In:
Annals of Nutrition and Metabolism, S. Karger AG, Vol. 58, No. 2 ( 2011), p. 150-157
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 Changes in lipid profiles have been shown to be associated with diet and apolipoprotein (APO) polymorphisms. Therefore, 2 polymorphisms, i.e. 〈 i 〉 APOA5- 〈 /i 〉 1131T 〉 C and 〈 i 〉 APOC3- 〈 /i 〉 482C 〉 T, and serum lipids were examined in a Chinese healthy young population with high-carbohydrate/low-fat (HC/LF) diet intervention. 〈 i 〉 Methods: 〈 /i 〉 After a wash-out diet for 7 days, 56 young adults (22.89 ± 1.80 years) received the HC/LF diet for 6 days. Body mass index (BMI) and fasting serum lipid profiles at baseline, after the wash-out diet, and after the HC/LF diet were measured. 〈 i 〉 Results: 〈 /i 〉 APOA5-1131C carriers had higher triglyceride (TG) and TG-rich lipoprotein TG (TRL-TG) levels at baseline and after the HC/LF diet, though this mainly corresponded to the female cohort. APOC3-482T carriers had higher TRL-TG levels following the wash-out and HC/LF diets, but these were not directly attributable to a single gender. 〈 i 〉 Conclusions: 〈 /i 〉 Both polymorphisms may play an important role in the elevated TG and TRL-TG levels induced by the HC/LF diet, especially in females, thus indicating a potential dietary prevention of coronary heart disease in this Chinese cohort.
Type of Medium:
Online Resource
ISSN:
0250-6807
,
1421-9697
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
1481977-6
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