ISSN:
1573-7276
Keywords:
metastasis
;
microvessel density
;
ovarian carcinoma
;
proto-oncogenes
;
resistance-related proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Relationships between the incidence of metastatic spread and microvessel density, expression of proto-oncogene products, or expression of resistance-related proteins were investigated in human ovarian carcinomas by immunohistochemistry. Ovarian carcinomas with a high microvessel density showed a significantly increased formation of metastases (P=0.005). Tumors with positive immunoreactivity of c-jun and c-myc products had a higher metastatic spread; however, these results were not statistically significant. A marginally significant correlation existed between the expression of erbB1 (EGFR) and metastatic spread (P=0.05). No significant relationship was found between the expression of the resistance-related proteins P-glycoprotein or glutathione S-transferase-π and the incidence of metastases. Furthermore, no correlation was detected between expression of the heat shock protein 70 and the occurrence of metastases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00053893
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