ISSN:
1573-4986
Keywords:
glycophospholipids
;
ceramide-1-phosphate sugars
;
azidosphingosine-1-phosphate sugars
;
glycosyl phosphite
;
glycosyl phosphate
;
O-glycosyl trichloroacetimidate
;
N-acetylneuraminic acid (Neu5Ac)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Ceramide-1-phosphate sugars were synthesized by direct glycosyl phosphite/phosphate andO-glycosyl trichloroacetimidate/phosphate exchange reactions, respectively. Thus, ceramide-1-O-phosphoric acid 5 gave with sialyl phosphite1 as sialyl donor directly β-linked sialyl phosphate6; deprotection afforded the corresponding glycophospholipid ceramide-1-phosphateN-acetylneuraminate7. Similarly, fromO-glucosyl- andO-galactosyltrichloroacetimidate10 and13 with phosphoric acid derivative5 glycosyl ceramide-1-phosphate sugars12 and15, respectively, were obtained.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00731442
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