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  • S. Karger AG  (9)
  • 2005-2009  (9)
  • 2008  (9)
  • 1
    Online Resource
    Online Resource
    Utility of the Rapid B-Type Natriuretic Peptide Assay for Detection of Cardiovascular Problems in Newborn Infants with Respiratory Difficulties
    S. Karger AG ; 2008
    In:  Neonatology Vol. 94, No. 1 ( 2008), p. 16-21
    Details
    In: Neonatology, S. Karger AG, Vol. 94, No. 1 ( 2008), p. 16-21
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Because the major problems of respiratory difficulties in newborn infants are due to cardiopulmonary problems, improving the early detection and referral of newborn infants with cardiovascular problems has been considered one of the primary goals of care in the neonatal intensive care unit. 〈 i 〉 Objective: 〈 /i 〉 To evaluate whether rapid plasma B-type natriuretic peptide (BNP) assay could be used as a screening test to detect the cardiovascular problems in newborn infants with respiratory difficulties. 〈 i 〉 Methods: 〈 /i 〉 We studied 73 newborn infants ≧34 weeks gestational age presenting with respiratory difficulties during the first few days after birth; they were divided into a cardiovascular problem group (CP group, n = 32) and a noncardiac problem group (NP group, n = 41) according to the presence of cardiovascular problems by clinical and/or echocardiographic studies in newborn infants with respiratory difficulties. 〈 i 〉 Results: 〈 /i 〉 On admission, the median (25–75%) BNP concentration of the CP group was significantly higher than that of the NP group [1,038 (578–1,435) vs. 240 (118–388) pg/ml, p 〈 0.001]. The best cutoff BNP values for differentiating the CP group were 346.0, 421.0, 570.5 and 191.5 pg/ml within 18 h, at 18–36 h, at 36–60 h and after 60 h of life, respectively. Although the plasma BNP measurement was not a single confirmative test, it was found to have a high sensitivity and a high negative predictive value for rapidly ruling out serious cardiovascular problems in neonatal respiratory difficulties. 〈 i 〉 Conclusion: 〈 /i 〉 A rapid plasma BNP assay may be useful for detection of cardiovascular problems in newborn infants with respiratory difficulties during the first few days after birth.
    Type of Medium: Online Resource
    ISSN: 1661-7800 , 1661-7819
    URL: Article
    DOI: 10.1159/000112584
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 2403535-X
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    〈i〉PDGFR〈/i〉α Gene Mutation and Protein Expression in Gastrointestinal Stromal Tumors
    S. Karger AG ; 2008
    In:  Oncology Vol. 74, No. 1-2 ( 2008), p. 88-95
    Details
    In: Oncology, S. Karger AG, Vol. 74, No. 1-2 ( 2008), p. 88-95
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 Mutation of the 〈 i 〉 PDGFR 〈 /i 〉 α is a potential candidate in the pathogenesis of 〈 i 〉 KIT 〈 /i 〉 wild-type gastrointestinal tumors (GISTs). In this study, we evaluated the prevalence of 〈 i 〉 PDGFR 〈 /i 〉 α mutations and corresponding protein expression in GISTs, to determine their usefulness in obtaining a prognosis. 〈 i 〉 Methods: 〈 /i 〉 Genomic DNA was extracted from paraffin-embedded tumor tissues from 194 GISTs. Exons 12, 14 and 18 of the 〈 i 〉 PDGFR 〈 /i 〉 α were amplified and sequenced. Immunohistochemical staining was performed in 179 patients. 〈 i 〉 Results: 〈 /i 〉 Mutations in the 〈 i 〉 PDGFR 〈 /i 〉 α were detected in 6 (3.1%) patients, and were observed solely in 〈 i 〉 KIT 〈 /i 〉 wild-type GISTs. Among the 6 patients with 〈 i 〉 PDGFR 〈 /i 〉 α gene mutations, 5 patients with localized GISTs showed no relapse after resection during the 19- to 80-month follow-up period. Intensity of PDGFRα expression was classified as 0 in 26 (14.5%), 1+ in 69 (38.5%), 2+ in 71 (39.7%) and 3+ in 13 (7.3%) patients. Levels of PDGFRα expression showed no correlation with relapse-free survival. 〈 i 〉 Conclusion: 〈 /i 〉 〈 i 〉 PDGFR 〈 /i 〉 α mutations in GISTs were found to be rare in this Korean population. Although localized GISTs with 〈 i 〉 PDGFR 〈 /i 〉 α mutations showed relatively good prognosis after resection, the difference was not statistically significant.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000139136
