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Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling (2012)

Irina Vetter; Filip Touska; Andreas Hess; Rachel Hinsbey; Simon Sattler; Angelika Lampert; Marina Sergejeva; Anastasia Sharov; Lindon S Collins; Mirjam Eberhardt; Matthias Engel; Peter J Cabot; John N Wood; Viktorie VlachováPeter W Reeh; Richard J Lewis; Katharina Zimmermann

Nature Publishing Group (NPG)

In: EMBO Journal

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Publikationsdatum: 2012-10-04

Beschreibung: Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling The EMBO Journal 31, 3795 (2012). doi:10.1038/emboj.2012.207 Authors: Irina Vetter, Filip Touska, Andreas Hess, Rachel Hinsbey, Simon Sattler, Angelika Lampert, Marina Sergejeva, Anastasia Sharov, Lindon S Collins, Mirjam Eberhardt, Matthias Engel, Peter J Cabot, John N Wood, Viktorie Vlachová, Peter W Reeh, Richard J Lewis & Katharina Zimmermann Ciguatoxins are sodium channel activator toxins that cause ciguatera, the most common form of ichthyosarcotoxism, which presents with peripheral sensory disturbances, including the pathognomonic symptom of cold allodynia which is characterized by intense stabbing and burning pain in response to mild cooling. We show that

Schlagwort(e): ciguatoxincold allodyniaNavnociceptorTRPA1

Print ISSN: 0261-4189

Digitale ISSN: 1460-2075

Thema: Biologie , Medizin

Publiziert von Nature Publishing Group (NPG) im Namen von The European Molecular Biology Organization (EMBO).

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Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119 (2012)

Shehab A Ismail; Yong-Xiang Chen; Mandy Miertzschke; Ingrid R Vetter; Carolin Koerner; Alfred Wittinghofer

Nature Publishing Group (NPG)

In: EMBO Journal

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Publikationsdatum: 2012-10-18

Beschreibung: The EMBO Journal 31, 4085 (2012). doi:10.1038/emboj.2012.257 Authors: Shehab A Ismail, Yong-Xiang Chen, Mandy Miertzschke, Ingrid R Vetter, Carolin Koerner & Alfred Wittinghofer Access to the ciliary membrane for trans-membrane or membrane-associated proteins is a regulated process. Previously, we have shown that the closely homologous small G proteins Arl2 and Arl3 allosterically regulate prenylated cargo release from PDEδ. UNC119/HRG4 is responsible for ciliary delivery of myristoylated cargo. Here,

Schlagwort(e): Arfsciliaprotein traffickingreleasing factorssmall G proteins

Print ISSN: 0261-4189

Digitale ISSN: 1460-2075

Thema: Biologie , Medizin

Publiziert von Nature Publishing Group (NPG) im Namen von The European Molecular Biology Organization (EMBO).

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Flagellin Perception Varies Quantitatively in Arabidopsis thaliana and Its Relatives (2012)

Vetter, M. M., Kronholm, I., He, F., Haweker, H., Reymond, M., Bergelson, J., Robatzek, S., de Meaux, J.

Oxford University Press

In: Molecular Biology and Evolution

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Publikationsdatum: 2012-05-16

Beschreibung: Much is known about the evolution of plant immunity components directed against specific pathogen strains: They show pervasive functional variation and have the potential to coevolve with pathogen populations. However, plants are effectively protected against most microbes by generalist immunity components that detect conserved pathogen-associated molecular patterns (PAMPs) and control the onset of PAMP-triggered immunity. In Arabidopsis thaliana , the receptor kinase flagellin sensing 2 (FLS2) confers recognition of bacterial flagellin (flg22) and activates a manifold defense response. To decipher the evolution of this system, we performed functional assays across a large set of A. thaliana genotypes and Brassicaceae relatives. We reveal extensive variation in flg22 perception, most of which results from changes in protein abundance. The observed variation correlates with both the severity of elicited defense responses and bacterial proliferation. We analyzed nucleotide variation segregating at FLS2 in A. thaliana and detected a pattern of variation suggestive of the rapid fixation of a novel adaptive allele. However, our study also shows that evolution at the receptor locus alone does not explain the evolution of flagellin perception; instead, components common to pathways downstream of PAMP perception likely contribute to the observed quantitative variation. Within and among close relatives, PAMP perception evolves quantitatively, which contrasts with the changes in recognition typically associated with the evolution of R genes.

Print ISSN: 0737-4038

Digitale ISSN: 1537-1719

Thema: Biologie

Publiziert von Oxford University Press

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GATA4 Is a Critical Regulator of Gonadectomy-Induced Adrenocortical Tumorigenesis in Mice (2012)

Krachulec, J., Vetter, M., Schrade, A., Lobs, A.-K., Bielinska, M., Cochran, R., Kyronlahti, A., Pihlajoki, M., Parviainen, H., Jay, P. Y., Heikinheimo, M., Wilson, D. B.

Oxford University Press

In: Endocrinology

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Publikationsdatum: 2012-06-12

Beschreibung: In response to gonadectomy certain inbred mouse strains develop sex steroidogenic adrenocortical neoplasms. One of the hallmarks of neoplastic transformation is expression of GATA4, a transcription factor normally present in gonadal but not adrenal steroidogenic cells of the adult mouse. To show that GATA4 directly modulates adrenocortical tumorigenesis and is not merely a marker of gonadal-like differentiation in the neoplasms, we studied mice with germline or conditional loss-of-function mutations in the Gata4 gene. Germline Gata4 haploinsufficiency was associated with attenuated tumor growth and reduced expression of sex steroidogenic genes in the adrenal glands of ovariectomized B6D2F1 and B6AF1 mice. At 12 months after ovariectomy, wild-type B6D2F1 mice had biochemical and histological evidence of adrenocortical estrogen production, whereas Gata4 +/– B6D2F1 mice did not. Germline Gata4 haploinsufficiency exacerbated the secondary phenotype of postovariectomy obesity in B6D2F1 mice, presumably by limiting ectopic estrogen production in the adrenal glands. Amhr2 -cre-mediated deletion of floxed Gata4 ( Gata4 F ) in nascent adrenocortical neoplasms of ovariectomized B6.129 mice reduced tumor growth and the expression of gonadal-like markers in a Gata4 F dose-dependent manner. We conclude that GATA4 is a key modifier of gonadectomy-induced adrenocortical neoplasia, postovariectomy obesity, and sex steroidogenic cell differentiation.

