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  • SAGE Publications  (16)
  • 2005-2009  (16)
  • 2009  (16)
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  • SAGE Publications  (16)
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  • 2005-2009  (16)
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  • 2009  (16)
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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  American Journal of Rhinology & Allergy Vol. 23, No. 5 ( 2009-09), p. 506-511
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 23, No. 5 ( 2009-09), p. 506-511
    Abstract: Patients with chronic rhinosinusitis (CRS) often remain symptomatic after technically proficient functional endoscopic sinus surgery. Current hypothesis indicates biofilms may contribute to the persistence of infection. However, few studies showed biofilms in postoperative patients. This study was designed to identify bacterial biofilms on postoperative mucosa, as well as to investigate the healing of sinus mucosa after surgery. Methods After intraoperative mucosa was obtained for assessment of biofilms, 27 patients were followed up for 6 months. Postoperative medications and symptoms were recorded. As indicated by endoscopic evaluation, biopsy specimens of postoperative edema, scar, or adhesion were obtained. Samples were prepared for scanning electron microscopy (SEM) and hematoxylin and eosin (H & E) staining. Results Fifteen postoperative samples were taken from the 20 patients with intraoperative biofilms. Under SEM, postoperative biofilms were identified in 4/6 scar samples and 5/9 edema samples. There was no significant difference in biofilm presence between samples of scar and edema. Microcolonies were also identified on postoperative scar under H & E staining. The presence of intraoperative and postoperative biofilms was correlated with the severity of preoperative Lund-MacKay computed tomography score and postoperative Lund-Kennedy endoscopic score. Compared with intraoperative samples, postoperative samples from the same nine patients significantly recovered from ciliary damage, metaplasia, and basement membrane thickness. Postoperative cultures were positive in samples with and without postoperative biofilms. Conclusion Biofilms persist after treatment, and may cause the unfavorable outcomes of surgery for CRS. The mucosa with biofilms can recover after surgery. Apparent bacterial plaque can be identified by H & E staining.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2554548-6
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  Journal of International Medical Research Vol. 37, No. 2 ( 2009-03), p. 511-519
    In: Journal of International Medical Research, SAGE Publications, Vol. 37, No. 2 ( 2009-03), p. 511-519
    Abstract: The present study explored the tissue-protective effect of erythropoietin in rats after experimental spinal cord injury (SCI) produced by dropping a weight onto surgically exposed spinal cord. Sixty rats were randomized to sham operation (spinal cord exposure; control), SCI plus intraperitoneal saline injection, or SCI plus intraperitoneal erythropoietin injection. Locomotor function was evaluated with Basso, Beattie and Bresnahan scores 1 day (24 h) and 7 days later, and rats were then killed for analysis of lesion site tissue. Compared with saline-treated SCI rats, erythropoietin-treated SCI rats showed significantly less locomotor dysfunction and faster locomotor recovery. Immunohistochemistry showed that erythropoietin-treated SCI rats had a significantly lower phospho-extracellular signal-regulated kinase (p-ERK) protein expression and a significantly higher mitogen-activated protein kinase phosphatase-1 (MKP-1) protein expression than saline-treated SCI rats. Haematoxylin–eosin staining showed progressive disruption of dorsal white matter and neuron loss after SCI; lesions were less severe and there was more neuron regeneration in the erythropoietin group than in the saline group. It is concluded that erythropoietin reduces pathological changes and SCI severity via down-regulation of p-ERK and up-regulation of MKP-1.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2082422-1
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  Journal of International Medical Research Vol. 37, No. 6 ( 2009-12), p. 1994-1999
    In: Journal of International Medical Research, SAGE Publications, Vol. 37, No. 6 ( 2009-12), p. 1994-1999
    Abstract: Parotid metastasis of nasopharyngeal carcinoma (NPC) is extremely rare. The current case report presents the history of a 41-year old male with the primary symptom of a right parotid gland mass who was diagnosed with NPC by histopathology in 2006 and was staged as having cT 3 N 2 M 0 disease (stage III, American Joint Committee on Cancer staging system, 2002). Histopathological examination of a partial excision of the mass on the right parotid and the neoplasm in the pharynx nasalis revealed poorly differentiated squamous cell carcinoma. The patient received radiotherapy and concurrent chemotherapy. Grade 2 skin reaction, grade 2 oropharyngeal mucositis and grade 3 xerostomia were detected during treatment. The patient achieved a complete clinical response by 1 month after treatment. At the last follow-up in August 2009, the patient was in a good condition and living a normal life. The primary symptom of parotid gland mass in patients with NPC is commonly misdiagnosed and a pathological analysis can be considered a reliable method for confirming diagnosis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2082422-1