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 3
    Online Resource
    Online Resource
    Generic and Disease-Specific Health-Related Quality of Life in Women with Coital Incontinence: A Prospective, Multicenter Study
    S. Karger AG ; 2008
    In:  Gynecologic and Obstetric Investigation Vol. 65, No. 1 ( 2008), p. 62-67
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 65, No. 1 ( 2008), p. 62-67
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 This study was carried out to evaluate the impact of coital incontinence on health-related quality of life (HRQOL) in women with lower urinary tract symptoms. 〈 i 〉 Methods: 〈 /i 〉 A total of 180 women with sexual activity were evaluated. To obtain HRQOL assessments, patients were asked to fill out the Bristol Female Lower Urinary Tract Symptoms and the Medical Outcomes Study Short Form (SF-36) questionnaires. 〈 i 〉 Results: 〈 /i 〉 The coital incontinence group had more frequently symptoms including urgency, urge incontinence, bladder pain, stress incontinence, unpredictable incontinence, nocturnal incontinence, reduced stream, and stopping flow than the no coital incontinence group. The frequency of incontinence and volume of leakage were also higher in the coital incontinence group than the no coital incontinence group. All symptom questions regarding sexual matters and quality of life except cutting down on fluid were more frequent in patients with coital incontinence than those without coital incontinence. Of the eight domains in the SF-36 questionnaire, five domains, namely, Physical functioning, Role-physical functioning, Social functioning, Role-emotional functioning, and Mental health were significantly different between the two groups. When comparing the Bristol Female Lower Urinary Tract Symptoms scores in the two groups, the scores in all domains except Voiding symptoms in the coital incontinence group were significantly higher than those in the no coital incontinence group. Patients with coital incontinence had more HRQOL impairment than those without coital incontinence. 〈 i 〉 Conclusions: 〈 /i 〉 Our study reveals that more emphasis should be placed on coital incontinence in the terminology of urinary incontinence.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000107978
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482695-1
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  • 4
    Online Resource
    Online Resource
    A Randomized Double-Blind, Placebo-Controlled Study to Establish the Effects of Spirulina in Elderly Koreans
    S. Karger AG ; 2008
    In:  Annals of Nutrition and Metabolism Vol. 52, No. 4 ( 2008), p. 322-328
    Details
    In: Annals of Nutrition and Metabolism, S. Karger AG, Vol. 52, No. 4 ( 2008), p. 322-328
    Abstract: 〈 i 〉 Aims: 〈 /i 〉 This study was conducted to determine the antioxidant capacity, immunomodulatory and lipid-lowering effects of spirulina in healthy elderly subjects and to document the effectiveness of spirulina as a functional food for the elderly. 〈 i 〉 Methods: 〈 /i 〉 A randomized double-blind, placebo-controlled study was performed. The subjects were 78 individuals aged 60–87 years and were randomly assigned in a blinded fashion to receive either spirulina or placebo. The elderly were instructed to consume the spirulina or placebo at home, 8 g/day, for 16 consecutive weeks. 〈 i 〉 Results: 〈 /i 〉 In male subjects, a significant plasma cholesterol-lowering effect was observed after the spirulina intervention (p 〈 0.05). Spirulina supplementation resulted in a significant rise in plasma interleukin (IL)-2 concentration, and a significant reduction in IL-6 concentration. A significant time-by-treatment intervention for total antioxidant status was observed between spirulina and placebo groups (p 〈 0.05). In female subjects, significant increases in IL-2 level and superoxide dismutase activity were observed (p 〈 0.05) after spirulina supplementation. There were significant reductions in total cholesterol in female subjects. 〈 i 〉 Conclusions: 〈 /i 〉 The results demonstrate that spirulina has favorable effects on lipid profiles, immune variables, and antioxidant capacity in healthy, elderly male and female subjects and is suitable as a functional food.
