In:
Blood Purification, S. Karger AG, Vol. 26, No. 4 ( 2008), p. 340-346
Abstract:
〈 i 〉 Background: 〈 /i 〉 Malnutrition is a predictor of cardiovascular disease in dialysis patients, but the mechanisms remain unknown. We investigated links between nutritional markers and arterial stiffness in continuous ambulatory peritoneal dialysis patients. 〈 i 〉 Methods: 〈 /i 〉 We evaluated the relationship between arterial stiffness evaluated by pulse-wave velocity (PWV) and four estimates of nutritional status (serum albumin, handgrip strength [HGS], subjective global assessment [SGA] , and bioelectrical impedance analysis phase angle [PA]) in 124 PD patients. 〈 i 〉 Results: 〈 /i 〉 Malnourished patients exhibited a significantly higher PWV than those classified as well-nourished by SGA (p 〈 0.05). Furthermore, PWV correlated negatively with albumin, HGS and PA (p 〈 0.001, respectively). PWV was also correlated with age, systolic blood pressure, and C-reactive protein. In multivariate regression analysis, albumin, HGS, SGA and PA were each independently associated with PWV after adjustment. 〈 i 〉 Conclusions: 〈 /i 〉 The significant association between each nutritional marker and PWV in PD patients was independent of inflammation and diabetic state, suggesting that malnutrition may contribute to vascular dysfunction.
Type of Medium:
Online Resource
ISSN:
0253-5068
,
1421-9735
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
1482025-0
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