Print ISSN: 0013-7227

Thema: Medizin

Publiziert von Oxford University Press im Namen von The Endocrine Society.

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Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster (2012)

Villar-Garea, A., Forne, I., Vetter, I., Kremmer, E., Thomae, A., Imhof, A.

Oxford University Press

In: Nucleic Acids Research

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Publikationsdatum: 2012-02-28

Beschreibung: Histone post-translational modifications play an important role in regulating chromatin structure and gene expression in vivo . Extensive studies investigated the post-translational modifications of the core histones H3 and H4 or the linker histone H1. Much less is known on the regulation of H2A and H2B modifications. Here, we show that a major modification of H2B in Drosophila melanogaster is the methylation of the N-terminal proline, which increases during fly development. Experiments performed in cultured cells revealed higher levels of H2B methylation when cells are dense, regardless of their cell cycle distribution. We identified dNTMT (CG1675) as the enzyme responsible for H2B methylation. We also found that the level of N-terminal methylation is regulated by dART8, an arginine methyltransferase that physically interacts with dNTMT and asymmetrically methylates H3R2. Our results demonstrate the existence of a complex containing two methyltransferases enzymes, which negatively influence each other’s activity.

Print ISSN: 0305-1048

Digitale ISSN: 1362-4962

Thema: Biologie

Publiziert von Oxford University Press

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Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities (2012)

Ryan T Jones; Sara M Vetter; John Montenieiri; Jennifer Holmes; Scott A Bernhardt; Kenneth L Gage

Nature Publishing Group (NPG)

In: ISME Journal

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Publikationsdatum: 2012-12-19

Beschreibung: Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities The ISME Journal 7, 224 (January 2013). doi:10.1038/ismej.2012.95 Authors: Ryan T Jones, Sara M Vetter, John Montenieiri, Jennifer Holmes, Scott A Bernhardt & Kenneth L Gage

Schlagwort(e): Bartonellaexperimental infectionplague

Print ISSN: 1751-7362

Digitale ISSN: 1751-7370

Thema: Biologie

Publiziert von Nature Publishing Group (NPG) im Namen von The International Society for Microbial Ecology (ISME).

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Technical comments on the data records from the Vernagtbach station for the period 1970 to 2001 (2012)

Escher-Vetter, Heidi

PANGAEA

In: EPIC3Bremerhaven, PANGAEA

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Publikationsdatum: 2019-07-17

Repository-Name: EPIC Alfred Wegener Institut

Materialart: PANGAEA Documentation , notRev

Format: application/pdf

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Hydrological and meteorological records from the Vernagtferner Basin - Vernagtbach station, for the years 1970 to 2001 (2012)

Escher-Vetter, Heidi ; Oerter, Hans ; Reinwarth, Oskar ; [weitere]

PANGAEA

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Publikationsdatum: 2023-05-12

Beschreibung: The Vernagtferner region has a long tradition of glaciological research performed by groups from Munich. It started in 1889, when Prof. Sebastian Finsterwalder from the Technical University in Munich produced the first map of a complete glacier based on terrestrial photogrammetry. Since then, numerous maps of the glacier have been made, describing the change in surface elevation for more than a century. These maps form the basis of the geodetic method of glacier mass balance determination, which provides volume changes as average data for the period between two surveys, i.e. typically for 10 years. Since the start of the glaciological method on Vernagtferner in 1964, annual as well as winter and summer mass balance data are available continuously. But only since 1973, the construction of the Vernagtbach station, approximately 1 km below the glacier margin at that time, provided the means to record a larger number of hydrological and meteorological parameters with a temporal resolution of typically 1 hour.

Schlagwort(e): Glaciers Austria; Pegelstation_Vernagtbach; Pegelstation_Vernagtbach_meteorology; UGS; Unmanned gauge station; Unmanned weather station/meteorological observation; UWST; Vernagtferner, Ötztaler Alpen, Austria

Materialart: Dataset

Format: application/zip, 87 datasets

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Hydrological records from the Vernagtferner Basin - Vernagtbach station, for the year 1987 (2012)

Escher-Vetter, Heidi ; Reinwarth, Oskar

PANGAEA

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Publikationsdatum: 2023-01-30

Schlagwort(e): DATE/TIME; Glaciers Austria; Pegelstation_Vernagtbach; River discharge; UGS; Unmanned gauge station; Vernagtferner, Ötztaler Alpen, Austria; Vertical standpipe monitoring

Materialart: Dataset

Format: text/tab-separated-values, 4416 data points

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Hydrological records from the Vernagtferner Basin - Vernagtbach station, for the year 1989 (2012)

Escher-Vetter, Heidi ; Reinwarth, Oskar

PANGAEA

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Publikationsdatum: 2023-01-30

Schlagwort(e): DATE/TIME; Glaciers Austria; Pegelstation_Vernagtbach; River discharge; UGS; Unmanned gauge station; Vernagtferner, Ötztaler Alpen, Austria; Vertical standpipe monitoring

Materialart: Dataset

Format: text/tab-separated-values, 4416 data points

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