    Type of Medium: Online Resource
    ISSN: 0250-6807 , 1421-9697
    URL: Article
    DOI: 10.1159/000151486
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1481977-6
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  • 5
    Online Resource
    Online Resource
    Serum Lactate Dehydrogenase Is a Novel Marker for the Evaluation of Disease Severity in the Early Stage of Toxic Epidermal Necrolysis
    S. Karger AG ; 2008
    In:  Dermatology Vol. 217, No. 3 ( 2008), p. 254-259
    Details
    In: Dermatology, S. Karger AG, Vol. 217, No. 3 ( 2008), p. 254-259
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 To evaluate serum lactate dehydrogenase (LDH) and its correlation with skin manifestations in patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). 〈 i 〉 Methods: 〈 /i 〉 Serum LDH levels were measured in 33 patients (17 SJS and 16 TEN), from initial hospital admission to remission stage. 〈 i 〉 Results: 〈 /i 〉 The mean LDH level was 920.82 ± 655.50 U/l in TEN and 595.35 ± 182.03 U/l in SJS (normal range: 218–472). We arbitrarily divided these patients into 2 groups, the first were admitted within 3 days of onset (early stage) and the second after 4 days of onset (late stage). The ratio of early- to late-stage patients was 7:9 in TEN and 7:10 in SJS. The mean LDH level for 7 TEN patients in the early stage was 1,319.14 ± 843.10 U/l, which was significantly higher than that of the SJS group (686.71 ± 171.81 U/l; p 〈 i 〉 = 〈 /i 〉 0.024). In the late-stage patients, the mean levels of TEN and SJS patients were 611.0 ± 160.33 and 531.4 ± 167.89 U/l, respectively; these differences between TEN and SJS were not significant. 〈 i 〉 Conclusion: 〈 /i 〉 Serum LDH levels can be used as a marker of disease severity in the early stage of TEN.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000148255
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482189-8
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  • 6
    Online Resource
    Online Resource
    Phase II Trial of S-1 in Combination with Oxaliplatin in Previously Untreated Patients with Recurrent or Inoperable Biliary Tract Cancer
    S. Karger AG ; 2008
    In:  Chemotherapy Vol. 54, No. 6 ( 2008), p. 479-484
    Details
    In: Chemotherapy, S. Karger AG, Vol. 54, No. 6 ( 2008), p. 479-484
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Biliary tract cancers are among the most aggressive tumors with a poor prognosis. We conducted a phase II study on combination chemotherapy consisting of S-1 and oxaliplatin in previously untreated patients . 〈 i 〉 Methods: 〈 /i 〉 Patients were treated with S-1 40 mg/m 〈 sup 〉 2 〈 /sup 〉 twice daily, administered orally on days 1–28, and 85 mg/m 〈 sup 〉 2 〈 /sup 〉 of oxaliplatin, administered via an intravenous 90-min infusion on days 1, 15 and 29. Treatments were repeated every 6 weeks. 〈 i 〉 Results: 〈 /i 〉 15 patients were enrolled: 9 patients (60%) had intrahepatic and 3 (20%) had extrahepatic cholangiocarcinoma, 2 (13.3%) had cancer of the ampulla of Vater and 1 patient had gall bladder cancer. Partial response was observed in 1 of the 15 (6.7%) patients. Stable disease was observed in 4 patients (26.7%). The median time to progression was 1.4 months (95% confidence interval, CI, 0.9–1.9), and the median overall survival was 3.1 months (95% CI, 0.0–7.0). Grade 3 hematologic toxicities included neutropenia (1, 6.7%) and thrombocytopenia (1, 6.7%). As the response rate in stage I did not justify progression to stage II (≧2/15), this study had to be discontinued in accordance with the established protocols. 〈 i 〉 Conclusion: 〈 /i 〉 The combination chemotherapy with S-1 and oxaliplatin utilized in this study resulted in no promising antitumor activity.
    Type of Medium: Online Resource
    ISSN: 0009-3157 , 1421-9794
    URL: Article
    DOI: 10.1159/000159624
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482111-4
    SSG: 15,3
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  • 7
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    Online Resource
    Increased Serum 90K and Galectin-3 Expression Are Associated with Advanced Stage and a Worse Prognosis in Diffuse Large B-Cell Lymphomas
    S. Karger AG ; 2008
    In:  Acta Haematologica Vol. 120, No. 4 ( 2008), p. 211-216
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 120, No. 4 ( 2008), p. 211-216
