, precipitation, global radiation, cloud cover, vapor pressure, and tributary water temperature) was conducted. The total mean error of the calibration results is –0.23 °C, the root mean square error amounts to 1.012 °C. All characteristics of the annual stratification cycle were reproduced accurately by the model. Additionally, the simulated deviations for all applied modifications of the input parameters for the sensitivity analysis can be differentiated in the high temporal resolution of monthly values for each specific depth. The smallest applied alteration to each modified input parameter caused a maximum deviation in the simulation results of at least 0.26 °C. The most sensitive reactions of the model can be observed through modifications of the input parameters air temperature and wind speed. Hence the results show that further investigations at Lake Ammersee, such as coupling the hydrodynamic model with chemo-dynamic models to assess the impact of changing climate on biochemical conditions within lakes, can be carried out using DYRESM. Copyright © 2012 John Wiley & Sons, Ltd.
    Print ISSN: 0885-6087
    Digitale ISSN: 1099-1085
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Publiziert von Wiley-Blackwell
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  • 3
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    Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119 (2012)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2012-10-18
    Beschreibung: The EMBO Journal 31, 4085 (2012). doi:10.1038/emboj.2012.257 Authors: Shehab A Ismail, Yong-Xiang Chen, Mandy Miertzschke, Ingrid R Vetter, Carolin Koerner & Alfred Wittinghofer Access to the ciliary membrane for trans-membrane or membrane-associated proteins is a regulated process. Previously, we have shown that the closely homologous small G proteins Arl2 and Arl3 allosterically regulate prenylated cargo release from PDEδ. UNC119/HRG4 is responsible for ciliary delivery of myristoylated cargo. Here,
    Schlagwort(e): Arfsciliaprotein traffickingreleasing factorssmall G proteins
    Print ISSN: 0261-4189
    Digitale ISSN: 1460-2075
    Thema: Biologie , Medizin
    Publiziert von Nature Publishing Group (NPG) im Namen von The European Molecular Biology Organization (EMBO).
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Flagellin Perception Varies Quantitatively in Arabidopsis thaliana and Its Relatives (2012)
    Oxford University Press
    Details
    Publikationsdatum: 2012-05-16
    Beschreibung: Much is known about the evolution of plant immunity components directed against specific pathogen strains: They show pervasive functional variation and have the potential to coevolve with pathogen populations. However, plants are effectively protected against most microbes by generalist immunity components that detect conserved pathogen-associated molecular patterns (PAMPs) and control the onset of PAMP-triggered immunity. In Arabidopsis thaliana , the receptor kinase flagellin sensing 2 (FLS2) confers recognition of bacterial flagellin (flg22) and activates a manifold defense response. To decipher the evolution of this system, we performed functional assays across a large set of A. thaliana genotypes and Brassicaceae relatives. We reveal extensive variation in flg22 perception, most of which results from changes in protein abundance. The observed variation correlates with both the severity of elicited defense responses and bacterial proliferation. We analyzed nucleotide variation segregating at FLS2 in A. thaliana and detected a pattern of variation suggestive of the rapid fixation of a novel adaptive allele. However, our study also shows that evolution at the receptor locus alone does not explain the evolution of flagellin perception; instead, components common to pathways downstream of PAMP perception likely contribute to the observed quantitative variation. Within and among close relatives, PAMP perception evolves quantitatively, which contrasts with the changes in recognition typically associated with the evolution of R genes.
    Print ISSN: 0737-4038
    Digitale ISSN: 1537-1719
    Thema: Biologie
    Publiziert von Oxford University Press
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  • 5
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    Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target (2012)
    Wiley-Blackwell
    Details
    Publikationsdatum: 2012-04-17
    Beschreibung: Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney cancer. Here, we integrated an unbiased genome-wide RNA interference screen for ccRCC survival regulators with an analysis of recurrently over-expressed genes in ccRCC to identify new therapeutic targets in this disease. One of the most potent survival regulators, the monocarboxylate transporter MCT4 (SLC16A3), impaired ccRCC viability in all 8 ccRCC lines tested and was the 7th most over-expressed gene in a meta-analysis of 5 ccRCC expression datasets. MCT4-silencing impaired secretion of lactate generated through glycolysis and induced cell cycle arrest and apoptosis. Silencing MCT4 resulted in intracellular acidosis, and reduction in intracellular ATP production together with partial reversion of the Warburg effect in ccRCC cell lines. Intratumoral heterogeneity in the intensity of MCT4 protein expression was observed in primary ccRCCs. MCT4 protein expression analysis based on the highest intensity of expression in primary ccRCCs was associated with poorer relapse free survival, whereas modal intensity correlated with Fuhrman nuclear grade. Consistent with the potential selection of subclones enriched for MCT4 expression during disease progression, MCT4 expression was greater at sites of metastatic disease. These data suggest that MCT4 may serve as a novel metabolic target to reverse the Warburg effect and limit disease progression in ccRCC. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    Print ISSN: 0022-3417
    Digitale ISSN: 1096-9896
    Thema: Medizin
    Publiziert von Wiley-Blackwell
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  • 6
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    Enhanced hepatocarcinogenesis in mouse models and human HCC by coordinate KLF6 depletion and increased mRNA splicing (2012)
    Wiley-Blackwell
    Details
    Publikationsdatum: 2012-05-02
    Beschreibung: Background: KLF6-SV1 ( SV1 ), the major splice variant of KLF6 , antagonizes the KLF6 tumor suppressor by an unknown mechanism. Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown. We sought to define the impact of SV1 on human outcomes and experimental murine hepatocarcinogenesis, and to elucidate its mechanism of action. Results: In HCV-related HCC, an increased ratio of SV1/KLF6 within the tumor was associated with more features of more advanced disease. Six months after a single injection of diethylnitrosamine (DEN), SV1 hepatocyte transgenic mice developed more histologically advanced tumors, whereas Klf6 -depleted mice developed bigger tumors compared to the Klf6 fl(+/+) control mice. Nine months after DEN, SV1 transgenic-mice with Klf6 -depletion had the greatest tumor burden. Primary mouse hepatocytes from both the SV1 transgenic animals and those with hepatocyte-specific Klf6 depletion displayed increased DNA synthesis, with an additive effect in hepatocytes harboring both SV1 over-expression and Klf6 depletion. Parallel results were obtained by viral SV1-transduction- and depletion of Klf6 through adenovirus-Cre infection of primary Klf6 fl(+/+) hepatocytes. Increased DNA synthesis was due to both enhanced cell proliferation and increased ploidy. Co-IP studies in 293T cells uncovered a direct interaction of transfected SV1 with KLF6 . Accelerated KLF6 degradation in the presence of SV1 was abrogated by the proteasome inhibitor MG132. Conclusion: Increased SV1/KLF6 ratio correlates with more aggressive HCC. In mice, an increased SV1/KLF6 ratio, generated either by increasing SV1, decreasing KLF6, or both, accelerates hepatic carcinogenesis. Moreover, SV1 binds directly to KLF6 and accelerates its degradation. These findings represent a novel mechanism underlying the antagonism of tumor suppressor gene function by a splice variant of the same gene. (H EPATOLOGY 2012.)