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  International Journal of Distributed Sensor Networks Vol. 5, No. 1 ( 2009-01-01), p. 12-12
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 5, No. 1 ( 2009-01-01), p. 12-12
    Abstract: Intelligent mobile phones equipped with a camera are very popular in our daily lives now. Face verification running on mobile phone provides not only a tool for the protection of the owner's authority but also an approach for verification from a distance. The combination of biometrics and telecommunication technologies possesses broad application potentials in information exchanges. However, there are also some critical issues needing solving. Usually the processing power and memory size of a mobile phone system are limited, and the acquisition images are suffered from the illumination changes. An acquisition image I(x,y) can be modeled as a product of the reflectance R and Illuminant effect L shown as I(x,y) = R(x,y)∗L(x,y). The reflectance attribution R(x,y) is the inherent feature of a human face for verification. Compared with the reflectance changes rapidly across the contour of a face, usually the illumination changes smoothly and slowly. If two pixels are located nearby, the ratio of the reflectance between these two pixels can be calculated via the ratio of their illuminations, which is approximately independent from illumination changes. Based on this invariant property of the ratio of illumination at a pixel to its surrounding neighbor illuminations, an illumination normalization technique was developed and adapted to the mobile system. A dedicated scheme composed of special wavelets called Gab features was proposed for representation of human faces. Gabor features reveal more structure information of images; however, the data dimensionality is becoming very high. An optimization processing was designed for searching the optimal Gabor node configuration and reducing the number of Gabor nodes effectively. To fit the limitation of the phone processor, all the floating point calculations were implemented with integer calculations, the feature extraction and discriminating verification algorithms were carefully designed to accelerate implementation and control the heap and stack sizes. A mobile based face verification system was developed and embedded in the Lenovo ET980 mobile phone, which is equipped with CPU Intel XScale PX270, memory 128MB Flash/64 MB SDRAM, and a 4 million pixel camera. The experiments testing on FERET fafb dataset show that the system Equal False Accept Rate and False Reject Rate achieved 1.51%; and the False Accept Rates achieved 2.12% and 6.81%, while the False Reject Rate at 1% and 0.1% respectively. The processing time is about 1 second. The performance of this system is quite well.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2192922-1
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  • 5
    In: Annals of Pharmacotherapy, SAGE Publications, Vol. 43, No. 4 ( 2009-04), p. 726-731
    Abstract: Ginkgo biloba is one of the most popular herbal supplements in the world. The supplement has been shown to induce the enzymatic activity of CYP2C19, the main cytochrome P450 isozyme involved in voriconazole metabolism. Because this enzyme exhibits genetic polymorphism, the inductive effect was expected to be modulated by the CYP2C19 metabolizer status. Objective: To examine the possible effects of Ginkgo biloba as an inducer of CYP2C19 on single-dose pharmacokinetics of voriconazole in Chinese volunteers genotyped as either CVP2C19 extensive or poor metabolizers. Methods: Fourteen healthy, nonsmoking volunteers–7 CYP2C19 extensive metabolizers (2C19*1/2C19*1) and 7 poor metabolizers (2C19*2/2C19*2)–were selected to participate in this study. Pharmacokinetics of oral voriconazole 200 mg after administration of Ginkgo biloba 120 mg twice daily for 12 days were determined for up to 24 hours by liquid chromatography–electrospray tandem mass spectrometry in a 2-phase randomized crossover study with 4-week washout between phases. Results: For extensive metabolizers, the median value for voriconazole area under the plasma concentration–time curve from zero to infinity (AUC 0-00 ) was 5.17 μg•h/mL after administration of voriconazole alone and 4.28 μg•/mL after voriconazole with Ginkgo biloba (p 〉 0.05). The other pharmacokinetic parameters of voriconazole such as AUC 0-24 , time to reach maximum concentration, half-life, and apparent clearance also did not change significantly for extensive metabolizers in the presence of Ginkgo biloba. Pharmacokinetic parameters followed a similar pattern for poor metabolizers. Conclusions: The results suggest that 12 days of treatment with Ginkgo biloba did not significantly alter the single-dose pharmacokinetics of voriconazole in either CYP2C19 extensive or poor metabolizers. Therefore, the pharmacokinetic interactions between voriconazole and Ginkgo biloba may have limited clinical significance.
