In:
Chemical Biology & Drug Design, Wiley, Vol. 78, No. 1 ( 2011-07), p. 94-100
Abstract:
Three natural products, 1,5‐diphenylpentan‐1‐one, 1,5‐diphenylpent‐2‐en‐1‐one, and 3‐hydroxy‐1,5‐diphenylpentan‐1‐one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as ‘pharmacophores’, a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity. All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities. Compound III with a furyl ring showed strong activities against plant pathogenic fungi. The IC 50 of compound ( E ) ‐1‐ ( 2,4‐dichlorophenyl ) ‐3‐ ( furan‐2‐yl ) ‐ ‐prop‐2‐en‐1‐one ( III 2 ) was 1.20 mg/L against Rhizoctonia solani , suggesting its strong potential as a novel antifungal drug.
Type of Medium:
Online Resource
ISSN:
1747-0277
,
1747-0285
DOI:
10.1111/jpp.2011.78.issue-1
DOI:
10.1111/j.1747-0285.2011.01082.x
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
2216600-2
SSG:
12
Permalink