    Print ISSN: 0270-9139
    Digitale ISSN: 1527-3350
    Thema: Medizin
    Publiziert von Wiley-Blackwell im Namen von The American Association for the Study of Liver Diseases.
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  • 7
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    GATA4 Is a Critical Regulator of Gonadectomy-Induced Adrenocortical Tumorigenesis in Mice (2012)
    Oxford University Press
    Details
    Publikationsdatum: 2012-06-12
    Beschreibung: In response to gonadectomy certain inbred mouse strains develop sex steroidogenic adrenocortical neoplasms. One of the hallmarks of neoplastic transformation is expression of GATA4, a transcription factor normally present in gonadal but not adrenal steroidogenic cells of the adult mouse. To show that GATA4 directly modulates adrenocortical tumorigenesis and is not merely a marker of gonadal-like differentiation in the neoplasms, we studied mice with germline or conditional loss-of-function mutations in the Gata4 gene. Germline Gata4 haploinsufficiency was associated with attenuated tumor growth and reduced expression of sex steroidogenic genes in the adrenal glands of ovariectomized B6D2F1 and B6AF1 mice. At 12 months after ovariectomy, wild-type B6D2F1 mice had biochemical and histological evidence of adrenocortical estrogen production, whereas Gata4 +/– B6D2F1 mice did not. Germline Gata4 haploinsufficiency exacerbated the secondary phenotype of postovariectomy obesity in B6D2F1 mice, presumably by limiting ectopic estrogen production in the adrenal glands. Amhr2 -cre-mediated deletion of floxed Gata4 ( Gata4 F ) in nascent adrenocortical neoplasms of ovariectomized B6.129 mice reduced tumor growth and the expression of gonadal-like markers in a Gata4 F dose-dependent manner. We conclude that GATA4 is a key modifier of gonadectomy-induced adrenocortical neoplasia, postovariectomy obesity, and sex steroidogenic cell differentiation.
    Print ISSN: 0013-7227
    Thema: Medizin
    Publiziert von Oxford University Press im Namen von The Endocrine Society.
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  • 8
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    Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster (2012)
    Oxford University Press
    Details
    Publikationsdatum: 2012-02-28
    Beschreibung: Histone post-translational modifications play an important role in regulating chromatin structure and gene expression in vivo . Extensive studies investigated the post-translational modifications of the core histones H3 and H4 or the linker histone H1. Much less is known on the regulation of H2A and H2B modifications. Here, we show that a major modification of H2B in Drosophila melanogaster is the methylation of the N-terminal proline, which increases during fly development. Experiments performed in cultured cells revealed higher levels of H2B methylation when cells are dense, regardless of their cell cycle distribution. We identified dNTMT (CG1675) as the enzyme responsible for H2B methylation. We also found that the level of N-terminal methylation is regulated by dART8, an arginine methyltransferase that physically interacts with dNTMT and asymmetrically methylates H3R2. Our results demonstrate the existence of a complex containing two methyltransferases enzymes, which negatively influence each other’s activity.
    Print ISSN: 0305-1048
    Digitale ISSN: 1362-4962
    Thema: Biologie
    Publiziert von Oxford University Press
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  • 9
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    Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities (2012)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2012-12-19
    Beschreibung: Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities The ISME Journal 7, 224 (January 2013). doi:10.1038/ismej.2012.95 Authors: Ryan T Jones, Sara M Vetter, John Montenieiri, Jennifer Holmes, Scott A Bernhardt & Kenneth L Gage
    Schlagwort(e): Bartonellaexperimental infectionplague
    Print ISSN: 1751-7362
    Digitale ISSN: 1751-7370
    Thema: Biologie
    Publiziert von Nature Publishing Group (NPG) im Namen von The International Society for Microbial Ecology (ISME).
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  • 10
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    Technical comments on the data records from the Vernagtbach station for the period 1970 to 2001 (2012)
    PANGAEA
    In:  EPIC3Bremerhaven, PANGAEA
    Details
    Publikationsdatum: 2019-07-17
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: PANGAEA Documentation , notRev
    Format: application/pdf
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