    Type of Medium: Online Resource
    ISSN: 1060-0280 , 1542-6270
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2053518-1
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  Experimental Biology and Medicine Vol. 234, No. 9 ( 2009-09), p. 1029-1036
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 234, No. 9 ( 2009-09), p. 1029-1036
    Abstract: Angiotensin II (Ang II) has been recognized as an apoptosis inducer in podocytes, but the mechanism of apoptosis induced by Ang II is unclear. Transient receptor potential cation channel 6 (TRPC6) is a calcium channel located in podocyte membrane. The present study evaluated the alteration of TRPC6 expression and the Ca 2+ influx involved in Ang II-induced podocyte apoptosis. The possible pathways related to TRPC6 in Ang II-induced podocyte apoptosis were also investigated. The apoptosis of mouse podocytes (MPC5) was induced by Ang II. The protein level of TRPC6 was increased markedly in response to Ang II stimulation, and the intracellular Ca 2+ concentration was elevated. By transfection with TRPC6 siRNA, Ang II-induced podocyte apoptosis and the transient Ca 2+ influx were inhibited. Treated with extracellular signal-regulated kinase (ERK) pathway specific inhibitor U0126 or nuclear factor-κB (NF-κB) pathway specific inhibitor ammonium pyrrolidinedithiocarbamate (PDTC) and Ang II, respectively in podocytes, not only was the TRPC6 up-regulation reduced, but the podocyte apoptosis was also decreased. Moreover, the translocation of NF-κB in nucleus resulted from Ang II was reduced by treatment with U0126. In conclusion, the enhancement expression of TRPC6 as well as the increased Ca 2+ influx mediated by TRPC6 channels contributed to the podocyte apoptosis. The activation of ERK pathway and subsequent translocation of NF-κB was possibly necessary for the up-regulation TRPC6 induced by Ang II.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2124, No. 1 ( 2009-01), p. 222-230
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2124, No. 1 ( 2009-01), p. 222-230
    Abstract: The distribution of time headway has long been a research topic because headway between vehicles is an important flow characteristic affecting safety, level of service, driver behavior, and capacity of a transportation system. However, almost all reported research on headway is focused on mixed vehicular flow without considering the difference in headway with respect to different vehicle types. In this paper, with the use of 1-day freeway traffic data from Interstate 35 in Austin, Texas, four time headway types based on different combinations of leading vehicles and following vehicles–-car–truck, truck–car, truck–truck, and car–car–-are analyzed at different traffic flow levels. Statistical comparisons between each vehicle type–specific headway and mixed vehicle–type headway are made to verify their significant differences. The paper demonstrates the necessity of vehicle type–specific headway study. The results of the paper not only identify qualitative differences between the vehicle type–specific headways and distributions, but also can be used as a reference for practical applications, especially for improving microscopic traffic simulation models.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2403378-9
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  Journal of International Medical Research Vol. 37, No. 1 ( 2009-02), p. 31-36
    In: Journal of International Medical Research, SAGE Publications, Vol. 37, No. 1 ( 2009-02), p. 31-36
    Abstract: Human cytomegalovirus (HCMV) infection is a common complication in transplant recipients. Sensitive, specific and timely diagnostic tests for the detection of HCMV infection remain essential for successful therapy. The results of three tests to detect HCMV in bone marrow and liver transplant recipients were compared: a pp65 antigenaemia assay, an immediate-early (IE) antigenaemia assay and an anti-HCMV immunoglobulin M (IgM) antibody enzyme-linked immunosorbent assay (ELISA). Of 1344 samples, 911 (67.8%) and 917 (68.2%) samples were positive for pp65 and IE, respectively. The coincidence level was 85.1%. There was no statistical difference after transplantation to the first positive detection of HCMV (mean first checkout time) between the pp65 and IE antigenaemia assays. Moreover, the levels of HCMV detected by the pp65 and IE antigenaemia assays were significantly correlated. The HCMV-positivity rate as detected by the anti-HCMV IgM ELISA was 11.1%, which was significantly different from the IE and pp65 antigenaemia assays. We suggest that the IE antigenaemia assay could replace the pp65 antigenaemia assay for monitoring active HCMV infection and early detection of HCMV infection.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2082422-1
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  The International Journal of Biological Markers Vol. 24, No. 4 ( 2009), p. 271-276
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 24, No. 4 ( 2009), p. 271-276
    Type of Medium: Online Resource
    ISSN: 0393-6155
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 1475778-3
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  The International Journal of Biological Markers Vol. 24, No. 4 ( 2009-10), p. 271-276
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 24, No. 4 ( 2009-10), p. 271-276
    Abstract: Quantum dots (QDs) as a biological labeling material for medical applications need to be evaluated for the sensitivity and stability of their fluorescence. Comparison of QD-based immunolabeling and commonly used immunohistochemical staining in detecting the expression of prostate stem cell antigen (PSCA) in bladder tumor tissues revealed that the two methods had similar sensitivity in the differential display of PSCA expression correlated with tumor stage and grade (κ=0.92, p 〈 0.001). In addition, the intensity of QD fluorescence remained stable for at least 10 days after conjugation to the PSCA protein and nearly 96% of the positive expression in samples lasted for one month.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 1475778-3
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