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  • 1
    Electronic Resource
    Electronic Resource
    A multipurpose, fast scan spectrophotometer for measuring turbid (biological) materials (1997)
    Springer
    Experimental biology online 2 (1997), S. 1-13 
    Details
    ISSN: 1430-3418
    Keywords: Spectrophotometer, fast scan ; light fiber, application ; absorption of turbid materials ; spectrophotometer, software ; absorption measurement, reflection measurement, luminescence measurement, fluorescence measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A new optical spectrophotometer has been developed, based on a recently patented monochromator for spectral measurements of clear and, in particular, of turbid materials in the millisecond time range. The number of optical and mechanical components of the spectrophotometer has been reduced to a minimum, resulting in excellent light throughput, a low stray-light level, low cost, compactness and rigidity. The spectrophotometer has been designed for all kinds of spectral measurements such as absorption, transmission, reflection and luminescence/radiation in a single-beam mode as documented by several examples. In principle, there is no restriction of wavelengths, ranging from UV to NIR and up to the IR range. As many functions as possible are relocated from the hardware to the software part of the design, which allows for extraordinary flexibility and simplicity. An appropriate computer program providing data acquisition, control and calibration functions as well as real-time display of spectra has been developed on the basis of a compiler language; indispensable “fast routines” are written in assembler language.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00898-997-0004-9
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Behavioural pharmacology of the non-competitive NMDA antagonists dextrorphan and ADCI: relations between locomotor stimulation, anticataleptic potential and forebrain dopamine metabolism (1997)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 355 (1997), S. 767-773 
    Details
    ISSN: 1432-1912
    Keywords: Key words N-Methyl-D-aspartate (NMDA) antagonists ; Locomotion ; Stereotypy ; Catalepsy ; Basal ganglia ; Dopamine antagonists ; Dopamine metabolism ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of systemic administration of the non-competitive N-methyl-D-aspartate (NMDA) antagonists dextrorphan (10–40mg/kg, i.p.) and [±]-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cycloheptan-5,10-imine (ADCI) (25–70mg/kg, i.p.) on basal ganglia-mediated behaviour and on forebrain dopamine metabolism were investigated in rats. Dextrorphan increased locomotor activity but did not induce stereotyped sniffing. ADCI failed to produce any significant motor stimulant and motor depressant actions. Both dextrorphan and ADCI dose-dependently antagonized catalepsy induced by the D-1 dopamine receptor antagonist SCH 23390 or the D-2 dopamine receptor antagonist haloperidol. Only the highest doses of dextrorphan and ADCI increased dopamine metabolism in the prefrontal cortex and/or in the nucleus accumbens, but not in the dorsal striatum. Our results show that dextrorphan and ADCI produce some of the behavioural effects (antagonism of experimentally induced catalepsy) and neurochemical actions (regionally selective stimulation of dopamine metabolism) that have previously been observed in the prototypical non-competitive NMDA antagonist, dizocilpine. The failure of ADCI to induce hyperlocomotion and stereotypy suggests that anticataleptic doses of ADCI may be devoid of the psychotomimetic actions commonly associated with non-competitive blockade of NMDA receptor function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005011
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  • 3
    Electronic Resource
    Electronic Resource
    Regioselective oxidative phenol couplings of 2,3′,4,6-tetrahydroxybenzophenone in cell cultures of Centaurium erythraea RAFN and Hypericum androsaemum L. (1997)
    Springer
    Planta 204 (1997), S. 64-69 
    Details
    ISSN: 1432-2048
    Keywords: Key words:Centaurium (cell cultures) ; Benzophenone cyclization (2 ; 3′ ; 4 ; 6-tetrahydroxybenzophenone) ; Cyto-chrome P450 oxidase ; Hypericum (cell cultures) ; Oxidative phenol coupling (regioselective couplings) ; Xanthone synthase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. A crucial step in plant xanthone biosynthesis is the cyclization of an intermediate benzophenone to a xanthone. In cultured cells of Centaurium erythraea RAFN, 2,3′,4,6-tetrahydroxybenzophenone (THBP) was shown to be intramolecularly coupled to 1,3,5-trihydroxyxanthone, whereas in cell cultures of Hypericum androsaemum L. it was coupled to form the isomeric 1,3,7-trihydroxyxanthone. These regioselective cyclizations that occur ortho and para, respectively, to the 3′-hydroxy group of the benzophenone depend on cytochrome P 450, as shown by the effectiveness of established P 450 inhibitors and blue-light-reversible carbon monoxide inhibition. Furthermore, the reactions absolutely require NADPH and O2. The underlying reaction mechanism is probably an oxidative phenol coupling that is catalyzed regioselectively by xanthone synthases. These enzymes are proposed to be cytochrome P 450 oxidases. The intramolecular cyclizations of THBP to 1,3,5- and 1,3,7-trihydroxyxanthones catalyzed by the two xanthone synthases represent an important branch point in the plant xanthone biosynthetic pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004250050230
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    Paper (German National Licenses)
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