    Abstract: The role of 90K and galectin-3 in cell-to-extracellular matrix adhesion and tumor metastasis has been reported, but little is known about their role in the prognosis and extranodal involvement of diffuse large B-cell lymphomas (DLBCL). Thus, we measured serum 90K concentration by enzyme-linked immunosorbent assay and tissue expression of galectin-3 by immunohistochemistry in newly diagnosed DLBCL patients. The mean serum 90K concentration was higher in DLBCL than in healthy controls (1,408.81 ± 89.45 vs. 980.94 ± 58.69 ng/ml, p = 0.036). High serum 90K (median value ≥1,249.50 ng/ml) and high galectin-3 expression (grade 3 positive staining in 〉 75% of cells) showed a significant association with stage III/IV, ≥2 extranodal involvements and risk of high/high-intermediate international prognostic index (p 〈 0.05). The complete response (CR) rate (86.9%, 20/23) in the low 90K group was higher than in the high 90K group (56.5%, 13/23). Among 14 patients with high galectin-3 expression, only 6 patients showed CR (42.9%). The time to progression and overall survival were shorter in the group with high 90K and galectin-3 expression (p 〈 0.05). In conclusion, serum 90K and galectin-3 expression might be useful markers to indicate the extent of lymphoma involvement and prognosis in DLBCL.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000193223
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 8
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    Extended Extrahepatic Bile Duct Resection to Avoid Performing Pancreatoduodenectomy in Patients with Mid Bile Duct Cancer
    S. Karger AG ; 2008
    In:  Digestive Surgery Vol. 25, No. 1 ( 2008), p. 74-79
    Details
    In: Digestive Surgery, S. Karger AG, Vol. 25, No. 1 ( 2008), p. 74-79
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 Since proximal-to-mid bile duct (BD) cancers often involve the proximal portion of the intrapancreatic BD, resection of the extrahepatic BD can result in a tumor-positive distal resection margin. It is essential that a surgical procedure is developed to obtain a tumor-free distal BD resection margin during extrahepatic BD resection, in which R0 resection can be achieved without performing pancreatoduodenectomy. 〈 i 〉 Methods: 〈 /i 〉 Based on preparatory clinicopathological analyses, excavation of the proximal intrapancreatic BD was designed to resemble a 2- to 3-cm-long funnel. The surgical procedure was a combination of the usual extrahepatic BD resection and funnel-shaped excavation of the proximal intrapancreatic BD. 〈 i 〉 Results: 〈 /i 〉 This unique procedure, called extended extrahepatic BD resection, was performed on 3 patients aged over 70 years with mid BD cancer. Deep intrapancreatic BD excavation per se required about 1 h. A tumor-free intrapancreatic BD resection margin was obtained in all 3 patients. Only minor complications occurred. Two patients are doing well without recurrence, at 20 and 14 months, respectively, and one is alive at 12 months with lymph node metastasis detected 1 month earlier. 〈 i 〉 Conclusion: 〈 /i 〉 By achieving R0 resection, this extended extrahepatic BD resection seems to benefit some proximal-to-mid BD cancer patients in whom pancreatoduodenectomy has a high operative risk.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    URL: Article
    DOI: 10.1159/000118025
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1468560-7
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  • 9
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    Cord Blood KL-6, a Specific Lung Injury Marker, Correlates with the Subsequent Development and Severity of Atypical Bronchopulmonary Dysplasia
    S. Karger AG ; 2008
    In:  Neonatology Vol. 93, No. 4 ( 2008), p. 223-229
    Details
    In: Neonatology, S. Karger AG, Vol. 93, No. 4 ( 2008), p. 223-229
    Abstract: 〈 i 〉 Background: 〈 /i 〉 A considerable number of preterm infants may have been exposed to inflammation in utero and may be born with an inflamed lung. 〈 i 〉 Objectives: 〈 /i 〉 To determine the impact of antenatal lung injury and inflammatory response on the pathogenesis of bronchopulmonary dysplasia (BPD) according to its clinical pattern, using KL-6 (as a lung injury marker) and C-reactive protein (CRP) (as a marker of inflammatory response). 〈 i 〉 Methods: 〈 /i 〉 In this case-control study, a total of 74 infants ( 〈 32 weeks of gestation) including BPD with minimal early lung disease (‘atypical’; 21 infants), BPD with significant early lung disease (‘classic’; 29 infants) and the non-BPD (24 infants) groups underwent KL-6 and CRP in cord blood determinations. 〈 i 〉 Results: 〈 /i 〉 The cord plasma KL-6 levels were significantly higher in the atypical and the total BPD groups than in the non-BPD group (median = 60.9 vs. 34.5 U/ml, p = 0.031; 43.5 vs. 34.5 U/ml, p = 0.02). However, the cord plasma CRP levels were not significantly different among the study groups. The cord plasma KL-6 levels in patients with atypical BPD were significantly higher in infants with moderate or severe BPD than in infants with mild BPD (median = 88.3 vs. 41.5 U/ml, p 〈 i 〉 = 〈 /i 〉 0.041) and were found to be significantly correlated with the duration of oxygen therapy (r = 0.502, p 〈 i 〉 = 〈 /i 〉 0.024). 〈 i 〉 Conclusions: 〈 /i 〉 The present study shows that cord plasma KL-6, a specific lung injury marker, is increased and objectively reflects disease severity in atypical BPD.
    Type of Medium: Online Resource
    ISSN: 1661-7800 , 1661-7819
    URL: Article
    DOI: 10.1159/000111100
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 2403535-X
    SSG: 12
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